LeishMANIAdb
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C3H1-type domain-containing protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
C3H1-type domain-containing protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4HVL6_LEIIN
TriTrypDb:
LINF_130013700
Length:
695

Annotations

Annotations by Jardim et al.

Protein modification, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 8
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0005730 nucleolus 5 1
GO:0043226 organelle 2 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HVL6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVL6

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 1
GO:0003723 RNA binding 4 1
GO:0005488 binding 1 1
GO:0097159 organic cyclic compound binding 2 1
GO:1901363 heterocyclic compound binding 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 606 610 PF00656 0.706
CLV_C14_Caspase3-7 639 643 PF00656 0.740
CLV_NRD_NRD_1 221 223 PF00675 0.711
CLV_NRD_NRD_1 287 289 PF00675 0.675
CLV_NRD_NRD_1 309 311 PF00675 0.670
CLV_NRD_NRD_1 499 501 PF00675 0.552
CLV_NRD_NRD_1 81 83 PF00675 0.455
CLV_PCSK_KEX2_1 221 223 PF00082 0.711
CLV_PCSK_KEX2_1 287 289 PF00082 0.675
CLV_PCSK_KEX2_1 309 311 PF00082 0.670
CLV_PCSK_KEX2_1 488 490 PF00082 0.552
CLV_PCSK_KEX2_1 499 501 PF00082 0.552
CLV_PCSK_KEX2_1 678 680 PF00082 0.694
CLV_PCSK_KEX2_1 690 692 PF00082 0.677
CLV_PCSK_KEX2_1 81 83 PF00082 0.455
CLV_PCSK_PC1ET2_1 488 490 PF00082 0.552
CLV_PCSK_PC1ET2_1 678 680 PF00082 0.694
CLV_PCSK_PC1ET2_1 690 692 PF00082 0.677
CLV_PCSK_SKI1_1 384 388 PF00082 0.404
CLV_PCSK_SKI1_1 453 457 PF00082 0.502
CLV_PCSK_SKI1_1 686 690 PF00082 0.755
DEG_SCF_FBW7_1 127 132 PF00400 0.691
DEG_SPOP_SBC_1 129 133 PF00917 0.671
DOC_AGCK_PIF_2 45 50 PF00069 0.432
DOC_CKS1_1 126 131 PF01111 0.700
DOC_CKS1_1 35 40 PF01111 0.461
DOC_MAPK_DCC_7 329 337 PF00069 0.556
DOC_MAPK_gen_1 389 396 PF00069 0.523
DOC_MAPK_MEF2A_6 389 396 PF00069 0.421
DOC_MAPK_NFAT4_5 389 397 PF00069 0.531
DOC_PP2B_LxvP_1 15 18 PF13499 0.440
DOC_USP7_MATH_1 129 133 PF00917 0.675
DOC_USP7_MATH_1 145 149 PF00917 0.440
DOC_USP7_MATH_1 524 528 PF00917 0.666
DOC_USP7_MATH_1 545 549 PF00917 0.799
DOC_USP7_MATH_1 554 558 PF00917 0.715
DOC_USP7_MATH_1 582 586 PF00917 0.757
DOC_USP7_MATH_1 588 592 PF00917 0.627
DOC_USP7_MATH_1 615 619 PF00917 0.656
DOC_USP7_UBL2_3 453 457 PF12436 0.502
DOC_USP7_UBL2_3 586 590 PF12436 0.663
DOC_USP7_UBL2_3 668 672 PF12436 0.700
DOC_USP7_UBL2_3 673 677 PF12436 0.697
DOC_USP7_UBL2_3 686 690 PF12436 0.477
DOC_WW_Pin1_4 125 130 PF00397 0.782
DOC_WW_Pin1_4 20 25 PF00397 0.521
DOC_WW_Pin1_4 34 39 PF00397 0.505
DOC_WW_Pin1_4 562 567 PF00397 0.641
DOC_WW_Pin1_4 584 589 PF00397 0.685
DOC_WW_Pin1_4 66 71 PF00397 0.482
DOC_WW_Pin1_4 95 100 PF00397 0.653
LIG_14-3-3_CanoR_1 323 329 PF00244 0.657
LIG_BIR_II_1 1 5 PF00653 0.492
LIG_BRCT_BRCA1_1 41 45 PF00533 0.435
LIG_CSL_BTD_1 15 18 PF09270 0.440
LIG_CtBP_PxDLS_1 38 42 PF00389 0.453
LIG_EH1_1 261 269 PF00400 0.599
LIG_FHA_1 12 18 PF00498 0.439
LIG_FHA_1 168 174 PF00498 0.652
LIG_FHA_1 25 31 PF00498 0.490
LIG_FHA_1 366 372 PF00498 0.438
LIG_FHA_2 339 345 PF00498 0.624
LIG_FHA_2 35 41 PF00498 0.529
LIG_FHA_2 598 604 PF00498 0.566
LIG_FHA_2 67 73 PF00498 0.474
LIG_IBAR_NPY_1 260 262 PF08397 0.708
LIG_Integrin_isoDGR_2 11 13 PF01839 0.571
LIG_Integrin_RGD_1 218 220 PF01839 0.764
LIG_IRF3_LxIS_1 5 10 PF10401 0.507
LIG_LIR_Apic_2 289 295 PF02991 0.673
LIG_LIR_Apic_2 348 353 PF02991 0.402
LIG_LIR_Gen_1 399 408 PF02991 0.552
LIG_LIR_Nem_3 399 403 PF02991 0.560
LIG_LIR_Nem_3 418 423 PF02991 0.222
LIG_LIR_Nem_3 42 48 PF02991 0.428
LIG_LIR_Nem_3 79 83 PF02991 0.475
LIG_NRBOX 168 174 PF00104 0.551
LIG_SH2_CRK 350 354 PF00017 0.477
LIG_SH2_CRK 96 100 PF00017 0.667
LIG_SH2_GRB2like 350 353 PF00017 0.468
LIG_SH2_NCK_1 96 100 PF00017 0.667
LIG_SH2_PTP2 35 38 PF00017 0.467
LIG_SH2_STAP1 234 238 PF00017 0.738
LIG_SH2_STAP1 50 54 PF00017 0.545
LIG_SH2_STAT3 50 53 PF00017 0.445
LIG_SH2_STAT5 35 38 PF00017 0.467
LIG_SH2_STAT5 425 428 PF00017 0.422
LIG_SH2_STAT5 46 49 PF00017 0.430
LIG_SH2_STAT5 514 517 PF00017 0.702
LIG_SH2_STAT5 8 11 PF00017 0.442
LIG_SH3_3 245 251 PF00018 0.640
LIG_SH3_3 337 343 PF00018 0.537
LIG_SH3_4 673 680 PF00018 0.790
LIG_TRAF2_1 399 402 PF00917 0.559
LIG_TRAF2_1 643 646 PF00917 0.803
LIG_UBA3_1 463 472 PF00899 0.484
MOD_CDK_SPxK_1 584 590 PF00069 0.665
MOD_CK1_1 132 138 PF00069 0.659
MOD_CK1_1 143 149 PF00069 0.753
MOD_CK1_1 564 570 PF00069 0.559
MOD_CK1_1 611 617 PF00069 0.641
MOD_CK1_1 618 624 PF00069 0.614
MOD_CK2_1 20 26 PF00069 0.507
MOD_CK2_1 338 344 PF00069 0.632
MOD_CK2_1 34 40 PF00069 0.470
MOD_CK2_1 396 402 PF00069 0.552
MOD_CK2_1 529 535 PF00069 0.678
MOD_CK2_1 66 72 PF00069 0.485
MOD_Cter_Amidation 285 288 PF01082 0.648
MOD_Cter_Amidation 387 390 PF01082 0.557
MOD_GlcNHglycan 1 4 PF01048 0.516
MOD_GlcNHglycan 143 146 PF01048 0.758
MOD_GlcNHglycan 147 150 PF01048 0.725
MOD_GlcNHglycan 164 167 PF01048 0.383
MOD_GlcNHglycan 183 186 PF01048 0.553
MOD_GlcNHglycan 284 287 PF01048 0.669
MOD_GlcNHglycan 517 520 PF01048 0.785
MOD_GlcNHglycan 552 555 PF01048 0.796
MOD_GlcNHglycan 613 616 PF01048 0.658
MOD_GlcNHglycan 632 636 PF01048 0.762
MOD_GSK3_1 125 132 PF00069 0.719
MOD_GSK3_1 140 147 PF00069 0.703
MOD_GSK3_1 177 184 PF00069 0.714
MOD_GSK3_1 18 25 PF00069 0.448
MOD_GSK3_1 228 235 PF00069 0.588
MOD_GSK3_1 282 289 PF00069 0.694
MOD_GSK3_1 311 318 PF00069 0.756
MOD_GSK3_1 515 522 PF00069 0.682
MOD_GSK3_1 550 557 PF00069 0.740
MOD_GSK3_1 578 585 PF00069 0.776
MOD_GSK3_1 609 616 PF00069 0.627
MOD_GSK3_1 617 624 PF00069 0.624
MOD_GSK3_1 7 14 PF00069 0.487
MOD_N-GLC_1 186 191 PF02516 0.750
MOD_NEK2_1 140 145 PF00069 0.696
MOD_NEK2_1 232 237 PF00069 0.733
MOD_NEK2_1 305 310 PF00069 0.648
MOD_NEK2_1 324 329 PF00069 0.409
MOD_NEK2_1 39 44 PF00069 0.442
MOD_NEK2_1 513 518 PF00069 0.701
MOD_NEK2_1 561 566 PF00069 0.645
MOD_NEK2_1 7 12 PF00069 0.440
MOD_PIKK_1 132 138 PF00454 0.656
MOD_PIKK_1 167 173 PF00454 0.648
MOD_PIKK_1 232 238 PF00454 0.735
MOD_PIKK_1 313 319 PF00454 0.769
MOD_PIKK_1 505 511 PF00454 0.600
MOD_PIKK_1 519 525 PF00454 0.495
MOD_PIKK_1 538 544 PF00454 0.694
MOD_PIKK_1 545 551 PF00454 0.687
MOD_PIKK_1 564 570 PF00454 0.470
MOD_PKA_1 686 692 PF00069 0.777
MOD_PKA_2 18 24 PF00069 0.538
MOD_PKA_2 286 292 PF00069 0.759
MOD_Plk_2-3 338 344 PF00069 0.552
MOD_Plk_2-3 529 535 PF00069 0.678
MOD_Plk_4 345 351 PF00069 0.452
MOD_Plk_4 365 371 PF00069 0.285
MOD_Plk_4 554 560 PF00069 0.775
MOD_ProDKin_1 125 131 PF00069 0.779
MOD_ProDKin_1 20 26 PF00069 0.514
MOD_ProDKin_1 34 40 PF00069 0.495
MOD_ProDKin_1 562 568 PF00069 0.640
MOD_ProDKin_1 584 590 PF00069 0.684
MOD_ProDKin_1 66 72 PF00069 0.485
MOD_ProDKin_1 95 101 PF00069 0.663
MOD_SUMO_rev_2 23 30 PF00179 0.605
MOD_SUMO_rev_2 344 349 PF00179 0.518
MOD_SUMO_rev_2 379 386 PF00179 0.480
MOD_SUMO_rev_2 399 406 PF00179 0.467
MOD_SUMO_rev_2 483 490 PF00179 0.644
MOD_SUMO_rev_2 657 666 PF00179 0.701
TRG_DiLeu_BaEn_2 85 91 PF01217 0.501
TRG_ENDOCYTIC_2 256 259 PF00928 0.721
TRG_ER_diArg_1 221 223 PF00400 0.770
TRG_ER_diArg_1 80 82 PF00400 0.447
TRG_NLS_Bipartite_1 667 682 PF00514 0.738
TRG_NLS_MonoExtC_3 676 681 PF00514 0.692
TRG_NLS_MonoExtC_3 689 694 PF00514 0.675
TRG_NLS_MonoExtN_4 665 671 PF00514 0.694
TRG_NLS_MonoExtN_4 674 681 PF00514 0.679
TRG_NLS_MonoExtN_4 687 694 PF00514 0.675

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PDX4 Leptomonas seymouri 54% 100%
A0A3S5H6P0 Leishmania donovani 99% 100%
A4H776 Leishmania braziliensis 86% 99%
E9APB2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
Q4QG66 Leishmania major 95% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS