Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HVK8_LEIIN

TriTrypDb:

LINF_130012900

Length:

223

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HVK8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVK8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	187	191	PF00656	0.756
CLV_C14_Caspase3-7	194	198	PF00656	0.665
CLV_C14_Caspase3-7	29	33	PF00656	0.740
CLV_NRD_NRD_1	107	109	PF00675	0.544
CLV_NRD_NRD_1	203	205	PF00675	0.809
CLV_NRD_NRD_1	210	212	PF00675	0.511
CLV_NRD_NRD_1	3	5	PF00675	0.751
CLV_PCSK_FUR_1	21	25	PF00082	0.819
CLV_PCSK_KEX2_1	107	109	PF00082	0.646
CLV_PCSK_KEX2_1	207	209	PF00082	0.729
CLV_PCSK_KEX2_1	23	25	PF00082	0.726
CLV_PCSK_KEX2_1	3	5	PF00082	0.751
CLV_PCSK_PC1ET2_1	207	209	PF00082	0.729
CLV_PCSK_PC1ET2_1	23	25	PF00082	0.726
CLV_PCSK_SKI1_1	115	119	PF00082	0.740
CLV_PCSK_SKI1_1	212	216	PF00082	0.647
CLV_PCSK_SKI1_1	93	97	PF00082	0.582
DEG_APCC_DBOX_1	92	100	PF00400	0.689
DEG_Nend_Nbox_1	1	3	PF02207	0.766
DEG_SPOP_SBC_1	25	29	PF00917	0.756
DOC_CYCLIN_yCln2_LP_2	99	105	PF00134	0.680
DOC_MAPK_gen_1	3	11	PF00069	0.755
DOC_USP7_MATH_1	149	153	PF00917	0.777
DOC_USP7_MATH_1	15	19	PF00917	0.686
DOC_USP7_MATH_1	188	192	PF00917	0.713
DOC_USP7_MATH_1	25	29	PF00917	0.598
DOC_USP7_MATH_1	31	35	PF00917	0.617
DOC_USP7_UBL2_3	118	122	PF12436	0.771
DOC_USP7_UBL2_3	201	205	PF12436	0.806
DOC_WW_Pin1_4	128	133	PF00397	0.588
DOC_WW_Pin1_4	147	152	PF00397	0.769
DOC_WW_Pin1_4	76	81	PF00397	0.612
LIG_14-3-3_CanoR_1	211	221	PF00244	0.734
LIG_14-3-3_CanoR_1	59	68	PF00244	0.668
LIG_FHA_1	213	219	PF00498	0.734
LIG_FHA_1	55	61	PF00498	0.696
LIG_FHA_1	77	83	PF00498	0.610
LIG_FHA_2	192	198	PF00498	0.710
LIG_HP1_1	102	106	PF01393	0.682
LIG_LIR_Gen_1	69	80	PF02991	0.672
LIG_LIR_Nem_3	63	68	PF02991	0.652
LIG_LIR_Nem_3	69	75	PF02991	0.556
LIG_PDZ_Class_2	218	223	PF00595	0.765
LIG_Pex14_1	54	58	PF04695	0.701
LIG_RPA_C_Fungi	103	115	PF08784	0.695
LIG_SH2_STAT5	46	49	PF00017	0.663
LIG_SH3_3	42	48	PF00018	0.581
LIG_SUMO_SIM_anti_2	190	197	PF11976	0.634
LIG_TRAF2_1	184	187	PF00917	0.652
LIG_TRAF2_1	35	38	PF00917	0.558
MOD_CK1_1	124	130	PF00069	0.766
MOD_CK1_1	157	163	PF00069	0.685
MOD_CK1_1	191	197	PF00069	0.694
MOD_CK1_1	203	209	PF00069	0.654
MOD_CK1_1	210	216	PF00069	0.579
MOD_CK2_1	31	37	PF00069	0.676
MOD_GlcNHglycan	123	126	PF01048	0.682
MOD_GlcNHglycan	13	16	PF01048	0.761
MOD_GlcNHglycan	137	140	PF01048	0.550
MOD_GlcNHglycan	151	154	PF01048	0.728
MOD_GlcNHglycan	17	20	PF01048	0.709
MOD_GlcNHglycan	215	218	PF01048	0.670
MOD_GlcNHglycan	28	31	PF01048	0.692
MOD_GlcNHglycan	32	36	PF01048	0.678
MOD_GSK3_1	11	18	PF00069	0.778
MOD_GSK3_1	124	131	PF00069	0.643
MOD_GSK3_1	143	150	PF00069	0.512
MOD_GSK3_1	196	203	PF00069	0.589
MOD_N-GLC_1	191	196	PF02516	0.569
MOD_NEK2_1	11	16	PF00069	0.577
MOD_NEK2_1	135	140	PF00069	0.759
MOD_NEK2_1	196	201	PF00069	0.725
MOD_NEK2_1	2	7	PF00069	0.724
MOD_NEK2_1	67	72	PF00069	0.605
MOD_PIKK_1	130	136	PF00454	0.760
MOD_PIKK_1	182	188	PF00454	0.657
MOD_PIKK_1	60	66	PF00454	0.668
MOD_PKA_1	200	206	PF00069	0.589
MOD_PKA_1	207	213	PF00069	0.600
MOD_PKA_2	2	8	PF00069	0.668
MOD_PKA_2	203	209	PF00069	0.645
MOD_PKA_2	210	216	PF00069	0.622
MOD_Plk_1	191	197	PF00069	0.558
MOD_Plk_4	67	73	PF00069	0.650
MOD_ProDKin_1	128	134	PF00069	0.587
MOD_ProDKin_1	147	153	PF00069	0.769
MOD_ProDKin_1	76	82	PF00069	0.610
TRG_ER_diArg_1	106	108	PF00400	0.543
TRG_ER_diArg_1	2	4	PF00400	0.763
TRG_NLS_MonoExtC_3	203	208	PF00514	0.807
TRG_NLS_MonoExtN_4	201	208	PF00514	0.805
TRG_Pf-PMV_PEXEL_1	115	120	PF00026	0.745

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8I9H5	Leishmania donovani	99%	100%
A4H769	Leishmania braziliensis	68%	100%
E9APA4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QG74	Leishmania major	89%	100%