LeishMANIAdb
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Putative 40S ribosomal protein S4

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative 40S ribosomal protein S4
Gene product:
40S ribosomal protein S4 - putative
Species:
Leishmania infantum
UniProt:
A4HVQ1_LEIIN
TriTrypDb:
LINF_130017300
Length:
480

Annotations

Annotations by Jardim et al.

Ribosomal Protein, 40S ribosomal S4

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 5
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 1
NetGPI no yes: 0, no: 1
Cellular components
Term Name Level Count
GO:0005840 ribosome 5 2
GO:0032991 protein-containing complex 1 2
GO:0043226 organelle 2 2
GO:0043228 non-membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043232 intracellular non-membrane-bounded organelle 4 2
GO:0110165 cellular anatomical entity 1 2
GO:1990904 ribonucleoprotein complex 2 2

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HVQ1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVQ1

Function

Biological processes
Term Name Level Count
GO:0006412 translation 4 2
GO:0006518 peptide metabolic process 4 2
GO:0006807 nitrogen compound metabolic process 2 2
GO:0008152 metabolic process 1 2
GO:0009058 biosynthetic process 2 2
GO:0009059 macromolecule biosynthetic process 4 2
GO:0009987 cellular process 1 2
GO:0019538 protein metabolic process 3 2
GO:0034641 cellular nitrogen compound metabolic process 3 2
GO:0034645 obsolete cellular macromolecule biosynthetic process 4 2
GO:0043043 peptide biosynthetic process 5 2
GO:0043170 macromolecule metabolic process 3 2
GO:0043603 amide metabolic process 3 2
GO:0043604 amide biosynthetic process 4 2
GO:0044237 cellular metabolic process 2 2
GO:0044238 primary metabolic process 2 2
GO:0044249 cellular biosynthetic process 3 2
GO:0044260 obsolete cellular macromolecule metabolic process 3 2
GO:0044271 cellular nitrogen compound biosynthetic process 4 2
GO:0071704 organic substance metabolic process 2 2
GO:1901564 organonitrogen compound metabolic process 3 2
GO:1901566 organonitrogen compound biosynthetic process 4 2
GO:1901576 organic substance biosynthetic process 3 2
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 2
GO:0003723 RNA binding 4 2
GO:0003735 structural constituent of ribosome 2 2
GO:0005198 structural molecule activity 1 2
GO:0005488 binding 1 2
GO:0019843 rRNA binding 5 2
GO:0097159 organic cyclic compound binding 2 2
GO:1901363 heterocyclic compound binding 2 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 198 200 PF00675 0.317
CLV_NRD_NRD_1 281 283 PF00675 0.137
CLV_NRD_NRD_1 466 468 PF00675 0.252
CLV_NRD_NRD_1 475 477 PF00675 0.349
CLV_NRD_NRD_1 478 480 PF00675 0.347
CLV_NRD_NRD_1 55 57 PF00675 0.324
CLV_PCSK_FUR_1 196 200 PF00082 0.321
CLV_PCSK_KEX2_1 198 200 PF00082 0.317
CLV_PCSK_KEX2_1 214 216 PF00082 0.137
CLV_PCSK_KEX2_1 281 283 PF00082 0.137
CLV_PCSK_KEX2_1 45 47 PF00082 0.335
CLV_PCSK_KEX2_1 55 57 PF00082 0.324
CLV_PCSK_KEX2_1 71 73 PF00082 0.306
CLV_PCSK_PC1ET2_1 214 216 PF00082 0.137
CLV_PCSK_PC1ET2_1 45 47 PF00082 0.335
CLV_PCSK_PC1ET2_1 71 73 PF00082 0.306
CLV_PCSK_PC7_1 51 57 PF00082 0.333
CLV_PCSK_SKI1_1 201 205 PF00082 0.316
CLV_PCSK_SKI1_1 207 211 PF00082 0.262
CLV_PCSK_SKI1_1 257 261 PF00082 0.137
CLV_PCSK_SKI1_1 312 316 PF00082 0.137
CLV_PCSK_SKI1_1 326 330 PF00082 0.137
DEG_APCC_DBOX_1 242 250 PF00400 0.337
DEG_APCC_DBOX_1 269 277 PF00400 0.337
DEG_APCC_DBOX_1 311 319 PF00400 0.337
DOC_CKS1_1 142 147 PF01111 0.137
DOC_CYCLIN_yCln2_LP_2 153 159 PF00134 0.137
DOC_MAPK_DCC_7 241 251 PF00069 0.337
DOC_MAPK_gen_1 241 250 PF00069 0.337
DOC_MAPK_gen_1 310 318 PF00069 0.337
DOC_MAPK_gen_1 369 376 PF00069 0.409
DOC_MAPK_gen_1 378 387 PF00069 0.391
DOC_MAPK_gen_1 393 402 PF00069 0.387
DOC_MAPK_HePTP_8 431 443 PF00069 0.337
DOC_MAPK_MEF2A_6 20 28 PF00069 0.504
DOC_MAPK_MEF2A_6 241 250 PF00069 0.337
DOC_MAPK_MEF2A_6 434 443 PF00069 0.337
DOC_MAPK_NFAT4_5 243 251 PF00069 0.337
DOC_PP2B_LxvP_1 153 156 PF13499 0.137
DOC_PP2B_LxvP_1 160 163 PF13499 0.496
DOC_PP2B_LxvP_1 216 219 PF13499 0.337
DOC_PP2B_LxvP_1 26 29 PF13499 0.505
DOC_USP7_MATH_1 314 318 PF00917 0.337
DOC_USP7_MATH_1 356 360 PF00917 0.337
DOC_USP7_MATH_1 79 83 PF00917 0.520
DOC_USP7_UBL2_3 207 211 PF12436 0.462
DOC_WW_Pin1_4 112 117 PF00397 0.499
DOC_WW_Pin1_4 141 146 PF00397 0.298
DOC_WW_Pin1_4 18 23 PF00397 0.500
DOC_WW_Pin1_4 85 90 PF00397 0.519
LIG_14-3-3_CanoR_1 103 110 PF00244 0.535
LIG_14-3-3_CanoR_1 111 116 PF00244 0.506
LIG_14-3-3_CanoR_1 143 149 PF00244 0.137
LIG_14-3-3_CanoR_1 187 191 PF00244 0.538
LIG_14-3-3_CanoR_1 72 77 PF00244 0.510
LIG_Actin_WH2_2 244 259 PF00022 0.337
LIG_APCC_ABBAyCdc20_2 56 62 PF00400 0.515
LIG_BIR_II_1 1 5 PF00653 0.492
LIG_BIR_III_4 416 420 PF00653 0.337
LIG_BRCT_BRCA1_1 128 132 PF00533 0.137
LIG_BRCT_BRCA1_1 137 141 PF00533 0.294
LIG_Clathr_ClatBox_1 273 277 PF01394 0.337
LIG_FHA_1 137 143 PF00498 0.296
LIG_FHA_1 144 150 PF00498 0.137
LIG_FHA_1 335 341 PF00498 0.337
LIG_FHA_1 61 67 PF00498 0.517
LIG_LIR_Apic_2 16 22 PF02991 0.500
LIG_LIR_Gen_1 35 41 PF02991 0.513
LIG_LIR_Nem_3 129 135 PF02991 0.137
LIG_LIR_Nem_3 189 193 PF02991 0.541
LIG_LIR_Nem_3 35 40 PF02991 0.514
LIG_MYND_1 116 120 PF01753 0.337
LIG_NRBOX 148 154 PF00104 0.137
LIG_SH2_CRK 19 23 PF00017 0.501
LIG_SH2_NCK_1 12 16 PF00017 0.500
LIG_SH2_SRC 7 10 PF00017 0.491
LIG_SH2_STAP1 258 262 PF00017 0.337
LIG_SH2_STAP1 60 64 PF00017 0.517
LIG_SH2_STAT5 12 15 PF00017 0.500
LIG_SH2_STAT5 151 154 PF00017 0.137
LIG_SH2_STAT5 334 337 PF00017 0.337
LIG_SH2_STAT5 60 63 PF00017 0.516
LIG_SH2_STAT5 64 67 PF00017 0.520
LIG_SH2_STAT5 7 10 PF00017 0.491
LIG_SH3_3 114 120 PF00018 0.491
LIG_SH3_3 227 233 PF00018 0.337
LIG_SH3_3 291 297 PF00018 0.337
LIG_SH3_3 438 444 PF00018 0.337
LIG_SUMO_SIM_par_1 314 320 PF11976 0.337
LIG_SUMO_SIM_par_1 340 345 PF11976 0.337
LIG_UBA3_1 248 257 PF00899 0.337
LIG_UBA3_1 36 45 PF00899 0.520
LIG_UBA3_1 429 434 PF00899 0.337
LIG_WRC_WIRS_1 190 195 PF05994 0.536
MOD_CK1_1 134 140 PF00069 0.354
MOD_CK1_1 147 153 PF00069 0.137
MOD_CK1_1 18 24 PF00069 0.501
MOD_CK1_1 225 231 PF00069 0.337
MOD_CK2_1 314 320 PF00069 0.337
MOD_CK2_1 415 421 PF00069 0.337
MOD_GlcNHglycan 416 420 PF01048 0.137
MOD_GSK3_1 131 138 PF00069 0.137
MOD_GSK3_1 143 150 PF00069 0.137
MOD_GSK3_1 161 168 PF00069 0.508
MOD_GSK3_1 356 363 PF00069 0.337
MOD_GSK3_1 58 65 PF00069 0.516
MOD_LATS_1 413 419 PF00433 0.337
MOD_N-GLC_1 32 37 PF02516 0.306
MOD_NEK2_1 439 444 PF00069 0.337
MOD_NEK2_2 32 37 PF00069 0.506
MOD_PKA_1 71 77 PF00069 0.510
MOD_PKA_2 102 108 PF00069 0.535
MOD_PKA_2 110 116 PF00069 0.509
MOD_PKA_2 170 176 PF00069 0.531
MOD_PKA_2 186 192 PF00069 0.539
MOD_PKA_2 71 77 PF00069 0.510
MOD_Plk_4 105 111 PF00069 0.535
MOD_Plk_4 137 143 PF00069 0.296
MOD_Plk_4 144 150 PF00069 0.137
MOD_Plk_4 189 195 PF00069 0.537
MOD_Plk_4 32 38 PF00069 0.506
MOD_Plk_4 360 366 PF00069 0.337
MOD_Plk_4 72 78 PF00069 0.512
MOD_ProDKin_1 112 118 PF00069 0.499
MOD_ProDKin_1 141 147 PF00069 0.137
MOD_ProDKin_1 18 24 PF00069 0.501
MOD_ProDKin_1 85 91 PF00069 0.523
MOD_SUMO_for_1 400 403 PF00179 0.406
MOD_SUMO_rev_2 277 287 PF00179 0.337
TRG_DiLeu_BaLyEn_6 114 119 PF01217 0.493
TRG_DiLeu_BaLyEn_6 457 462 PF01217 0.337
TRG_DiLeu_LyEn_5 244 249 PF01217 0.368
TRG_ER_diArg_1 196 199 PF00400 0.524
TRG_ER_diArg_1 233 236 PF00400 0.337
TRG_ER_diArg_1 252 255 PF00400 0.337
TRG_ER_diArg_1 280 282 PF00400 0.337
TRG_ER_diArg_1 350 353 PF00400 0.337
TRG_ER_diArg_1 393 396 PF00400 0.372
TRG_NLS_MonoExtC_3 475 480 PF00514 0.548
TRG_NLS_MonoExtN_4 473 480 PF00514 0.543

Homologs

Protein Taxonomy Sequence identity Coverage
A0A1D8PCI6 CANAL 51% 100%
A1RS06 PYRIL 37% 100%
A2BMD1 HYPBU 33% 100%
A3DNB9 STAMF 35% 100%
A3MWZ7 PYRCJ 36% 100%
A4FWA9 METM5 35% 100%
A4WLL4 PYRAR 35% 100%
A4YCX8 METS5 28% 100%
A5UL76 METS3 33% 100%
A6UQ56 METVS 33% 100%
A6UWV0 META3 32% 100%
A6VGZ7 METM7 34% 100%
A8ACD4 IGNH4 33% 100%
A8MB20 CALMQ 30% 100%
A9A9Q2 METM6 34% 100%
B0R668 HALS3 28% 100%
B1L778 KORCO 32% 100%
B1Y9S4 PYRNV 36% 100%
B8D5V8 DESA1 32% 100%
B9LSR5 HALLT 30% 100%
C3MQ71 SULIL 29% 100%
C3MVJ0 SULIM 29% 100%
C3N5T9 SULIA 29% 100%
C3NEF5 SULIY 29% 100%
C3NH97 SULIN 29% 100%
C4KHG8 SULIK 29% 100%
O05634 SULAC 30% 100%
O22424 MAIZE 51% 100%
O26123 METTH 38% 100%
O28366 ARCFU 33% 100%
O59430 PYRHO 38% 100%
O59950 YARLI 50% 100%
O62738 MONDO 53% 100%
O62739 MONDO 53% 100%
O81363 PRUAR 49% 100%
P0C233 TETTH 47% 100%
P0CX35 YEAST 51% 100%
P0CX36 YEAST 51% 100%
P14023 METVA 33% 100%
P22090 HUMAN 51% 100%
P22510 HALMA 28% 100%
P41042 DROME 52% 100%
P46299 GOSHI 52% 100%
P46300 SOLTU 52% 100%
P47836 CHICK 53% 100%
P47837 CANAX 49% 100%
P47961 CRIGR 53% 100%
P49204 ARATH 52% 100%
P49398 ORYSJ 53% 100%
P49401 XENLA 53% 100%
P51405 DICDI 48% 100%
P54039 METJA 35% 100%
P55832 HORSE 54% 100%
P62428 METMP 33% 100%
P62429 NANEQ 31% 100%
P62701 HUMAN 53% 100%
P62702 MOUSE 53% 100%
P62703 RAT 53% 100%
P62704 MESAU 53% 100%
P62705 FELCA 53% 100%
P79103 BOVIN 53% 100%
P79183 MACFU 51% 100%
P87158 SCHPO 51% 100%
Q0W1X6 METAR 31% 100%
Q2FT37 METHJ 30% 100%
Q2NFW9 METST 34% 100%
Q3IMX6 NATPD 27% 100%
Q40941 BIGNA 22% 100%
Q46GA7 METBF 33% 100%
Q4GXU6 CARGR 51% 100%
Q4PMB3 IXOSC 52% 100%
Q56230 THEAC 33% 100%
Q56FH2 LYSTE 53% 100%
Q5JJG0 THEKO 37% 100%
Q5UAP0 BOMMO 52% 100%
Q642H9 DANRE 53% 100%
Q6GVM7 PANTR 51% 100%
Q6L1B5 PICTO 28% 100%
Q6PBC4 XENTR 53% 100%
Q76MY1 MACFU 53% 100%
Q76N24 CHLAE 53% 100%
Q861U7 PONPY 51% 100%
Q861U8 GORGO 51% 100%
Q861U9 PANTR 51% 100%
Q861V0 PANPA 51% 100%
Q8PV38 METMA 32% 100%
Q8SRB9 ENCCU 35% 100%
Q8TD47 HUMAN 49% 100%
Q8TRT5 METAC 33% 100%
Q8TW18 METKA 35% 100%
Q8U011 PYRFU 37% 100%
Q8VYK6 ARATH 52% 100%
Q8ZTD3 PYRAE 34% 100%
Q90YS0 ICTPU 53% 100%
Q93VH9 ARATH 53% 100%
Q95V34 SPOFR 51% 100%
Q975J2 SULTO 29% 100%
Q97BW4 THEVO 34% 100%
Q9HPC2 HALSA 28% 100%
Q9N3X2 CAEEL 52% 100%
Q9P4W9 SCHPO 51% 100%
Q9USW5 SCHPO 51% 100%
Q9UX94 SACS2 29% 100%
Q9V1U8 PYRAB 37% 100%
Q9YF85 AERPE 37% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS