Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Calcium-activated chloride channel - putative

Species:

Leishmania infantum

UniProt:

A4HVK2_LEIIN

TriTrypDb:

LINF_130012300

Length:

977

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7
GO:0005886	plasma membrane	3	1

Expansion

Sequence features

A4HVK2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVK2

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006811	monoatomic ion transport	4	1
GO:0006820	monoatomic anion transport	5	1
GO:0006821	chloride transport	7	1
GO:0009987	cellular process	1	1
GO:0015698	inorganic anion transport	6	1
GO:0034220	monoatomic ion transmembrane transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0055085	transmembrane transport	2	1
GO:0098656	monoatomic anion transmembrane transport	4	1
GO:0098660	inorganic ion transmembrane transport	4	1
GO:0098661	inorganic anion transmembrane transport	5	1
GO:1902476	chloride transmembrane transport	6	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0005216	monoatomic ion channel activity	4	1
GO:0005253	monoatomic anion channel activity	5	1
GO:0005254	chloride channel activity	6	1
GO:0008509	monoatomic anion transmembrane transporter activity	4	1
GO:0015075	monoatomic ion transmembrane transporter activity	3	1
GO:0015103	inorganic anion transmembrane transporter activity	4	1
GO:0015108	chloride transmembrane transporter activity	5	1
GO:0015267	channel activity	4	1
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	1
GO:0022803	passive transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	277	281	PF00656	0.639
CLV_C14_Caspase3-7	360	364	PF00656	0.564
CLV_MEL_PAP_1	970	976	PF00089	0.298
CLV_NRD_NRD_1	14	16	PF00675	0.519
CLV_NRD_NRD_1	197	199	PF00675	0.446
CLV_NRD_NRD_1	489	491	PF00675	0.489
CLV_NRD_NRD_1	521	523	PF00675	0.271
CLV_NRD_NRD_1	613	615	PF00675	0.506
CLV_NRD_NRD_1	731	733	PF00675	0.506
CLV_NRD_NRD_1	735	737	PF00675	0.477
CLV_NRD_NRD_1	761	763	PF00675	0.454
CLV_NRD_NRD_1	833	835	PF00675	0.252
CLV_NRD_NRD_1	967	969	PF00675	0.240
CLV_PCSK_FUR_1	195	199	PF00082	0.392
CLV_PCSK_KEX2_1	16	18	PF00082	0.506
CLV_PCSK_KEX2_1	197	199	PF00082	0.446
CLV_PCSK_KEX2_1	291	293	PF00082	0.519
CLV_PCSK_KEX2_1	489	491	PF00082	0.489
CLV_PCSK_KEX2_1	521	523	PF00082	0.271
CLV_PCSK_KEX2_1	613	615	PF00082	0.506
CLV_PCSK_KEX2_1	675	677	PF00082	0.245
CLV_PCSK_KEX2_1	730	732	PF00082	0.506
CLV_PCSK_KEX2_1	735	737	PF00082	0.469
CLV_PCSK_KEX2_1	761	763	PF00082	0.454
CLV_PCSK_KEX2_1	833	835	PF00082	0.252
CLV_PCSK_PC1ET2_1	16	18	PF00082	0.506
CLV_PCSK_PC1ET2_1	291	293	PF00082	0.497
CLV_PCSK_PC1ET2_1	675	677	PF00082	0.245
CLV_PCSK_PC7_1	12	18	PF00082	0.440
CLV_PCSK_PC7_1	731	737	PF00082	0.428
CLV_PCSK_SKI1_1	164	168	PF00082	0.418
CLV_PCSK_SKI1_1	404	408	PF00082	0.297
CLV_PCSK_SKI1_1	448	452	PF00082	0.365
CLV_PCSK_SKI1_1	538	542	PF00082	0.211
CLV_PCSK_SKI1_1	654	658	PF00082	0.296
CLV_PCSK_SKI1_1	670	674	PF00082	0.272
CLV_PCSK_SKI1_1	676	680	PF00082	0.259
CLV_PCSK_SKI1_1	687	691	PF00082	0.245
CLV_PCSK_SKI1_1	706	710	PF00082	0.452
CLV_PCSK_SKI1_1	735	739	PF00082	0.571
CLV_Separin_Metazoa	93	97	PF03568	0.722
DEG_APCC_DBOX_1	821	829	PF00400	0.452
DEG_SPOP_SBC_1	481	485	PF00917	0.287
DOC_ANK_TNKS_1	613	620	PF00023	0.306
DOC_CKS1_1	754	759	PF01111	0.246
DOC_CKS1_1	956	961	PF01111	0.452
DOC_CYCLIN_RxL_1	729	741	PF00134	0.228
DOC_CYCLIN_yCln2_LP_2	167	173	PF00134	0.597
DOC_CYCLIN_yCln2_LP_2	560	566	PF00134	0.439
DOC_MAPK_DCC_7	833	841	PF00069	0.506
DOC_MAPK_gen_1	833	841	PF00069	0.452
DOC_MAPK_gen_1	966	976	PF00069	0.544
DOC_MAPK_MEF2A_6	319	326	PF00069	0.524
DOC_MAPK_MEF2A_6	833	841	PF00069	0.452
DOC_MAPK_RevD_3	475	490	PF00069	0.254
DOC_PP1_RVXF_1	685	691	PF00149	0.355
DOC_PP2B_LxvP_1	607	610	PF13499	0.252
DOC_PP2B_LxvP_1	74	77	PF13499	0.665
DOC_PP4_MxPP_1	632	635	PF00568	0.256
DOC_USP7_MATH_1	212	216	PF00917	0.680
DOC_USP7_MATH_1	284	288	PF00917	0.720
DOC_USP7_MATH_1	398	402	PF00917	0.570
DOC_USP7_MATH_1	427	431	PF00917	0.506
DOC_USP7_MATH_1	45	49	PF00917	0.694
DOC_USP7_MATH_1	480	484	PF00917	0.303
DOC_USP7_MATH_1	570	574	PF00917	0.489
DOC_USP7_MATH_1	77	81	PF00917	0.719
DOC_USP7_MATH_1	807	811	PF00917	0.289
DOC_USP7_MATH_1	867	871	PF00917	0.289
DOC_WW_Pin1_4	344	349	PF00397	0.549
DOC_WW_Pin1_4	380	385	PF00397	0.633
DOC_WW_Pin1_4	545	550	PF00397	0.472
DOC_WW_Pin1_4	745	750	PF00397	0.335
DOC_WW_Pin1_4	753	758	PF00397	0.314
DOC_WW_Pin1_4	768	773	PF00397	0.221
DOC_WW_Pin1_4	955	960	PF00397	0.452
LIG_14-3-3_CanoR_1	132	142	PF00244	0.636
LIG_14-3-3_CanoR_1	197	205	PF00244	0.693
LIG_14-3-3_CanoR_1	301	305	PF00244	0.641
LIG_14-3-3_CanoR_1	36	40	PF00244	0.648
LIG_14-3-3_CanoR_1	489	493	PF00244	0.306
LIG_14-3-3_CanoR_1	521	530	PF00244	0.471
LIG_14-3-3_CanoR_1	567	574	PF00244	0.506
LIG_14-3-3_CanoR_1	670	675	PF00244	0.489
LIG_14-3-3_CanoR_1	716	725	PF00244	0.267
LIG_14-3-3_CanoR_1	914	919	PF00244	0.254
LIG_14-3-3_CanoR_1	973	977	PF00244	0.593
LIG_Actin_WH2_2	170	187	PF00022	0.588
LIG_Actin_WH2_2	451	469	PF00022	0.365
LIG_APCC_ABBA_1	58	63	PF00400	0.672
LIG_BIR_II_1	1	5	PF00653	0.620
LIG_BRCT_BRCA1_1	645	649	PF00533	0.289
LIG_BRCT_BRCA1_1	822	826	PF00533	0.452
LIG_deltaCOP1_diTrp_1	405	412	PF00928	0.508
LIG_EH1_1	626	634	PF00400	0.272
LIG_FHA_1	176	182	PF00498	0.546
LIG_FHA_1	381	387	PF00498	0.601
LIG_FHA_1	504	510	PF00498	0.309
LIG_FHA_1	549	555	PF00498	0.478
LIG_FHA_1	573	579	PF00498	0.371
LIG_FHA_1	584	590	PF00498	0.226
LIG_FHA_1	861	867	PF00498	0.288
LIG_FHA_1	882	888	PF00498	0.272
LIG_FHA_1	907	913	PF00498	0.242
LIG_FHA_1	965	971	PF00498	0.489
LIG_FHA_2	158	164	PF00498	0.638
LIG_FHA_2	231	237	PF00498	0.546
LIG_FHA_2	275	281	PF00498	0.641
LIG_FHA_2	420	426	PF00498	0.550
LIG_FHA_2	655	661	PF00498	0.437
LIG_FHA_2	746	752	PF00498	0.228
LIG_FHA_2	956	962	PF00498	0.506
LIG_FHA_2	97	103	PF00498	0.654
LIG_GBD_Chelix_1	142	150	PF00786	0.399
LIG_IRF3_LxIS_1	417	424	PF10401	0.563
LIG_LIR_Apic_2	300	305	PF02991	0.575
LIG_LIR_Gen_1	118	127	PF02991	0.599
LIG_LIR_Gen_1	136	146	PF02991	0.606
LIG_LIR_Gen_1	405	414	PF02991	0.513
LIG_LIR_Gen_1	646	656	PF02991	0.314
LIG_LIR_Gen_1	707	718	PF02991	0.228
LIG_LIR_Gen_1	788	796	PF02991	0.261
LIG_LIR_Gen_1	810	819	PF02991	0.289
LIG_LIR_Nem_3	118	122	PF02991	0.606
LIG_LIR_Nem_3	136	142	PF02991	0.616
LIG_LIR_Nem_3	405	411	PF02991	0.505
LIG_LIR_Nem_3	573	579	PF02991	0.365
LIG_LIR_Nem_3	646	652	PF02991	0.328
LIG_LIR_Nem_3	684	688	PF02991	0.285
LIG_LIR_Nem_3	707	713	PF02991	0.237
LIG_LIR_Nem_3	810	814	PF02991	0.289
LIG_LIR_Nem_3	846	850	PF02991	0.504
LIG_NRBOX	245	251	PF00104	0.566
LIG_NRBOX	373	379	PF00104	0.520
LIG_PCNA_yPIPBox_3	180	193	PF02747	0.576
LIG_PCNA_yPIPBox_3	366	374	PF02747	0.561
LIG_Pex14_1	442	446	PF04695	0.452
LIG_Pex14_1	876	880	PF04695	0.237
LIG_Pex14_2	354	358	PF04695	0.527
LIG_Pex14_2	438	442	PF04695	0.452
LIG_Pex14_2	877	881	PF04695	0.299
LIG_PTB_Apo_2	658	665	PF02174	0.428
LIG_PTB_Phospho_1	658	664	PF10480	0.454
LIG_Rb_pABgroove_1	777	785	PF01858	0.272
LIG_RPA_C_Fungi	725	737	PF08784	0.331
LIG_SH2_CRK	302	306	PF00017	0.448
LIG_SH2_CRK	685	689	PF00017	0.289
LIG_SH2_CRK	936	940	PF00017	0.268
LIG_SH2_NCK_1	302	306	PF00017	0.496
LIG_SH2_NCK_1	971	975	PF00017	0.406
LIG_SH2_PTP2	119	122	PF00017	0.503
LIG_SH2_PTP2	710	713	PF00017	0.268
LIG_SH2_PTP2	798	801	PF00017	0.268
LIG_SH2_SRC	139	142	PF00017	0.522
LIG_SH2_SRC	241	244	PF00017	0.425
LIG_SH2_STAP1	139	143	PF00017	0.507
LIG_SH2_STAP1	446	450	PF00017	0.289
LIG_SH2_STAP1	638	642	PF00017	0.279
LIG_SH2_STAP1	783	787	PF00017	0.268
LIG_SH2_STAT5	119	122	PF00017	0.503
LIG_SH2_STAT5	228	231	PF00017	0.521
LIG_SH2_STAT5	241	244	PF00017	0.485
LIG_SH2_STAT5	431	434	PF00017	0.328
LIG_SH2_STAT5	655	658	PF00017	0.365
LIG_SH2_STAT5	710	713	PF00017	0.289
LIG_SH2_STAT5	798	801	PF00017	0.268
LIG_SH2_STAT5	830	833	PF00017	0.289
LIG_SH2_STAT5	880	883	PF00017	0.268
LIG_SH2_STAT5	936	939	PF00017	0.316
LIG_SH2_STAT5	942	945	PF00017	0.269
LIG_SH3_2	95	100	PF14604	0.594
LIG_SH3_3	149	155	PF00018	0.692
LIG_SH3_3	206	212	PF00018	0.606
LIG_SH3_3	251	257	PF00018	0.518
LIG_SH3_3	349	355	PF00018	0.397
LIG_SH3_3	381	387	PF00018	0.469
LIG_SH3_3	474	480	PF00018	0.333
LIG_SH3_3	597	603	PF00018	0.289
LIG_SH3_3	751	757	PF00018	0.391
LIG_SH3_3	92	98	PF00018	0.615
LIG_SH3_3	953	959	PF00018	0.289
LIG_SH3_4	154	161	PF00018	0.522
LIG_Sin3_3	474	481	PF02671	0.316
LIG_SUMO_SIM_anti_2	497	502	PF11976	0.365
LIG_SUMO_SIM_anti_2	810	816	PF11976	0.289
LIG_SUMO_SIM_par_1	777	784	PF11976	0.316
LIG_SUMO_SIM_par_1	816	823	PF11976	0.268
LIG_SUMO_SIM_par_1	863	870	PF11976	0.341
LIG_SxIP_EBH_1	716	729	PF03271	0.316
LIG_TRAF2_1	160	163	PF00917	0.527
LIG_TRAF2_1	233	236	PF00917	0.497
LIG_TRAF2_1	60	63	PF00917	0.647
LIG_TRAF2_1	772	775	PF00917	0.279
LIG_TYR_ITIM	934	939	PF00017	0.316
LIG_UBA3_1	648	654	PF00899	0.285
LIG_WRC_WIRS_1	22	27	PF05994	0.566
LIG_WRC_WIRS_1	279	284	PF05994	0.578
LIG_WRC_WIRS_1	808	813	PF05994	0.289
MOD_CDK_SPK_2	955	960	PF00069	0.289
MOD_CK1_1	234	240	PF00069	0.456
MOD_CK1_1	266	272	PF00069	0.753
MOD_CK1_1	300	306	PF00069	0.509
MOD_CK1_1	32	38	PF00069	0.596
MOD_CK1_1	410	416	PF00069	0.467
MOD_CK1_1	461	467	PF00069	0.290
MOD_CK1_1	484	490	PF00069	0.340
MOD_CK1_1	54	60	PF00069	0.772
MOD_CK1_1	747	753	PF00069	0.357
MOD_CK1_1	768	774	PF00069	0.365
MOD_CK1_1	870	876	PF00069	0.362
MOD_CK1_1	900	906	PF00069	0.367
MOD_CK2_1	157	163	PF00069	0.547
MOD_CK2_1	230	236	PF00069	0.502
MOD_CK2_1	419	425	PF00069	0.428
MOD_CK2_1	654	660	PF00069	0.268
MOD_CK2_1	745	751	PF00069	0.256
MOD_CK2_1	768	774	PF00069	0.297
MOD_CK2_1	955	961	PF00069	0.365
MOD_CK2_1	96	102	PF00069	0.581
MOD_GlcNHglycan	218	221	PF01048	0.670
MOD_GlcNHglycan	269	272	PF01048	0.579
MOD_GlcNHglycan	400	403	PF01048	0.438
MOD_GlcNHglycan	412	415	PF01048	0.392
MOD_GlcNHglycan	523	526	PF01048	0.292
MOD_GlcNHglycan	53	56	PF01048	0.664
MOD_GlcNHglycan	700	704	PF01048	0.401
MOD_GlcNHglycan	740	743	PF01048	0.358
MOD_GlcNHglycan	762	765	PF01048	0.358
MOD_GlcNHglycan	79	82	PF01048	0.589
MOD_GlcNHglycan	892	895	PF01048	0.346
MOD_GlcNHglycan	899	902	PF01048	0.307
MOD_GSK3_1	212	219	PF00069	0.575
MOD_GSK3_1	230	237	PF00069	0.460
MOD_GSK3_1	262	269	PF00069	0.598
MOD_GSK3_1	270	277	PF00069	0.597
MOD_GSK3_1	31	38	PF00069	0.609
MOD_GSK3_1	318	325	PF00069	0.410
MOD_GSK3_1	406	413	PF00069	0.359
MOD_GSK3_1	458	465	PF00069	0.299
MOD_GSK3_1	480	487	PF00069	0.293
MOD_GSK3_1	548	555	PF00069	0.306
MOD_GSK3_1	566	573	PF00069	0.371
MOD_GSK3_1	598	605	PF00069	0.365
MOD_GSK3_1	643	650	PF00069	0.313
MOD_GSK3_1	712	719	PF00069	0.367
MOD_GSK3_1	738	745	PF00069	0.358
MOD_GSK3_1	752	759	PF00069	0.346
MOD_GSK3_1	866	873	PF00069	0.331
MOD_GSK3_1	879	886	PF00069	0.255
MOD_N-GLC_1	203	208	PF02516	0.493
MOD_N-GLC_1	274	279	PF02516	0.557
MOD_N-GLC_1	77	82	PF02516	0.623
MOD_N-GLC_1	843	848	PF02516	0.289
MOD_NEK2_1	216	221	PF00069	0.596
MOD_NEK2_1	407	412	PF00069	0.362
MOD_NEK2_1	462	467	PF00069	0.347
MOD_NEK2_1	488	493	PF00069	0.326
MOD_NEK2_1	503	508	PF00069	0.283
MOD_NEK2_1	583	588	PF00069	0.326
MOD_NEK2_1	590	595	PF00069	0.256
MOD_NEK2_1	622	627	PF00069	0.289
MOD_NEK2_1	636	641	PF00069	0.289
MOD_NEK2_1	681	686	PF00069	0.289
MOD_NEK2_1	718	723	PF00069	0.326
MOD_NEK2_1	725	730	PF00069	0.256
MOD_NEK2_1	738	743	PF00069	0.160
MOD_NEK2_1	760	765	PF00069	0.285
MOD_NEK2_1	866	871	PF00069	0.268
MOD_NEK2_1	881	886	PF00069	0.284
MOD_PKA_1	521	527	PF00069	0.289
MOD_PKA_2	267	273	PF00069	0.524
MOD_PKA_2	300	306	PF00069	0.556
MOD_PKA_2	35	41	PF00069	0.569
MOD_PKA_2	488	494	PF00069	0.365
MOD_PKA_2	521	527	PF00069	0.318
MOD_PKA_2	566	572	PF00069	0.335
MOD_PKA_2	738	744	PF00069	0.411
MOD_PKA_2	760	766	PF00069	0.292
MOD_Plk_1	234	240	PF00069	0.418
MOD_Plk_1	274	280	PF00069	0.558
MOD_Plk_1	843	849	PF00069	0.289
MOD_Plk_2-3	231	237	PF00069	0.421
MOD_Plk_4	115	121	PF00069	0.512
MOD_Plk_4	21	27	PF00069	0.572
MOD_Plk_4	35	41	PF00069	0.518
MOD_Plk_4	407	413	PF00069	0.369
MOD_Plk_4	427	433	PF00069	0.160
MOD_Plk_4	458	464	PF00069	0.299
MOD_Plk_4	504	510	PF00069	0.348
MOD_Plk_4	643	649	PF00069	0.278
MOD_Plk_4	718	724	PF00069	0.391
MOD_Plk_4	807	813	PF00069	0.289
MOD_Plk_4	860	866	PF00069	0.282
MOD_ProDKin_1	344	350	PF00069	0.413
MOD_ProDKin_1	380	386	PF00069	0.538
MOD_ProDKin_1	545	551	PF00069	0.317
MOD_ProDKin_1	745	751	PF00069	0.406
MOD_ProDKin_1	753	759	PF00069	0.376
MOD_ProDKin_1	768	774	PF00069	0.246
MOD_ProDKin_1	955	961	PF00069	0.289
MOD_SUMO_rev_2	4	8	PF00179	0.542
TRG_DiLeu_BaEn_1	63	68	PF01217	0.606
TRG_DiLeu_BaEn_3	774	780	PF01217	0.232
TRG_DiLeu_BaEn_4	162	168	PF01217	0.514
TRG_DiLeu_BaLyEn_6	345	350	PF01217	0.406
TRG_DiLeu_BaLyEn_6	365	370	PF01217	0.319
TRG_DiLeu_LyEn_5	62	67	PF01217	0.606
TRG_ENDOCYTIC_2	119	122	PF00928	0.503
TRG_ENDOCYTIC_2	139	142	PF00928	0.389
TRG_ENDOCYTIC_2	440	443	PF00928	0.312
TRG_ENDOCYTIC_2	530	533	PF00928	0.289
TRG_ENDOCYTIC_2	685	688	PF00928	0.289
TRG_ENDOCYTIC_2	710	713	PF00928	0.268
TRG_ENDOCYTIC_2	798	801	PF00928	0.347
TRG_ENDOCYTIC_2	936	939	PF00928	0.268
TRG_ENDOCYTIC_2	971	974	PF00928	0.328
TRG_ER_diArg_1	195	198	PF00400	0.541
TRG_ER_diArg_1	366	369	PF00400	0.353
TRG_ER_diArg_1	488	490	PF00400	0.341
TRG_ER_diArg_1	612	614	PF00400	0.365
TRG_ER_diArg_1	695	698	PF00400	0.292
TRG_ER_diArg_1	730	732	PF00400	0.289
TRG_ER_diArg_1	734	736	PF00400	0.289
TRG_ER_diArg_1	760	762	PF00400	0.292
TRG_ER_diArg_1	832	834	PF00400	0.289
TRG_NES_CRM1_1	236	252	PF08389	0.594
TRG_NES_CRM1_1	784	795	PF08389	0.341
TRG_NLS_MonoExtC_3	14	19	PF00514	0.515
TRG_NLS_MonoExtN_4	12	19	PF00514	0.556
TRG_Pf-PMV_PEXEL_1	144	148	PF00026	0.515
TRG_Pf-PMV_PEXEL_1	328	332	PF00026	0.448
TRG_Pf-PMV_PEXEL_1	372	376	PF00026	0.388
TRG_Pf-PMV_PEXEL_1	613	618	PF00026	0.365
TRG_Pf-PMV_PEXEL_1	968	972	PF00026	0.371

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDJ1	Leptomonas seymouri	50%	89%
A0A3S5H6N8	Leishmania donovani	99%	100%
A2AHL1	Mus musculus	23%	100%
A4H763	Leishmania braziliensis	71%	99%
E9AP98	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	99%
Q4QG80	Leishmania major	92%	100%