LeishMANIAdb
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Putative N(2), N(2)-dimethylguanosine tRNA methyltransferase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative N(2), N(2)-dimethylguanosine tRNA methyltransferase
Gene product:
N(2) - N(2)-dimethylguanosine tRNA methyltransferase - putative
Species:
Leishmania infantum
UniProt:
A4HVM2_LEIIN
TriTrypDb:
LINF_130014300
Length:
725

Annotations

Annotations by Jardim et al.

tRNA synthetase, N(2), N(2)-dimethylguanosine tRNA methyltransferase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HVM2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVM2

Function

Biological processes
Term Name Level Count
GO:0001510 RNA methylation 4 1
GO:0002940 tRNA N2-guanine methylation 6 1
GO:0006139 nucleobase-containing compound metabolic process 3 1
GO:0006396 RNA processing 6 1
GO:0006399 tRNA metabolic process 7 1
GO:0006400 tRNA modification 6 1
GO:0006725 cellular aromatic compound metabolic process 3 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008033 tRNA processing 8 1
GO:0008152 metabolic process 1 1
GO:0009451 RNA modification 5 1
GO:0009987 cellular process 1 1
GO:0016070 RNA metabolic process 5 1
GO:0030488 tRNA methylation 5 1
GO:0032259 methylation 2 1
GO:0034470 ncRNA processing 7 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0034660 ncRNA metabolic process 6 1
GO:0043170 macromolecule metabolic process 3 1
GO:0043412 macromolecule modification 4 1
GO:0043414 macromolecule methylation 3 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0044260 obsolete cellular macromolecule metabolic process 3 1
GO:0046483 heterocycle metabolic process 3 1
GO:0071704 organic substance metabolic process 2 1
GO:0090304 nucleic acid metabolic process 4 1
GO:1901360 organic cyclic compound metabolic process 3 1
Molecular functions
Term Name Level Count
GO:0000049 tRNA binding 5 12
GO:0003676 nucleic acid binding 3 12
GO:0003723 RNA binding 4 12
GO:0003824 catalytic activity 1 12
GO:0004809 tRNA (guanine-N2-)-methyltransferase activity 6 12
GO:0005488 binding 1 12
GO:0008168 methyltransferase activity 4 12
GO:0008170 N-methyltransferase activity 5 12
GO:0008173 RNA methyltransferase activity 4 12
GO:0008175 tRNA methyltransferase activity 5 12
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 5 12
GO:0016423 tRNA (guanine) methyltransferase activity 6 12
GO:0016740 transferase activity 2 12
GO:0016741 transferase activity, transferring one-carbon groups 3 12
GO:0097159 organic cyclic compound binding 2 12
GO:0140098 catalytic activity, acting on RNA 3 12
GO:0140101 catalytic activity, acting on a tRNA 4 12
GO:0140640 catalytic activity, acting on a nucleic acid 2 12
GO:1901363 heterocyclic compound binding 2 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 279 283 PF00656 0.266
CLV_C14_Caspase3-7 55 59 PF00656 0.622
