Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HVK3_LEIIN

TriTrypDb:

LINF_130012400

Length:

218

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HVK3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVK3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	156	158	PF00675	0.334
CLV_NRD_NRD_1	71	73	PF00675	0.433
CLV_PCSK_KEX2_1	136	138	PF00082	0.431
CLV_PCSK_KEX2_1	156	158	PF00082	0.198
CLV_PCSK_KEX2_1	71	73	PF00082	0.457
CLV_PCSK_PC1ET2_1	136	138	PF00082	0.453
CLV_PCSK_SKI1_1	80	84	PF00082	0.445
DEG_Nend_Nbox_1	1	3	PF02207	0.535
DOC_MAPK_gen_1	136	144	PF00069	0.480
DOC_MAPK_gen_1	156	164	PF00069	0.213
DOC_MAPK_MEF2A_6	136	144	PF00069	0.480
DOC_PP1_RVXF_1	186	193	PF00149	0.379
DOC_PP1_RVXF_1	208	214	PF00149	0.380
DOC_PP4_FxxP_1	168	171	PF00568	0.283
DOC_USP7_MATH_1	113	117	PF00917	0.444
DOC_USP7_MATH_1	206	210	PF00917	0.365
DOC_USP7_MATH_1	33	37	PF00917	0.799
DOC_USP7_MATH_1	99	103	PF00917	0.578
LIG_14-3-3_CanoR_1	150	158	PF00244	0.324
LIG_14-3-3_CanoR_1	159	163	PF00244	0.352
LIG_14-3-3_CanoR_1	4	8	PF00244	0.585
LIG_BRCT_BRCA1_1	160	164	PF00533	0.333
LIG_LIR_Nem_3	133	138	PF02991	0.415
LIG_LIR_Nem_3	161	167	PF02991	0.414
LIG_LIR_Nem_3	81	86	PF02991	0.596
LIG_PCNA_yPIPBox_3	172	181	PF02747	0.432
LIG_Pex14_1	78	82	PF04695	0.378
LIG_Pex14_2	164	168	PF04695	0.380
LIG_REV1ctd_RIR_1	80	89	PF16727	0.465
LIG_SH2_SRC	88	91	PF00017	0.543
LIG_SH2_STAP1	160	164	PF00017	0.384
LIG_SH2_STAT5	146	149	PF00017	0.331
LIG_SH3_3	119	125	PF00018	0.474
LIG_TRAF2_1	125	128	PF00917	0.383
MOD_CK1_1	41	47	PF00069	0.600
MOD_CK2_1	149	155	PF00069	0.351
MOD_CK2_1	99	105	PF00069	0.486
MOD_GlcNHglycan	12	15	PF01048	0.664
MOD_GlcNHglycan	152	155	PF01048	0.358
MOD_GlcNHglycan	64	67	PF01048	0.548
MOD_GSK3_1	38	45	PF00069	0.688
MOD_N-GLC_1	38	43	PF02516	0.564
MOD_NEK2_1	108	113	PF00069	0.592
MOD_NEK2_2	78	83	PF00069	0.519
MOD_PIKK_1	47	53	PF00454	0.565
MOD_PKA_2	108	114	PF00069	0.507
MOD_PKA_2	138	144	PF00069	0.413
MOD_PKA_2	149	155	PF00069	0.294
MOD_PKA_2	158	164	PF00069	0.277
MOD_PKA_2	3	9	PF00069	0.596
MOD_Plk_1	78	84	PF00069	0.507
MOD_Plk_4	182	188	PF00069	0.517
MOD_Plk_4	3	9	PF00069	0.672
MOD_Plk_4	78	84	PF00069	0.523
MOD_SUMO_for_1	100	103	PF00179	0.508
MOD_SUMO_rev_2	128	138	PF00179	0.518
TRG_DiLeu_BaEn_1	182	187	PF01217	0.360
TRG_DiLeu_BaEn_4	127	133	PF01217	0.374
TRG_DiLeu_BaEn_4	202	208	PF01217	0.399
TRG_ER_diArg_1	137	140	PF00400	0.432
TRG_ER_diArg_1	156	159	PF00400	0.216
TRG_NES_CRM1_1	205	218	PF08389	0.399
TRG_NLS_MonoExtC_3	135	140	PF00514	0.497

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7D0	Leptomonas seymouri	65%	87%
A0A0S4JSG2	Bodo saltans	25%	78%
A0A1X0NNP5	Trypanosomatidae	45%	100%
A0A3S7WSJ5	Leishmania donovani	99%	100%
A4H764	Leishmania braziliensis	84%	100%
D0A6Q4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AP99	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QG79	Leishmania major	95%	100%
V5DBN2	Trypanosoma cruzi	55%	77%