NDK domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Dpy-30 motif containing protein - putative

Species:

Leishmania infantum

UniProt:

A4HVN3_LEIIN

TriTrypDb:

LINF_130015500

Length:

239

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HVN3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVN3

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016310	phosphorylation	5	2
GO:0044237	cellular metabolic process	2	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016301	kinase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	137	141	PF00656	0.371
CLV_C14_Caspase3-7	3	7	PF00656	0.616
CLV_NRD_NRD_1	153	155	PF00675	0.565
CLV_NRD_NRD_1	32	34	PF00675	0.408
CLV_PCSK_KEX2_1	32	34	PF00082	0.444
CLV_PCSK_SKI1_1	198	202	PF00082	0.230
CLV_PCSK_SKI1_1	21	25	PF00082	0.275
DEG_APCC_DBOX_1	52	60	PF00400	0.531
DEG_SIAH_1	76	84	PF03145	0.503
DEG_SPOP_SBC_1	91	95	PF00917	0.484
DOC_CKS1_1	25	30	PF01111	0.367
DOC_CYCLIN_RxL_1	149	161	PF00134	0.531
DOC_CYCLIN_RxL_1	18	27	PF00134	0.397
DOC_CYCLIN_yCln2_LP_2	75	78	PF00134	0.551
DOC_MAPK_gen_1	168	175	PF00069	0.392
DOC_MAPK_MEF2A_6	168	175	PF00069	0.350
DOC_PP2B_LxvP_1	75	78	PF13499	0.646
DOC_USP7_MATH_1	167	171	PF00917	0.449
DOC_USP7_MATH_1	4	8	PF00917	0.582
DOC_WW_Pin1_4	234	239	PF00397	0.553
DOC_WW_Pin1_4	24	29	PF00397	0.431
LIG_BIR_II_1	1	5	PF00653	0.675
LIG_BIR_III_3	1	5	PF00653	0.675
LIG_BRCT_BRCA1_1	93	97	PF00533	0.619
LIG_FHA_1	109	115	PF00498	0.472
LIG_FHA_1	183	189	PF00498	0.594
LIG_FHA_1	97	103	PF00498	0.545
LIG_LIR_Gen_1	111	118	PF02991	0.346
LIG_LIR_Gen_1	46	56	PF02991	0.328
LIG_LIR_Nem_3	111	116	PF02991	0.347
LIG_LIR_Nem_3	35	39	PF02991	0.368
LIG_LIR_Nem_3	46	52	PF02991	0.261
LIG_SH2_PTP2	113	116	PF00017	0.297
LIG_SH2_STAT5	113	116	PF00017	0.249
LIG_SH2_STAT5	192	195	PF00017	0.414
LIG_SH2_STAT5	39	42	PF00017	0.407
LIG_SH3_1	210	216	PF00018	0.425
LIG_SH3_2	213	218	PF14604	0.425
LIG_SH3_3	210	216	PF00018	0.454
LIG_SH3_3	77	83	PF00018	0.659
LIG_SUMO_SIM_anti_2	170	175	PF11976	0.455
LIG_SUMO_SIM_par_1	22	27	PF11976	0.397
LIG_TYR_ITSM	109	116	PF00017	0.410
LIG_WRC_WIRS_1	126	131	PF05994	0.400
MOD_CK1_1	186	192	PF00069	0.559
MOD_CK2_1	125	131	PF00069	0.287
MOD_Cter_Amidation	152	155	PF01082	0.471
MOD_GlcNHglycan	185	188	PF01048	0.540
MOD_GlcNHglycan	2	5	PF01048	0.617
MOD_GSK3_1	125	132	PF00069	0.492
MOD_GSK3_1	182	189	PF00069	0.481
MOD_GSK3_1	4	11	PF00069	0.623
MOD_GSK3_1	92	99	PF00069	0.442
MOD_N-GLC_1	226	231	PF02516	0.418
MOD_NEK2_1	108	113	PF00069	0.422
MOD_NEK2_1	117	122	PF00069	0.414
MOD_NEK2_1	125	130	PF00069	0.403
MOD_NEK2_1	15	20	PF00069	0.459
MOD_NEK2_1	158	163	PF00069	0.478
MOD_NEK2_1	71	76	PF00069	0.452
MOD_PIKK_1	129	135	PF00454	0.483
MOD_PIKK_1	226	232	PF00454	0.599
MOD_Plk_1	71	77	PF00069	0.533
MOD_Plk_4	125	131	PF00069	0.410
MOD_Plk_4	97	103	PF00069	0.543
MOD_ProDKin_1	24	30	PF00069	0.428
MOD_SUMO_rev_2	3	10	PF00179	0.448
TRG_DiLeu_BaEn_1	54	59	PF01217	0.457
TRG_DiLeu_BaEn_4	54	60	PF01217	0.411
TRG_DiLeu_LyEn_5	54	59	PF01217	0.457
TRG_ENDOCYTIC_2	113	116	PF00928	0.249
TRG_Pf-PMV_PEXEL_1	177	181	PF00026	0.392
TRG_Pf-PMV_PEXEL_1	218	223	PF00026	0.217
TRG_Pf-PMV_PEXEL_1	57	62	PF00026	0.364

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P894	Leptomonas seymouri	60%	97%
A0A0S4JTH8	Bodo saltans	35%	100%
A0A1X0NPH5	Trypanosomatidae	36%	82%
A0A3S7WSM5	Leishmania donovani	100%	100%
A0A422NGD0	Trypanosoma rangeli	40%	92%
A4H793	Leishmania braziliensis	78%	100%
D0A6L3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	91%
E9APC9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	98%
P56597	Homo sapiens	23%	100%
Q4QG49	Leishmania major	93%	100%
V5DBS4	Trypanosoma cruzi	40%	92%