CLV_C14_Caspase3-7 716 720 PF00656 0.685
CLV_NRD_NRD_1 394 396 PF00675 0.486
CLV_NRD_NRD_1 405 407 PF00675 0.519
CLV_NRD_NRD_1 439 441 PF00675 0.563
CLV_NRD_NRD_1 698 700 PF00675 0.575
CLV_NRD_NRD_1 96 98 PF00675 0.286
CLV_PCSK_FUR_1 437 441 PF00082 0.557
CLV_PCSK_KEX2_1 222 224 PF00082 0.505
CLV_PCSK_KEX2_1 393 395 PF00082 0.482
CLV_PCSK_KEX2_1 405 407 PF00082 0.511
CLV_PCSK_KEX2_1 439 441 PF00082 0.766
CLV_PCSK_KEX2_1 443 445 PF00082 0.795
CLV_PCSK_KEX2_1 697 699 PF00082 0.567
CLV_PCSK_KEX2_1 95 97 PF00082 0.302
CLV_PCSK_PC1ET2_1 222 224 PF00082 0.476
CLV_PCSK_PC1ET2_1 443 445 PF00082 0.796
CLV_PCSK_PC7_1 390 396 PF00082 0.635
CLV_PCSK_PC7_1 439 445 PF00082 0.629
CLV_PCSK_SKI1_1 122 126 PF00082 0.365
CLV_PCSK_SKI1_1 240 244 PF00082 0.455
CLV_PCSK_SKI1_1 268 272 PF00082 0.300
CLV_PCSK_SKI1_1 314 318 PF00082 0.266
CLV_PCSK_SKI1_1 344 348 PF00082 0.337
CLV_PCSK_SKI1_1 553 557 PF00082 0.358
CLV_PCSK_SKI1_1 617 621 PF00082 0.300
CLV_PCSK_SKI1_1 657 661 PF00082 0.580
DEG_APCC_DBOX_1 313 321 PF00400 0.281
DEG_APCC_DBOX_1 552 560 PF00400 0.411
DEG_SCF_FBW7_2 659 666 PF00400 0.497
DEG_SPOP_SBC_1 39 43 PF00917 0.588
DEG_SPOP_SBC_1 493 497 PF00917 0.254
DOC_ANK_TNKS_1 677 684 PF00023 0.426
DOC_CKS1_1 580 585 PF01111 0.360
DOC_CKS1_1 660 665 PF01111 0.495
DOC_CYCLIN_RxL_1 309 321 PF00134 0.266
DOC_CYCLIN_RxL_1 654 662 PF00134 0.563
DOC_CYCLIN_yCln2_LP_2 511 517 PF00134 0.325
DOC_MAPK_DCC_7 329 337 PF00069 0.269
DOC_MAPK_DCC_7 607 616 PF00069 0.277
DOC_MAPK_gen_1 268 278 PF00069 0.281
DOC_MAPK_gen_1 326 334 PF00069 0.266
DOC_MAPK_MEF2A_6 329 337 PF00069 0.269
DOC_MAPK_MEF2A_6 547 556 PF00069 0.277
DOC_MAPK_MEF2A_6 607 616 PF00069 0.277
DOC_PP2B_LxvP_1 32 35 PF13499 0.411
DOC_PP4_FxxP_1 330 333 PF00568 0.393
DOC_PP4_FxxP_1 67 70 PF00568 0.266
DOC_USP7_MATH_1 213 217 PF00917 0.547
DOC_USP7_MATH_1 231 235 PF00917 0.630
DOC_USP7_MATH_1 255 259 PF00917 0.316
DOC_USP7_MATH_1 386 390 PF00917 0.331
DOC_USP7_MATH_1 39 43 PF00917 0.651
DOC_USP7_MATH_1 429 433 PF00917 0.727
DOC_USP7_MATH_1 469 473 PF00917 0.525
DOC_USP7_MATH_1 641 645 PF00917 0.692
DOC_USP7_MATH_1 650 654 PF00917 0.637
DOC_USP7_UBL2_3 643 647 PF12436 0.563
DOC_WW_Pin1_4 14 19 PF00397 0.486
DOC_WW_Pin1_4 184 189 PF00397 0.708
DOC_WW_Pin1_4 233 238 PF00397 0.567
DOC_WW_Pin1_4 257 262 PF00397 0.314
DOC_WW_Pin1_4 467 472 PF00397 0.505
DOC_WW_Pin1_4 477 482 PF00397 0.455
DOC_WW_Pin1_4 579 584 PF00397 0.360
DOC_WW_Pin1_4 659 664 PF00397 0.443
LIG_14-3-3_CanoR_1 378 388 PF00244 0.411
LIG_14-3-3_CanoR_1 473 477 PF00244 0.451
LIG_14-3-3_CanoR_1 536 542 PF00244 0.397
LIG_14-3-3_CanoR_1 88 94 PF00244 0.393
LIG_Actin_WH2_2 100 118 PF00022 0.281
LIG_Actin_WH2_2 75 92 PF00022 0.331
LIG_APCC_ABBA_1 335 340 PF00400 0.266
LIG_BIR_II_1 1 5 PF00653 0.522
LIG_BRCT_BRCA1_1 4 8 PF00533 0.398
LIG_FAT_LD_1 526 534 PF03623 0.355
LIG_FHA_1 234 240 PF00498 0.521
LIG_FHA_1 26 32 PF00498 0.390
LIG_FHA_1 547 553 PF00498 0.369
LIG_FHA_1 580 586 PF00498 0.325
LIG_FHA_2 103 109 PF00498 0.266
LIG_FHA_2 156 162 PF00498 0.389
LIG_FHA_2 277 283 PF00498 0.266
LIG_GSK3_LRP6_1 579 584 PF00069 0.271
LIG_IRF3_LxIS_1 74 81 PF10401 0.403
LIG_LIR_Apic_2 373 379 PF02991 0.331
LIG_LIR_Gen_1 573 581 PF02991 0.267
LIG_LIR_Gen_1 84 94 PF02991 0.325
LIG_LIR_Nem_3 264 270 PF02991 0.381
LIG_LIR_Nem_3 573 577 PF02991 0.306
LIG_LIR_Nem_3 84 89 PF02991 0.325
LIG_LYPXL_yS_3 156 159 PF13949 0.524
LIG_MYND_1 237 241 PF01753 0.423
LIG_NRBOX 525 531 PF00104 0.266
LIG_PCNA_yPIPBox_3 240 251 PF02747 0.329
LIG_PTB_Apo_2 123 130 PF02174 0.411
LIG_PTB_Apo_2 143 150 PF02174 0.411
LIG_PTB_Phospho_1 123 129 PF10480 0.411
LIG_PTB_Phospho_1 143 149 PF10480 0.411
LIG_REV1ctd_RIR_1 344 352 PF16727 0.325
LIG_SH2_CRK 10 14 PF00017 0.496
LIG_SH2_CRK 149 153 PF00017 0.411
LIG_SH2_CRK 350 354 PF00017 0.281
LIG_SH2_CRK 516 520 PF00017 0.281
LIG_SH2_NCK_1 516 520 PF00017 0.266
LIG_SH2_NCK_1 68 72 PF00017 0.266
LIG_SH2_PTP2 574 577 PF00017 0.411
LIG_SH2_SRC 129 132 PF00017 0.325
LIG_SH2_STAP1 10 14 PF00017 0.570
LIG_SH2_STAT3 365 368 PF00017 0.296
LIG_SH2_STAT5 129 132 PF00017 0.343
LIG_SH2_STAT5 342 345 PF00017 0.266
LIG_SH2_STAT5 566 569 PF00017 0.434
LIG_SH2_STAT5 574 577 PF00017 0.386
LIG_SH3_1 686 692 PF00018 0.453
LIG_SH3_2 468 473 PF14604 0.447
LIG_SH3_3 151 157 PF00018 0.493
LIG_SH3_3 224 230 PF00018 0.531
LIG_SH3_3 28 34 PF00018 0.366
LIG_SH3_3 465 471 PF00018 0.427
LIG_SH3_3 557 563 PF00018 0.294
LIG_SH3_3 574 580 PF00018 0.199
LIG_SH3_3 686 692 PF00018 0.453
LIG_SUMO_SIM_anti_2 102 108 PF11976 0.360
LIG_SUMO_SIM_anti_2 79 84 PF11976 0.309
LIG_SUMO_SIM_par_1 249 254 PF11976 0.272
LIG_SUMO_SIM_par_1 81 87 PF11976 0.331
LIG_TRAF2_1 389 392 PF00917 0.287
LIG_TRAF2_1 416 419 PF00917 0.581
LIG_TRAF2_1 53 56 PF00917 0.601
LIG_TRAF2_1 555 558 PF00917 0.281
LIG_TRFH_1 565 569 PF08558 0.331
LIG_TYR_ITIM 154 159 PF00017 0.433
LIG_UBA3_1 615 623 PF00899 0.337
MOD_CDC14_SPxK_1 470 473 PF00782 0.586
MOD_CDK_SPK_2 184 189 PF00069 0.585
MOD_CDK_SPxK_1 467 473 PF00069 0.532
MOD_CDK_SPxxK_3 233 240 PF00069 0.409
MOD_CK1_1 2 8 PF00069 0.546
MOD_CK1_1 280 286 PF00069 0.280
MOD_CK1_1 370 376 PF00069 0.474
MOD_CK1_1 472 478 PF00069 0.538
MOD_CK1_1 489 495 PF00069 0.536
MOD_CK1_1 50 56 PF00069 0.689
MOD_CK2_1 102 108 PF00069 0.266
MOD_CK2_1 155 161 PF00069 0.386
MOD_CK2_1 386 392 PF00069 0.364
MOD_CK2_1 39 45 PF00069 0.553
MOD_CK2_1 439 445 PF00069 0.693
MOD_CK2_1 50 56 PF00069 0.695
MOD_CK2_1 78 84 PF00069 0.403
MOD_Cter_Amidation 220 223 PF01082 0.522
MOD_GlcNHglycan 110 113 PF01048 0.266
MOD_GlcNHglycan 181 184 PF01048 0.660
MOD_GlcNHglycan 216 219 PF01048 0.503
MOD_GlcNHglycan 232 236 PF01048 0.677
MOD_GlcNHglycan 257 260 PF01048 0.298
MOD_GlcNHglycan 282 285 PF01048 0.322
MOD_GlcNHglycan 358 361 PF01048 0.421
MOD_GlcNHglycan 372 375 PF01048 0.423
MOD_GlcNHglycan 4 7 PF01048 0.398
MOD_GlcNHglycan 42 45 PF01048 0.634
MOD_GlcNHglycan 488 491 PF01048 0.589
MOD_GlcNHglycan 511 514 PF01048 0.273
MOD_GlcNHglycan 721 724 PF01048 0.789
MOD_GSK3_1 22 29 PF00069 0.511
MOD_GSK3_1 231 238 PF00069 0.519
MOD_GSK3_1 276 283 PF00069 0.314
MOD_GSK3_1 429 436 PF00069 0.695
MOD_GSK3_1 47 54 PF00069 0.670
MOD_GSK3_1 489 496 PF00069 0.562
MOD_GSK3_1 505 512 PF00069 0.299
MOD_GSK3_1 651 658 PF00069 0.626
MOD_LATS_1 295 301 PF00433 0.266
MOD_N-GLC_1 214 219 PF02516 0.547
MOD_N-GLC_1 50 55 PF02516 0.720
MOD_NEK2_1 110 115 PF00069 0.280
MOD_NEK2_1 214 219 PF00069 0.395
MOD_NEK2_1 276 281 PF00069 0.279
MOD_NEK2_1 290 295 PF00069 0.266
MOD_NEK2_1 367 372 PF00069 0.333
MOD_NEK2_1 78 83 PF00069 0.403
MOD_NEK2_2 333 338 PF00069 0.266
MOD_PIKK_1 517 523 PF00454 0.281
MOD_PIKK_1 594 600 PF00454 0.266
MOD_PK_1 76 82 PF00069 0.266
MOD_PKA_1 439 445 PF00069 0.564
MOD_PKA_2 386 392 PF00069 0.373
MOD_PKA_2 439 445 PF00069 0.700
MOD_PKA_2 472 478 PF00069 0.570
MOD_PKA_2 535 541 PF00069 0.353
MOD_PKA_2 546 552 PF00069 0.295
MOD_PKA_2 594 600 PF00069 0.281
MOD_PKA_2 89 95 PF00069 0.337
MOD_PKB_1 437 445 PF00069 0.560
MOD_PKB_1 95 103 PF00069 0.411
MOD_Plk_1 667 673 PF00069 0.365
MOD_Plk_1 76 82 PF00069 0.276
MOD_Plk_2-3 102 108 PF00069 0.360
MOD_Plk_4 155 161 PF00069 0.422
MOD_Plk_4 505 511 PF00069 0.356
MOD_Plk_4 570 576 PF00069 0.266
MOD_ProDKin_1 14 20 PF00069 0.487
MOD_ProDKin_1 184 190 PF00069 0.694
MOD_ProDKin_1 233 239 PF00069 0.562
MOD_ProDKin_1 257 263 PF00069 0.314
MOD_ProDKin_1 467 473 PF00069 0.504
MOD_ProDKin_1 477 483 PF00069 0.458
MOD_ProDKin_1 579 585 PF00069 0.360
MOD_ProDKin_1 659 665 PF00069 0.447
MOD_SUMO_rev_2 414 422 PF00179 0.721
MOD_SUMO_rev_2 642 650 PF00179 0.648
TRG_DiLeu_BaLyEn_6 238 243 PF01217 0.413
TRG_DiLeu_BaLyEn_6 330 335 PF01217 0.302
TRG_ENDOCYTIC_2 10 13 PF00928 0.488
TRG_ENDOCYTIC_2 121 124 PF00928 0.289
TRG_ENDOCYTIC_2 149 152 PF00928 0.411
TRG_ENDOCYTIC_2 156 159 PF00928 0.524
TRG_ENDOCYTIC_2 298 301 PF00928 0.266
TRG_ENDOCYTIC_2 574 577 PF00928 0.411
TRG_ER_diArg_1 393 395 PF00400 0.566
TRG_ER_diArg_1 405 408 PF00400 0.580
TRG_ER_diArg_1 437 440 PF00400 0.556
TRG_ER_diArg_1 677 680 PF00400 0.520
TRG_ER_diArg_1 696 699 PF00400 0.705
TRG_ER_diArg_1 88 91 PF00400 0.283
TRG_ER_diArg_1 94 97 PF00400 0.279
TRG_Pf-PMV_PEXEL_1 240 244 PF00026 0.421
TRG_Pf-PMV_PEXEL_1 268 272 PF00026 0.300

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PF43 Leptomonas seymouri 68% 99%
A0A0S4IT52 Bodo saltans 47% 100%
A0A1X0NNC1 Trypanosomatidae 49% 96%
A0A3R7KAT5 Trypanosoma rangeli 51% 100%
A0A3S7WSL8 Leishmania donovani 100% 100%
A4H782 Leishmania braziliensis 79% 100%
D0A6N2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 50% 100%
E9APB8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
Q4QG60 Leishmania major 93% 99%
V5BB27 Trypanosoma cruzi 52% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS