LeishMANIAdb
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TPH domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
TPH domain-containing protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4HVN9_LEIIN
TriTrypDb:
LINF_130016100
Length:
515

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005739 mitochondrion 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HVN9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVN9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 293 297 PF00656 0.577
CLV_C14_Caspase3-7 394 398 PF00656 0.814
CLV_C14_Caspase3-7 94 98 PF00656 0.596
CLV_NRD_NRD_1 12 14 PF00675 0.551
CLV_NRD_NRD_1 151 153 PF00675 0.552
CLV_NRD_NRD_1 217 219 PF00675 0.493
CLV_NRD_NRD_1 227 229 PF00675 0.539
CLV_NRD_NRD_1 249 251 PF00675 0.623
CLV_NRD_NRD_1 315 317 PF00675 0.537
CLV_NRD_NRD_1 402 404 PF00675 0.664
CLV_NRD_NRD_1 427 429 PF00675 0.578
CLV_NRD_NRD_1 444 446 PF00675 0.376
CLV_NRD_NRD_1 467 469 PF00675 0.507
CLV_NRD_NRD_1 473 475 PF00675 0.532
CLV_NRD_NRD_1 508 510 PF00675 0.614
CLV_NRD_NRD_1 58 60 PF00675 0.589
CLV_NRD_NRD_1 6 8 PF00675 0.604
CLV_NRD_NRD_1 66 68 PF00675 0.509
CLV_PCSK_KEX2_1 12 14 PF00082 0.603
CLV_PCSK_KEX2_1 163 165 PF00082 0.478
CLV_PCSK_KEX2_1 217 219 PF00082 0.547
CLV_PCSK_KEX2_1 249 251 PF00082 0.650
CLV_PCSK_KEX2_1 299 301 PF00082 0.516
CLV_PCSK_KEX2_1 344 346 PF00082 0.627
CLV_PCSK_KEX2_1 402 404 PF00082 0.685
CLV_PCSK_KEX2_1 427 429 PF00082 0.571
CLV_PCSK_KEX2_1 444 446 PF00082 0.363
CLV_PCSK_KEX2_1 462 464 PF00082 0.521
CLV_PCSK_KEX2_1 467 469 PF00082 0.503
CLV_PCSK_KEX2_1 473 475 PF00082 0.487
CLV_PCSK_KEX2_1 65 67 PF00082 0.555
CLV_PCSK_PC1ET2_1 163 165 PF00082 0.499
CLV_PCSK_PC1ET2_1 299 301 PF00082 0.529
CLV_PCSK_PC1ET2_1 344 346 PF00082 0.498
CLV_PCSK_PC1ET2_1 462 464 PF00082 0.648
CLV_PCSK_PC7_1 463 469 PF00082 0.596
CLV_PCSK_SKI1_1 159 163 PF00082 0.602
CLV_PCSK_SKI1_1 191 195 PF00082 0.561
CLV_PCSK_SKI1_1 265 269 PF00082 0.700
CLV_PCSK_SKI1_1 509 513 PF00082 0.552
DEG_APCC_DBOX_1 123 131 PF00400 0.620
DOC_CYCLIN_yClb5_NLxxxL_5 203 211 PF00134 0.550
DOC_MAPK_gen_1 444 451 PF00069 0.629
DOC_PP1_RVXF_1 33 40 PF00149 0.607
DOC_USP7_MATH_1 396 400 PF00917 0.784
DOC_USP7_UBL2_3 159 163 PF12436 0.477
DOC_USP7_UBL2_3 358 362 PF12436 0.588
DOC_USP7_UBL2_3 416 420 PF12436 0.553
LIG_14-3-3_CanoR_1 137 143 PF00244 0.542
LIG_14-3-3_CanoR_1 316 322 PF00244 0.438
LIG_BIR_II_1 1 5 PF00653 0.693
LIG_CaM_IQ_9 454 470 PF13499 0.522
LIG_FHA_1 336 342 PF00498 0.610
LIG_FHA_1 76 82 PF00498 0.646
LIG_FHA_2 267 273 PF00498 0.626
LIG_Integrin_RGD_1 386 388 PF01839 0.763
LIG_LIR_Nem_3 488 494 PF02991 0.490
LIG_PCNA_PIPBox_1 103 112 PF02747 0.584
LIG_PCNA_yPIPBox_3 198 211 PF02747 0.547
LIG_PCNA_yPIPBox_3 96 110 PF02747 0.589
LIG_PTB_Apo_2 253 260 PF02174 0.650
LIG_PTB_Phospho_1 253 259 PF10480 0.681
LIG_Rb_pABgroove_1 347 355 PF01858 0.631
LIG_REV1ctd_RIR_1 37 46 PF16727 0.624
LIG_SH2_SRC 494 497 PF00017 0.498
LIG_SH2_STAP1 110 114 PF00017 0.575
LIG_SH2_STAP1 353 357 PF00017 0.561
LIG_SH2_STAP1 422 426 PF00017 0.601
LIG_SH2_STAT3 110 113 PF00017 0.578
LIG_SH2_STAT3 324 327 PF00017 0.674
LIG_SH2_STAT3 336 339 PF00017 0.704
LIG_SH2_STAT3 429 432 PF00017 0.648
LIG_SH2_STAT5 324 327 PF00017 0.641
LIG_SH2_STAT5 45 48 PF00017 0.620
LIG_SH2_STAT5 494 497 PF00017 0.459
LIG_TRAF2_1 123 126 PF00917 0.591
LIG_TRAF2_1 235 238 PF00917 0.526
LIG_TRAF2_1 290 293 PF00917 0.542
LIG_TRAF2_1 312 315 PF00917 0.634
LIG_TRAF2_1 328 331 PF00917 0.451
LIG_TRAF2_1 482 485 PF00917 0.579
MOD_CK2_1 266 272 PF00069 0.683
MOD_CK2_1 30 36 PF00069 0.553
MOD_GlcNHglycan 391 394 PF01048 0.789
MOD_NEK2_1 1 6 PF00069 0.699
MOD_NEK2_1 24 29 PF00069 0.651
MOD_NEK2_1 43 48 PF00069 0.611
MOD_NEK2_1 69 74 PF00069 0.578
MOD_PIKK_1 335 341 PF00454 0.593
MOD_PIKK_1 45 51 PF00454 0.689
MOD_PIKK_1 509 515 PF00454 0.670
MOD_PK_1 294 300 PF00069 0.568
MOD_PKA_1 317 323 PF00069 0.441
MOD_PKA_1 344 350 PF00069 0.477
MOD_PKA_1 509 515 PF00069 0.662
MOD_PKA_2 344 350 PF00069 0.477
MOD_PKA_2 55 61 PF00069 0.657
MOD_PKB_1 65 73 PF00069 0.540
MOD_Plk_1 24 30 PF00069 0.650
MOD_Plk_4 206 212 PF00069 0.548
MOD_Plk_4 344 350 PF00069 0.567
MOD_Plk_4 494 500 PF00069 0.586
MOD_SUMO_for_1 162 165 PF00179 0.527
MOD_SUMO_for_1 282 285 PF00179 0.670
MOD_SUMO_for_1 328 331 PF00179 0.638
MOD_SUMO_rev_2 115 121 PF00179 0.564
MOD_SUMO_rev_2 291 295 PF00179 0.568
MOD_SUMO_rev_2 314 319 PF00179 0.636
MOD_SUMO_rev_2 376 383 PF00179 0.644
TRG_ENDOCYTIC_2 158 161 PF00928 0.634
TRG_ER_diArg_1 11 13 PF00400 0.611
TRG_ER_diArg_1 134 137 PF00400 0.572
TRG_ER_diArg_1 249 252 PF00400 0.677
TRG_ER_diArg_1 426 428 PF00400 0.600
TRG_ER_diArg_1 65 67 PF00400 0.552
TRG_Pf-PMV_PEXEL_1 104 108 PF00026 0.587
TRG_Pf-PMV_PEXEL_1 112 116 PF00026 0.577
TRG_Pf-PMV_PEXEL_1 175 180 PF00026 0.540

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PD47 Leptomonas seymouri 64% 96%
A0A1X0NPL9 Trypanosomatidae 38% 100%
A0A3R7MPR3 Trypanosoma rangeli 37% 100%
A0A3S5H6P4 Leishmania donovani 100% 100%
A4H797 Leishmania braziliensis 85% 100%
D0A6K6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 33% 100%
E9APD5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
Q4QG43 Leishmania major 96% 100%
V5BBN8 Trypanosoma cruzi 37% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS