LeishMANIAdb
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Protein kinase domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Protein kinase domain-containing protein
Gene product:
protein kinase - putative
Species:
Leishmania infantum
UniProt:
A4HVK6_LEIIN
TriTrypDb:
LINF_130012700 *
Length:
715

Annotations

Annotations by Jardim et al.

Protein kinase, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) yes yes: 3
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0005737 cytoplasm 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HVK6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVK6

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 7
GO:0006793 phosphorus metabolic process 3 7
GO:0006796 phosphate-containing compound metabolic process 4 7
GO:0006807 nitrogen compound metabolic process 2 7
GO:0008152 metabolic process 1 7
GO:0009987 cellular process 1 7
GO:0016310 phosphorylation 5 7
GO:0019538 protein metabolic process 3 7
GO:0036211 protein modification process 4 7
GO:0043170 macromolecule metabolic process 3 7
GO:0043412 macromolecule modification 4 7
GO:0044237 cellular metabolic process 2 7
GO:0044238 primary metabolic process 2 7
GO:0071704 organic substance metabolic process 2 7
GO:1901564 organonitrogen compound metabolic process 3 7
GO:0007165 signal transduction 2 1
GO:0035556 intracellular signal transduction 3 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0065007 biological regulation 1 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 7
GO:0003824 catalytic activity 1 7
GO:0004672 protein kinase activity 3 7
GO:0005488 binding 1 7
GO:0005524 ATP binding 5 7
GO:0016301 kinase activity 4 7
GO:0016740 transferase activity 2 7
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 7
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 7
GO:0017076 purine nucleotide binding 4 7
GO:0030554 adenyl nucleotide binding 5 7
GO:0032553 ribonucleotide binding 3 7
GO:0032555 purine ribonucleotide binding 4 7
GO:0032559 adenyl ribonucleotide binding 5 7
GO:0035639 purine ribonucleoside triphosphate binding 4 7
GO:0036094 small molecule binding 2 7
GO:0043167 ion binding 2 7
GO:0043168 anion binding 3 7
GO:0097159 organic cyclic compound binding 2 7
GO:0097367 carbohydrate derivative binding 2 7
GO:0140096 catalytic activity, acting on a protein 2 7
GO:1901265 nucleoside phosphate binding 3 7
GO:1901363 heterocyclic compound binding 2 7
GO:0004674 protein serine/threonine kinase activity 4 1
GO:0004707 MAP kinase activity 5 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 159 163 PF00656 0.385
CLV_C14_Caspase3-7 276 280 PF00656 0.432
CLV_C14_Caspase3-7 35 39 PF00656 0.511
CLV_C14_Caspase3-7 392 396 PF00656 0.631
CLV_C14_Caspase3-7 487 491 PF00656 0.337
CLV_NRD_NRD_1 297 299 PF00675 0.523
CLV_NRD_NRD_1 427 429 PF00675 0.337
CLV_PCSK_KEX2_1 120 122 PF00082 0.478
CLV_PCSK_KEX2_1 297 299 PF00082 0.447
CLV_PCSK_KEX2_1 660 662 PF00082 0.547
CLV_PCSK_PC1ET2_1 120 122 PF00082 0.475
CLV_PCSK_PC1ET2_1 660 662 PF00082 0.547
CLV_PCSK_SKI1_1 203 207 PF00082 0.426
CLV_PCSK_SKI1_1 275 279 PF00082 0.454
CLV_PCSK_SKI1_1 429 433 PF00082 0.337
CLV_PCSK_SKI1_1 450 454 PF00082 0.357
CLV_PCSK_SKI1_1 537 541 PF00082 0.337
CLV_PCSK_SKI1_1 578 582 PF00082 0.357
CLV_PCSK_SKI1_1 587 591 PF00082 0.337
CLV_PCSK_SKI1_1 677 681 PF00082 0.410
CLV_Separin_Metazoa 604 608 PF03568 0.310
DEG_APCC_DBOX_1 676 684 PF00400 0.408
DEG_COP1_1 656 665 PF00400 0.497
DEG_Nend_UBRbox_1 1 4 PF02207 0.502
DEG_ODPH_VHL_1 288 301 PF01847 0.467
DEG_SPOP_SBC_1 32 36 PF00917 0.500
DEG_SPOP_SBC_1 341 345 PF00917 0.606
DEG_SPOP_SBC_1 390 394 PF00917 0.628
DEG_SPOP_SBC_1 49 53 PF00917 0.470
DOC_CYCLIN_RxL_1 200 207 PF00134 0.406
DOC_CYCLIN_RxL_1 534 544 PF00134 0.337
DOC_CYCLIN_yCln2_LP_2 368 374 PF00134 0.569
DOC_MAPK_gen_1 120 126 PF00069 0.458
DOC_MAPK_gen_1 450 459 PF00069 0.337
DOC_MAPK_RevD_3 107 121 PF00069 0.516
DOC_PP4_FxxP_1 238 241 PF00568 0.383
DOC_USP7_MATH_1 116 120 PF00917 0.524
DOC_USP7_MATH_1 311 315 PF00917 0.637
DOC_USP7_MATH_1 32 36 PF00917 0.500
DOC_USP7_MATH_1 341 345 PF00917 0.646
DOC_USP7_MATH_1 390 394 PF00917 0.644
DOC_USP7_MATH_1 419 423 PF00917 0.482
DOC_USP7_MATH_1 561 565 PF00917 0.356
DOC_USP7_UBL2_3 586 590 PF12436 0.337
DOC_WW_Pin1_4 24 29 PF00397 0.512
DOC_WW_Pin1_4 313 318 PF00397 0.659
DOC_WW_Pin1_4 505 510 PF00397 0.467
DOC_WW_Pin1_4 596 601 PF00397 0.388
DOC_WW_Pin1_4 605 610 PF00397 0.293
LIG_14-3-3_CanoR_1 66 70 PF00244 0.503
LIG_Actin_WH2_2 259 277 PF00022 0.395
LIG_BRCT_BRCA1_1 58 62 PF00533 0.484
LIG_EH_1 640 644 PF12763 0.365
LIG_eIF4E_1 191 197 PF01652 0.404
LIG_FHA_1 102 108 PF00498 0.557
LIG_FHA_1 131 137 PF00498 0.438
LIG_FHA_1 191 197 PF00498 0.431
LIG_FHA_1 216 222 PF00498 0.396
LIG_FHA_1 415 421 PF00498 0.613
LIG_FHA_1 480 486 PF00498 0.537
LIG_FHA_1 499 505 PF00498 0.260
LIG_FHA_1 50 56 PF00498 0.570
LIG_FHA_1 575 581 PF00498 0.413
LIG_FHA_1 597 603 PF00498 0.413
LIG_FHA_2 181 187 PF00498 0.536
LIG_FHA_2 271 277 PF00498 0.403
LIG_FHA_2 282 288 PF00498 0.444
LIG_FHA_2 390 396 PF00498 0.638
LIG_FHA_2 485 491 PF00498 0.374
LIG_FHA_2 599 605 PF00498 0.310
LIG_LIR_Apic_2 236 241 PF02991 0.389
LIG_LIR_Apic_2 493 499 PF02991 0.337
LIG_LIR_Gen_1 135 145 PF02991 0.419
LIG_LIR_Gen_1 249 256 PF02991 0.426
LIG_LIR_Gen_1 261 272 PF02991 0.392
LIG_LIR_Gen_1 693 700 PF02991 0.431
LIG_LIR_Nem_3 12 16 PF02991 0.492
LIG_LIR_Nem_3 135 140 PF02991 0.417
LIG_LIR_Nem_3 141 146 PF02991 0.447
LIG_LIR_Nem_3 153 157 PF02991 0.630
LIG_LIR_Nem_3 236 242 PF02991 0.391
LIG_LIR_Nem_3 249 253 PF02991 0.427
LIG_LIR_Nem_3 259 263 PF02991 0.405
LIG_LIR_Nem_3 424 430 PF02991 0.337
LIG_LIR_Nem_3 516 521 PF02991 0.340
LIG_LIR_Nem_3 553 558 PF02991 0.337
LIG_LIR_Nem_3 647 652 PF02991 0.531
LIG_LIR_Nem_3 693 698 PF02991 0.471
LIG_NRBOX 135 141 PF00104 0.480
LIG_NRBOX 601 607 PF00104 0.310
LIG_PTB_Apo_2 638 645 PF02174 0.337
LIG_REV1ctd_RIR_1 641 650 PF16727 0.505
LIG_SH2_CRK 13 17 PF00017 0.486
LIG_SH2_CRK 154 158 PF00017 0.420
LIG_SH2_CRK 250 254 PF00017 0.421
LIG_SH2_CRK 649 653 PF00017 0.526
LIG_SH2_NCK_1 143 147 PF00017 0.404
LIG_SH2_NCK_1 177 181 PF00017 0.472
LIG_SH2_NCK_1 496 500 PF00017 0.337
LIG_SH2_SRC 177 180 PF00017 0.470
LIG_SH2_SRC 649 652 PF00017 0.529
LIG_SH2_STAP1 250 254 PF00017 0.400
LIG_SH2_STAP1 292 296 PF00017 0.421
LIG_SH2_STAP1 541 545 PF00017 0.337
LIG_SH2_STAT5 156 159 PF00017 0.466
LIG_SH2_STAT5 264 267 PF00017 0.370
LIG_SH2_STAT5 272 275 PF00017 0.395
LIG_SH2_STAT5 441 444 PF00017 0.355
LIG_SH2_STAT5 484 487 PF00017 0.413
LIG_SH2_STAT5 541 544 PF00017 0.337
LIG_SH3_3 408 414 PF00018 0.564
LIG_SH3_3 52 58 PF00018 0.494
LIG_SH3_3 649 655 PF00018 0.579
LIG_SH3_3 92 98 PF00018 0.521
LIG_SUMO_SIM_anti_2 51 60 PF11976 0.491
LIG_SUMO_SIM_par_1 416 422 PF11976 0.527
LIG_SUMO_SIM_par_1 500 508 PF11976 0.413
LIG_SUMO_SIM_par_1 51 60 PF11976 0.491
LIG_TRAF2_1 173 176 PF00917 0.549
LIG_TRAF2_1 183 186 PF00917 0.468
LIG_TYR_ITIM 11 16 PF00017 0.492
LIG_TYR_ITIM 439 444 PF00017 0.327
MOD_CDK_SPxK_1 315 321 PF00069 0.587
MOD_CK1_1 315 321 PF00069 0.729
MOD_CK1_1 36 42 PF00069 0.515
MOD_CK1_1 462 468 PF00069 0.337
MOD_CK1_1 60 66 PF00069 0.506
MOD_CK2_1 138 144 PF00069 0.405
MOD_CK2_1 180 186 PF00069 0.546
MOD_CK2_1 270 276 PF00069 0.401
MOD_CK2_1 281 287 PF00069 0.454
MOD_CK2_1 340 346 PF00069 0.739
MOD_CK2_1 561 567 PF00069 0.408
MOD_CK2_1 598 604 PF00069 0.310
MOD_CK2_1 6 12 PF00069 0.496
MOD_GlcNHglycan 158 161 PF01048 0.379
MOD_GlcNHglycan 233 236 PF01048 0.389
MOD_GlcNHglycan 349 352 PF01048 0.694
MOD_GlcNHglycan 42 45 PF01048 0.519
MOD_GlcNHglycan 560 564 PF01048 0.336
MOD_GlcNHglycan 674 677 PF01048 0.434
MOD_GlcNHglycan 71 74 PF01048 0.574
MOD_GlcNHglycan 87 90 PF01048 0.545
MOD_GSK3_1 277 284 PF00069 0.435
MOD_GSK3_1 311 318 PF00069 0.727
MOD_GSK3_1 32 39 PF00069 0.603
MOD_GSK3_1 341 348 PF00069 0.772
MOD_GSK3_1 360 367 PF00069 0.520
MOD_GSK3_1 546 553 PF00069 0.377
MOD_GSK3_1 56 63 PF00069 0.487
MOD_GSK3_1 561 568 PF00069 0.305
MOD_GSK3_1 588 595 PF00069 0.316
MOD_GSK3_1 65 72 PF00069 0.591
MOD_GSK3_1 668 675 PF00069 0.474
MOD_N-GLC_1 478 483 PF02516 0.416
MOD_N-GLC_1 490 495 PF02516 0.274
MOD_NEK2_1 270 275 PF00069 0.393
MOD_NEK2_1 278 283 PF00069 0.444
MOD_NEK2_1 31 36 PF00069 0.567
MOD_NEK2_1 459 464 PF00069 0.337
MOD_NEK2_1 50 55 PF00069 0.524
MOD_NEK2_1 539 544 PF00069 0.337
MOD_NEK2_1 581 586 PF00069 0.374
MOD_NEK2_1 588 593 PF00069 0.375
MOD_NEK2_1 6 11 PF00069 0.496
MOD_NEK2_1 694 699 PF00069 0.441
MOD_NEK2_2 65 70 PF00069 0.503
MOD_PIKK_1 101 107 PF00454 0.509
MOD_PIKK_1 490 496 PF00454 0.357
MOD_PIKK_1 546 552 PF00454 0.365
MOD_PK_1 661 667 PF00069 0.529
MOD_PKA_2 320 326 PF00069 0.693
MOD_PKA_2 36 42 PF00069 0.636
MOD_PKA_2 465 471 PF00069 0.370
MOD_PKA_2 631 637 PF00069 0.337
MOD_PKA_2 65 71 PF00069 0.502
MOD_Plk_1 130 136 PF00069 0.537
MOD_Plk_1 178 184 PF00069 0.589
MOD_Plk_1 270 276 PF00069 0.401
MOD_Plk_1 278 284 PF00069 0.444
MOD_Plk_1 459 465 PF00069 0.337
MOD_Plk_1 490 496 PF00069 0.367
MOD_Plk_1 73 79 PF00069 0.507
MOD_Plk_2-3 246 252 PF00069 0.490
MOD_Plk_4 108 114 PF00069 0.567
MOD_Plk_4 192 198 PF00069 0.399
MOD_Plk_4 249 255 PF00069 0.420
MOD_Plk_4 278 284 PF00069 0.628
MOD_Plk_4 291 297 PF00069 0.405
MOD_Plk_4 484 490 PF00069 0.337
MOD_Plk_4 50 56 PF00069 0.498
MOD_Plk_4 550 556 PF00069 0.337
MOD_Plk_4 57 63 PF00069 0.472
MOD_Plk_4 694 700 PF00069 0.476
MOD_Plk_4 73 79 PF00069 0.478
MOD_ProDKin_1 24 30 PF00069 0.513
MOD_ProDKin_1 313 319 PF00069 0.660
MOD_ProDKin_1 505 511 PF00069 0.467
MOD_ProDKin_1 596 602 PF00069 0.388
MOD_ProDKin_1 605 611 PF00069 0.293
MOD_SUMO_for_1 327 330 PF00179 0.595
MOD_SUMO_for_1 452 455 PF00179 0.337
MOD_SUMO_for_1 700 703 PF00179 0.521
MOD_SUMO_rev_2 686 694 PF00179 0.461
MOD_SUMO_rev_2 703 708 PF00179 0.462
TRG_DiLeu_BaEn_1 135 140 PF01217 0.403
TRG_DiLeu_BaLyEn_6 1 6 PF01217 0.498
TRG_DiLeu_BaLyEn_6 21 26 PF01217 0.456
TRG_DiLeu_BaLyEn_6 297 302 PF01217 0.401
TRG_ENDOCYTIC_2 13 16 PF00928 0.491
TRG_ENDOCYTIC_2 143 146 PF00928 0.408
TRG_ENDOCYTIC_2 154 157 PF00928 0.432
TRG_ENDOCYTIC_2 250 253 PF00928 0.422
TRG_ENDOCYTIC_2 264 267 PF00928 0.370
TRG_ENDOCYTIC_2 427 430 PF00928 0.360
TRG_ENDOCYTIC_2 433 436 PF00928 0.383
TRG_ENDOCYTIC_2 441 444 PF00928 0.415
TRG_ENDOCYTIC_2 649 652 PF00928 0.626
TRG_ER_diArg_1 1 4 PF00400 0.502
TRG_ER_diArg_1 296 298 PF00400 0.520
TRG_ER_FFAT_1 175 183 PF00635 0.494
TRG_Pf-PMV_PEXEL_1 203 207 PF00026 0.426
TRG_Pf-PMV_PEXEL_1 450 455 PF00026 0.337
TRG_Pf-PMV_PEXEL_1 556 560 PF00026 0.337

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HZJ0 Leptomonas seymouri 71% 100%
A0A3Q8I9M4 Leishmania donovani 100% 100%
A4H767 Leishmania braziliensis 82% 100%
E9APA2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 94%
Q4QG76 Leishmania major 89% 92%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS