Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HVK7_LEIIN

TriTrypDb:

LINF_130012800

Length:

694

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HVK7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVK7

Function

Biological processes
Term	Name	Level	Count
GO:0002097	tRNA wobble base modification	7	7
GO:0002098	tRNA wobble uridine modification	8	7
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006396	RNA processing	6	7
GO:0006399	tRNA metabolic process	7	7
GO:0006400	tRNA modification	6	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008033	tRNA processing	8	7
GO:0008152	metabolic process	1	7
GO:0009451	RNA modification	5	7
GO:0009987	cellular process	1	7
GO:0016070	RNA metabolic process	5	7
GO:0034227	tRNA thio-modification	7	7
GO:0034470	ncRNA processing	7	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0034660	ncRNA metabolic process	6	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0046483	heterocycle metabolic process	3	7
GO:0071704	organic substance metabolic process	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7
GO:0002143	tRNA wobble position uridine thiolation	8	1

Molecular functions
Term	Name	Level	Count
GO:0000049	tRNA binding	5	7
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7
GO:0003824	catalytic activity	1	1
GO:0016740	transferase activity	2	1
GO:0016782	transferase activity, transferring sulphur-containing groups	3	1
GO:0016783	sulfurtransferase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	616	620	PF00656	0.633
CLV_NRD_NRD_1	172	174	PF00675	0.534
CLV_NRD_NRD_1	324	326	PF00675	0.397
CLV_NRD_NRD_1	524	526	PF00675	0.637
CLV_NRD_NRD_1	82	84	PF00675	0.566
CLV_PCSK_KEX2_1	194	196	PF00082	0.588
CLV_PCSK_KEX2_1	82	84	PF00082	0.566
CLV_PCSK_PC1ET2_1	194	196	PF00082	0.588
CLV_PCSK_PC7_1	78	84	PF00082	0.499
CLV_PCSK_SKI1_1	286	290	PF00082	0.515
CLV_PCSK_SKI1_1	299	303	PF00082	0.331
CLV_PCSK_SKI1_1	407	411	PF00082	0.352
CLV_PCSK_SKI1_1	420	424	PF00082	0.400
CLV_PCSK_SKI1_1	525	529	PF00082	0.729
CLV_Separin_Metazoa	491	495	PF03568	0.459
DEG_SCF_FBW7_1	219	225	PF00400	0.731
DEG_SCF_FBW7_1	605	610	PF00400	0.650
DEG_SPOP_SBC_1	137	141	PF00917	0.698
DEG_SPOP_SBC_1	598	602	PF00917	0.531
DOC_CKS1_1	219	224	PF01111	0.732
DOC_CYCLIN_yCln2_LP_2	542	548	PF00134	0.557
DOC_MAPK_gen_1	369	376	PF00069	0.453
DOC_PP2B_LxvP_1	130	133	PF13499	0.403
DOC_PP2B_LxvP_1	542	545	PF13499	0.577
DOC_USP7_MATH_1	108	112	PF00917	0.633
DOC_USP7_MATH_1	113	117	PF00917	0.536
DOC_USP7_MATH_1	137	141	PF00917	0.632
DOC_USP7_MATH_1	143	147	PF00917	0.648
DOC_USP7_MATH_1	222	226	PF00917	0.611
DOC_USP7_MATH_1	249	253	PF00917	0.696
DOC_USP7_MATH_1	348	352	PF00917	0.710
DOC_USP7_MATH_1	449	453	PF00917	0.528
DOC_USP7_MATH_1	607	611	PF00917	0.703
DOC_USP7_MATH_1	612	616	PF00917	0.649
DOC_USP7_MATH_1	621	625	PF00917	0.669
DOC_USP7_MATH_1	679	683	PF00917	0.574
DOC_USP7_UBL2_3	194	198	PF12436	0.714
DOC_USP7_UBL2_3	522	526	PF12436	0.712
DOC_WW_Pin1_4	103	108	PF00397	0.535
DOC_WW_Pin1_4	109	114	PF00397	0.575
DOC_WW_Pin1_4	139	144	PF00397	0.670
DOC_WW_Pin1_4	218	223	PF00397	0.732
DOC_WW_Pin1_4	237	242	PF00397	0.539
DOC_WW_Pin1_4	438	443	PF00397	0.397
DOC_WW_Pin1_4	48	53	PF00397	0.393
DOC_WW_Pin1_4	499	504	PF00397	0.566
DOC_WW_Pin1_4	603	608	PF00397	0.797
DOC_WW_Pin1_4	610	615	PF00397	0.690
DOC_WW_Pin1_4	624	629	PF00397	0.512
DOC_WW_Pin1_4	84	89	PF00397	0.578
LIG_14-3-3_CanoR_1	100	108	PF00244	0.608
LIG_14-3-3_CanoR_1	160	166	PF00244	0.452
LIG_14-3-3_CanoR_1	293	303	PF00244	0.389
LIG_14-3-3_CanoR_1	307	312	PF00244	0.469
LIG_14-3-3_CanoR_1	407	416	PF00244	0.415
LIG_14-3-3_CanoR_1	417	423	PF00244	0.307
LIG_14-3-3_CanoR_1	553	562	PF00244	0.456
LIG_APCC_ABBA_1	546	551	PF00400	0.464
LIG_BIR_III_2	644	648	PF00653	0.465
LIG_CSL_BTD_1	645	648	PF09270	0.468
LIG_deltaCOP1_diTrp_1	644	651	PF00928	0.517
LIG_EH1_1	458	466	PF00400	0.347
LIG_EVH1_1	132	136	PF00568	0.534
LIG_EVH1_2	647	651	PF00568	0.476
LIG_FHA_1	202	208	PF00498	0.642
LIG_FHA_1	257	263	PF00498	0.518
LIG_FHA_1	408	414	PF00498	0.479
LIG_FHA_1	439	445	PF00498	0.391
LIG_FHA_1	448	454	PF00498	0.438
LIG_FHA_1	681	687	PF00498	0.524
LIG_FHA_2	162	168	PF00498	0.504
LIG_FHA_2	249	255	PF00498	0.568
LIG_FHA_2	614	620	PF00498	0.661
LIG_FHA_2	655	661	PF00498	0.656
LIG_LIR_Gen_1	166	176	PF02991	0.447
LIG_LIR_Gen_1	300	311	PF02991	0.467
LIG_LIR_Gen_1	470	479	PF02991	0.379
LIG_LIR_Nem_3	166	172	PF02991	0.443
LIG_LIR_Nem_3	27	32	PF02991	0.369
LIG_LIR_Nem_3	300	306	PF02991	0.388
LIG_LIR_Nem_3	470	476	PF02991	0.373
LIG_SH2_CRK	303	307	PF00017	0.396
LIG_SH2_CRK	430	434	PF00017	0.462
LIG_SH2_STAP1	273	277	PF00017	0.481
LIG_SH2_STAP1	287	291	PF00017	0.394
LIG_SH2_STAT3	175	178	PF00017	0.492
LIG_SH2_STAT3	637	640	PF00017	0.416
LIG_SH2_STAT5	175	178	PF00017	0.544
LIG_SH2_STAT5	24	27	PF00017	0.364
LIG_SH2_STAT5	281	284	PF00017	0.400
LIG_SH2_STAT5	32	35	PF00017	0.355
LIG_SH2_STAT5	430	433	PF00017	0.464
LIG_SH2_STAT5	440	443	PF00017	0.387
LIG_SH3_3	128	134	PF00018	0.397
LIG_SUMO_SIM_anti_2	116	122	PF11976	0.479
LIG_SUMO_SIM_par_1	595	603	PF11976	0.574
LIG_TRAF2_1	164	167	PF00917	0.453
LIG_TRAF2_1	338	341	PF00917	0.652
LIG_TRAF2_1	488	491	PF00917	0.418
LIG_TYR_ITIM	428	433	PF00017	0.519
LIG_WW_3	179	183	PF00397	0.584
MOD_CDK_SPK_2	603	608	PF00069	0.694
MOD_CDK_SPxK_1	84	90	PF00069	0.586
MOD_CDK_SPxxK_3	103	110	PF00069	0.656
MOD_CK1_1	139	145	PF00069	0.708
MOD_CK1_1	218	224	PF00069	0.629
MOD_CK1_1	233	239	PF00069	0.655
MOD_CK1_1	252	258	PF00069	0.493
MOD_CK1_1	292	298	PF00069	0.418
MOD_CK1_1	467	473	PF00069	0.574
MOD_CK1_1	516	522	PF00069	0.612
MOD_CK1_1	577	583	PF00069	0.487
MOD_CK1_1	600	606	PF00069	0.625
MOD_CK1_1	610	616	PF00069	0.590
MOD_CK1_1	624	630	PF00069	0.480
MOD_CK1_1	664	670	PF00069	0.615
MOD_CK1_1	99	105	PF00069	0.712
MOD_CK2_1	160	166	PF00069	0.442
MOD_CK2_1	248	254	PF00069	0.578
MOD_CK2_1	294	300	PF00069	0.403
MOD_CK2_1	553	559	PF00069	0.521
MOD_CK2_1	619	625	PF00069	0.638
MOD_CK2_1	652	658	PF00069	0.761
MOD_GlcNHglycan	151	154	PF01048	0.621
MOD_GlcNHglycan	232	235	PF01048	0.674
MOD_GlcNHglycan	236	239	PF01048	0.688
MOD_GlcNHglycan	251	254	PF01048	0.510
MOD_GlcNHglycan	277	280	PF01048	0.454
MOD_GlcNHglycan	499	502	PF01048	0.755
MOD_GlcNHglycan	518	521	PF01048	0.580
MOD_GlcNHglycan	57	60	PF01048	0.396
MOD_GlcNHglycan	602	605	PF01048	0.628
MOD_GlcNHglycan	609	612	PF01048	0.531
MOD_GlcNHglycan	621	624	PF01048	0.547
MOD_GlcNHglycan	654	657	PF01048	0.573
MOD_GSK3_1	109	116	PF00069	0.561
MOD_GSK3_1	137	144	PF00069	0.637
MOD_GSK3_1	218	225	PF00069	0.697
MOD_GSK3_1	230	237	PF00069	0.620
MOD_GSK3_1	248	255	PF00069	0.522
MOD_GSK3_1	271	278	PF00069	0.414
MOD_GSK3_1	363	370	PF00069	0.607
MOD_GSK3_1	443	450	PF00069	0.589
MOD_GSK3_1	516	523	PF00069	0.670
MOD_GSK3_1	599	606	PF00069	0.697
MOD_GSK3_1	661	668	PF00069	0.612
MOD_GSK3_1	96	103	PF00069	0.647
MOD_N-GLC_1	497	502	PF02516	0.530
MOD_N-GLC_1	585	590	PF02516	0.485
MOD_N-GLC_1	664	669	PF02516	0.659
MOD_NEK2_1	114	119	PF00069	0.511
MOD_NEK2_1	138	143	PF00069	0.684
MOD_NEK2_1	277	282	PF00069	0.536
MOD_NEK2_1	289	294	PF00069	0.377
MOD_NEK2_1	363	368	PF00069	0.662
MOD_NEK2_1	375	380	PF00069	0.330
MOD_NEK2_1	464	469	PF00069	0.455
MOD_NEK2_1	597	602	PF00069	0.656
MOD_NEK2_2	449	454	PF00069	0.524
MOD_OFUCOSY	574	581	PF10250	0.439
MOD_PIKK_1	514	520	PF00454	0.695
MOD_PKA_2	161	167	PF00069	0.422
MOD_PKA_2	271	277	PF00069	0.415
MOD_PKA_2	292	298	PF00069	0.397
MOD_PKA_2	607	613	PF00069	0.703
MOD_PKA_2	652	658	PF00069	0.618
MOD_PKA_2	99	105	PF00069	0.737
MOD_PKB_1	305	313	PF00069	0.464
MOD_Plk_2-3	654	660	PF00069	0.645
MOD_Plk_4	10	16	PF00069	0.386
MOD_Plk_4	114	120	PF00069	0.520
MOD_Plk_4	277	283	PF00069	0.520
MOD_Plk_4	561	567	PF00069	0.507
MOD_Plk_4	60	66	PF00069	0.402
MOD_Plk_4	613	619	PF00069	0.622
MOD_Plk_4	646	652	PF00069	0.522
MOD_ProDKin_1	103	109	PF00069	0.534
MOD_ProDKin_1	139	145	PF00069	0.668
MOD_ProDKin_1	218	224	PF00069	0.732
MOD_ProDKin_1	237	243	PF00069	0.539
MOD_ProDKin_1	438	444	PF00069	0.395
MOD_ProDKin_1	48	54	PF00069	0.390
MOD_ProDKin_1	499	505	PF00069	0.568
MOD_ProDKin_1	603	609	PF00069	0.799
MOD_ProDKin_1	610	616	PF00069	0.692
MOD_ProDKin_1	624	630	PF00069	0.498
MOD_ProDKin_1	84	90	PF00069	0.587
TRG_ENDOCYTIC_2	273	276	PF00928	0.527
TRG_ENDOCYTIC_2	303	306	PF00928	0.394
TRG_ENDOCYTIC_2	430	433	PF00928	0.541
TRG_ENDOCYTIC_2	468	471	PF00928	0.432
TRG_ER_diArg_1	81	83	PF00400	0.544
TRG_NLS_MonoExtC_3	193	198	PF00514	0.648
TRG_NLS_MonoExtN_4	194	201	PF00514	0.656
TRG_Pf-PMV_PEXEL_1	68	72	PF00026	0.374

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDC5	Leptomonas seymouri	43%	100%
A0A3Q8I9K2	Leishmania donovani	99%	100%
A4H768	Leishmania braziliensis	68%	97%
E9APA3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	98%
Q4QG75	Leishmania major	88%	99%