LeishMANIAdb
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Nucleobase transporter

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Nucleobase transporter
Gene product:
nucleobase transporter
Species:
Leishmania infantum
UniProt:
A4HVP9_LEIIN
TriTrypDb:
LINF_130017100
Length:
501

Annotations

LeishMANIAdb annotations

An expanded family of eukaryotic equlibrative nuceloside transporters.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 4
Forrest at al. (procyclic) no yes: 4
Silverman et al. no yes: 0
Pissara et al. yes yes: 45
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 10
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 53
NetGPI no yes: 0, no: 53
Cellular components
Term Name Level Count
GO:0016020 membrane 2 54
GO:0110165 cellular anatomical entity 1 54
GO:0005886 plasma membrane 3 5

Expansion

Sequence features

A4HVP9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVP9

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 2
GO:0015851 nucleobase transport 5 2
GO:0051179 localization 1 2
GO:0051234 establishment of localization 2 2
GO:0071702 organic substance transport 4 2
GO:0071705 nitrogen compound transport 4 2
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 54
GO:0005337 nucleoside transmembrane transporter activity 4 54
GO:0015932 nucleobase-containing compound transmembrane transporter activity 3 54
GO:0022857 transmembrane transporter activity 2 54
GO:1901505 carbohydrate derivative transmembrane transporter activity 3 54
GO:0015205 nucleobase transmembrane transporter activity 3 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 317 321 PF00656 0.530
CLV_NRD_NRD_1 289 291 PF00675 0.499
CLV_NRD_NRD_1 86 88 PF00675 0.308
CLV_PCSK_KEX2_1 230 232 PF00082 0.268
CLV_PCSK_KEX2_1 289 291 PF00082 0.358
CLV_PCSK_PC1ET2_1 230 232 PF00082 0.237
CLV_PCSK_SKI1_1 227 231 PF00082 0.262
CLV_PCSK_SKI1_1 326 330 PF00082 0.380
CLV_PCSK_SKI1_1 416 420 PF00082 0.323
CLV_PCSK_SKI1_1 43 47 PF00082 0.489
DEG_Nend_Nbox_1 1 3 PF02207 0.602
DEG_SPOP_SBC_1 168 172 PF00917 0.331
DOC_ANK_TNKS_1 288 295 PF00023 0.588
DOC_CDC14_PxL_1 361 369 PF14671 0.448
DOC_CKS1_1 81 86 PF01111 0.355
DOC_CYCLIN_yClb1_LxF_4 60 66 PF00134 0.327
DOC_MAPK_gen_1 336 345 PF00069 0.486
DOC_MAPK_gen_1 373 383 PF00069 0.363
DOC_MAPK_gen_1 87 93 PF00069 0.522
DOC_MAPK_HePTP_8 91 103 PF00069 0.501
DOC_MAPK_MEF2A_6 336 345 PF00069 0.446
DOC_MAPK_MEF2A_6 376 385 PF00069 0.377
DOC_MAPK_MEF2A_6 416 424 PF00069 0.347
DOC_MAPK_MEF2A_6 94 103 PF00069 0.334
DOC_MAPK_NFAT4_5 94 102 PF00069 0.425
DOC_PP2B_LxvP_1 110 113 PF13499 0.323
DOC_PP2B_LxvP_1 362 365 PF13499 0.328
DOC_PP2B_LxvP_1 367 370 PF13499 0.247
DOC_PP4_FxxP_1 345 348 PF00568 0.555
DOC_PP4_FxxP_1 401 404 PF00568 0.558
DOC_USP7_MATH_1 295 299 PF00917 0.788
DOC_USP7_MATH_1 30 34 PF00917 0.380
DOC_USP7_MATH_1 484 488 PF00917 0.374
DOC_USP7_UBL2_3 287 291 PF12436 0.764
DOC_WW_Pin1_4 52 57 PF00397 0.444
DOC_WW_Pin1_4 80 85 PF00397 0.396
LIG_14-3-3_CanoR_1 214 219 PF00244 0.498
LIG_14-3-3_CanoR_1 326 334 PF00244 0.564
LIG_14-3-3_CanoR_1 394 400 PF00244 0.323
LIG_14-3-3_CanoR_1 464 473 PF00244 0.518
LIG_14-3-3_CanoR_1 87 92 PF00244 0.485
LIG_Actin_WH2_2 174 192 PF00022 0.480
LIG_BIR_III_4 390 394 PF00653 0.296
LIG_BRCT_BRCA1_1 211 215 PF00533 0.456
LIG_BRCT_BRCA1_1 397 401 PF00533 0.473
LIG_BRCT_BRCA1_1 454 458 PF00533 0.430
LIG_BRCT_BRCA1_1 54 58 PF00533 0.415
LIG_BRCT_BRCA1_1 89 93 PF00533 0.513
LIG_Clathr_ClatBox_1 101 105 PF01394 0.370
LIG_EH1_1 356 364 PF00400 0.417
LIG_eIF4E_1 14 20 PF01652 0.338
LIG_eIF4E_1 438 444 PF01652 0.343
LIG_FHA_1 14 20 PF00498 0.331
LIG_FHA_1 378 384 PF00498 0.352
LIG_FHA_1 71 77 PF00498 0.333
LIG_FHA_2 315 321 PF00498 0.488
LIG_FHA_2 327 333 PF00498 0.499
LIG_LIR_Apic_2 398 404 PF02991 0.570
LIG_LIR_Gen_1 105 114 PF02991 0.344
LIG_LIR_Gen_1 143 153 PF02991 0.480
LIG_LIR_Gen_1 182 193 PF02991 0.289
LIG_LIR_Gen_1 375 386 PF02991 0.336
LIG_LIR_Gen_1 423 432 PF02991 0.389
LIG_LIR_Nem_3 105 110 PF02991 0.281
LIG_LIR_Nem_3 143 148 PF02991 0.490
LIG_LIR_Nem_3 182 188 PF02991 0.297
LIG_LIR_Nem_3 212 218 PF02991 0.403
LIG_LIR_Nem_3 225 229 PF02991 0.440
LIG_LIR_Nem_3 275 280 PF02991 0.758
LIG_LIR_Nem_3 337 343 PF02991 0.535
LIG_LIR_Nem_3 375 381 PF02991 0.295
LIG_LIR_Nem_3 40 44 PF02991 0.322
LIG_LIR_Nem_3 423 427 PF02991 0.366
LIG_LIR_Nem_3 455 461 PF02991 0.282
LIG_LIR_Nem_3 64 68 PF02991 0.288
LIG_LIR_Nem_3 90 96 PF02991 0.514
LIG_Pex14_2 161 165 PF04695 0.338
LIG_Pex14_2 354 358 PF04695 0.276
LIG_Pex14_2 424 428 PF04695 0.351
LIG_PTB_Apo_2 445 452 PF02174 0.326
LIG_SH2_CRK 145 149 PF00017 0.476
LIG_SH2_CRK 185 189 PF00017 0.315
LIG_SH2_NCK_1 145 149 PF00017 0.514
LIG_SH2_NCK_1 66 70 PF00017 0.394
LIG_SH2_SRC 12 15 PF00017 0.421
LIG_SH2_SRC 139 142 PF00017 0.379
LIG_SH2_SRC 430 433 PF00017 0.313
LIG_SH2_STAP1 14 18 PF00017 0.348
LIG_SH2_STAP1 185 189 PF00017 0.277
LIG_SH2_STAT5 12 15 PF00017 0.332
LIG_SH2_STAT5 139 142 PF00017 0.356
LIG_SH2_STAT5 193 196 PF00017 0.292
LIG_SH2_STAT5 430 433 PF00017 0.291
LIG_SH2_STAT5 438 441 PF00017 0.336
LIG_SH3_1 429 435 PF00018 0.171
LIG_SH3_3 429 435 PF00018 0.285
LIG_SH3_3 454 460 PF00018 0.398
LIG_SH3_3 495 501 PF00018 0.500
LIG_SH3_3 50 56 PF00018 0.310
LIG_SH3_3 78 84 PF00018 0.338
LIG_SUMO_SIM_anti_2 360 366 PF11976 0.448
LIG_SUMO_SIM_anti_2 380 385 PF11976 0.311
LIG_SUMO_SIM_par_1 360 366 PF11976 0.377
LIG_TRAF2_1 247 250 PF00917 0.503
LIG_TYR_ITSM 141 148 PF00017 0.472
LIG_WRC_WIRS_1 62 67 PF05994 0.277
MOD_CDK_SPxxK_3 80 87 PF00069 0.391
MOD_CK1_1 70 76 PF00069 0.317
MOD_CK2_1 135 141 PF00069 0.384
MOD_CK2_1 326 332 PF00069 0.516
MOD_CK2_1 4 10 PF00069 0.532
MOD_GlcNHglycan 156 159 PF01048 0.304
MOD_GlcNHglycan 165 168 PF01048 0.326
MOD_GlcNHglycan 32 35 PF01048 0.552
MOD_GlcNHglycan 488 491 PF01048 0.312
MOD_GSK3_1 163 170 PF00069 0.308
MOD_GSK3_1 177 184 PF00069 0.280
MOD_GSK3_1 252 259 PF00069 0.509
MOD_GSK3_1 295 302 PF00069 0.779
MOD_GSK3_1 314 321 PF00069 0.453
MOD_N-GLC_1 252 257 PF02516 0.359
MOD_N-GLC_1 3 8 PF02516 0.280
MOD_N-GLC_1 326 331 PF02516 0.286
MOD_NEK2_1 127 132 PF00069 0.378
MOD_NEK2_1 140 145 PF00069 0.474
MOD_NEK2_1 147 152 PF00069 0.457
MOD_NEK2_1 194 199 PF00069 0.342
MOD_NEK2_1 20 25 PF00069 0.311
MOD_NEK2_1 209 214 PF00069 0.226
MOD_NEK2_1 252 257 PF00069 0.561
MOD_NEK2_1 3 8 PF00069 0.543
MOD_NEK2_1 334 339 PF00069 0.494
MOD_NEK2_1 357 362 PF00069 0.356
MOD_NEK2_1 444 449 PF00069 0.395
MOD_NEK2_1 89 94 PF00069 0.496
MOD_NEK2_1 97 102 PF00069 0.293
MOD_NEK2_2 395 400 PF00069 0.219
MOD_PIKK_1 115 121 PF00454 0.364
MOD_PIKK_1 70 76 PF00454 0.264
MOD_PKA_1 87 93 PF00069 0.485
MOD_Plk_1 140 146 PF00069 0.498
MOD_Plk_1 181 187 PF00069 0.216
MOD_Plk_1 252 258 PF00069 0.529
MOD_Plk_1 3 9 PF00069 0.645
MOD_Plk_2-3 299 305 PF00069 0.545
MOD_Plk_4 135 141 PF00069 0.376
MOD_Plk_4 184 190 PF00069 0.276
MOD_Plk_4 20 26 PF00069 0.339
MOD_Plk_4 357 363 PF00069 0.293
MOD_Plk_4 420 426 PF00069 0.323
MOD_Plk_4 61 67 PF00069 0.292
MOD_Plk_4 77 83 PF00069 0.299
MOD_Plk_4 97 103 PF00069 0.234
MOD_ProDKin_1 52 58 PF00069 0.438
MOD_ProDKin_1 80 86 PF00069 0.389
TRG_ENDOCYTIC_2 145 148 PF00928 0.485
TRG_ENDOCYTIC_2 185 188 PF00928 0.299
TRG_ENDOCYTIC_2 193 196 PF00928 0.280
TRG_ENDOCYTIC_2 277 280 PF00928 0.732
TRG_ENDOCYTIC_2 438 441 PF00928 0.368

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P486 Leptomonas seymouri 38% 100%
A0A0N0P6Z5 Leptomonas seymouri 31% 100%
A0A0N1I1J0 Leptomonas seymouri 34% 100%
A0A0N1I8E8 Leptomonas seymouri 28% 100%
A0A0N1PBQ1 Leptomonas seymouri 68% 99%
A0A0S4JBS4 Bodo saltans 33% 100%
A0A1X0NN91 Trypanosomatidae 52% 100%
A0A1X0NPL0 Trypanosomatidae 55% 100%
A0A1X0NV38 Trypanosomatidae 36% 100%
A0A1X0NWJ5 Trypanosomatidae 37% 100%
A0A3Q8ICX7 Leishmania donovani 99% 100%
A0A3R7NQR3 Trypanosoma rangeli 55% 100%
A0A3S7WTL0 Leishmania donovani 33% 100%
A0A3S7XAS5 Leishmania donovani 33% 100%
A0A422MQ08 Trypanosoma rangeli 34% 100%
A0A422N8M2 Trypanosoma rangeli 29% 100%
A0A422NHH9 Trypanosoma rangeli 30% 100%
A0A422NR81 Trypanosoma rangeli 33% 100%
A1L272 Danio rerio 22% 97%
A4H6I0 Leishmania braziliensis 35% 100%
A4H7A5 Leishmania braziliensis 80% 100%
A4HG96 Leishmania braziliensis 27% 96%
A4HP60 Leishmania braziliensis 34% 98%
A4HUW2 Leishmania infantum 37% 100%
A4HWK9 Leishmania infantum 33% 100%
A4IDG6 Leishmania infantum 33% 100%
C9ZJU3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 34% 100%
C9ZJU5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 34% 100%
C9ZJU7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 33% 100%
C9ZKT6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 100%
C9ZN88 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 31% 100%
C9ZY31 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 34% 100%
C9ZZR9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 25% 100%
D0A6J2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 51% 100%
D0A6J4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 51% 100%
D0A6J6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 51% 100%
E9AGM5 Leishmania infantum 33% 100%
E9AGM6 Leishmania infantum 33% 100%
E9AGM7 Leishmania infantum 33% 100%
E9ANK1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 99%
E9APE5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 100%
E9AQB5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 99%
E9AQB6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 99%
E9ASW8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 98%
O76343 Leishmania donovani 33% 100%
Q4Q1M9 Leishmania major 33% 98%
Q4QF58 Leishmania major 33% 100%
Q4QF59 Leishmania major 33% 100%
Q4QG33 Leishmania major 92% 100%
Q4QH25 Leishmania major 37% 100%
Q7RTT9 Homo sapiens 22% 95%
Q8R139 Mus musculus 22% 95%
V5BGB1 Trypanosoma cruzi 56% 100%
V5BRM5 Trypanosoma cruzi 35% 100%
V5DSF4 Trypanosoma cruzi 33% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS