Uncharacterized protein

Quick info Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HVM8_LEIIN

TriTrypDb:

LINF_130014900

Length:

462

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4HVM8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVM8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	267	271	PF00656	0.519
CLV_C14_Caspase3-7	311	315	PF00656	0.630
CLV_NRD_NRD_1	114	116	PF00675	0.573
CLV_NRD_NRD_1	158	160	PF00675	0.678
CLV_NRD_NRD_1	213	215	PF00675	0.511
CLV_NRD_NRD_1	273	275	PF00675	0.617
CLV_NRD_NRD_1	286	288	PF00675	0.618
CLV_NRD_NRD_1	347	349	PF00675	0.583
CLV_NRD_NRD_1	350	352	PF00675	0.547
CLV_NRD_NRD_1	366	368	PF00675	0.549
CLV_NRD_NRD_1	52	54	PF00675	0.540
CLV_PCSK_FUR_1	287	291	PF00082	0.614
CLV_PCSK_FUR_1	348	352	PF00082	0.548
CLV_PCSK_KEX2_1	114	116	PF00082	0.573
CLV_PCSK_KEX2_1	158	160	PF00082	0.632
CLV_PCSK_KEX2_1	213	215	PF00082	0.506
CLV_PCSK_KEX2_1	273	275	PF00082	0.679
CLV_PCSK_KEX2_1	289	291	PF00082	0.578
CLV_PCSK_KEX2_1	347	349	PF00082	0.561
CLV_PCSK_KEX2_1	35	37	PF00082	0.676
CLV_PCSK_KEX2_1	350	352	PF00082	0.522
CLV_PCSK_KEX2_1	366	368	PF00082	0.387
CLV_PCSK_KEX2_1	52	54	PF00082	0.539
CLV_PCSK_PC1ET2_1	289	291	PF00082	0.616
CLV_PCSK_PC1ET2_1	35	37	PF00082	0.599
CLV_PCSK_SKI1_1	350	354	PF00082	0.619
CLV_PCSK_SKI1_1	356	360	PF00082	0.460
CLV_PCSK_SKI1_1	409	413	PF00082	0.298
CLV_PCSK_SKI1_1	422	426	PF00082	0.329
DEG_APCC_DBOX_1	380	388	PF00400	0.407
DEG_Nend_UBRbox_1	1	4	PF02207	0.597
DEG_SCF_FBW7_1	9	16	PF00400	0.537
DOC_CKS1_1	160	165	PF01111	0.699
DOC_CKS1_1	40	45	PF01111	0.677
DOC_CYCLIN_RxL_1	419	429	PF00134	0.334
DOC_CYCLIN_yCln2_LP_2	140	146	PF00134	0.471
DOC_MAPK_MEF2A_6	231	240	PF00069	0.471
DOC_MAPK_RevD_3	200	214	PF00069	0.390
DOC_PP1_RVXF_1	407	413	PF00149	0.299
DOC_PP4_FxxP_1	440	443	PF00568	0.435
DOC_USP7_MATH_1	13	17	PF00917	0.643
DOC_USP7_MATH_1	164	168	PF00917	0.740
DOC_USP7_MATH_1	173	177	PF00917	0.502
DOC_USP7_MATH_1	24	28	PF00917	0.537
DOC_USP7_MATH_1	30	34	PF00917	0.478
DOC_USP7_MATH_1	377	381	PF00917	0.384
DOC_USP7_MATH_1	59	63	PF00917	0.548
DOC_USP7_MATH_2	189	195	PF00917	0.631
DOC_USP7_UBL2_3	180	184	PF12436	0.622
DOC_USP7_UBL2_3	60	64	PF12436	0.488
DOC_WW_Pin1_4	159	164	PF00397	0.669
DOC_WW_Pin1_4	276	281	PF00397	0.615
DOC_WW_Pin1_4	39	44	PF00397	0.704
DOC_WW_Pin1_4	9	14	PF00397	0.600
LIG_14-3-3_CanoR_1	121	126	PF00244	0.457
LIG_14-3-3_CanoR_1	330	338	PF00244	0.593
LIG_14-3-3_CanoR_1	435	439	PF00244	0.327
LIG_BRCT_BRCA1_1	436	440	PF00533	0.396
LIG_Clathr_ClatBox_1	237	241	PF01394	0.456
LIG_FHA_1	64	70	PF00498	0.452
LIG_FHA_1	97	103	PF00498	0.459
LIG_FHA_2	324	330	PF00498	0.584
LIG_FHA_2	331	337	PF00498	0.585
LIG_FHA_2	445	451	PF00498	0.391
LIG_FHA_2	70	76	PF00498	0.454
LIG_LIR_Apic_2	437	443	PF02991	0.423
LIG_LIR_Nem_3	399	404	PF02991	0.327
LIG_LIR_Nem_3	75	81	PF02991	0.441
LIG_Pex14_2	397	401	PF04695	0.333
LIG_SH2_CRK	89	93	PF00017	0.369
LIG_SH2_STAP1	404	408	PF00017	0.339
LIG_SH2_STAP1	96	100	PF00017	0.399
LIG_SH2_STAT5	217	220	PF00017	0.427
LIG_SH2_STAT5	451	454	PF00017	0.414
LIG_SH2_STAT5	89	92	PF00017	0.399
LIG_SH3_3	157	163	PF00018	0.687
LIG_SH3_3	223	229	PF00018	0.395
LIG_SH3_3	34	40	PF00018	0.581
LIG_SUMO_SIM_par_1	66	72	PF11976	0.454
LIG_SUMO_SIM_par_1	97	103	PF11976	0.444
LIG_TRFH_1	428	432	PF08558	0.434
LIG_UBA3_1	237	242	PF00899	0.444
MOD_CK1_1	167	173	PF00069	0.609
MOD_CK1_1	194	200	PF00069	0.547
MOD_CK1_1	276	282	PF00069	0.639
MOD_CK1_1	3	9	PF00069	0.632
MOD_CK1_1	399	405	PF00069	0.299
MOD_CK1_1	91	97	PF00069	0.342
MOD_CK2_1	323	329	PF00069	0.664
MOD_CK2_1	399	405	PF00069	0.325
MOD_CK2_1	444	450	PF00069	0.415
MOD_CK2_1	456	462	PF00069	0.386
MOD_CK2_1	69	75	PF00069	0.465
MOD_CK2_1	91	97	PF00069	0.457
MOD_Cter_Amidation	33	36	PF01082	0.547
MOD_Cter_Amidation	345	348	PF01082	0.597
MOD_DYRK1A_RPxSP_1	159	163	PF00069	0.634
MOD_GlcNHglycan	134	137	PF01048	0.501
MOD_GlcNHglycan	177	180	PF01048	0.662
MOD_GlcNHglycan	243	246	PF01048	0.602
MOD_GlcNHglycan	26	29	PF01048	0.656
MOD_GlcNHglycan	275	278	PF01048	0.640
MOD_GlcNHglycan	3	6	PF01048	0.634
MOD_GlcNHglycan	32	35	PF01048	0.594
MOD_GlcNHglycan	356	359	PF01048	0.465
MOD_GSK3_1	128	135	PF00069	0.374
MOD_GSK3_1	154	161	PF00069	0.564
MOD_GSK3_1	167	174	PF00069	0.661
MOD_GSK3_1	252	259	PF00069	0.599
MOD_GSK3_1	279	286	PF00069	0.591
MOD_GSK3_1	346	353	PF00069	0.601
MOD_GSK3_1	434	441	PF00069	0.326
MOD_GSK3_1	59	66	PF00069	0.539
MOD_GSK3_1	9	16	PF00069	0.597
MOD_LATS_1	328	334	PF00433	0.595
MOD_LATS_1	45	51	PF00433	0.543
MOD_N-GLC_1	24	29	PF02516	0.653
MOD_N-GLC_1	456	461	PF02516	0.466
MOD_NEK2_1	1	6	PF00069	0.640
MOD_NEK2_1	151	156	PF00069	0.545
MOD_NEK2_1	352	357	PF00069	0.580
MOD_NEK2_1	434	439	PF00069	0.322
MOD_NEK2_1	444	449	PF00069	0.485
MOD_NEK2_2	136	141	PF00069	0.347
MOD_NEK2_2	88	93	PF00069	0.321
MOD_PIKK_1	451	457	PF00454	0.339
MOD_PKA_1	158	164	PF00069	0.585
MOD_PKA_1	273	279	PF00069	0.570
MOD_PKA_1	350	356	PF00069	0.572
MOD_PKA_2	158	164	PF00069	0.585
MOD_PKA_2	273	279	PF00069	0.570
MOD_PKA_2	346	352	PF00069	0.636
MOD_PKA_2	434	440	PF00069	0.340
MOD_PKB_1	128	136	PF00069	0.364
MOD_PKB_1	348	356	PF00069	0.557
MOD_Plk_1	136	142	PF00069	0.350
MOD_Plk_1	194	200	PF00069	0.547
MOD_Plk_1	456	462	PF00069	0.480
MOD_Plk_1	96	102	PF00069	0.414
MOD_Plk_2-3	456	462	PF00069	0.480
MOD_Plk_4	356	362	PF00069	0.493
MOD_Plk_4	414	420	PF00069	0.312
MOD_Plk_4	434	440	PF00069	0.320
MOD_Plk_4	65	71	PF00069	0.468
MOD_ProDKin_1	159	165	PF00069	0.669
MOD_ProDKin_1	276	282	PF00069	0.615
MOD_ProDKin_1	39	45	PF00069	0.706
MOD_ProDKin_1	9	15	PF00069	0.598
MOD_SUMO_for_1	257	260	PF00179	0.646
MOD_SUMO_for_1	308	311	PF00179	0.660
MOD_SUMO_rev_2	161	170	PF00179	0.596
TRG_DiLeu_BaLyEn_6	112	117	PF01217	0.488
TRG_ENDOCYTIC_2	89	92	PF00928	0.361
TRG_ER_diArg_1	114	116	PF00400	0.575
TRG_ER_diArg_1	127	130	PF00400	0.288
TRG_ER_diArg_1	158	160	PF00400	0.628
TRG_ER_diArg_1	212	214	PF00400	0.414
TRG_ER_diArg_1	290	293	PF00400	0.654
TRG_ER_diArg_1	347	350	PF00400	0.567
TRG_ER_diArg_1	365	367	PF00400	0.500
TRG_ER_diArg_1	387	390	PF00400	0.332
TRG_NLS_Bipartite_1	273	293	PF00514	0.514
TRG_NLS_MonoCore_2	286	291	PF00514	0.526
TRG_NLS_MonoExtC_3	287	292	PF00514	0.529
TRG_NLS_MonoExtN_4	284	291	PF00514	0.521

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7S2	Leptomonas seymouri	49%	100%
A0A3S5H6P2	Leishmania donovani	100%	100%
A4H788	Leishmania braziliensis	72%	100%
E9APC4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QG54	Leishmania major	89%	100%