DNA/RNA non-specific endonuclease-like protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA/RNA non-specific endonuclease-like protein

Species:

Leishmania infantum

UniProt:

A4HVQ5_LEIIN

TriTrypDb:

LINF_130017900

Length:

880

Annotations

Annotations by Jardim et al.

Nucleases, DNA/RNA non-specific endonuclease-like

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3
GO:0005634	nucleus	5	1
GO:0005743	mitochondrial inner membrane	5	1
GO:0019866	organelle inner membrane	4	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HVQ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVQ5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	6
GO:0003824	catalytic activity	1	6
GO:0004518	nuclease activity	4	6
GO:0004519	endonuclease activity	5	6
GO:0005488	binding	1	6
GO:0016787	hydrolase activity	2	6
GO:0016788	hydrolase activity, acting on ester bonds	3	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6
GO:0097159	organic cyclic compound binding	2	6
GO:1901363	heterocyclic compound binding	2	6
GO:0000014	single-stranded DNA endodeoxyribonuclease activity	6	1
GO:0004520	DNA endonuclease activity	5	1
GO:0004521	RNA endonuclease activity	5	1
GO:0004536	DNA nuclease activity	4	1
GO:0004540	RNA nuclease activity	4	1
GO:0140097	catalytic activity, acting on DNA	3	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	837	841	PF00656	0.475
CLV_NRD_NRD_1	112	114	PF00675	0.547
CLV_NRD_NRD_1	177	179	PF00675	0.689
CLV_NRD_NRD_1	212	214	PF00675	0.675
CLV_NRD_NRD_1	227	229	PF00675	0.713
CLV_NRD_NRD_1	398	400	PF00675	0.528
CLV_NRD_NRD_1	417	419	PF00675	0.406
CLV_NRD_NRD_1	497	499	PF00675	0.674
CLV_NRD_NRD_1	538	540	PF00675	0.694
CLV_NRD_NRD_1	63	65	PF00675	0.450
CLV_NRD_NRD_1	700	702	PF00675	0.725
CLV_NRD_NRD_1	765	767	PF00675	0.640
CLV_NRD_NRD_1	784	786	PF00675	0.707
CLV_PCSK_FUR_1	396	400	PF00082	0.528
CLV_PCSK_FUR_1	781	785	PF00082	0.682
CLV_PCSK_KEX2_1	112	114	PF00082	0.547
CLV_PCSK_KEX2_1	177	179	PF00082	0.689
CLV_PCSK_KEX2_1	212	214	PF00082	0.717
CLV_PCSK_KEX2_1	227	229	PF00082	0.713
CLV_PCSK_KEX2_1	295	297	PF00082	0.722
CLV_PCSK_KEX2_1	398	400	PF00082	0.528
CLV_PCSK_KEX2_1	417	419	PF00082	0.406
CLV_PCSK_KEX2_1	538	540	PF00082	0.691
CLV_PCSK_KEX2_1	565	567	PF00082	0.732
CLV_PCSK_KEX2_1	63	65	PF00082	0.454
CLV_PCSK_KEX2_1	652	654	PF00082	0.574
CLV_PCSK_KEX2_1	699	701	PF00082	0.738
CLV_PCSK_KEX2_1	765	767	PF00082	0.640
CLV_PCSK_KEX2_1	781	783	PF00082	0.710
CLV_PCSK_KEX2_1	784	786	PF00082	0.696
CLV_PCSK_PC1ET2_1	295	297	PF00082	0.770
CLV_PCSK_PC1ET2_1	565	567	PF00082	0.732
CLV_PCSK_PC1ET2_1	652	654	PF00082	0.574
CLV_PCSK_PC7_1	291	297	PF00082	0.648
CLV_PCSK_SKI1_1	112	116	PF00082	0.519
CLV_PCSK_SKI1_1	186	190	PF00082	0.776
CLV_PCSK_SKI1_1	353	357	PF00082	0.685
CLV_PCSK_SKI1_1	402	406	PF00082	0.513
CLV_PCSK_SKI1_1	756	760	PF00082	0.584
DEG_APCC_DBOX_1	190	198	PF00400	0.518
DEG_APCC_DBOX_1	252	260	PF00400	0.465
DEG_SCF_FBW7_1	133	138	PF00400	0.687
DEG_SPOP_SBC_1	516	520	PF00917	0.495
DOC_ANK_TNKS_1	600	607	PF00023	0.489
DOC_ANK_TNKS_1	870	877	PF00023	0.419
DOC_CKS1_1	132	137	PF01111	0.689
DOC_CYCLIN_RxL_1	109	117	PF00134	0.635
DOC_CYCLIN_RxL_1	475	485	PF00134	0.298
DOC_CYCLIN_yCln2_LP_2	16	22	PF00134	0.231
DOC_CYCLIN_yCln2_LP_2	197	203	PF00134	0.512
DOC_CYCLIN_yCln2_LP_2	259	265	PF00134	0.478
DOC_MAPK_gen_1	186	196	PF00069	0.512
DOC_MAPK_gen_1	250	259	PF00069	0.471
DOC_MAPK_gen_1	396	406	PF00069	0.345
DOC_MAPK_gen_1	541	551	PF00069	0.434
DOC_MAPK_gen_1	636	644	PF00069	0.425
DOC_MAPK_gen_1	652	659	PF00069	0.428
DOC_MAPK_HePTP_8	43	55	PF00069	0.263
DOC_MAPK_JIP1_4	253	259	PF00069	0.468
DOC_MAPK_MEF2A_6	357	366	PF00069	0.359
DOC_MAPK_MEF2A_6	46	55	PF00069	0.238
DOC_MAPK_MEF2A_6	638	646	PF00069	0.360
DOC_MAPK_MEF2A_6	8	16	PF00069	0.422
DOC_MAPK_MEF2A_6	847	854	PF00069	0.419
DOC_PP1_RVXF_1	275	282	PF00149	0.551
DOC_PP1_RVXF_1	39	46	PF00149	0.245
DOC_PP1_RVXF_1	400	407	PF00149	0.313
DOC_PP2B_LxvP_1	102	105	PF13499	0.606
DOC_PP2B_LxvP_1	25	28	PF13499	0.220
DOC_PP2B_LxvP_1	364	367	PF13499	0.380
DOC_PP2B_LxvP_1	587	590	PF13499	0.434
DOC_PP2B_LxvP_1	723	726	PF13499	0.383
DOC_PP2B_LxvP_1	744	747	PF13499	0.382
DOC_PP4_FxxP_1	550	553	PF00568	0.479
DOC_USP7_MATH_1	135	139	PF00917	0.694
DOC_USP7_MATH_1	142	146	PF00917	0.640
DOC_USP7_MATH_1	219	223	PF00917	0.439
DOC_USP7_MATH_1	263	267	PF00917	0.501
DOC_USP7_MATH_1	294	298	PF00917	0.493
DOC_USP7_MATH_1	301	305	PF00917	0.444
DOC_USP7_MATH_1	435	439	PF00917	0.328
DOC_USP7_MATH_1	516	520	PF00917	0.519
DOC_USP7_MATH_1	564	568	PF00917	0.490
DOC_USP7_MATH_1	577	581	PF00917	0.326
DOC_USP7_MATH_1	627	631	PF00917	0.436
DOC_USP7_MATH_1	676	680	PF00917	0.488
DOC_USP7_MATH_1	719	723	PF00917	0.436
DOC_USP7_MATH_1	764	768	PF00917	0.525
DOC_USP7_MATH_1	772	776	PF00917	0.384
DOC_USP7_MATH_1	802	806	PF00917	0.388
DOC_USP7_MATH_1	848	852	PF00917	0.504
DOC_USP7_MATH_1	92	96	PF00917	0.687
DOC_WW_Pin1_4	131	136	PF00397	0.697
DOC_WW_Pin1_4	138	143	PF00397	0.680
DOC_WW_Pin1_4	15	20	PF00397	0.238
DOC_WW_Pin1_4	196	201	PF00397	0.560
DOC_WW_Pin1_4	258	263	PF00397	0.474
DOC_WW_Pin1_4	358	363	PF00397	0.431
DOC_WW_Pin1_4	36	41	PF00397	0.407
DOC_WW_Pin1_4	439	444	PF00397	0.298
DOC_WW_Pin1_4	549	554	PF00397	0.473
DOC_WW_Pin1_4	669	674	PF00397	0.540
DOC_WW_Pin1_4	704	709	PF00397	0.555
DOC_WW_Pin1_4	71	76	PF00397	0.639
DOC_WW_Pin1_4	710	715	PF00397	0.519
DOC_WW_Pin1_4	8	13	PF00397	0.599
DOC_WW_Pin1_4	93	98	PF00397	0.611
LIG_14-3-3_CanoR_1	181	190	PF00244	0.488
LIG_14-3-3_CanoR_1	213	223	PF00244	0.475
LIG_14-3-3_CanoR_1	368	374	PF00244	0.278
LIG_14-3-3_CanoR_1	380	384	PF00244	0.260
LIG_14-3-3_CanoR_1	402	407	PF00244	0.328
LIG_14-3-3_CanoR_1	541	551	PF00244	0.517
LIG_14-3-3_CanoR_1	63	72	PF00244	0.653
LIG_14-3-3_CanoR_1	663	673	PF00244	0.453
LIG_14-3-3_CanoR_1	784	794	PF00244	0.471
LIG_14-3-3_CanoR_1	855	861	PF00244	0.420
LIG_Actin_WH2_2	47	65	PF00022	0.263
LIG_BRCT_BRCA1_1	313	317	PF00533	0.451
LIG_BRCT_BRCA1_1	41	45	PF00533	0.222
LIG_BRCT_BRCA1_1	546	550	PF00533	0.486
LIG_BRCT_BRCA1_1	774	778	PF00533	0.439
LIG_CSL_BTD_1	624	627	PF09270	0.431
LIG_deltaCOP1_diTrp_1	620	626	PF00928	0.443
LIG_FHA_1	154	160	PF00498	0.380
LIG_FHA_1	224	230	PF00498	0.479
LIG_FHA_1	281	287	PF00498	0.493
LIG_FHA_1	288	294	PF00498	0.476
LIG_FHA_1	306	312	PF00498	0.499
LIG_FHA_1	501	507	PF00498	0.553
LIG_FHA_1	508	514	PF00498	0.571
LIG_FHA_1	652	658	PF00498	0.448
LIG_FHA_1	670	676	PF00498	0.612
LIG_FHA_1	757	763	PF00498	0.409
LIG_FHA_1	808	814	PF00498	0.385
LIG_FHA_2	182	188	PF00498	0.462
LIG_FHA_2	273	279	PF00498	0.483
LIG_FHA_2	64	70	PF00498	0.633
LIG_FHA_2	835	841	PF00498	0.520
LIG_HCF-1_HBM_1	117	120	PF13415	0.638
LIG_LIR_Apic_2	187	193	PF02991	0.493
LIG_LIR_Apic_2	547	553	PF02991	0.483
LIG_LIR_Apic_2	710	714	PF02991	0.480
LIG_LIR_Gen_1	856	864	PF02991	0.478
LIG_LIR_Gen_1	98	108	PF02991	0.589
LIG_LIR_LC3C_4	805	808	PF02991	0.376
LIG_LIR_Nem_3	208	214	PF02991	0.500
LIG_LIR_Nem_3	372	378	PF02991	0.274
LIG_LIR_Nem_3	382	387	PF02991	0.266
LIG_LIR_Nem_3	42	48	PF02991	0.231
LIG_LIR_Nem_3	727	733	PF02991	0.449
LIG_LIR_Nem_3	856	861	PF02991	0.558
LIG_LIR_Nem_3	98	103	PF02991	0.642
LIG_NRBOX	21	27	PF00104	0.263
LIG_PAM2_1	196	208	PF00658	0.474
LIG_PCNA_yPIPBox_3	460	470	PF02747	0.323
LIG_Pex14_1	384	388	PF04695	0.328
LIG_Pex14_2	730	734	PF04695	0.345
LIG_REV1ctd_RIR_1	404	414	PF16727	0.328
LIG_RPA_C_Fungi	761	773	PF08784	0.445
LIG_SH2_CRK	190	194	PF00017	0.771
LIG_SH2_CRK	375	379	PF00017	0.380
LIG_SH2_NCK_1	375	379	PF00017	0.380
LIG_SH2_SRC	375	378	PF00017	0.380
LIG_SH2_STAT3	477	480	PF00017	0.327
LIG_SH2_STAT5	120	123	PF00017	0.577
LIG_SH2_STAT5	183	186	PF00017	0.569
LIG_SH2_STAT5	388	391	PF00017	0.511
LIG_SH2_STAT5	477	480	PF00017	0.380
LIG_SH3_2	144	149	PF14604	0.620
LIG_SH3_3	141	147	PF00018	0.606
LIG_SH3_3	680	686	PF00018	0.558
LIG_SH3_3	69	75	PF00018	0.647
LIG_SH3_3	711	717	PF00018	0.690
LIG_SH3_3	744	750	PF00018	0.520
LIG_SH3_3	91	97	PF00018	0.557
LIG_SUMO_SIM_par_1	10	18	PF11976	0.231
LIG_SUMO_SIM_par_1	34	39	PF11976	0.518
LIG_SUMO_SIM_par_1	809	814	PF11976	0.433
LIG_SUMO_SIM_par_1	819	826	PF11976	0.356
LIG_TRFH_1	100	104	PF08558	0.531
LIG_TRFH_1	24	28	PF08558	0.231
LIG_TRFH_1	858	862	PF08558	0.526
LIG_TYR_ITIM	373	378	PF00017	0.380
LIG_WW_3	527	531	PF00397	0.634
MOD_CDC14_SPxK_1	261	264	PF00782	0.584
MOD_CDC14_SPxK_1	552	555	PF00782	0.587
MOD_CDK_SPK_2	36	41	PF00069	0.489
MOD_CDK_SPxK_1	258	264	PF00069	0.564
MOD_CDK_SPxK_1	549	555	PF00069	0.624
MOD_CK1_1	137	143	PF00069	0.647
MOD_CK1_1	252	258	PF00069	0.627
MOD_CK1_1	266	272	PF00069	0.601
MOD_CK1_1	304	310	PF00069	0.578
MOD_CK1_1	39	45	PF00069	0.231
MOD_CK1_1	545	551	PF00069	0.542
MOD_CK1_1	567	573	PF00069	0.593
MOD_CK1_1	666	672	PF00069	0.554
MOD_CK1_1	707	713	PF00069	0.689
MOD_CK1_1	777	783	PF00069	0.574
MOD_CK1_1	792	798	PF00069	0.428
MOD_CK1_1	81	87	PF00069	0.572
MOD_CK1_1	838	844	PF00069	0.623
MOD_CK1_1	95	101	PF00069	0.537
MOD_CK2_1	181	187	PF00069	0.607
MOD_CK2_1	219	225	PF00069	0.569
MOD_CK2_1	272	278	PF00069	0.617
MOD_CK2_1	509	515	PF00069	0.551
MOD_CK2_1	63	69	PF00069	0.556
MOD_CK2_1	806	812	PF00069	0.443
MOD_CK2_1	817	823	PF00069	0.470
MOD_CMANNOS	621	624	PF00535	0.582
MOD_Cter_Amidation	536	539	PF01082	0.569
MOD_GlcNHglycan	217	220	PF01048	0.572
MOD_GlcNHglycan	269	272	PF01048	0.603
MOD_GlcNHglycan	296	299	PF01048	0.658
MOD_GlcNHglycan	313	316	PF01048	0.533
MOD_GlcNHglycan	342	345	PF01048	0.602
MOD_GlcNHglycan	353	356	PF01048	0.565
MOD_GlcNHglycan	544	547	PF01048	0.612
MOD_GlcNHglycan	569	572	PF01048	0.589
MOD_GlcNHglycan	593	596	PF01048	0.622
MOD_GlcNHglycan	629	632	PF01048	0.624
MOD_GlcNHglycan	829	832	PF01048	0.518
MOD_GSK3_1	131	138	PF00069	0.653
MOD_GSK3_1	169	176	PF00069	0.581
MOD_GSK3_1	215	222	PF00069	0.585
MOD_GSK3_1	263	270	PF00069	0.721
MOD_GSK3_1	301	308	PF00069	0.603
MOD_GSK3_1	311	318	PF00069	0.511
MOD_GSK3_1	342	349	PF00069	0.617
MOD_GSK3_1	408	415	PF00069	0.348
MOD_GSK3_1	435	442	PF00069	0.518
MOD_GSK3_1	507	514	PF00069	0.639
MOD_GSK3_1	545	552	PF00069	0.567
MOD_GSK3_1	591	598	PF00069	0.580
MOD_GSK3_1	63	70	PF00069	0.540
MOD_GSK3_1	658	665	PF00069	0.650
MOD_GSK3_1	78	85	PF00069	0.578
MOD_GSK3_1	785	792	PF00069	0.640
MOD_GSK3_1	798	805	PF00069	0.392
MOD_GSK3_1	823	830	PF00069	0.470
MOD_GSK3_1	831	838	PF00069	0.406
MOD_LATS_1	265	271	PF00433	0.659
MOD_LATS_1	61	67	PF00433	0.518
MOD_N-GLC_1	8	13	PF02516	0.449
MOD_N-GLC_2	401	403	PF02516	0.316
MOD_NEK2_1	150	155	PF00069	0.443
MOD_NEK2_1	173	178	PF00069	0.531
MOD_NEK2_1	214	219	PF00069	0.581
MOD_NEK2_1	29	34	PF00069	0.498
MOD_NEK2_1	311	316	PF00069	0.562
MOD_NEK2_1	412	417	PF00069	0.380
MOD_NEK2_1	62	67	PF00069	0.537
MOD_NEK2_1	729	734	PF00069	0.401
MOD_NEK2_1	806	811	PF00069	0.497
MOD_NEK2_1	817	822	PF00069	0.460
MOD_NEK2_2	719	724	PF00069	0.447
MOD_NMyristoyl	1	7	PF02799	0.432
MOD_PIKK_1	142	148	PF00454	0.584
MOD_PIKK_1	181	187	PF00454	0.607
MOD_PIKK_1	517	523	PF00454	0.681
MOD_PIKK_1	63	69	PF00454	0.501
MOD_PKA_1	498	504	PF00069	0.538
MOD_PKA_1	565	571	PF00069	0.629
MOD_PKA_1	63	69	PF00069	0.548
MOD_PKA_1	765	771	PF00069	0.512
MOD_PKA_2	249	255	PF00069	0.636
MOD_PKA_2	263	269	PF00069	0.607
MOD_PKA_2	272	278	PF00069	0.532
MOD_PKA_2	304	310	PF00069	0.655
MOD_PKA_2	320	326	PF00069	0.467
MOD_PKA_2	379	385	PF00069	0.333
MOD_PKA_2	390	396	PF00069	0.295
MOD_PKA_2	565	571	PF00069	0.605
MOD_PKA_2	577	583	PF00069	0.408
MOD_PKA_2	62	68	PF00069	0.558
MOD_PKA_2	662	668	PF00069	0.598
MOD_PKA_2	764	770	PF00069	0.571
MOD_PKA_2	786	792	PF00069	0.620
MOD_PKA_2	838	844	PF00069	0.623
MOD_PKB_1	496	504	PF00069	0.534
MOD_PKB_1	783	791	PF00069	0.589
MOD_PKB_1	825	833	PF00069	0.505
MOD_Plk_1	408	414	PF00069	0.380
MOD_Plk_4	169	175	PF00069	0.423
MOD_Plk_4	205	211	PF00069	0.571
MOD_Plk_4	252	258	PF00069	0.623
MOD_Plk_4	29	35	PF00069	0.487
MOD_Plk_4	379	385	PF00069	0.409
MOD_Plk_4	545	551	PF00069	0.525
MOD_Plk_4	719	725	PF00069	0.535
MOD_Plk_4	817	823	PF00069	0.448
MOD_Plk_4	95	101	PF00069	0.565
MOD_ProDKin_1	131	137	PF00069	0.616
MOD_ProDKin_1	138	144	PF00069	0.589
MOD_ProDKin_1	15	21	PF00069	0.238
MOD_ProDKin_1	196	202	PF00069	0.703
MOD_ProDKin_1	258	264	PF00069	0.592
MOD_ProDKin_1	358	364	PF00069	0.510
MOD_ProDKin_1	36	42	PF00069	0.490
MOD_ProDKin_1	439	445	PF00069	0.337
MOD_ProDKin_1	549	555	PF00069	0.583
MOD_ProDKin_1	669	675	PF00069	0.675
MOD_ProDKin_1	704	710	PF00069	0.699
MOD_ProDKin_1	71	77	PF00069	0.534
MOD_ProDKin_1	8	14	PF00069	0.479
MOD_ProDKin_1	93	99	PF00069	0.494
TRG_DiLeu_BaEn_1	740	745	PF01217	0.453
TRG_DiLeu_BaLyEn_6	110	115	PF01217	0.571
TRG_DiLeu_BaLyEn_6	359	364	PF01217	0.539
TRG_DiLeu_BaLyEn_6	582	587	PF01217	0.460
TRG_DiLeu_BaLyEn_6	683	688	PF01217	0.555
TRG_DiLeu_BaLyEn_6	9	14	PF01217	0.449
TRG_ENDOCYTIC_2	375	378	PF00928	0.380
TRG_ER_diArg_1	112	114	PF00400	0.538
TRG_ER_diArg_1	211	213	PF00400	0.587
TRG_ER_diArg_1	227	229	PF00400	0.638
TRG_ER_diArg_1	396	399	PF00400	0.380
TRG_ER_diArg_1	417	419	PF00400	0.378
TRG_ER_diArg_1	538	541	PF00400	0.630
TRG_ER_diArg_1	62	64	PF00400	0.548
TRG_ER_diArg_1	691	694	PF00400	0.555
TRG_ER_diArg_1	699	701	PF00400	0.595
TRG_ER_diArg_1	781	784	PF00400	0.632
TRG_ER_diArg_1	824	827	PF00400	0.454
TRG_ER_diArg_1	864	867	PF00400	0.626
TRG_NES_CRM1_1	797	812	PF08389	0.425
TRG_Pf-PMV_PEXEL_1	112	117	PF00026	0.581
TRG_Pf-PMV_PEXEL_1	245	249	PF00026	0.598
TRG_Pf-PMV_PEXEL_1	574	579	PF00026	0.521

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8I9Q8	Leishmania donovani	100%	100%
A4H7B0	Leishmania braziliensis	64%	100%
E9APF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	99%
Q4QG27	Leishmania major	86%	100%