LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Ubiquitin-like protein

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Ubiquitin-like protein
Gene product:
ubiquitin-like protein
Species:
Leishmania infantum
UniProt:
A4HVK1_LEIIN
TriTrypDb:
LINF_130012200
Length:
847

Annotations

Annotations by Jardim et al.

Protein modification, Ubiquitin-like

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Phosphorylation

Amastigote: 294, 692, 733, 763, 807, 808
Promastigote: 649, 662
Promastigote/Amastigote: 687, 757

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HVK1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVK1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 192 196 PF00656 0.523
CLV_C14_Caspase3-7 363 367 PF00656 0.432
CLV_C14_Caspase3-7 703 707 PF00656 0.539
CLV_C14_Caspase3-7 724 728 PF00656 0.612
CLV_NRD_NRD_1 373 375 PF00675 0.414
CLV_NRD_NRD_1 473 475 PF00675 0.426
CLV_NRD_NRD_1 644 646 PF00675 0.563
CLV_PCSK_FUR_1 371 375 PF00082 0.414
CLV_PCSK_KEX2_1 373 375 PF00082 0.414
CLV_PCSK_KEX2_1 473 475 PF00082 0.423
CLV_PCSK_KEX2_1 644 646 PF00082 0.468
CLV_PCSK_SKI1_1 681 685 PF00082 0.466
CLV_PCSK_SKI1_1 736 740 PF00082 0.627
CLV_Separin_Metazoa 537 541 PF03568 0.310
DEG_Nend_UBRbox_1 1 4 PF02207 0.401
DEG_SCF_FBW7_1 154 161 PF00400 0.544
DOC_CKS1_1 745 750 PF01111 0.574
DOC_CYCLIN_yCln2_LP_2 664 667 PF00134 0.460
DOC_MAPK_gen_1 371 381 PF00069 0.520
DOC_MAPK_gen_1 644 652 PF00069 0.550
DOC_PIKK_1 14 22 PF02985 0.235
DOC_PP2B_LxvP_1 444 447 PF13499 0.403
DOC_PP2B_LxvP_1 463 466 PF13499 0.217
DOC_PP2B_LxvP_1 664 667 PF13499 0.460
DOC_PP4_FxxP_1 100 103 PF00568 0.605
DOC_SPAK_OSR1_1 34 38 PF12202 0.457
DOC_USP7_MATH_1 10 14 PF00917 0.410
DOC_USP7_MATH_1 110 114 PF00917 0.507
DOC_USP7_MATH_1 127 131 PF00917 0.446
DOC_USP7_MATH_1 160 164 PF00917 0.538
DOC_USP7_MATH_1 189 193 PF00917 0.578
DOC_USP7_MATH_1 216 220 PF00917 0.495
DOC_USP7_MATH_1 239 243 PF00917 0.569
DOC_USP7_MATH_1 266 270 PF00917 0.529
DOC_USP7_MATH_1 337 341 PF00917 0.573
DOC_USP7_MATH_1 40 44 PF00917 0.442
DOC_USP7_MATH_1 516 520 PF00917 0.433
DOC_USP7_MATH_1 525 529 PF00917 0.338
DOC_USP7_MATH_1 619 623 PF00917 0.360
DOC_USP7_MATH_1 674 678 PF00917 0.518
DOC_USP7_MATH_1 754 758 PF00917 0.482
DOC_USP7_MATH_2 744 750 PF00917 0.553
DOC_WW_Pin1_4 154 159 PF00397 0.601
DOC_WW_Pin1_4 161 166 PF00397 0.539
DOC_WW_Pin1_4 252 257 PF00397 0.623
DOC_WW_Pin1_4 289 294 PF00397 0.602
DOC_WW_Pin1_4 323 328 PF00397 0.600
DOC_WW_Pin1_4 339 344 PF00397 0.444
DOC_WW_Pin1_4 358 363 PF00397 0.352
DOC_WW_Pin1_4 427 432 PF00397 0.449
DOC_WW_Pin1_4 478 483 PF00397 0.425
DOC_WW_Pin1_4 622 627 PF00397 0.395
DOC_WW_Pin1_4 659 664 PF00397 0.571
DOC_WW_Pin1_4 736 741 PF00397 0.625
DOC_WW_Pin1_4 744 749 PF00397 0.527
DOC_WW_Pin1_4 805 810 PF00397 0.549
LIG_14-3-3_CanoR_1 28 32 PF00244 0.442
LIG_14-3-3_CanoR_1 373 381 PF00244 0.483
LIG_14-3-3_CanoR_1 393 397 PF00244 0.444
LIG_14-3-3_CanoR_1 494 503 PF00244 0.385
LIG_14-3-3_CanoR_1 555 563 PF00244 0.382
LIG_14-3-3_CanoR_1 644 652 PF00244 0.460
LIG_14-3-3_CanoR_1 681 686 PF00244 0.447
LIG_14-3-3_CanoR_1 760 768 PF00244 0.409
LIG_14-3-3_CanoR_1 788 794 PF00244 0.417
LIG_14-3-3_CanoR_1 826 835 PF00244 0.514
LIG_Actin_WH2_2 12 30 PF00022 0.287
LIG_BIR_III_2 366 370 PF00653 0.423
LIG_BRCT_BRCA1_1 136 140 PF00533 0.678
LIG_BRCT_BRCA1_1 589 593 PF00533 0.332
LIG_BRCT_BRCA1_1 648 652 PF00533 0.468
LIG_deltaCOP1_diTrp_1 830 835 PF00928 0.745
LIG_FHA_1 216 222 PF00498 0.526
LIG_FHA_1 39 45 PF00498 0.457
LIG_FHA_1 428 434 PF00498 0.480
LIG_FHA_1 659 665 PF00498 0.632
LIG_FHA_1 67 73 PF00498 0.457
LIG_FHA_1 793 799 PF00498 0.432
LIG_FHA_2 21 27 PF00498 0.457
LIG_FHA_2 253 259 PF00498 0.577
LIG_FHA_2 359 365 PF00498 0.481
LIG_FHA_2 398 404 PF00498 0.608
LIG_FHA_2 521 527 PF00498 0.427
LIG_HCF-1_HBM_1 543 546 PF13415 0.361
LIG_IBAR_NPY_1 838 840 PF08397 0.537
LIG_LIR_Apic_2 395 399 PF02991 0.584
LIG_LIR_Gen_1 113 123 PF02991 0.544
LIG_LIR_Gen_1 543 553 PF02991 0.358
LIG_LIR_Gen_1 712 723 PF02991 0.692
LIG_LIR_Nem_3 113 118 PF02991 0.581
LIG_LIR_Nem_3 124 128 PF02991 0.577
LIG_LIR_Nem_3 543 549 PF02991 0.359
LIG_LIR_Nem_3 712 718 PF02991 0.646
LIG_LYPXL_yS_3 614 617 PF13949 0.426
LIG_MYND_1 663 667 PF01753 0.501
LIG_NRBOX 627 633 PF00104 0.384
LIG_NRP_CendR_1 846 847 PF00754 0.552
LIG_Pex14_1 635 639 PF04695 0.402
LIG_SH2_CRK 115 119 PF00017 0.530
LIG_SH2_PTP2 546 549 PF00017 0.352
LIG_SH2_SRC 541 544 PF00017 0.355
LIG_SH2_STAP1 639 643 PF00017 0.434
LIG_SH2_STAT3 346 349 PF00017 0.532
LIG_SH2_STAT5 117 120 PF00017 0.528
LIG_SH2_STAT5 541 544 PF00017 0.355
LIG_SH2_STAT5 546 549 PF00017 0.306
LIG_SH2_STAT5 574 577 PF00017 0.334
LIG_SH2_STAT5 789 792 PF00017 0.448
LIG_SH3_2 667 672 PF14604 0.452
LIG_SH3_3 292 298 PF00018 0.665
LIG_SH3_3 657 663 PF00018 0.573
LIG_SH3_3 664 670 PF00018 0.484
LIG_SH3_3 70 76 PF00018 0.457
LIG_SH3_3 806 812 PF00018 0.577
LIG_SUMO_SIM_anti_2 12 20 PF11976 0.303
LIG_SUMO_SIM_par_1 12 20 PF11976 0.303
LIG_SxIP_EBH_1 371 385 PF03271 0.482
LIG_TRAF2_1 361 364 PF00917 0.482
LIG_TRAF2_1 400 403 PF00917 0.586
LIG_TRAF2_1 466 469 PF00917 0.333
LIG_TRAF2_1 764 767 PF00917 0.404
LIG_WW_3 326 330 PF00397 0.555
MOD_CDC14_SPxK_1 326 329 PF00782 0.598
MOD_CDK_SPK_2 736 741 PF00069 0.583
MOD_CDK_SPxK_1 323 329 PF00069 0.602
MOD_CK1_1 106 112 PF00069 0.572
MOD_CK1_1 134 140 PF00069 0.524
MOD_CK1_1 152 158 PF00069 0.458
MOD_CK1_1 161 167 PF00069 0.514
MOD_CK1_1 180 186 PF00069 0.430
MOD_CK1_1 227 233 PF00069 0.555
MOD_CK1_1 271 277 PF00069 0.488
MOD_CK1_1 291 297 PF00069 0.515
MOD_CK1_1 423 429 PF00069 0.558
MOD_CK1_1 554 560 PF00069 0.564
MOD_CK1_1 58 64 PF00069 0.309
MOD_CK1_1 622 628 PF00069 0.348
MOD_CK1_1 646 652 PF00069 0.478
MOD_CK1_1 750 756 PF00069 0.460
MOD_CK1_1 805 811 PF00069 0.504
MOD_CK2_1 20 26 PF00069 0.309
MOD_CK2_1 252 258 PF00069 0.588
MOD_CK2_1 358 364 PF00069 0.480
MOD_CK2_1 397 403 PF00069 0.608
MOD_CK2_1 520 526 PF00069 0.439
MOD_CK2_1 760 766 PF00069 0.450
MOD_CK2_1 774 780 PF00069 0.318
MOD_CK2_1 812 818 PF00069 0.552
MOD_CMANNOS 832 835 PF00535 0.606
MOD_GlcNHglycan 112 115 PF01048 0.565
MOD_GlcNHglycan 118 121 PF01048 0.519
MOD_GlcNHglycan 154 157 PF01048 0.592
MOD_GlcNHglycan 191 194 PF01048 0.572
MOD_GlcNHglycan 268 271 PF01048 0.510
MOD_GlcNHglycan 423 426 PF01048 0.602
MOD_GlcNHglycan 503 506 PF01048 0.348
MOD_GlcNHglycan 518 521 PF01048 0.367
MOD_GlcNHglycan 556 559 PF01048 0.399
MOD_GlcNHglycan 581 584 PF01048 0.359
MOD_GlcNHglycan 589 592 PF01048 0.296
MOD_GlcNHglycan 607 610 PF01048 0.280
MOD_GlcNHglycan 676 679 PF01048 0.488
MOD_GlcNHglycan 732 735 PF01048 0.513
MOD_GlcNHglycan 751 755 PF01048 0.453
MOD_GlcNHglycan 762 765 PF01048 0.439
MOD_GlcNHglycan 804 807 PF01048 0.576
MOD_GlcNHglycan 842 845 PF01048 0.506
MOD_GlcNHglycan 88 93 PF01048 0.600
MOD_GSK3_1 106 113 PF00069 0.563
MOD_GSK3_1 127 134 PF00069 0.535
MOD_GSK3_1 154 161 PF00069 0.597
MOD_GSK3_1 223 230 PF00069 0.538
MOD_GSK3_1 248 255 PF00069 0.607
MOD_GSK3_1 256 263 PF00069 0.543
MOD_GSK3_1 266 273 PF00069 0.430
MOD_GSK3_1 315 322 PF00069 0.568
MOD_GSK3_1 388 395 PF00069 0.599
MOD_GSK3_1 416 423 PF00069 0.584
MOD_GSK3_1 436 443 PF00069 0.231
MOD_GSK3_1 455 462 PF00069 0.214
MOD_GSK3_1 5 12 PF00069 0.294
MOD_GSK3_1 511 518 PF00069 0.410
MOD_GSK3_1 600 607 PF00069 0.360
MOD_GSK3_1 618 625 PF00069 0.299
MOD_GSK3_1 639 646 PF00069 0.434
MOD_GSK3_1 654 661 PF00069 0.570
MOD_GSK3_1 691 698 PF00069 0.527
MOD_GSK3_1 746 753 PF00069 0.534
MOD_GSK3_1 822 829 PF00069 0.614
MOD_N-GLC_1 20 25 PF02516 0.256
MOD_N-GLC_1 417 422 PF02516 0.605
MOD_N-GLC_1 455 460 PF02516 0.310
MOD_N-GLC_1 475 480 PF02516 0.369
MOD_N-GLC_1 821 826 PF02516 0.556
MOD_NEK2_1 128 133 PF00069 0.507
MOD_NEK2_1 224 229 PF00069 0.507
MOD_NEK2_1 27 32 PF00069 0.287
MOD_NEK2_1 319 324 PF00069 0.618
MOD_NEK2_1 501 506 PF00069 0.359
MOD_NEK2_1 545 550 PF00069 0.324
MOD_NEK2_1 553 558 PF00069 0.396
MOD_NEK2_1 577 582 PF00069 0.377
MOD_NEK2_1 604 609 PF00069 0.401
MOD_NEK2_1 627 632 PF00069 0.383
MOD_NEK2_2 40 45 PF00069 0.287
MOD_NEK2_2 639 644 PF00069 0.397
MOD_PIKK_1 216 222 PF00454 0.526
MOD_PIKK_1 239 245 PF00454 0.585
MOD_PIKK_1 374 380 PF00454 0.565
MOD_PIKK_1 425 431 PF00454 0.504
MOD_PIKK_1 508 514 PF00454 0.409
MOD_PIKK_1 525 531 PF00454 0.256
MOD_PIKK_1 654 660 PF00454 0.517
MOD_PIKK_1 754 760 PF00454 0.481
MOD_PIKK_1 792 798 PF00454 0.396
MOD_PKA_1 373 379 PF00069 0.373
MOD_PKA_2 27 33 PF00069 0.287
MOD_PKA_2 373 379 PF00069 0.429
MOD_PKA_2 392 398 PF00069 0.489
MOD_PKA_2 409 415 PF00069 0.614
MOD_PKA_2 5 11 PF00069 0.369
MOD_PKA_2 554 560 PF00069 0.387
MOD_PKA_2 643 649 PF00069 0.531
MOD_PKA_2 787 793 PF00069 0.409
MOD_PKB_1 371 379 PF00069 0.373
MOD_Plk_1 20 26 PF00069 0.256
MOD_Plk_1 455 461 PF00069 0.311
MOD_Plk_1 639 645 PF00069 0.402
MOD_Plk_1 646 652 PF00069 0.366
MOD_Plk_1 750 756 PF00069 0.481
MOD_Plk_2-3 20 26 PF00069 0.309
MOD_Plk_4 224 230 PF00069 0.539
MOD_Plk_4 27 33 PF00069 0.287
MOD_Plk_4 349 355 PF00069 0.542
MOD_Plk_4 455 461 PF00069 0.313
MOD_Plk_4 545 551 PF00069 0.454
MOD_Plk_4 600 606 PF00069 0.353
MOD_Plk_4 619 625 PF00069 0.269
MOD_Plk_4 627 633 PF00069 0.329
MOD_Plk_4 684 690 PF00069 0.502
MOD_ProDKin_1 154 160 PF00069 0.600
MOD_ProDKin_1 161 167 PF00069 0.539
MOD_ProDKin_1 252 258 PF00069 0.622
MOD_ProDKin_1 289 295 PF00069 0.601
MOD_ProDKin_1 323 329 PF00069 0.602
MOD_ProDKin_1 339 345 PF00069 0.446
MOD_ProDKin_1 358 364 PF00069 0.348
MOD_ProDKin_1 427 433 PF00069 0.439
MOD_ProDKin_1 478 484 PF00069 0.418
MOD_ProDKin_1 622 628 PF00069 0.391
MOD_ProDKin_1 659 665 PF00069 0.569
MOD_ProDKin_1 736 742 PF00069 0.623
MOD_ProDKin_1 744 750 PF00069 0.524
MOD_ProDKin_1 805 811 PF00069 0.549
TRG_DiLeu_BaLyEn_6 42 47 PF01217 0.309
TRG_DiLeu_BaLyEn_6 660 665 PF01217 0.497
TRG_ENDOCYTIC_2 115 118 PF00928 0.628
TRG_ENDOCYTIC_2 546 549 PF00928 0.352
TRG_ENDOCYTIC_2 574 577 PF00928 0.334
TRG_ENDOCYTIC_2 614 617 PF00928 0.426
TRG_ER_diArg_1 371 374 PF00400 0.416
TRG_ER_diArg_1 473 475 PF00400 0.421
TRG_ER_diArg_1 48 51 PF00400 0.309
TRG_ER_diArg_1 643 645 PF00400 0.458
TRG_NES_CRM1_1 26 38 PF08389 0.309
TRG_NES_CRM1_1 435 448 PF08389 0.407
TRG_NES_CRM1_1 537 551 PF08389 0.356
TRG_Pf-PMV_PEXEL_1 373 378 PF00026 0.417
TRG_Pf-PMV_PEXEL_1 494 498 PF00026 0.398
TRG_Pf-PMV_PEXEL_1 720 724 PF00026 0.599

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S7WSG5 Leishmania donovani 99% 100%
A4H762 Leishmania braziliensis 69% 97%
E9AP97 Leishmania mexicana (strain MHOM/GT/2001/U1103) 84% 97%
Q4QG81 Leishmania major 90% 99%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS