LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
Putative GTPase activating protein for Arf - putative
Species:
Leishmania infantum
UniProt:
A4HVJ9_LEIIN
TriTrypDb:
LINF_130012000
Length:
442

Annotations

Annotations by Jardim et al.

ER/Golgi Proteins, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Cellular components
Term Name Level Count
GO:0000139 Golgi membrane 5 1
GO:0016020 membrane 2 1
GO:0031090 organelle membrane 3 1
GO:0098588 bounding membrane of organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HVJ9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVJ9

Function

Biological processes
Term Name Level Count
GO:0006901 vesicle coating 6 1
GO:0006996 organelle organization 4 1
GO:0009987 cellular process 1 1
GO:0016043 cellular component organization 3 1
GO:0016050 vesicle organization 5 1
GO:0048200 Golgi transport vesicle coating 7 1
GO:0048205 COPI coating of Golgi vesicle 8 1
GO:0071840 cellular component organization or biogenesis 2 1
Molecular functions
Term Name Level Count
GO:0005096 GTPase activator activity 4 8
GO:0008047 enzyme activator activity 3 8
GO:0030234 enzyme regulator activity 2 8
GO:0030695 GTPase regulator activity 4 8
GO:0060589 nucleoside-triphosphatase regulator activity 3 8
GO:0098772 molecular function regulator activity 1 8
GO:0140677 molecular function activator activity 2 8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 405 409 PF00656 0.557
CLV_NRD_NRD_1 252 254 PF00675 0.538
CLV_PCSK_KEX2_1 118 120 PF00082 0.380
CLV_PCSK_PC1ET2_1 118 120 PF00082 0.371
CLV_PCSK_SKI1_1 352 356 PF00082 0.555
CLV_PCSK_SKI1_1 436 440 PF00082 0.430
CLV_PCSK_SKI1_1 84 88 PF00082 0.297
CLV_PCSK_SKI1_1 94 98 PF00082 0.242
DEG_SCF_FBW7_1 170 177 PF00400 0.565
DOC_MAPK_gen_1 58 66 PF00069 0.273
DOC_MAPK_MEF2A_6 58 66 PF00069 0.273
DOC_MAPK_MEF2A_6 78 87 PF00069 0.349
DOC_MAPK_RevD_3 190 206 PF00069 0.541
DOC_PP1_RVXF_1 28 34 PF00149 0.273
DOC_PP2B_LxvP_1 7 10 PF13499 0.477
DOC_PP4_FxxP_1 33 36 PF00568 0.273
DOC_USP7_MATH_1 165 169 PF00917 0.656
DOC_USP7_MATH_1 172 176 PF00917 0.596
DOC_USP7_MATH_1 194 198 PF00917 0.551
DOC_USP7_MATH_1 393 397 PF00917 0.624
DOC_USP7_MATH_1 416 420 PF00917 0.490
DOC_USP7_UBL2_3 217 221 PF12436 0.732
DOC_USP7_UBL2_3 94 98 PF12436 0.333
DOC_WW_Pin1_4 108 113 PF00397 0.424
DOC_WW_Pin1_4 135 140 PF00397 0.563
DOC_WW_Pin1_4 145 150 PF00397 0.507
DOC_WW_Pin1_4 153 158 PF00397 0.507
DOC_WW_Pin1_4 168 173 PF00397 0.540
DOC_WW_Pin1_4 174 179 PF00397 0.604
DOC_WW_Pin1_4 182 187 PF00397 0.652
DOC_WW_Pin1_4 352 357 PF00397 0.700
LIG_BIR_II_1 1 5 PF00653 0.518
LIG_BRCT_BRCA1_1 155 159 PF00533 0.561
LIG_FHA_1 2 8 PF00498 0.578
LIG_FHA_1 202 208 PF00498 0.607
LIG_FHA_1 235 241 PF00498 0.555
LIG_FHA_1 299 305 PF00498 0.652
LIG_FHA_1 339 345 PF00498 0.521
LIG_FHA_1 353 359 PF00498 0.556
LIG_FHA_1 426 432 PF00498 0.491
LIG_FHA_1 44 50 PF00498 0.252
LIG_FHA_2 10 16 PF00498 0.441
LIG_FHA_2 403 409 PF00498 0.573
LIG_LIR_Apic_2 107 112 PF02991 0.432
LIG_LIR_Gen_1 41 50 PF02991 0.273
LIG_LIR_Nem_3 156 162 PF02991 0.477
LIG_LIR_Nem_3 372 376 PF02991 0.517
LIG_LIR_Nem_3 41 45 PF02991 0.309
LIG_LIR_Nem_3 46 50 PF02991 0.308
LIG_MYND_1 356 360 PF01753 0.511
LIG_PDZ_Class_3 437 442 PF00595 0.438
LIG_PTB_Apo_2 375 382 PF02174 0.550
LIG_PTB_Phospho_1 375 381 PF10480 0.550
LIG_SH2_CRK 109 113 PF00017 0.370
LIG_SH2_NCK_1 109 113 PF00017 0.410
LIG_SH2_STAP1 246 250 PF00017 0.540
LIG_SH2_STAT5 109 112 PF00017 0.407
LIG_SH2_STAT5 381 384 PF00017 0.572
LIG_SH2_STAT5 387 390 PF00017 0.621
LIG_SH3_1 283 289 PF00018 0.644
LIG_SH3_2 326 331 PF14604 0.571
LIG_SH3_3 159 165 PF00018 0.492
LIG_SH3_3 283 289 PF00018 0.644
LIG_SH3_3 323 329 PF00018 0.604
LIG_SH3_3 353 359 PF00018 0.667
LIG_SUMO_SIM_anti_2 18 24 PF11976 0.301
LIG_SUMO_SIM_par_1 191 197 PF11976 0.509
LIG_TRAF2_1 12 15 PF00917 0.451
MOD_CK1_1 107 113 PF00069 0.401
MOD_CK1_1 148 154 PF00069 0.593
MOD_CK1_1 168 174 PF00069 0.560
MOD_CK1_1 185 191 PF00069 0.617
MOD_CK1_1 197 203 PF00069 0.539
MOD_CK1_1 347 353 PF00069 0.546
MOD_CK1_1 41 47 PF00069 0.280
MOD_CK2_1 9 15 PF00069 0.445
MOD_Cter_Amidation 217 220 PF01082 0.616
MOD_DYRK1A_RPxSP_1 352 356 PF00069 0.598
MOD_GlcNHglycan 135 138 PF01048 0.553
MOD_GlcNHglycan 174 177 PF01048 0.646
MOD_GlcNHglycan 209 212 PF01048 0.619
MOD_GlcNHglycan 344 347 PF01048 0.596
MOD_GlcNHglycan 352 355 PF01048 0.648
MOD_GlcNHglycan 363 366 PF01048 0.713
MOD_GlcNHglycan 389 392 PF01048 0.603
MOD_GlcNHglycan 396 399 PF01048 0.717
MOD_GlcNHglycan 422 425 PF01048 0.522
MOD_GlcNHglycan 70 73 PF01048 0.333
MOD_GSK3_1 104 111 PF00069 0.451
MOD_GSK3_1 166 173 PF00069 0.597
MOD_GSK3_1 174 181 PF00069 0.612
MOD_GSK3_1 193 200 PF00069 0.403
MOD_GSK3_1 338 345 PF00069 0.546
MOD_GSK3_1 350 357 PF00069 0.705
MOD_GSK3_1 383 390 PF00069 0.608
MOD_GSK3_1 416 423 PF00069 0.497
MOD_GSK3_1 64 71 PF00069 0.293
MOD_N-GLC_1 338 343 PF02516 0.566
MOD_NEK2_1 1 6 PF00069 0.608
MOD_NEK2_1 207 212 PF00069 0.586
MOD_NEK2_1 316 321 PF00069 0.625
MOD_NEK2_1 361 366 PF00069 0.636
MOD_NEK2_1 420 425 PF00069 0.527
MOD_PIKK_1 292 298 PF00454 0.508
MOD_PKA_2 298 304 PF00069 0.739
MOD_PKA_2 393 399 PF00069 0.656
MOD_Plk_1 126 132 PF00069 0.350
MOD_Plk_1 383 389 PF00069 0.574
MOD_Plk_4 104 110 PF00069 0.333
MOD_Plk_4 155 161 PF00069 0.560
MOD_Plk_4 276 282 PF00069 0.545
MOD_ProDKin_1 108 114 PF00069 0.417
MOD_ProDKin_1 135 141 PF00069 0.570
MOD_ProDKin_1 145 151 PF00069 0.502
MOD_ProDKin_1 153 159 PF00069 0.508
MOD_ProDKin_1 168 174 PF00069 0.542
MOD_ProDKin_1 182 188 PF00069 0.651
MOD_ProDKin_1 352 358 PF00069 0.701
MOD_SUMO_rev_2 11 19 PF00179 0.385
TRG_DiLeu_BaEn_1 15 20 PF01217 0.422
TRG_ENDOCYTIC_2 117 120 PF00928 0.377
TRG_ENDOCYTIC_2 47 50 PF00928 0.313
TRG_NLS_Bipartite_1 205 223 PF00514 0.550
TRG_NLS_MonoExtN_4 217 223 PF00514 0.536
TRG_Pf-PMV_PEXEL_1 24 28 PF00026 0.349
TRG_Pf-PMV_PEXEL_1 374 379 PF00026 0.592
TRG_Pf-PMV_PEXEL_1 418 422 PF00026 0.541

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I148 Leptomonas seymouri 61% 99%
A0A0S4JHE6 Bodo saltans 38% 100%
A0A3Q8IHZ4 Leishmania donovani 100% 100%
A1L520 Bos taurus 28% 85%
A4H760 Leishmania braziliensis 76% 100%
E9AP95 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 99%
Q28CM8 Xenopus tropicalis 28% 84%
Q3MID3 Rattus norvegicus 28% 85%
Q4QG83 Leishmania major 91% 98%
Q5RAT7 Pongo abelii 28% 85%
Q8N6H7 Homo sapiens 27% 85%
Q99K28 Mus musculus 27% 85%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS