RING-type E3 ubiquitin transferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

U-box domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4HVJ4_LEIIN

TriTrypDb:

LINF_130011500

Length:

704

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HVJ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVJ4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004842	ubiquitin-protein transferase activity	4	11
GO:0016740	transferase activity	2	11
GO:0019787	ubiquitin-like protein transferase activity	3	11
GO:0140096	catalytic activity, acting on a protein	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	195	199	PF00656	0.735
CLV_C14_Caspase3-7	210	214	PF00656	0.592
CLV_NRD_NRD_1	596	598	PF00675	0.734
CLV_PCSK_FUR_1	694	698	PF00082	0.480
CLV_PCSK_KEX2_1	595	597	PF00082	0.733
CLV_PCSK_KEX2_1	616	618	PF00082	0.749
CLV_PCSK_KEX2_1	696	698	PF00082	0.607
CLV_PCSK_PC1ET2_1	616	618	PF00082	0.725
CLV_PCSK_PC1ET2_1	696	698	PF00082	0.640
CLV_PCSK_SKI1_1	123	127	PF00082	0.533
CLV_PCSK_SKI1_1	142	146	PF00082	0.525
CLV_PCSK_SKI1_1	319	323	PF00082	0.568
CLV_PCSK_SKI1_1	398	402	PF00082	0.347
DEG_APCC_DBOX_1	141	149	PF00400	0.568
DEG_SCF_TRCP1_1	525	530	PF00400	0.513
DEG_SCF_TRCP1_1	610	615	PF00400	0.585
DOC_CYCLIN_yCln2_LP_2	186	192	PF00134	0.390
DOC_MAPK_gen_1	639	647	PF00069	0.339
DOC_MAPK_MEF2A_6	425	432	PF00069	0.517
DOC_PP1_RVXF_1	247	253	PF00149	0.511
DOC_PP1_RVXF_1	393	400	PF00149	0.339
DOC_PP2B_LxvP_1	186	189	PF13499	0.517
DOC_USP7_MATH_1	179	183	PF00917	0.515
DOC_USP7_MATH_1	201	205	PF00917	0.740
DOC_USP7_MATH_1	211	215	PF00917	0.721
DOC_USP7_MATH_1	25	29	PF00917	0.559
DOC_USP7_MATH_1	557	561	PF00917	0.599
DOC_USP7_MATH_1	6	10	PF00917	0.508
DOC_USP7_MATH_1	608	612	PF00917	0.807
DOC_WW_Pin1_4	115	120	PF00397	0.512
DOC_WW_Pin1_4	257	262	PF00397	0.606
DOC_WW_Pin1_4	362	367	PF00397	0.696
DOC_WW_Pin1_4	454	459	PF00397	0.538
LIG_14-3-3_CanoR_1	249	253	PF00244	0.507
LIG_14-3-3_CanoR_1	330	335	PF00244	0.464
LIG_14-3-3_CanoR_1	478	482	PF00244	0.618
LIG_14-3-3_CanoR_1	588	594	PF00244	0.744
LIG_14-3-3_CanoR_1	597	607	PF00244	0.761
LIG_Actin_WH2_2	384	400	PF00022	0.447
LIG_Actin_WH2_2	633	650	PF00022	0.378
LIG_BIR_II_1	1	5	PF00653	0.470
LIG_BRCT_BRCA1_1	518	522	PF00533	0.466
LIG_Clathr_ClatBox_1	441	445	PF01394	0.453
LIG_Clathr_ClatBox_1	555	559	PF01394	0.521
LIG_CtBP_PxDLS_1	261	265	PF00389	0.735
LIG_CtBP_PxDLS_1	458	462	PF00389	0.512
LIG_FAT_LD_1	241	249	PF03623	0.538
LIG_FHA_1	125	131	PF00498	0.376
LIG_FHA_1	15	21	PF00498	0.459
LIG_FHA_1	185	191	PF00498	0.473
LIG_FHA_1	35	41	PF00498	0.473
LIG_FHA_1	377	383	PF00498	0.606
LIG_FHA_1	386	392	PF00498	0.376
LIG_FHA_1	407	413	PF00498	0.477
LIG_FHA_1	454	460	PF00498	0.482
LIG_FHA_1	573	579	PF00498	0.624
LIG_FHA_1	635	641	PF00498	0.335
LIG_FHA_1	88	94	PF00498	0.418
LIG_FHA_2	132	138	PF00498	0.461
LIG_FHA_2	193	199	PF00498	0.635
LIG_FHA_2	208	214	PF00498	0.696
LIG_FHA_2	33	39	PF00498	0.516
LIG_FHA_2	571	577	PF00498	0.599
LIG_GBD_Chelix_1	140	148	PF00786	0.475
LIG_GBD_Chelix_1	349	357	PF00786	0.335
LIG_LIR_Gen_1	124	133	PF02991	0.486
LIG_LIR_Gen_1	302	311	PF02991	0.426
LIG_LIR_Gen_1	654	663	PF02991	0.447
LIG_LIR_Nem_3	124	129	PF02991	0.490
LIG_LIR_Nem_3	170	176	PF02991	0.390
LIG_LIR_Nem_3	302	307	PF02991	0.424
LIG_LIR_Nem_3	462	468	PF02991	0.409
LIG_LIR_Nem_3	508	512	PF02991	0.468
LIG_LIR_Nem_3	518	524	PF02991	0.502
LIG_LIR_Nem_3	654	658	PF02991	0.447
LIG_MLH1_MIPbox_1	518	522	PF16413	0.510
LIG_NRBOX	240	246	PF00104	0.536
LIG_NRBOX	48	54	PF00104	0.473
LIG_NRBOX	573	579	PF00104	0.608
LIG_PCNA_PIPBox_1	177	186	PF02747	0.523
LIG_PCNA_yPIPBox_3	101	110	PF02747	0.608
LIG_Pex14_1	300	304	PF04695	0.510
LIG_SH2_CRK	465	469	PF00017	0.485
LIG_SH2_SRC	268	271	PF00017	0.584
LIG_SH2_STAP1	136	140	PF00017	0.522
LIG_SH2_STAP1	184	188	PF00017	0.508
LIG_SH2_STAP1	268	272	PF00017	0.623
LIG_SH2_STAT5	632	635	PF00017	0.355
LIG_SH3_3	452	458	PF00018	0.570
LIG_SH3_3	492	498	PF00018	0.689
LIG_SH3_3	80	86	PF00018	0.488
LIG_Sin3_3	141	148	PF02671	0.493
LIG_SUMO_SIM_anti_2	226	234	PF11976	0.481
LIG_SUMO_SIM_anti_2	530	536	PF11976	0.443
LIG_SUMO_SIM_par_1	440	445	PF11976	0.339
LIG_SUMO_SIM_par_1	554	560	PF11976	0.570
LIG_TRAF2_1	103	106	PF00917	0.487
LIG_TRAF2_1	43	46	PF00917	0.612
LIG_TRAF2_1	539	542	PF00917	0.496
LIG_UBA3_1	468	476	PF00899	0.443
LIG_WRC_WIRS_1	216	221	PF05994	0.627
MOD_CK1_1	118	124	PF00069	0.560
MOD_CK1_1	204	210	PF00069	0.748
MOD_CK1_1	215	221	PF00069	0.510
MOD_CK1_1	260	266	PF00069	0.681
MOD_CK1_1	302	308	PF00069	0.494
MOD_CK1_1	34	40	PF00069	0.489
MOD_CK1_1	370	376	PF00069	0.627
MOD_CK1_1	385	391	PF00069	0.467
MOD_CK1_1	482	488	PF00069	0.686
MOD_CK1_1	598	604	PF00069	0.664
MOD_CK1_1	611	617	PF00069	0.807
MOD_CK1_1	672	678	PF00069	0.480
MOD_CK1_1	99	105	PF00069	0.572
MOD_CK2_1	111	117	PF00069	0.578
MOD_CK2_1	118	124	PF00069	0.500
MOD_CK2_1	179	185	PF00069	0.463
MOD_CK2_1	248	254	PF00069	0.482
MOD_CK2_1	570	576	PF00069	0.634
MOD_CK2_1	6	12	PF00069	0.575
MOD_CK2_1	672	678	PF00069	0.480
MOD_CK2_1	99	105	PF00069	0.474
MOD_GlcNHglycan	113	116	PF01048	0.716
MOD_GlcNHglycan	120	123	PF01048	0.487
MOD_GlcNHglycan	206	209	PF01048	0.725
MOD_GlcNHglycan	23	26	PF01048	0.452
MOD_GlcNHglycan	27	30	PF01048	0.447
MOD_GlcNHglycan	287	290	PF01048	0.622
MOD_GlcNHglycan	301	304	PF01048	0.369
MOD_GlcNHglycan	342	345	PF01048	0.511
MOD_GlcNHglycan	362	365	PF01048	0.725
MOD_GlcNHglycan	371	375	PF01048	0.551
MOD_GlcNHglycan	489	492	PF01048	0.763
MOD_GlcNHglycan	525	528	PF01048	0.585
MOD_GlcNHglycan	578	581	PF01048	0.688
MOD_GlcNHglycan	591	594	PF01048	0.645
MOD_GlcNHglycan	597	600	PF01048	0.518
MOD_GlcNHglycan	610	613	PF01048	0.715
MOD_GlcNHglycan	62	65	PF01048	0.521
MOD_GlcNHglycan	671	674	PF01048	0.447
MOD_GSK3_1	111	118	PF00069	0.489
MOD_GSK3_1	131	138	PF00069	0.470
MOD_GSK3_1	14	21	PF00069	0.459
MOD_GSK3_1	152	159	PF00069	0.492
MOD_GSK3_1	184	191	PF00069	0.421
MOD_GSK3_1	207	214	PF00069	0.647
MOD_GSK3_1	244	251	PF00069	0.490
MOD_GSK3_1	253	260	PF00069	0.599
MOD_GSK3_1	385	392	PF00069	0.508
MOD_GSK3_1	479	486	PF00069	0.608
MOD_GSK3_1	523	530	PF00069	0.528
MOD_GSK3_1	572	579	PF00069	0.589
MOD_GSK3_1	608	615	PF00069	0.727
MOD_GSK3_1	96	103	PF00069	0.568
MOD_N-GLC_1	100	105	PF02516	0.452
MOD_N-GLC_1	257	262	PF02516	0.657
MOD_N-GLC_1	459	464	PF02516	0.464
MOD_N-GLC_1	482	487	PF02516	0.638
MOD_N-GLC_1	527	532	PF02516	0.490
MOD_N-GLC_1	60	65	PF02516	0.560
MOD_N-GLC_1	608	613	PF02516	0.721
MOD_NEK2_1	108	113	PF00069	0.496
MOD_NEK2_1	131	136	PF00069	0.397
MOD_NEK2_1	156	161	PF00069	0.404
MOD_NEK2_1	244	249	PF00069	0.533
MOD_NEK2_1	412	417	PF00069	0.404
MOD_NEK2_1	461	466	PF00069	0.428
MOD_NEK2_1	468	473	PF00069	0.390
MOD_NEK2_1	570	575	PF00069	0.520
MOD_NEK2_1	589	594	PF00069	0.616
MOD_NEK2_1	60	65	PF00069	0.517
MOD_NEK2_1	93	98	PF00069	0.481
MOD_NEK2_2	179	184	PF00069	0.485
MOD_PIKK_1	557	563	PF00454	0.590
MOD_PIKK_1	587	593	PF00454	0.732
MOD_PIKK_1	78	84	PF00454	0.486
MOD_PK_1	55	61	PF00069	0.476
MOD_PKA_1	595	601	PF00069	0.670
MOD_PKA_1	623	629	PF00069	0.558
MOD_PKA_1	696	702	PF00069	0.660
MOD_PKA_2	131	137	PF00069	0.390
MOD_PKA_2	248	254	PF00069	0.534
MOD_PKA_2	477	483	PF00069	0.637
MOD_PKA_2	587	593	PF00069	0.737
MOD_PKA_2	595	601	PF00069	0.764
MOD_PKA_2	618	624	PF00069	0.692
MOD_PKA_2	696	702	PF00069	0.664
MOD_PKB_1	328	336	PF00069	0.508
MOD_Plk_1	100	106	PF00069	0.442
MOD_Plk_1	184	190	PF00069	0.517
MOD_Plk_1	212	218	PF00069	0.518
MOD_Plk_1	516	522	PF00069	0.404
MOD_Plk_1	527	533	PF00069	0.403
MOD_Plk_2-3	517	523	PF00069	0.575
MOD_Plk_4	152	158	PF00069	0.523
MOD_Plk_4	179	185	PF00069	0.414
MOD_Plk_4	382	388	PF00069	0.506
MOD_Plk_4	389	395	PF00069	0.480
MOD_Plk_4	517	523	PF00069	0.429
MOD_Plk_4	55	61	PF00069	0.452
MOD_ProDKin_1	115	121	PF00069	0.500
MOD_ProDKin_1	257	263	PF00069	0.611
MOD_ProDKin_1	362	368	PF00069	0.689
MOD_ProDKin_1	454	460	PF00069	0.537
MOD_SUMO_rev_2	316	324	PF00179	0.528
TRG_DiLeu_BaLyEn_6	139	144	PF01217	0.545
TRG_DiLeu_BaLyEn_6	171	176	PF01217	0.507
TRG_DiLeu_BaLyEn_6	236	241	PF01217	0.563
TRG_DiLeu_BaLyEn_6	327	332	PF01217	0.515
TRG_ENDOCYTIC_2	434	437	PF00928	0.395
TRG_ENDOCYTIC_2	465	468	PF00928	0.488
TRG_ER_diArg_1	327	330	PF00400	0.526
TRG_ER_diArg_1	594	597	PF00400	0.732
TRG_ER_diArg_1	617	620	PF00400	0.594
TRG_NES_CRM1_1	501	516	PF08389	0.559
TRG_NES_CRM1_1	554	566	PF08389	0.534
TRG_NLS_MonoExtC_3	615	620	PF00514	0.656
TRG_NLS_MonoExtN_4	619	626	PF00514	0.637
TRG_Pf-PMV_PEXEL_1	142	146	PF00026	0.507
TRG_Pf-PMV_PEXEL_1	330	334	PF00026	0.513

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILP8	Leptomonas seymouri	62%	100%
A0A1X0NN36	Trypanosomatidae	29%	100%
A0A3S7WSF2	Leishmania donovani	99%	100%
A0A422NQL1	Trypanosoma rangeli	30%	100%
A4H755	Leishmania braziliensis	81%	100%
D0A6R1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AP90	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QG88	Leishmania major	94%	100%
V5BAU6	Trypanosoma cruzi	31%	100%