Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HVL8_LEIIN

TriTrypDb:

LINF_130013900

Length:

616

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HVL8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVL8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	439	443	PF00656	0.634
CLV_NRD_NRD_1	152	154	PF00675	0.587
CLV_NRD_NRD_1	166	168	PF00675	0.596
CLV_NRD_NRD_1	205	207	PF00675	0.585
CLV_NRD_NRD_1	209	211	PF00675	0.549
CLV_NRD_NRD_1	221	223	PF00675	0.569
CLV_NRD_NRD_1	260	262	PF00675	0.572
CLV_NRD_NRD_1	291	293	PF00675	0.582
CLV_NRD_NRD_1	33	35	PF00675	0.709
CLV_NRD_NRD_1	406	408	PF00675	0.780
CLV_NRD_NRD_1	52	54	PF00675	0.628
CLV_NRD_NRD_1	553	555	PF00675	0.763
CLV_NRD_NRD_1	578	580	PF00675	0.805
CLV_NRD_NRD_1	581	583	PF00675	0.845
CLV_PCSK_FUR_1	579	583	PF00082	0.739
CLV_PCSK_KEX2_1	152	154	PF00082	0.587
CLV_PCSK_KEX2_1	166	168	PF00082	0.596
CLV_PCSK_KEX2_1	171	173	PF00082	0.590
CLV_PCSK_KEX2_1	209	211	PF00082	0.549
CLV_PCSK_KEX2_1	260	262	PF00082	0.580
CLV_PCSK_KEX2_1	286	288	PF00082	0.535
CLV_PCSK_KEX2_1	290	292	PF00082	0.539
CLV_PCSK_KEX2_1	301	303	PF00082	0.497
CLV_PCSK_KEX2_1	33	35	PF00082	0.563
CLV_PCSK_KEX2_1	51	53	PF00082	0.674
CLV_PCSK_KEX2_1	553	555	PF00082	0.763
CLV_PCSK_KEX2_1	577	579	PF00082	0.782
CLV_PCSK_KEX2_1	581	583	PF00082	0.836
CLV_PCSK_KEX2_1	68	70	PF00082	0.488
CLV_PCSK_KEX2_1	81	83	PF00082	0.604
CLV_PCSK_PC1ET2_1	171	173	PF00082	0.590
CLV_PCSK_PC1ET2_1	286	288	PF00082	0.591
CLV_PCSK_PC1ET2_1	301	303	PF00082	0.565
CLV_PCSK_PC1ET2_1	51	53	PF00082	0.674
CLV_PCSK_PC1ET2_1	68	70	PF00082	0.488
CLV_PCSK_PC1ET2_1	81	83	PF00082	0.604
CLV_PCSK_PC7_1	167	173	PF00082	0.588
CLV_PCSK_PC7_1	287	293	PF00082	0.539
CLV_PCSK_PC7_1	577	583	PF00082	0.761
CLV_PCSK_SKI1_1	210	214	PF00082	0.558
CLV_PCSK_SKI1_1	229	233	PF00082	0.619
CLV_PCSK_SKI1_1	265	269	PF00082	0.518
CLV_PCSK_SKI1_1	302	306	PF00082	0.563
CLV_PCSK_SKI1_1	461	465	PF00082	0.641
DEG_Nend_UBRbox_1	1	4	PF02207	0.500
DEG_SPOP_SBC_1	107	111	PF00917	0.718
DEG_SPOP_SBC_1	369	373	PF00917	0.667
DOC_CKS1_1	516	521	PF01111	0.652
DOC_CYCLIN_RxL_1	298	308	PF00134	0.581
DOC_MAPK_gen_1	177	183	PF00069	0.683
DOC_MAPK_gen_1	206	217	PF00069	0.563
DOC_MAPK_gen_1	260	272	PF00069	0.565
DOC_MAPK_gen_1	286	297	PF00069	0.593
DOC_MAPK_gen_1	472	480	PF00069	0.599
DOC_MAPK_gen_1	560	567	PF00069	0.752
DOC_MAPK_MEF2A_6	209	217	PF00069	0.556
DOC_MAPK_MEF2A_6	290	299	PF00069	0.600
DOC_MAPK_NFAT4_5	210	218	PF00069	0.562
DOC_PP1_RVXF_1	238	244	PF00149	0.601
DOC_PP1_RVXF_1	299	306	PF00149	0.576
DOC_PP2B_LxvP_1	334	337	PF13499	0.595
DOC_PP4_FxxP_1	146	149	PF00568	0.564
DOC_USP7_MATH_1	107	111	PF00917	0.685
DOC_USP7_MATH_1	117	121	PF00917	0.699
DOC_USP7_MATH_1	135	139	PF00917	0.623
DOC_USP7_MATH_1	279	283	PF00917	0.583
DOC_USP7_MATH_1	368	372	PF00917	0.701
DOC_USP7_MATH_1	416	420	PF00917	0.774
DOC_USP7_MATH_1	549	553	PF00917	0.715
DOC_USP7_MATH_1	584	588	PF00917	0.821
DOC_USP7_UBL2_3	262	266	PF12436	0.558
DOC_WW_Pin1_4	109	114	PF00397	0.659
DOC_WW_Pin1_4	145	150	PF00397	0.566
DOC_WW_Pin1_4	424	429	PF00397	0.804
DOC_WW_Pin1_4	515	520	PF00397	0.809
DOC_WW_Pin1_4	523	528	PF00397	0.673
DOC_WW_Pin1_4	598	603	PF00397	0.728
LIG_14-3-3_CanoR_1	209	213	PF00244	0.565
LIG_14-3-3_CanoR_1	461	467	PF00244	0.662
LIG_14-3-3_CanoR_1	474	480	PF00244	0.503
LIG_14-3-3_CanoR_1	9	18	PF00244	0.512
LIG_Actin_WH2_2	71	86	PF00022	0.614
LIG_APCC_ABBAyCdc20_2	301	307	PF00400	0.567
LIG_BIR_III_2	504	508	PF00653	0.707
LIG_BRCT_BRCA1_1	142	146	PF00533	0.632
LIG_BRCT_BRCA1_1	227	231	PF00533	0.621
LIG_deltaCOP1_diTrp_1	64	74	PF00928	0.596
LIG_DLG_GKlike_1	291	299	PF00625	0.703
LIG_FHA_1	320	326	PF00498	0.600
LIG_FHA_1	333	339	PF00498	0.573
LIG_FHA_1	462	468	PF00498	0.722
LIG_FHA_1	473	479	PF00498	0.536
LIG_FHA_1	485	491	PF00498	0.522
LIG_FHA_1	85	91	PF00498	0.632
LIG_FHA_2	203	209	PF00498	0.627
LIG_FHA_2	214	220	PF00498	0.508
LIG_FHA_2	308	314	PF00498	0.647
LIG_Integrin_RGD_1	400	402	PF01839	0.742
LIG_LIR_Apic_2	143	149	PF02991	0.616
LIG_LIR_Gen_1	141	150	PF02991	0.602
LIG_LIR_Gen_1	211	220	PF02991	0.568
LIG_LIR_Gen_1	70	78	PF02991	0.595
LIG_LIR_Nem_3	141	145	PF02991	0.609
LIG_LIR_Nem_3	211	215	PF02991	0.553
LIG_LIR_Nem_3	70	74	PF02991	0.541
LIG_MYND_1	498	502	PF01753	0.689
LIG_MYND_1	612	616	PF01753	0.516
LIG_Pex14_2	142	146	PF04695	0.605
LIG_SH2_CRK	274	278	PF00017	0.601
LIG_SH2_CRK	56	60	PF00017	0.686
LIG_SH2_GRB2like	20	23	PF00017	0.527
LIG_SH2_STAP1	56	60	PF00017	0.788
LIG_SH2_STAT5	144	147	PF00017	0.598
LIG_SH2_STAT5	20	23	PF00017	0.473
LIG_SH2_STAT5	276	279	PF00017	0.592
LIG_SH2_STAT5	6	9	PF00017	0.498
LIG_SH3_1	610	616	PF00018	0.538
LIG_SH3_3	324	330	PF00018	0.549
LIG_SH3_3	445	451	PF00018	0.710
LIG_SH3_3	492	498	PF00018	0.679
LIG_SH3_3	610	616	PF00018	0.636
LIG_SH3_CIN85_PxpxPR_1	602	607	PF14604	0.718
LIG_Sin3_3	361	368	PF02671	0.668
LIG_SUMO_SIM_anti_2	179	185	PF11976	0.581
LIG_SUMO_SIM_anti_2	452	458	PF11976	0.763
LIG_SUMO_SIM_par_1	179	185	PF11976	0.581
LIG_SUMO_SIM_par_1	452	458	PF11976	0.763
LIG_TRAF2_1	383	386	PF00917	0.729
LIG_TYR_ITIM	272	277	PF00017	0.602
LIG_UBA3_1	295	301	PF00899	0.601
MOD_CDC14_SPxK_1	427	430	PF00782	0.725
MOD_CDK_SPK_2	525	530	PF00069	0.689
MOD_CDK_SPK_2	600	605	PF00069	0.715
MOD_CDK_SPxK_1	424	430	PF00069	0.721
MOD_CDK_SPxxK_3	145	152	PF00069	0.565
MOD_CDK_SPxxK_3	523	530	PF00069	0.740
MOD_CDK_SPxxK_3	598	605	PF00069	0.755
MOD_CK1_1	109	115	PF00069	0.660
MOD_CK1_1	11	17	PF00069	0.511
MOD_CK1_1	138	144	PF00069	0.713
MOD_CK1_1	182	188	PF00069	0.585
MOD_CK1_1	38	44	PF00069	0.655
MOD_CK1_1	412	418	PF00069	0.747
MOD_CK1_1	424	430	PF00069	0.787
MOD_CK1_1	552	558	PF00069	0.689
MOD_CK1_1	596	602	PF00069	0.802
MOD_CK1_1	73	79	PF00069	0.576
MOD_CK2_1	145	151	PF00069	0.588
MOD_CK2_1	202	208	PF00069	0.640
MOD_CK2_1	213	219	PF00069	0.498
MOD_CK2_1	584	590	PF00069	0.810
MOD_Cter_Amidation	299	302	PF01082	0.599
MOD_Cter_Amidation	49	52	PF01082	0.729
MOD_GlcNHglycan	119	122	PF01048	0.776
MOD_GlcNHglycan	349	352	PF01048	0.759
MOD_GlcNHglycan	353	356	PF01048	0.704
MOD_GlcNHglycan	372	375	PF01048	0.663
MOD_GlcNHglycan	411	414	PF01048	0.777
MOD_GlcNHglycan	418	421	PF01048	0.707
MOD_GlcNHglycan	42	45	PF01048	0.709
MOD_GlcNHglycan	424	427	PF01048	0.613
MOD_GlcNHglycan	432	435	PF01048	0.572
MOD_GlcNHglycan	491	494	PF01048	0.755
MOD_GlcNHglycan	539	542	PF01048	0.760
MOD_GlcNHglycan	555	558	PF01048	0.560
MOD_GlcNHglycan	585	589	PF01048	0.757
MOD_GlcNHglycan	75	78	PF01048	0.597
MOD_GlcNHglycan	87	90	PF01048	0.636
MOD_GlcNHglycan	94	97	PF01048	0.622
MOD_GSK3_1	10	17	PF00069	0.509
MOD_GSK3_1	140	147	PF00069	0.633
MOD_GSK3_1	18	25	PF00069	0.501
MOD_GSK3_1	303	310	PF00069	0.622
MOD_GSK3_1	315	322	PF00069	0.613
MOD_GSK3_1	332	339	PF00069	0.657
MOD_GSK3_1	347	354	PF00069	0.595
MOD_GSK3_1	35	42	PF00069	0.643
MOD_GSK3_1	411	418	PF00069	0.720
MOD_GSK3_1	457	464	PF00069	0.628
MOD_GSK3_1	484	491	PF00069	0.596
MOD_GSK3_1	525	532	PF00069	0.800
MOD_GSK3_1	548	555	PF00069	0.716
MOD_GSK3_1	584	591	PF00069	0.791
MOD_GSK3_1	593	600	PF00069	0.713
MOD_GSK3_1	69	76	PF00069	0.582
MOD_N-GLC_1	483	488	PF02516	0.571
MOD_NEK2_1	16	21	PF00069	0.527
MOD_NEK2_1	213	218	PF00069	0.562
MOD_NEK2_1	305	310	PF00069	0.473
MOD_NEK2_1	466	471	PF00069	0.636
MOD_NEK2_1	489	494	PF00069	0.611
MOD_PIKK_1	588	594	PF00454	0.762
MOD_PKA_1	291	297	PF00069	0.696
MOD_PKA_1	553	559	PF00069	0.687
MOD_PKA_2	208	214	PF00069	0.539
MOD_PKA_2	291	297	PF00069	0.696
MOD_PKA_2	38	44	PF00069	0.727
MOD_PKA_2	473	479	PF00069	0.594
MOD_PKA_2	484	490	PF00069	0.650
MOD_PKA_2	552	558	PF00069	0.689
MOD_PKA_2	8	14	PF00069	0.502
MOD_PKB_1	159	167	PF00069	0.483
MOD_PKB_1	37	45	PF00069	0.688
MOD_PKB_1	82	90	PF00069	0.630
MOD_Plk_1	315	321	PF00069	0.726
MOD_Plk_1	69	75	PF00069	0.537
MOD_Plk_4	179	185	PF00069	0.577
MOD_Plk_4	279	285	PF00069	0.585
MOD_Plk_4	291	297	PF00069	0.594
MOD_Plk_4	462	468	PF00069	0.614
MOD_Plk_4	70	76	PF00069	0.575
MOD_ProDKin_1	109	115	PF00069	0.663
MOD_ProDKin_1	145	151	PF00069	0.566
MOD_ProDKin_1	424	430	PF00069	0.807
MOD_ProDKin_1	515	521	PF00069	0.811
MOD_ProDKin_1	523	529	PF00069	0.671
MOD_ProDKin_1	598	604	PF00069	0.726
MOD_SUMO_rev_2	225	233	PF00179	0.653
MOD_SUMO_rev_2	235	242	PF00179	0.535
MOD_SUMO_rev_2	373	383	PF00179	0.684
TRG_DiLeu_BaEn_1	340	345	PF01217	0.603
TRG_DiLeu_BaEn_2	207	213	PF01217	0.656
TRG_DiLeu_BaEn_2	69	75	PF01217	0.595
TRG_DiLeu_BaLyEn_6	299	304	PF01217	0.605
TRG_DiLeu_LyEn_5	340	345	PF01217	0.603
TRG_ENDOCYTIC_2	274	277	PF00928	0.566
TRG_ENDOCYTIC_2	56	59	PF00928	0.693
TRG_ER_diArg_1	259	261	PF00400	0.585
TRG_ER_diArg_1	290	292	PF00400	0.601
TRG_ER_diArg_1	33	35	PF00400	0.745
TRG_ER_diArg_1	36	39	PF00400	0.765
TRG_ER_diArg_1	52	55	PF00400	0.470
TRG_ER_diArg_1	564	567	PF00400	0.760
TRG_ER_diArg_1	577	579	PF00400	0.645
TRG_ER_diArg_1	604	607	PF00400	0.720
TRG_NLS_Bipartite_1	33	55	PF00514	0.563
TRG_NLS_Bipartite_1	577	598	PF00514	0.625
TRG_NLS_MonoExtC_3	50	55	PF00514	0.712
TRG_Pf-PMV_PEXEL_1	343	347	PF00026	0.624

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I995	Leptomonas seymouri	57%	100%
A0A3Q8II04	Leishmania donovani	99%	98%
A4H778	Leishmania braziliensis	72%	100%
E9APB4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QG64	Leishmania major	90%	100%