LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
Metallopeptidase family M24 - putative
Species:
Leishmania infantum
UniProt:
A4HVJ6_LEIIN
TriTrypDb:
LINF_130011700
Length:
574

Annotations

Annotations by Jardim et al.

Proteases, Metallopeptidase family M24

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 6
Silverman et al. no yes: 3
Pissara et al. no yes: 12
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 12
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 16
NetGPI no yes: 0, no: 16
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 2
GO:0005730 nucleolus 5 1
GO:0043226 organelle 2 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HVJ6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVJ6

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 5
GO:0004177 aminopeptidase activity 5 5
GO:0008233 peptidase activity 3 5
GO:0008238 exopeptidase activity 4 5
GO:0016787 hydrolase activity 2 5
GO:0140096 catalytic activity, acting on a protein 2 5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_MEL_PAP_1 486 492 PF00089 0.270
CLV_NRD_NRD_1 129 131 PF00675 0.591
CLV_NRD_NRD_1 292 294 PF00675 0.209
CLV_NRD_NRD_1 371 373 PF00675 0.418
CLV_NRD_NRD_1 418 420 PF00675 0.301
CLV_NRD_NRD_1 537 539 PF00675 0.422
CLV_NRD_NRD_1 62 64 PF00675 0.667
CLV_NRD_NRD_1 72 74 PF00675 0.666
CLV_PCSK_FUR_1 18 22 PF00082 0.498
CLV_PCSK_FUR_1 356 360 PF00082 0.284
CLV_PCSK_FUR_1 70 74 PF00082 0.661
CLV_PCSK_KEX2_1 129 131 PF00082 0.598
CLV_PCSK_KEX2_1 20 22 PF00082 0.470
CLV_PCSK_KEX2_1 214 216 PF00082 0.330
CLV_PCSK_KEX2_1 291 293 PF00082 0.213
CLV_PCSK_KEX2_1 358 360 PF00082 0.328
CLV_PCSK_KEX2_1 371 373 PF00082 0.402
CLV_PCSK_KEX2_1 418 420 PF00082 0.301
CLV_PCSK_KEX2_1 499 501 PF00082 0.316
CLV_PCSK_KEX2_1 537 539 PF00082 0.483
CLV_PCSK_KEX2_1 563 565 PF00082 0.534
CLV_PCSK_KEX2_1 72 74 PF00082 0.658
CLV_PCSK_PC1ET2_1 20 22 PF00082 0.470
CLV_PCSK_PC1ET2_1 214 216 PF00082 0.318
CLV_PCSK_PC1ET2_1 358 360 PF00082 0.328
CLV_PCSK_PC1ET2_1 499 501 PF00082 0.360
CLV_PCSK_PC1ET2_1 563 565 PF00082 0.536
CLV_PCSK_SKI1_1 113 117 PF00082 0.535
CLV_PCSK_SKI1_1 202 206 PF00082 0.334
CLV_PCSK_SKI1_1 314 318 PF00082 0.301
CLV_PCSK_SKI1_1 371 375 PF00082 0.431
CLV_PCSK_SKI1_1 412 416 PF00082 0.415
CLV_PCSK_SKI1_1 499 503 PF00082 0.357
CLV_PCSK_SKI1_1 64 68 PF00082 0.674
CLV_Separin_Metazoa 60 64 PF03568 0.524
DEG_APCC_DBOX_1 128 136 PF00400 0.461
DEG_APCC_DBOX_1 313 321 PF00400 0.229
DEG_APCC_DBOX_1 62 70 PF00400 0.569
DEG_COP1_1 354 365 PF00400 0.260
DOC_ANK_TNKS_1 358 365 PF00023 0.264
DOC_CKS1_1 513 518 PF01111 0.471
DOC_CYCLIN_RxL_1 199 208 PF00134 0.323
DOC_CYCLIN_yCln2_LP_2 536 542 PF00134 0.329
DOC_MAPK_FxFP_2 445 448 PF00069 0.393
DOC_MAPK_gen_1 18 27 PF00069 0.491
DOC_MAPK_gen_1 459 466 PF00069 0.399
DOC_MAPK_MEF2A_6 11 19 PF00069 0.465
DOC_MAPK_MEF2A_6 247 256 PF00069 0.213
DOC_MAPK_MEF2A_6 459 466 PF00069 0.306
DOC_PP4_FxxP_1 445 448 PF00568 0.393
DOC_USP7_MATH_1 48 52 PF00917 0.735
DOC_USP7_MATH_1 521 525 PF00917 0.425
DOC_USP7_MATH_1 7 11 PF00917 0.607
DOC_USP7_MATH_1 85 89 PF00917 0.558
DOC_USP7_UBL2_3 95 99 PF12436 0.573
DOC_WW_Pin1_4 115 120 PF00397 0.525
DOC_WW_Pin1_4 233 238 PF00397 0.358
DOC_WW_Pin1_4 417 422 PF00397 0.438
DOC_WW_Pin1_4 512 517 PF00397 0.428
DOC_WW_Pin1_4 556 561 PF00397 0.577
DOC_WW_Pin1_4 80 85 PF00397 0.475
DOC_WW_Pin1_4 87 92 PF00397 0.459
LIG_14-3-3_CanoR_1 111 119 PF00244 0.561
LIG_14-3-3_CanoR_1 21 26 PF00244 0.526
LIG_14-3-3_CanoR_1 218 223 PF00244 0.248
LIG_14-3-3_CanoR_1 291 300 PF00244 0.348
LIG_14-3-3_CanoR_1 371 378 PF00244 0.418
LIG_14-3-3_CanoR_1 406 416 PF00244 0.398
LIG_14-3-3_CanoR_1 429 437 PF00244 0.317
LIG_14-3-3_CanoR_1 489 495 PF00244 0.261
LIG_14-3-3_CanoR_1 500 504 PF00244 0.297
LIG_14-3-3_CanoR_1 520 528 PF00244 0.222
LIG_14-3-3_CanoR_1 63 67 PF00244 0.538
LIG_14-3-3_CanoR_1 73 79 PF00244 0.505
LIG_Actin_WH2_2 311 327 PF00022 0.358
LIG_BRCT_BRCA1_1 124 128 PF00533 0.579
LIG_DLG_GKlike_1 23 30 PF00625 0.472
LIG_FHA_1 184 190 PF00498 0.252
LIG_FHA_1 268 274 PF00498 0.273
LIG_FHA_1 332 338 PF00498 0.264
LIG_FHA_1 491 497 PF00498 0.291
LIG_FHA_1 508 514 PF00498 0.406
LIG_FHA_1 56 62 PF00498 0.665
LIG_FHA_1 63 69 PF00498 0.724
LIG_FHA_2 190 196 PF00498 0.320
LIG_FHA_2 280 286 PF00498 0.331
LIG_FHA_2 372 378 PF00498 0.453
LIG_FHA_2 406 412 PF00498 0.402
LIG_FHA_2 418 424 PF00498 0.298
LIG_FHA_2 434 440 PF00498 0.426
LIG_FHA_2 520 526 PF00498 0.504
LIG_LIR_Apic_2 442 448 PF02991 0.395
LIG_LIR_Gen_1 541 549 PF02991 0.412
LIG_LIR_Nem_3 541 545 PF02991 0.381
LIG_MAD2 67 75 PF02301 0.527
LIG_PCNA_yPIPBox_3 218 232 PF02747 0.285
LIG_PCNA_yPIPBox_3 325 337 PF02747 0.298
LIG_Pex14_2 445 449 PF04695 0.390
LIG_PTAP_UEV_1 508 513 PF05743 0.327
LIG_RPA_C_Fungi 18 30 PF08784 0.596
LIG_SH2_STAT3 344 347 PF00017 0.358
LIG_SH2_STAT5 485 488 PF00017 0.332
LIG_SH3_3 506 512 PF00018 0.348
LIG_SUMO_SIM_anti_2 531 537 PF11976 0.456
LIG_SUMO_SIM_par_1 269 275 PF11976 0.365
LIG_SUMO_SIM_par_1 491 497 PF11976 0.298
LIG_TRAF2_1 436 439 PF00917 0.352
MOD_CDC14_SPxK_1 236 239 PF00782 0.358
MOD_CDK_SPxK_1 233 239 PF00069 0.358
MOD_CDK_SPxxK_3 115 122 PF00069 0.443
MOD_CDK_SPxxK_3 556 563 PF00069 0.573
MOD_CK1_1 221 227 PF00069 0.269
MOD_CK1_1 279 285 PF00069 0.299
MOD_CK1_1 301 307 PF00069 0.363
MOD_CK1_1 354 360 PF00069 0.273
MOD_CK1_1 51 57 PF00069 0.706
MOD_CK1_1 524 530 PF00069 0.484
MOD_CK1_1 558 564 PF00069 0.576
MOD_CK1_1 77 83 PF00069 0.618
MOD_CK2_1 143 149 PF00069 0.521
MOD_CK2_1 189 195 PF00069 0.216
MOD_CK2_1 224 230 PF00069 0.345
MOD_CK2_1 405 411 PF00069 0.400
MOD_CK2_1 433 439 PF00069 0.371
MOD_CK2_1 519 525 PF00069 0.573
MOD_Cter_Amidation 212 215 PF01082 0.308
MOD_GlcNHglycan 106 109 PF01048 0.610
MOD_GlcNHglycan 11 14 PF01048 0.455
MOD_GlcNHglycan 124 127 PF01048 0.473
MOD_GlcNHglycan 265 268 PF01048 0.275
MOD_GlcNHglycan 278 281 PF01048 0.234
MOD_GlcNHglycan 303 306 PF01048 0.341
MOD_GlcNHglycan 46 49 PF01048 0.668
MOD_GlcNHglycan 490 493 PF01048 0.248
MOD_GlcNHglycan 5 8 PF01048 0.525
MOD_GlcNHglycan 54 57 PF01048 0.720
MOD_GlcNHglycan 560 563 PF01048 0.482
MOD_GSK3_1 100 107 PF00069 0.635
MOD_GSK3_1 111 118 PF00069 0.541
MOD_GSK3_1 149 156 PF00069 0.432
MOD_GSK3_1 19 26 PF00069 0.459
MOD_GSK3_1 263 270 PF00069 0.267
MOD_GSK3_1 272 279 PF00069 0.283
MOD_GSK3_1 292 299 PF00069 0.290
MOD_GSK3_1 3 10 PF00069 0.478
MOD_GSK3_1 44 51 PF00069 0.697
MOD_GSK3_1 484 491 PF00069 0.320
MOD_GSK3_1 52 59 PF00069 0.498
MOD_GSK3_1 73 80 PF00069 0.624
MOD_GSK3_1 83 90 PF00069 0.568
MOD_N-GLC_1 154 159 PF02516 0.485
MOD_N-GLC_1 224 229 PF02516 0.229
MOD_N-GLC_1 233 238 PF02516 0.229
MOD_N-GLC_1 354 359 PF02516 0.252
MOD_N-GLC_1 433 438 PF02516 0.416
MOD_NEK2_1 154 159 PF00069 0.485
MOD_NEK2_1 19 24 PF00069 0.533
MOD_NEK2_1 205 210 PF00069 0.433
MOD_NEK2_1 490 495 PF00069 0.292
MOD_NEK2_1 78 83 PF00069 0.548
MOD_NEK2_2 62 67 PF00069 0.461
MOD_NEK2_2 94 99 PF00069 0.475
MOD_PIKK_1 120 126 PF00454 0.652
MOD_PIKK_1 428 434 PF00454 0.283
MOD_PKA_1 291 297 PF00069 0.216
MOD_PKA_1 371 377 PF00069 0.415
MOD_PKA_1 499 505 PF00069 0.304
MOD_PKA_2 13 19 PF00069 0.468
MOD_PKA_2 291 297 PF00069 0.403
MOD_PKA_2 371 377 PF00069 0.415
MOD_PKA_2 405 411 PF00069 0.369
MOD_PKA_2 428 434 PF00069 0.378
MOD_PKA_2 488 494 PF00069 0.259
MOD_PKA_2 499 505 PF00069 0.279
MOD_PKA_2 519 525 PF00069 0.228
MOD_PKA_2 62 68 PF00069 0.501
MOD_PKB_1 111 119 PF00069 0.531
MOD_PKB_1 21 29 PF00069 0.463
MOD_PKB_1 291 299 PF00069 0.177
MOD_Plk_1 149 155 PF00069 0.497
MOD_Plk_1 224 230 PF00069 0.229
MOD_Plk_1 433 439 PF00069 0.497
MOD_Plk_1 48 54 PF00069 0.507
MOD_Plk_1 524 530 PF00069 0.526
MOD_Plk_4 149 155 PF00069 0.368
MOD_Plk_4 412 418 PF00069 0.290
MOD_Plk_4 499 505 PF00069 0.294
MOD_Plk_4 74 80 PF00069 0.513
MOD_ProDKin_1 115 121 PF00069 0.522
MOD_ProDKin_1 233 239 PF00069 0.358
MOD_ProDKin_1 417 423 PF00069 0.450
MOD_ProDKin_1 512 518 PF00069 0.427
MOD_ProDKin_1 556 562 PF00069 0.574
MOD_ProDKin_1 80 86 PF00069 0.475
MOD_ProDKin_1 87 93 PF00069 0.462
TRG_DiLeu_BaEn_1 531 536 PF01217 0.262
TRG_ER_diArg_1 128 130 PF00400 0.521
TRG_ER_diArg_1 291 293 PF00400 0.148
TRG_ER_diArg_1 371 373 PF00400 0.418
TRG_ER_diArg_1 417 419 PF00400 0.295
TRG_ER_diArg_1 536 538 PF00400 0.478
TRG_ER_diArg_1 564 567 PF00400 0.558
TRG_ER_diArg_1 69 72 PF00400 0.668
TRG_NLS_MonoExtC_3 562 568 PF00514 0.488
TRG_NLS_MonoExtN_4 18 24 PF00514 0.493
TRG_NLS_MonoExtN_4 560 567 PF00514 0.493
TRG_Pf-PMV_PEXEL_1 130 134 PF00026 0.530

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IM06 Leptomonas seymouri 69% 99%
A0A0S4J160 Bodo saltans 31% 100%
A0A1X0NPS8 Trypanosomatidae 46% 100%
A0A3Q8IBA7 Leishmania donovani 31% 94%
A0A3Q8IBP5 Leishmania donovani 99% 100%
A0A3R7KN75 Trypanosoma rangeli 45% 100%
A4H757 Leishmania braziliensis 81% 99%
A4H9X3 Leishmania braziliensis 31% 99%
D0A6Q9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 45% 100%
E9AGR8 Leishmania infantum 31% 94%
E9AP92 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 97%
E9ARW7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 94%
O60180 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 24% 100%
Q4QDK5 Leishmania major 31% 94%
Q4QG86 Leishmania major 93% 100%
V5BFG1 Trypanosoma cruzi 46% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS