Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Thiamin pyrophosphokinase - vitamin B1 binding domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4HVQ2_LEIIN

TriTrypDb:

LINF_130017400

Length:

543

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HVQ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVQ2

Function

Biological processes
Term	Name	Level	Count
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006766	vitamin metabolic process	3	11
GO:0006767	water-soluble vitamin metabolic process	4	11
GO:0006790	sulfur compound metabolic process	3	11
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009110	vitamin biosynthetic process	4	11
GO:0009229	thiamine diphosphate biosynthetic process	5	11
GO:0009987	cellular process	1	11
GO:0018130	heterocycle biosynthetic process	4	11
GO:0019438	aromatic compound biosynthetic process	4	11
GO:0019637	organophosphate metabolic process	3	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0042357	thiamine diphosphate metabolic process	4	11
GO:0042364	water-soluble vitamin biosynthetic process	5	11
GO:0042723	thiamine-containing compound metabolic process	4	11
GO:0042724	thiamine-containing compound biosynthetic process	5	11
GO:0044237	cellular metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11
GO:0044271	cellular nitrogen compound biosynthetic process	4	11
GO:0044272	sulfur compound biosynthetic process	4	11
GO:0044281	small molecule metabolic process	2	11
GO:0044283	small molecule biosynthetic process	3	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0072527	pyrimidine-containing compound metabolic process	4	11
GO:0072528	pyrimidine-containing compound biosynthetic process	5	11
GO:0090407	organophosphate biosynthetic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:1901362	organic cyclic compound biosynthetic process	4	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:1901566	organonitrogen compound biosynthetic process	4	11
GO:1901576	organic substance biosynthetic process	3	11
GO:0016310	phosphorylation	5	9

