Succinate dehydrogenase assembly factor 3

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Complex1 LYR-like - putative

Species:

Leishmania infantum

UniProt:

A4HVL0_LEIIN

TriTrypDb:

LINF_130013100

Length:

252

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005759	mitochondrial matrix	5	7
GO:0031974	membrane-enclosed lumen	2	7
GO:0043233	organelle lumen	3	7
GO:0070013	intracellular organelle lumen	4	7
GO:0110165	cellular anatomical entity	1	7
GO:0005758	mitochondrial intermembrane space	6	1
GO:0031970	organelle envelope lumen	5	1

Expansion

Sequence features

A4HVL0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVL0

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	7
GO:0016043	cellular component organization	3	7
GO:0022607	cellular component assembly	4	7
GO:0033108	mitochondrial respiratory chain complex assembly	6	7
GO:0034552	respiratory chain complex II assembly	6	7
GO:0034553	mitochondrial respiratory chain complex II assembly	7	7
GO:0043933	protein-containing complex organization	4	7
GO:0065003	protein-containing complex assembly	5	7
GO:0071840	cellular component organization or biogenesis	2	7
GO:0006082	organic acid metabolic process	3	1
GO:0006105	succinate metabolic process	7	1
GO:0008152	metabolic process	1	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0043436	oxoacid metabolic process	4	1
GO:0043648	dicarboxylic acid metabolic process	6	1
GO:0044237	cellular metabolic process	2	1
GO:0044281	small molecule metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	147	151	PF00656	0.517
CLV_NRD_NRD_1	117	119	PF00675	0.285
CLV_PCSK_KEX2_1	117	119	PF00082	0.285
CLV_PCSK_KEX2_1	221	223	PF00082	0.274
CLV_PCSK_PC1ET2_1	221	223	PF00082	0.274
CLV_PCSK_SKI1_1	163	167	PF00082	0.274
CLV_PCSK_SKI1_1	214	218	PF00082	0.303
CLV_PCSK_SKI1_1	221	225	PF00082	0.429
CLV_PCSK_SKI1_1	236	240	PF00082	0.471
CLV_PCSK_SKI1_1	91	95	PF00082	0.391
CLV_PCSK_SKI1_1	99	103	PF00082	0.287
DEG_APCC_DBOX_1	67	75	PF00400	0.431
DEG_MDM2_SWIB_1	196	204	PF02201	0.474
DOC_CKS1_1	165	170	PF01111	0.462
DOC_CYCLIN_RxL_1	157	169	PF00134	0.483
DOC_CYCLIN_RxL_1	218	227	PF00134	0.581
DOC_MAPK_gen_1	96	104	PF00069	0.474
DOC_PP1_RVXF_1	89	95	PF00149	0.388
DOC_USP7_MATH_1	49	53	PF00917	0.567
DOC_USP7_MATH_1	5	9	PF00917	0.590
DOC_USP7_MATH_1	75	79	PF00917	0.412
DOC_WW_Pin1_4	164	169	PF00397	0.608
DOC_WW_Pin1_4	84	89	PF00397	0.552
LIG_14-3-3_CanoR_1	243	251	PF00244	0.500
LIG_14-3-3_CanoR_1	68	72	PF00244	0.537
LIG_Actin_WH2_2	228	245	PF00022	0.467
LIG_Actin_WH2_2	52	70	PF00022	0.487
LIG_deltaCOP1_diTrp_1	82	90	PF00928	0.404
LIG_eIF4E_1	160	166	PF01652	0.462
LIG_FHA_2	145	151	PF00498	0.567
LIG_FHA_2	210	216	PF00498	0.474
LIG_LIR_Apic_2	82	88	PF02991	0.491
LIG_LIR_Gen_1	199	208	PF02991	0.474
LIG_LIR_Gen_1	63	74	PF02991	0.486
LIG_LIR_Gen_1	82	88	PF02991	0.366
LIG_LIR_Nem_3	158	164	PF02991	0.570
LIG_LIR_Nem_3	199	204	PF02991	0.474
LIG_LIR_Nem_3	63	69	PF02991	0.505
LIG_NRBOX	161	167	PF00104	0.474
LIG_Pex14_1	90	94	PF04695	0.379
LIG_Pex14_2	173	177	PF04695	0.474
LIG_Pex14_2	196	200	PF04695	0.474
LIG_REV1ctd_RIR_1	237	247	PF16727	0.492
LIG_SH2_CRK	98	102	PF00017	0.474
LIG_SH2_SRC	201	204	PF00017	0.474
LIG_SH2_STAP1	197	201	PF00017	0.474
LIG_SH2_STAT3	203	206	PF00017	0.503
LIG_SH2_STAT5	160	163	PF00017	0.471
LIG_SH2_STAT5	164	167	PF00017	0.476
LIG_SH2_STAT5	203	206	PF00017	0.474
LIG_SH2_STAT5	66	69	PF00017	0.500
LIG_SH3_3	12	18	PF00018	0.524
LIG_TRFH_1	164	168	PF08558	0.462
LIG_UBA3_1	101	107	PF00899	0.474
MOD_CDK_SPxxK_3	84	91	PF00069	0.478
MOD_CK1_1	112	118	PF00069	0.474
MOD_CK1_1	126	132	PF00069	0.474
MOD_CK1_1	135	141	PF00069	0.474
MOD_CK1_1	209	215	PF00069	0.474
MOD_CK2_1	149	155	PF00069	0.455
MOD_CK2_1	196	202	PF00069	0.539
MOD_CK2_1	209	215	PF00069	0.432
MOD_GlcNHglycan	125	128	PF01048	0.288
MOD_GlcNHglycan	208	211	PF01048	0.396
MOD_GlcNHglycan	24	27	PF01048	0.499
MOD_GlcNHglycan	45	48	PF01048	0.637
MOD_GlcNHglycan	51	54	PF01048	0.644
MOD_GlcNHglycan	7	10	PF01048	0.665
MOD_GSK3_1	131	138	PF00069	0.526
MOD_N-GLC_1	57	62	PF02516	0.558
MOD_NEK2_1	196	201	PF00069	0.474
MOD_NEK2_1	242	247	PF00069	0.525
MOD_NEK2_1	67	72	PF00069	0.460
MOD_NEK2_1	97	102	PF00069	0.516
MOD_NMyristoyl	1	7	PF02799	0.550
MOD_PIKK_1	132	138	PF00454	0.526
MOD_PIKK_1	242	248	PF00454	0.529
MOD_PIKK_1	75	81	PF00454	0.430
MOD_PKA_2	242	248	PF00069	0.494
MOD_PKA_2	67	73	PF00069	0.467
MOD_Plk_1	149	155	PF00069	0.481
MOD_Plk_1	57	63	PF00069	0.556
MOD_Plk_4	196	202	PF00069	0.481
MOD_Plk_4	51	57	PF00069	0.519
MOD_ProDKin_1	164	170	PF00069	0.608
MOD_ProDKin_1	84	90	PF00069	0.543
MOD_SUMO_rev_2	226	231	PF00179	0.539
TRG_DiLeu_BaLyEn_6	219	224	PF01217	0.453
TRG_ENDOCYTIC_2	201	204	PF00928	0.474
TRG_ENDOCYTIC_2	21	24	PF00928	0.524
TRG_ENDOCYTIC_2	66	69	PF00928	0.500
TRG_ENDOCYTIC_2	98	101	PF00928	0.474
TRG_Pf-PMV_PEXEL_1	222	226	PF00026	0.493

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7R0	Leptomonas seymouri	65%	80%
A0A3S5H6N9	Leishmania donovani	100%	100%
A4H770	Leishmania braziliensis	82%	100%
E9APA6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	98%
Q4QG72	Leishmania major	92%	100%