LeishMANIAdb
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Protein-tyrosine-phosphatase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Protein-tyrosine-phosphatase
Gene product:
Dual specificity phosphatase - catalytic domain containing protein - putative
Species:
Leishmania infantum
UniProt:
A4HVK5_LEIIN
TriTrypDb:
LINF_130012600
Length:
551

Annotations

Annotations by Jardim et al.

Phosphatase, Dual specificity phosphatase, catalytic domain

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HVK5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVK5

Function

Biological processes
Term Name Level Count
GO:0006793 phosphorus metabolic process 3 7
GO:0006796 phosphate-containing compound metabolic process 4 7
GO:0008152 metabolic process 1 7
GO:0009987 cellular process 1 7
GO:0016311 dephosphorylation 5 7
GO:0044237 cellular metabolic process 2 7
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 7
GO:0016787 hydrolase activity 2 7
GO:0016788 hydrolase activity, acting on ester bonds 3 7
GO:0016791 phosphatase activity 5 7
GO:0042578 phosphoric ester hydrolase activity 4 7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 247 251 PF00656 0.673
CLV_C14_Caspase3-7 98 102 PF00656 0.492
CLV_NRD_NRD_1 357 359 PF00675 0.463
CLV_NRD_NRD_1 536 538 PF00675 0.443
CLV_NRD_NRD_1 64 66 PF00675 0.456
CLV_PCSK_FUR_1 355 359 PF00082 0.460
CLV_PCSK_KEX2_1 357 359 PF00082 0.463
CLV_PCSK_KEX2_1 536 538 PF00082 0.443
CLV_PCSK_KEX2_1 66 68 PF00082 0.458
CLV_PCSK_PC1ET2_1 66 68 PF00082 0.506
CLV_PCSK_PC7_1 62 68 PF00082 0.521
CLV_PCSK_SKI1_1 109 113 PF00082 0.542
CLV_PCSK_SKI1_1 121 125 PF00082 0.586
CLV_PCSK_SKI1_1 201 205 PF00082 0.497
CLV_PCSK_SKI1_1 294 298 PF00082 0.549
CLV_PCSK_SKI1_1 357 361 PF00082 0.468
CLV_PCSK_SKI1_1 416 420 PF00082 0.609
CLV_PCSK_SKI1_1 67 71 PF00082 0.467
CLV_PCSK_SKI1_1 72 76 PF00082 0.538
DEG_APCC_DBOX_1 108 116 PF00400 0.551
DEG_Nend_Nbox_1 1 3 PF02207 0.492
DOC_CKS1_1 359 364 PF01111 0.407
DOC_CKS1_1 541 546 PF01111 0.558
DOC_CYCLIN_RxL_1 62 73 PF00134 0.447
DOC_CYCLIN_yCln2_LP_2 444 450 PF00134 0.581
DOC_CYCLIN_yCln2_LP_2 461 467 PF00134 0.445
DOC_CYCLIN_yCln2_LP_2 541 547 PF00134 0.565
DOC_MAPK_gen_1 62 71 PF00069 0.469
DOC_MAPK_HePTP_8 515 527 PF00069 0.398
DOC_MAPK_MEF2A_6 518 527 PF00069 0.398
DOC_MAPK_RevD_3 52 67 PF00069 0.407
DOC_PP2B_LxvP_1 461 464 PF13499 0.449
DOC_USP7_MATH_1 147 151 PF00917 0.702
DOC_USP7_MATH_1 152 156 PF00917 0.709
DOC_USP7_MATH_1 194 198 PF00917 0.541
DOC_USP7_MATH_1 215 219 PF00917 0.512
DOC_USP7_MATH_1 243 247 PF00917 0.553
DOC_USP7_MATH_1 311 315 PF00917 0.614
DOC_USP7_MATH_1 495 499 PF00917 0.532
DOC_USP7_MATH_1 81 85 PF00917 0.634
DOC_WW_Pin1_4 187 192 PF00397 0.577
DOC_WW_Pin1_4 210 215 PF00397 0.583
DOC_WW_Pin1_4 25 30 PF00397 0.537
DOC_WW_Pin1_4 298 303 PF00397 0.573
DOC_WW_Pin1_4 324 329 PF00397 0.599
DOC_WW_Pin1_4 358 363 PF00397 0.418
DOC_WW_Pin1_4 402 407 PF00397 0.611
DOC_WW_Pin1_4 474 479 PF00397 0.376
DOC_WW_Pin1_4 540 545 PF00397 0.590
DOC_WW_Pin1_4 8 13 PF00397 0.377
DOC_WW_Pin1_4 83 88 PF00397 0.666
DOC_WW_Pin1_4 93 98 PF00397 0.690
LIG_14-3-3_CanoR_1 109 115 PF00244 0.548
LIG_14-3-3_CanoR_1 121 126 PF00244 0.588
LIG_14-3-3_CanoR_1 227 231 PF00244 0.578
LIG_14-3-3_CanoR_1 357 362 PF00244 0.496
LIG_14-3-3_CanoR_1 420 430 PF00244 0.577
LIG_14-3-3_CanoR_1 494 504 PF00244 0.512
LIG_14-3-3_CanoR_1 536 540 PF00244 0.364
LIG_14-3-3_CanoR_1 82 89 PF00244 0.636
LIG_Actin_WH2_2 263 281 PF00022 0.491
LIG_Actin_WH2_2 419 437 PF00022 0.427
LIG_Actin_WH2_2 479 496 PF00022 0.444
LIG_BRCT_BRCA1_1 306 310 PF00533 0.542
LIG_Clathr_ClatBox_1 483 487 PF01394 0.345
LIG_CSL_BTD_1 144 147 PF09270 0.591
LIG_FHA_1 103 109 PF00498 0.651
LIG_FHA_1 331 337 PF00498 0.448
LIG_FHA_1 358 364 PF00498 0.448
LIG_FHA_1 380 386 PF00498 0.409
LIG_FHA_1 9 15 PF00498 0.373
LIG_FHA_2 349 355 PF00498 0.462
LIG_FHA_2 4 10 PF00498 0.426
LIG_GBD_Chelix_1 284 292 PF00786 0.431
LIG_LIR_Gen_1 104 115 PF02991 0.630
LIG_LIR_Nem_3 104 110 PF02991 0.637
LIG_LIR_Nem_3 505 510 PF02991 0.388
LIG_NRBOX 287 293 PF00104 0.510
LIG_NRBOX 53 59 PF00104 0.459
LIG_SH2_CRK 339 343 PF00017 0.510
LIG_SH2_CRK 507 511 PF00017 0.310
LIG_SH2_STAT3 161 164 PF00017 0.556
LIG_SH3_2 544 549 PF14604 0.601
LIG_SH3_3 141 147 PF00018 0.550
LIG_SH3_3 296 302 PF00018 0.580
LIG_SH3_3 374 380 PF00018 0.465
LIG_SH3_3 444 450 PF00018 0.637
LIG_SH3_3 541 547 PF00018 0.721
LIG_SH3_3 91 97 PF00018 0.681
LIG_SUMO_SIM_par_1 206 213 PF11976 0.413
LIG_TYR_ITIM 483 488 PF00017 0.338
LIG_UBA3_1 70 75 PF00899 0.516
LIG_WW_3 79 83 PF00397 0.752
MOD_CDC14_SPxK_1 546 549 PF00782 0.606
MOD_CDK_SPxK_1 543 549 PF00069 0.594
MOD_CK1_1 150 156 PF00069 0.670
MOD_CK1_1 218 224 PF00069 0.459
MOD_CK1_1 229 235 PF00069 0.621
MOD_CK1_1 28 34 PF00069 0.735
MOD_CK1_1 399 405 PF00069 0.616
MOD_CK2_1 348 354 PF00069 0.467
MOD_CK2_1 495 501 PF00069 0.474
MOD_GlcNHglycan 149 152 PF01048 0.609
MOD_GlcNHglycan 154 157 PF01048 0.534
MOD_GlcNHglycan 254 257 PF01048 0.417
MOD_GlcNHglycan 30 33 PF01048 0.587
MOD_GlcNHglycan 313 316 PF01048 0.710
MOD_GlcNHglycan 402 405 PF01048 0.504
MOD_GlcNHglycan 497 500 PF01048 0.538
MOD_GlcNHglycan 527 530 PF01048 0.503
MOD_GlcNHglycan 76 79 PF01048 0.697
MOD_GlcNHglycan 83 86 PF01048 0.658
MOD_GlcNHglycan 97 100 PF01048 0.742
MOD_GSK3_1 146 153 PF00069 0.738
MOD_GSK3_1 19 26 PF00069 0.494
MOD_GSK3_1 190 197 PF00069 0.682
MOD_GSK3_1 225 232 PF00069 0.642
MOD_GSK3_1 294 301 PF00069 0.660
MOD_GSK3_1 3 10 PF00069 0.431
MOD_GSK3_1 305 312 PF00069 0.686
MOD_GSK3_1 379 386 PF00069 0.497
MOD_GSK3_1 392 399 PF00069 0.419
MOD_GSK3_1 414 421 PF00069 0.490
MOD_GSK3_1 472 479 PF00069 0.368
MOD_GSK3_1 70 77 PF00069 0.696
MOD_GSK3_1 81 88 PF00069 0.651
MOD_N-GLC_1 134 139 PF02516 0.582
MOD_N-GLC_2 524 526 PF02516 0.457
MOD_NEK2_1 110 115 PF00069 0.568
MOD_NEK2_1 192 197 PF00069 0.539
MOD_NEK2_1 305 310 PF00069 0.735
MOD_NEK2_1 400 405 PF00069 0.585
MOD_NEK2_1 429 434 PF00069 0.416
MOD_NEK2_1 472 477 PF00069 0.379
MOD_NEK2_1 53 58 PF00069 0.358
MOD_NEK2_1 7 12 PF00069 0.499
MOD_NEK2_1 70 75 PF00069 0.576
MOD_NEK2_2 102 107 PF00069 0.591
MOD_NEK2_2 194 199 PF00069 0.494
MOD_PIKK_1 379 385 PF00454 0.488
MOD_PIKK_1 434 440 PF00454 0.507
MOD_PIKK_1 455 461 PF00454 0.508
MOD_PIKK_1 488 494 PF00454 0.328
MOD_PK_1 476 482 PF00069 0.348
MOD_PKA_1 357 363 PF00069 0.448
MOD_PKA_2 226 232 PF00069 0.580
MOD_PKA_2 3 9 PF00069 0.470
MOD_PKA_2 357 363 PF00069 0.496
MOD_PKA_2 535 541 PF00069 0.445
MOD_PKA_2 81 87 PF00069 0.638
MOD_PKB_1 355 363 PF00069 0.450
MOD_Plk_1 134 140 PF00069 0.531
MOD_Plk_1 218 224 PF00069 0.399
MOD_Plk_1 317 323 PF00069 0.611
MOD_Plk_1 330 336 PF00069 0.394
MOD_Plk_4 102 108 PF00069 0.679
MOD_Plk_4 110 116 PF00069 0.464
MOD_Plk_4 476 482 PF00069 0.348
MOD_Plk_4 53 59 PF00069 0.398
MOD_Plk_4 530 536 PF00069 0.411
MOD_ProDKin_1 187 193 PF00069 0.574
MOD_ProDKin_1 210 216 PF00069 0.578
MOD_ProDKin_1 25 31 PF00069 0.545
MOD_ProDKin_1 298 304 PF00069 0.577
MOD_ProDKin_1 324 330 PF00069 0.587
MOD_ProDKin_1 358 364 PF00069 0.415
MOD_ProDKin_1 402 408 PF00069 0.611
MOD_ProDKin_1 474 480 PF00069 0.375
MOD_ProDKin_1 540 546 PF00069 0.598
MOD_ProDKin_1 8 14 PF00069 0.374
MOD_ProDKin_1 83 89 PF00069 0.664
MOD_ProDKin_1 93 99 PF00069 0.686
TRG_DiLeu_BaEn_1 425 430 PF01217 0.447
TRG_DiLeu_BaLyEn_6 287 292 PF01217 0.441
TRG_DiLeu_BaLyEn_6 359 364 PF01217 0.407
TRG_ENDOCYTIC_2 339 342 PF00928 0.509
TRG_ENDOCYTIC_2 485 488 PF00928 0.353
TRG_ENDOCYTIC_2 507 510 PF00928 0.310
TRG_ER_diArg_1 355 358 PF00400 0.467
TRG_ER_diArg_1 535 537 PF00400 0.376
TRG_NLS_MonoExtN_4 62 69 PF00514 0.502
TRG_Pf-PMV_PEXEL_1 279 283 PF00026 0.441
TRG_Pf-PMV_PEXEL_1 427 431 PF00026 0.454

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PEI5 Leptomonas seymouri 30% 93%
A0A3S7WSG2 Leishmania donovani 99% 100%
A4H766 Leishmania braziliensis 69% 100%
E9APA1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 84% 100%
Q4QG77 Leishmania major 90% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS