GPN-loop GTPase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

GPN-loop GTPase

Gene product:

XPA-interacting protein - putative

Species:

Leishmania infantum

UniProt:

A4HVQ6_LEIIN

TriTrypDb:

LINF_130018000

Length:

327

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	12
GO:0005737	cytoplasm	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

A4HVQ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVQ6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0003924	GTPase activity	7	12
GO:0005488	binding	1	12
GO:0005525	GTP binding	5	12
GO:0016462	pyrophosphatase activity	5	12
GO:0016787	hydrolase activity	2	12
GO:0016817	hydrolase activity, acting on acid anhydrides	3	12
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	12
GO:0017076	purine nucleotide binding	4	12
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	12
GO:0019001	guanyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032561	guanyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	18	22	PF00656	0.452
CLV_C14_Caspase3-7	75	79	PF00656	0.526
CLV_NRD_NRD_1	224	226	PF00675	0.600
CLV_NRD_NRD_1	230	232	PF00675	0.627
CLV_PCSK_KEX2_1	224	226	PF00082	0.600
CLV_PCSK_KEX2_1	230	232	PF00082	0.627
DEG_SPOP_SBC_1	15	19	PF00917	0.447
DEG_SPOP_SBC_1	2	6	PF00917	0.613
DOC_CKS1_1	127	132	PF01111	0.429
DOC_MAPK_DCC_7	186	194	PF00069	0.495
DOC_MAPK_HePTP_8	183	195	PF00069	0.429
DOC_MAPK_MEF2A_6	186	195	PF00069	0.429
DOC_USP7_MATH_1	223	227	PF00917	0.623
DOC_USP7_MATH_1	256	260	PF00917	0.711
DOC_USP7_MATH_1	293	297	PF00917	0.342
DOC_USP7_MATH_1	301	305	PF00917	0.404
DOC_USP7_MATH_1	322	326	PF00917	0.571
DOC_USP7_MATH_1	49	53	PF00917	0.388
DOC_USP7_MATH_1	8	12	PF00917	0.648
DOC_WW_Pin1_4	10	15	PF00397	0.691
DOC_WW_Pin1_4	126	131	PF00397	0.429
DOC_WW_Pin1_4	166	171	PF00397	0.474
DOC_WW_Pin1_4	21	26	PF00397	0.363
DOC_WW_Pin1_4	65	70	PF00397	0.533
LIG_14-3-3_CanoR_1	165	170	PF00244	0.495
LIG_EH1_1	108	116	PF00400	0.440
LIG_FHA_1	153	159	PF00498	0.443
LIG_FHA_1	196	202	PF00498	0.454
LIG_FHA_1	21	27	PF00498	0.480
LIG_FHA_1	37	43	PF00498	0.405
LIG_FHA_1	49	55	PF00498	0.440
LIG_FHA_2	16	22	PF00498	0.465
LIG_HP1_1	25	29	PF01393	0.322
LIG_LIR_Gen_1	121	130	PF02991	0.430
LIG_LIR_Gen_1	285	295	PF02991	0.448
LIG_LIR_Gen_1	56	65	PF02991	0.472
LIG_LIR_Nem_3	121	127	PF02991	0.430
LIG_LIR_Nem_3	147	152	PF02991	0.485
LIG_LIR_Nem_3	285	290	PF02991	0.478
LIG_LIR_Nem_3	56	61	PF02991	0.472
LIG_LIR_Nem_3	79	85	PF02991	0.442
LIG_Pex14_2	282	286	PF04695	0.410
LIG_SH2_CRK	292	296	PF00017	0.457
LIG_SH2_NCK_1	292	296	PF00017	0.397
LIG_SH2_STAT5	57	60	PF00017	0.440
LIG_SH3_3	124	130	PF00018	0.440
LIG_SH3_3	164	170	PF00018	0.526
LIG_SH3_3	217	223	PF00018	0.526
LIG_SUMO_SIM_anti_2	23	30	PF11976	0.445
LIG_SUMO_SIM_par_1	110	116	PF11976	0.472
LIG_TRFH_1	89	93	PF08558	0.440
LIG_TYR_ITIM	290	295	PF00017	0.457
LIG_TYR_ITIM	80	85	PF00017	0.429
MOD_CK1_1	169	175	PF00069	0.454
MOD_CK1_1	202	208	PF00069	0.526
MOD_CK1_1	226	232	PF00069	0.662
MOD_CK1_1	296	302	PF00069	0.438
MOD_CK2_1	110	116	PF00069	0.454
MOD_GlcNHglycan	10	13	PF01048	0.722
MOD_GlcNHglycan	138	141	PF01048	0.229
MOD_GlcNHglycan	18	21	PF01048	0.507
MOD_GlcNHglycan	180	183	PF01048	0.332
MOD_GlcNHglycan	201	204	PF01048	0.326
MOD_GlcNHglycan	233	236	PF01048	0.691
MOD_GlcNHglycan	295	298	PF01048	0.339
MOD_GlcNHglycan	324	327	PF01048	0.499
MOD_GlcNHglycan	51	54	PF01048	0.285
MOD_GlcNHglycan	6	9	PF01048	0.642
MOD_GSK3_1	134	141	PF00069	0.441
MOD_GSK3_1	16	23	PF00069	0.606
MOD_GSK3_1	165	172	PF00069	0.497
MOD_GSK3_1	173	180	PF00069	0.469
MOD_GSK3_1	195	202	PF00069	0.436
MOD_GSK3_1	267	274	PF00069	0.482
MOD_GSK3_1	33	40	PF00069	0.458
MOD_GSK3_1	4	11	PF00069	0.685
MOD_GSK3_1	49	56	PF00069	0.477
MOD_N-GLC_1	195	200	PF02516	0.229
MOD_N-GLC_1	226	231	PF02516	0.693
MOD_NEK2_1	1	6	PF00069	0.642
MOD_NEK2_1	103	108	PF00069	0.429
MOD_NEK2_1	136	141	PF00069	0.429
MOD_NEK2_1	173	178	PF00069	0.429
MOD_NEK2_1	275	280	PF00069	0.353
MOD_NEK2_1	33	38	PF00069	0.440
MOD_PIKK_1	256	262	PF00454	0.667
MOD_PKA_1	118	124	PF00069	0.491
MOD_PKA_2	223	229	PF00069	0.643
MOD_PKA_2	76	82	PF00069	0.429
MOD_Plk_4	110	116	PF00069	0.528
MOD_Plk_4	152	158	PF00069	0.441
MOD_Plk_4	169	175	PF00069	0.429
MOD_Plk_4	202	208	PF00069	0.473
MOD_Plk_4	277	283	PF00069	0.395
MOD_Plk_4	37	43	PF00069	0.440
MOD_ProDKin_1	10	16	PF00069	0.690
MOD_ProDKin_1	126	132	PF00069	0.429
MOD_ProDKin_1	166	172	PF00069	0.474
MOD_ProDKin_1	21	27	PF00069	0.350
MOD_ProDKin_1	65	71	PF00069	0.533
TRG_ENDOCYTIC_2	287	290	PF00928	0.373
TRG_ENDOCYTIC_2	292	295	PF00928	0.323
TRG_ENDOCYTIC_2	82	85	PF00928	0.429
TRG_ER_diArg_1	223	225	PF00400	0.488

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0Y6	Leptomonas seymouri	77%	99%
A0A0N1PCL7	Leptomonas seymouri	28%	100%
A0A0S4IST9	Bodo saltans	49%	95%
A0A1X0NNH8	Trypanosomatidae	55%	100%
A0A3R7KPX1	Trypanosoma rangeli	59%	100%
A0A3S7WSM7	Leishmania donovani	100%	100%
A0A3S7WZ40	Leishmania donovani	31%	100%
A4FUD1	Bos taurus	41%	88%
A4H7B1	Leishmania braziliensis	89%	100%
A4HEQ4	Leishmania braziliensis	25%	98%
A4I1I3	Leishmania infantum	31%	100%
D0A6I5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9APF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
E9AXL8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
O42906	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	41%	89%
P46577	Caenorhabditis elegans	39%	92%
P47122	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	44%	85%
Q4IQT8	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	25%	100%
Q4Q9V4	Leishmania major	30%	100%
Q4QG26	Leishmania major	95%	100%
Q54C25	Dictyostelium discoideum	44%	83%
Q54TE7	Dictyostelium discoideum	25%	100%
Q56XY2	Arabidopsis thaliana	27%	100%
Q8VCE2	Mus musculus	41%	88%
Q8W586	Arabidopsis thaliana	43%	86%
Q9HCN4	Homo sapiens	42%	87%
V5A2Y8	Trypanosoma cruzi	60%	98%