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0004788	thiamine diphosphokinase activity	5	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016778	diphosphotransferase activity	4	11
GO:0017076	purine nucleotide binding	4	11
GO:0019842	vitamin binding	3	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0030975	thiamine binding	3	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0043169	cation binding	3	11
GO:0043178	alcohol binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11
GO:1901681	sulfur compound binding	2	11
GO:0016301	kinase activity	4	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	167	171	PF00656	0.430
CLV_NRD_NRD_1	18	20	PF00675	0.401
CLV_NRD_NRD_1	186	188	PF00675	0.627
CLV_NRD_NRD_1	220	222	PF00675	0.522
CLV_NRD_NRD_1	329	331	PF00675	0.388
CLV_PCSK_FUR_1	218	222	PF00082	0.520
CLV_PCSK_FUR_1	327	331	PF00082	0.346
CLV_PCSK_KEX2_1	117	119	PF00082	0.391
CLV_PCSK_KEX2_1	122	124	PF00082	0.405
CLV_PCSK_KEX2_1	185	187	PF00082	0.618
CLV_PCSK_KEX2_1	198	200	PF00082	0.464
CLV_PCSK_KEX2_1	218	220	PF00082	0.403
CLV_PCSK_KEX2_1	329	331	PF00082	0.497
CLV_PCSK_PC1ET2_1	117	119	PF00082	0.426
CLV_PCSK_PC1ET2_1	122	124	PF00082	0.477
CLV_PCSK_PC1ET2_1	198	200	PF00082	0.464
CLV_PCSK_PC7_1	118	124	PF00082	0.317
CLV_PCSK_SKI1_1	198	202	PF00082	0.445
CLV_PCSK_SKI1_1	329	333	PF00082	0.530
CLV_PCSK_SKI1_1	467	471	PF00082	0.334
CLV_Separin_Metazoa	182	186	PF03568	0.568
DEG_APCC_DBOX_1	328	336	PF00400	0.395
DOC_CKS1_1	233	238	PF01111	0.531
DOC_CYCLIN_RxL_1	326	336	PF00134	0.397
DOC_MAPK_MEF2A_6	262	270	PF00069	0.409
DOC_MAPK_MEF2A_6	353	360	PF00069	0.522
DOC_PP1_RVXF_1	196	203	PF00149	0.462
DOC_PP1_RVXF_1	465	471	PF00149	0.491
DOC_PP2B_LxvP_1	407	410	PF13499	0.435
DOC_PP2B_LxvP_1	526	529	PF13499	0.438
DOC_PP2B_PxIxI_1	355	361	PF00149	0.345
DOC_USP7_MATH_1	136	140	PF00917	0.429
DOC_USP7_MATH_1	43	47	PF00917	0.380
DOC_USP7_MATH_1	94	98	PF00917	0.672
DOC_WW_Pin1_4	229	234	PF00397	0.559
DOC_WW_Pin1_4	290	295	PF00397	0.578
DOC_WW_Pin1_4	479	484	PF00397	0.589
DOC_WW_Pin1_4	52	57	PF00397	0.357
DOC_WW_Pin1_4	90	95	PF00397	0.703
LIG_14-3-3_CanoR_1	19	28	PF00244	0.462
LIG_APCC_ABBAyCdc20_2	198	204	PF00400	0.483
LIG_BIR_II_1	1	5	PF00653	0.683
LIG_BIR_III_2	180	184	PF00653	0.558
LIG_BRCT_BRCA1_1	249	253	PF00533	0.392
LIG_BRCT_BRCA1_1	297	301	PF00533	0.401
LIG_BRCT_BRCA1_1	337	341	PF00533	0.479
LIG_BRCT_BRCA1_2	249	255	PF00533	0.412
LIG_EVH1_2	520	524	PF00568	0.359
LIG_FHA_1	16	22	PF00498	0.402
LIG_FHA_1	232	238	PF00498	0.602
LIG_FHA_1	31	37	PF00498	0.489
LIG_FHA_1	311	317	PF00498	0.536
LIG_FHA_1	350	356	PF00498	0.413
LIG_FHA_1	403	409	PF00498	0.347
LIG_FHA_1	440	446	PF00498	0.509
LIG_FHA_1	479	485	PF00498	0.484
LIG_FHA_1	523	529	PF00498	0.422
LIG_FHA_2	210	216	PF00498	0.419
LIG_FHA_2	233	239	PF00498	0.557
LIG_FHA_2	57	63	PF00498	0.474
LIG_GBD_Chelix_1	142	150	PF00786	0.329
LIG_LIR_Apic_2	5	10	PF02991	0.526
LIG_LIR_Gen_1	110	121	PF02991	0.407
LIG_LIR_Gen_1	238	246	PF02991	0.511
LIG_LIR_Gen_1	298	308	PF02991	0.307
LIG_LIR_Gen_1	65	70	PF02991	0.383
LIG_LIR_Nem_3	110	116	PF02991	0.342
LIG_LIR_Nem_3	238	243	PF02991	0.544
LIG_LIR_Nem_3	298	304	PF02991	0.307
LIG_LIR_Nem_3	369	375	PF02991	0.470
LIG_LIR_Nem_3	45	51	PF02991	0.450
LIG_LIR_Nem_3	455	460	PF02991	0.577
LIG_LIR_Nem_3	60	66	PF02991	0.356
LIG_SH2_CRK	113	117	PF00017	0.454
LIG_SH2_CRK	381	385	PF00017	0.493
LIG_SH2_CRK	393	397	PF00017	0.425
LIG_SH2_CRK	7	11	PF00017	0.522
LIG_SH2_NCK_1	381	385	PF00017	0.385
LIG_SH2_PTP2	66	69	PF00017	0.440
LIG_SH2_STAP1	381	385	PF00017	0.385
LIG_SH2_STAT5	105	108	PF00017	0.346
LIG_SH2_STAT5	119	122	PF00017	0.396
LIG_SH2_STAT5	460	463	PF00017	0.555
LIG_SH2_STAT5	66	69	PF00017	0.372
LIG_SH3_3	230	236	PF00018	0.539
LIG_SH3_3	238	244	PF00018	0.479
LIG_SH3_3	265	271	PF00018	0.399
LIG_SH3_3	405	411	PF00018	0.409
LIG_SH3_3	477	483	PF00018	0.585
LIG_SH3_3	495	501	PF00018	0.593
LIG_SH3_3	510	516	PF00018	0.673
LIG_SUMO_SIM_par_1	208	215	PF11976	0.405
LIG_SUMO_SIM_par_1	481	488	PF11976	0.459
LIG_SUMO_SIM_par_1	49	55	PF11976	0.380
LIG_TRFH_1	240	244	PF08558	0.362
LIG_TYR_ITIM	379	384	PF00017	0.397
LIG_UBA3_1	387	392	PF00899	0.384
LIG_WW_3	182	186	PF00397	0.568
MOD_CK1_1	132	138	PF00069	0.467
MOD_CK1_1	205	211	PF00069	0.325
MOD_CK1_1	232	238	PF00069	0.495
MOD_CK1_1	334	340	PF00069	0.550
MOD_CK1_1	412	418	PF00069	0.571
MOD_CK2_1	209	215	PF00069	0.436
MOD_CK2_1	232	238	PF00069	0.695
MOD_CK2_1	309	315	PF00069	0.392
MOD_GlcNHglycan	129	132	PF01048	0.684
MOD_GlcNHglycan	138	141	PF01048	0.451
MOD_GlcNHglycan	228	232	PF01048	0.633
MOD_GlcNHglycan	337	340	PF01048	0.539
MOD_GlcNHglycan	415	418	PF01048	0.538
MOD_GlcNHglycan	474	477	PF01048	0.331
MOD_GlcNHglycan	502	505	PF01048	0.681
MOD_GSK3_1	127	134	PF00069	0.580
MOD_GSK3_1	153	160	PF00069	0.466
MOD_GSK3_1	205	212	PF00069	0.408
MOD_GSK3_1	227	234	PF00069	0.696
MOD_GSK3_1	290	297	PF00069	0.473
MOD_GSK3_1	30	37	PF00069	0.710
MOD_GSK3_1	331	338	PF00069	0.534
MOD_GSK3_1	409	416	PF00069	0.598
MOD_GSK3_1	472	479	PF00069	0.346
MOD_GSK3_1	52	59	PF00069	0.416
MOD_GSK3_1	90	97	PF00069	0.554
MOD_NEK2_1	141	146	PF00069	0.524
MOD_NEK2_1	202	207	PF00069	0.398
MOD_NEK2_1	331	336	PF00069	0.579
MOD_NEK2_2	43	48	PF00069	0.382
MOD_PIKK_1	402	408	PF00454	0.308
MOD_PIKK_1	458	464	PF00454	0.348
MOD_PIKK_1	9	15	PF00454	0.609
MOD_PKA_2	420	426	PF00069	0.598
MOD_PKB_1	225	233	PF00069	0.691
MOD_Plk_1	294	300	PF00069	0.528
MOD_Plk_1	43	49	PF00069	0.419
MOD_Plk_4	209	215	PF00069	0.441
MOD_Plk_4	3	9	PF00069	0.542
MOD_Plk_4	43	49	PF00069	0.435
MOD_Plk_4	519	525	PF00069	0.401
MOD_Plk_4	62	68	PF00069	0.351
MOD_ProDKin_1	229	235	PF00069	0.554
MOD_ProDKin_1	290	296	PF00069	0.565
MOD_ProDKin_1	479	485	PF00069	0.484
MOD_ProDKin_1	52	58	PF00069	0.354
MOD_ProDKin_1	90	96	PF00069	0.705
TRG_DiLeu_BaEn_1	238	243	PF01217	0.389
TRG_DiLeu_BaLyEn_6	196	201	PF01217	0.425
TRG_DiLeu_BaLyEn_6	327	332	PF01217	0.329
TRG_ENDOCYTIC_2	113	116	PF00928	0.337
TRG_ENDOCYTIC_2	381	384	PF00928	0.498
TRG_ENDOCYTIC_2	393	396	PF00928	0.434
TRG_ENDOCYTIC_2	66	69	PF00928	0.386
TRG_ER_diArg_1	184	187	PF00400	0.585
TRG_ER_diArg_1	217	220	PF00400	0.452
TRG_ER_diArg_1	327	330	PF00400	0.384
TRG_ER_diArg_1	74	77	PF00400	0.498
TRG_NES_CRM1_1	278	292	PF08389	0.470
TRG_Pf-PMV_PEXEL_1	199	204	PF00026	0.367
TRG_Pf-PMV_PEXEL_1	329	333	PF00026	0.420

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFZ8	Leptomonas seymouri	43%	100%
A0A1X0NMY7	Trypanosomatidae	30%	100%
A0A3Q8IBS6	Leishmania donovani	99%	99%
A0A422N0R9	Trypanosoma rangeli	27%	100%
A4H7A7	Leishmania braziliensis	71%	100%
D0A6I9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9APE8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QG30	Leishmania major	88%	100%
V5ARR9	Trypanosoma cruzi	26%	100%