Uncharacterized protein

Quick info Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HVM8_LEIIN

TriTrypDb:

LINF_130014900

Length:

462

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

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Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

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Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4HVM8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVM8

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	267	271	PF00656	0.519
CLV_C14_Caspase3-7	311	315	PF00656	0.630
CLV_NRD_NRD_1	114	116	PF00675	0.573
CLV_NRD_NRD_1	158	160	PF00675	0.678
CLV_NRD_NRD_1	213	215	PF00675	0.511
CLV_NRD_NRD_1	273	275	PF00675	0.617
CLV_NRD_NRD_1	286	288	PF00675	0.618
CLV_NRD_NRD_1	347	349	PF00675	0.583
CLV_NRD_NRD_1	350	352	PF00675	0.547
CLV_NRD_NRD_1	366	368	PF00675	0.549

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7S2	Leptomonas seymouri	49%	100%
A0A3S5H6P2	Leishmania donovani	100%	100%
A4H788	Leishmania braziliensis	72%	100%
E9APC4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QG54	Leishmania major	89%	100%

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