LeishMANIAdb
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Putative lectin

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative lectin
Gene product:
mannose-specific lectin - putative
Species:
Leishmania infantum
UniProt:
A4HVJ5_LEIIN
TriTrypDb:
LINF_130011600
Length:
448

Annotations

Annotations by Jardim et al.

Membrane associated proteins, lectin

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 10
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 8
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Cellular components
Term Name Level Count
GO:0016020 membrane 2 6
GO:0110165 cellular anatomical entity 1 6

Expansion

Sequence features

A4HVJ5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVJ5

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005488 binding 1 6
GO:0030246 carbohydrate binding 2 6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 138 140 PF00675 0.481
CLV_NRD_NRD_1 392 394 PF00675 0.541
CLV_NRD_NRD_1 407 409 PF00675 0.608
CLV_NRD_NRD_1 428 430 PF00675 0.660
CLV_NRD_NRD_1 431 433 PF00675 0.650
CLV_NRD_NRD_1 434 436 PF00675 0.619
CLV_PCSK_FUR_1 426 430 PF00082 0.766
CLV_PCSK_FUR_1 432 436 PF00082 0.797
CLV_PCSK_KEX2_1 138 140 PF00082 0.481
CLV_PCSK_KEX2_1 392 394 PF00082 0.525
CLV_PCSK_KEX2_1 407 409 PF00082 0.608
CLV_PCSK_KEX2_1 428 430 PF00082 0.773
CLV_PCSK_KEX2_1 431 433 PF00082 0.788
CLV_PCSK_KEX2_1 434 436 PF00082 0.782
CLV_PCSK_PC7_1 424 430 PF00082 0.619
CLV_PCSK_SKI1_1 17 21 PF00082 0.391
DEG_SCF_FBW7_2 8 15 PF00400 0.419
DOC_MAPK_gen_1 138 146 PF00069 0.280
DOC_MAPK_MEF2A_6 138 146 PF00069 0.322
DOC_MAPK_MEF2A_6 192 199 PF00069 0.281
DOC_MIT_MIM_1 388 397 PF04212 0.481
DOC_PP1_RVXF_1 185 192 PF00149 0.278
DOC_PP2B_LxvP_1 216 219 PF13499 0.281
DOC_PP4_FxxP_1 112 115 PF00568 0.292
DOC_PP4_FxxP_1 117 120 PF00568 0.272
DOC_PP4_FxxP_1 28 31 PF00568 0.281
DOC_USP7_MATH_1 142 146 PF00917 0.315
DOC_WW_Pin1_4 243 248 PF00397 0.406
DOC_WW_Pin1_4 435 440 PF00397 0.657
DOC_WW_Pin1_4 8 13 PF00397 0.401
LIG_14-3-3_CanoR_1 119 124 PF00244 0.278
LIG_14-3-3_CanoR_1 258 263 PF00244 0.551
LIG_14-3-3_CanoR_1 281 287 PF00244 0.600
LIG_BIR_II_1 1 5 PF00653 0.534
LIG_BIR_III_3 1 5 PF00653 0.534
LIG_BRCT_BRCA1_1 169 173 PF00533 0.315
LIG_FHA_1 18 24 PF00498 0.376
LIG_FHA_1 206 212 PF00498 0.354
LIG_FHA_1 229 235 PF00498 0.281
LIG_FHA_1 262 268 PF00498 0.587
LIG_FHA_1 281 287 PF00498 0.528
LIG_FHA_1 374 380 PF00498 0.709
LIG_FHA_1 404 410 PF00498 0.605
LIG_FHA_1 48 54 PF00498 0.231
LIG_FHA_1 66 72 PF00498 0.307
LIG_FHA_2 204 210 PF00498 0.331
LIG_HP1_1 142 146 PF01393 0.315
LIG_LIR_Apic_2 27 31 PF02991 0.281
LIG_LIR_Gen_1 239 249 PF02991 0.338
LIG_LIR_Gen_1 54 62 PF02991 0.281
LIG_LIR_Gen_1 80 90 PF02991 0.281
LIG_LIR_Nem_3 121 126 PF02991 0.314
LIG_LIR_Nem_3 174 178 PF02991 0.280
LIG_LIR_Nem_3 239 245 PF02991 0.322
LIG_LIR_Nem_3 54 60 PF02991 0.281
LIG_LIR_Nem_3 80 85 PF02991 0.281
LIG_MYND_1 8 12 PF01753 0.422
LIG_Pex14_2 126 130 PF04695 0.281
LIG_SH2_GRB2like 133 136 PF00017 0.281
LIG_SH2_GRB2like 273 276 PF00017 0.521
LIG_SH2_PTP2 57 60 PF00017 0.281
LIG_SH2_SRC 309 312 PF00017 0.621
LIG_SH2_SRC 321 324 PF00017 0.577
LIG_SH2_SRC 333 336 PF00017 0.575
LIG_SH2_SRC 345 348 PF00017 0.563
LIG_SH2_SRC 357 360 PF00017 0.517
LIG_SH2_STAP1 253 257 PF00017 0.497
LIG_SH2_STAP1 273 277 PF00017 0.457
LIG_SH2_STAT5 190 193 PF00017 0.288
LIG_SH2_STAT5 198 201 PF00017 0.271
LIG_SH2_STAT5 224 227 PF00017 0.261
LIG_SH2_STAT5 57 60 PF00017 0.281
LIG_SH3_3 103 109 PF00018 0.226
LIG_SH3_3 87 93 PF00018 0.315
LIG_TRAF2_1 12 15 PF00917 0.477
LIG_WW_3 108 112 PF00397 0.315
MOD_CDK_SPK_2 435 440 PF00069 0.631
MOD_CK1_1 167 173 PF00069 0.305
MOD_CK1_1 200 206 PF00069 0.348
MOD_CK1_1 228 234 PF00069 0.292
MOD_CK1_1 48 54 PF00069 0.287
MOD_CK2_1 203 209 PF00069 0.315
MOD_DYRK1A_RPxSP_1 435 439 PF00069 0.655
MOD_GlcNHglycan 227 230 PF01048 0.512
MOD_GlcNHglycan 371 374 PF01048 0.618
MOD_GlcNHglycan 47 50 PF01048 0.514
MOD_GSK3_1 228 235 PF00069 0.286
MOD_GSK3_1 257 264 PF00069 0.657
MOD_GSK3_1 281 288 PF00069 0.607
MOD_GSK3_1 369 376 PF00069 0.657
MOD_GSK3_1 47 54 PF00069 0.278
MOD_NEK2_1 164 169 PF00069 0.315
MOD_NEK2_1 211 216 PF00069 0.359
MOD_NEK2_1 225 230 PF00069 0.241
MOD_PIKK_1 312 318 PF00454 0.668
MOD_PIKK_1 324 330 PF00454 0.645
MOD_PIKK_1 336 342 PF00454 0.721
MOD_PIKK_1 348 354 PF00454 0.560
MOD_PIKK_1 63 69 PF00454 0.278
MOD_PKA_2 118 124 PF00069 0.278
MOD_PKA_2 200 206 PF00069 0.367
MOD_PKA_2 257 263 PF00069 0.542
MOD_PKA_2 280 286 PF00069 0.581
MOD_PKA_2 403 409 PF00069 0.606
MOD_PKA_2 58 64 PF00069 0.281
MOD_Plk_4 142 148 PF00069 0.281
MOD_Plk_4 291 297 PF00069 0.610
MOD_Plk_4 48 54 PF00069 0.281
MOD_ProDKin_1 243 249 PF00069 0.424
MOD_ProDKin_1 435 441 PF00069 0.655
MOD_ProDKin_1 8 14 PF00069 0.392
MOD_SUMO_for_1 191 194 PF00179 0.315
TRG_DiLeu_BaEn_1 412 417 PF01217 0.537
TRG_DiLeu_BaLyEn_6 28 33 PF01217 0.281
TRG_ENDOCYTIC_2 224 227 PF00928 0.261
TRG_ENDOCYTIC_2 57 60 PF00928 0.281
TRG_ENDOCYTIC_2 91 94 PF00928 0.306
TRG_ER_diArg_1 384 387 PF00400 0.557
TRG_ER_diArg_1 392 394 PF00400 0.481
TRG_ER_diArg_1 407 409 PF00400 0.608
TRG_ER_diArg_1 426 429 PF00400 0.551
TRG_ER_diArg_1 430 432 PF00400 0.649
TRG_ER_diArg_1 433 435 PF00400 0.616
TRG_Pf-PMV_PEXEL_1 176 180 PF00026 0.479
TRG_Pf-PMV_PEXEL_1 392 396 PF00026 0.547
TRG_Pf-PMV_PEXEL_1 407 411 PF00026 0.580

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PD81 Leptomonas seymouri 62% 100%
A0A3Q8I8H3 Leishmania donovani 100% 100%
A4H756 Leishmania braziliensis 72% 100%
E9AP91 Leishmania mexicana (strain MHOM/GT/2001/U1103) 83% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS