Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HVJ1_LEIIN

TriTrypDb:

LINF_130011100

Length:

424

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HVJ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVJ1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	116	122	PF00089	0.553
CLV_NRD_NRD_1	118	120	PF00675	0.697
CLV_NRD_NRD_1	181	183	PF00675	0.643
CLV_NRD_NRD_1	275	277	PF00675	0.461
CLV_NRD_NRD_1	304	306	PF00675	0.435
CLV_NRD_NRD_1	311	313	PF00675	0.430
CLV_NRD_NRD_1	326	328	PF00675	0.441
CLV_NRD_NRD_1	380	382	PF00675	0.431
CLV_NRD_NRD_1	393	395	PF00675	0.417
CLV_NRD_NRD_1	73	75	PF00675	0.597
CLV_PCSK_KEX2_1	118	120	PF00082	0.697
CLV_PCSK_KEX2_1	275	277	PF00082	0.461
CLV_PCSK_KEX2_1	304	306	PF00082	0.435
CLV_PCSK_KEX2_1	311	313	PF00082	0.430
CLV_PCSK_SKI1_1	311	315	PF00082	0.468
CLV_PCSK_SKI1_1	341	345	PF00082	0.417
CLV_PCSK_SKI1_1	381	385	PF00082	0.496
CLV_PCSK_SKI1_1	408	412	PF00082	0.418
DEG_APCC_DBOX_1	407	415	PF00400	0.401
DEG_SCF_FBW7_1	211	216	PF00400	0.651
DEG_SCF_FBW7_1	35	42	PF00400	0.627
DEG_SPOP_SBC_1	131	135	PF00917	0.633
DEG_SPOP_SBC_1	152	156	PF00917	0.659
DEG_SPOP_SBC_1	251	255	PF00917	0.623
DEG_SPOP_SBC_1	59	63	PF00917	0.590
DEG_SPOP_SBC_1	86	90	PF00917	0.629
DEG_SPOP_SBC_1	92	96	PF00917	0.577
DOC_CKS1_1	210	215	PF01111	0.660
DOC_CKS1_1	36	41	PF01111	0.630
DOC_MAPK_DCC_7	412	420	PF00069	0.487
DOC_MAPK_MEF2A_6	412	420	PF00069	0.487
DOC_USP7_MATH_1	108	112	PF00917	0.465
DOC_USP7_MATH_1	131	135	PF00917	0.653
DOC_USP7_MATH_1	146	150	PF00917	0.527
DOC_USP7_MATH_1	153	157	PF00917	0.625
DOC_USP7_MATH_1	229	233	PF00917	0.736
DOC_USP7_MATH_1	251	255	PF00917	0.614
DOC_USP7_MATH_1	290	294	PF00917	0.431
DOC_USP7_MATH_1	402	406	PF00917	0.351
DOC_USP7_MATH_1	59	63	PF00917	0.590
DOC_USP7_MATH_1	86	90	PF00917	0.616
DOC_USP7_MATH_1	92	96	PF00917	0.590
DOC_USP7_UBL2_3	75	79	PF12436	0.524
DOC_WW_Pin1_4	127	132	PF00397	0.740
DOC_WW_Pin1_4	154	159	PF00397	0.647
DOC_WW_Pin1_4	171	176	PF00397	0.491
DOC_WW_Pin1_4	209	214	PF00397	0.646
DOC_WW_Pin1_4	28	33	PF00397	0.520
DOC_WW_Pin1_4	35	40	PF00397	0.584
LIG_14-3-3_CanoR_1	304	313	PF00244	0.429
LIG_14-3-3_CanoR_1	381	390	PF00244	0.553
LIG_APCC_ABBA_1	313	318	PF00400	0.430
LIG_APCC_ABBAyCdc20_2	312	318	PF00400	0.430
LIG_BRCT_BRCA1_1	23	27	PF00533	0.589
LIG_EH_1	47	51	PF12763	0.612
LIG_FHA_1	135	141	PF00498	0.591
LIG_FHA_1	217	223	PF00498	0.593
LIG_FHA_1	290	296	PF00498	0.469
LIG_FHA_1	40	46	PF00498	0.647
LIG_FHA_1	79	85	PF00498	0.650
LIG_FHA_1	94	100	PF00498	0.483
LIG_FHA_2	319	325	PF00498	0.449
LIG_LIR_Gen_1	9	19	PF02991	0.582
LIG_LIR_Nem_3	9	14	PF02991	0.678
LIG_LYPXL_yS_3	18	21	PF13949	0.584
LIG_PCNA_yPIPBox_3	352	362	PF02747	0.403
LIG_SH2_CRK	11	15	PF00017	0.628
LIG_SH2_CRK	189	193	PF00017	0.494
LIG_SH2_CRK	224	228	PF00017	0.665
LIG_SH3_3	212	218	PF00018	0.669
LIG_SH3_3	263	269	PF00018	0.547
LIG_SH3_3	46	52	PF00018	0.552
LIG_SUMO_SIM_anti_2	388	394	PF11976	0.418
LIG_SUMO_SIM_par_1	94	102	PF11976	0.559
LIG_TRAF2_1	322	325	PF00917	0.426
LIG_TRAF2_1	333	336	PF00917	0.420
LIG_TYR_ITIM	222	227	PF00017	0.635
MOD_CK1_1	104	110	PF00069	0.604
MOD_CK1_1	129	135	PF00069	0.595
MOD_CK1_1	154	160	PF00069	0.703
MOD_CK1_1	216	222	PF00069	0.624
MOD_CK1_1	254	260	PF00069	0.617
MOD_CK1_1	281	287	PF00069	0.508
MOD_CK1_1	58	64	PF00069	0.767
MOD_CK1_1	73	79	PF00069	0.539
MOD_CK1_1	82	88	PF00069	0.556
MOD_CK1_1	95	101	PF00069	0.677
MOD_CK2_1	318	324	PF00069	0.475
MOD_Cter_Amidation	309	312	PF01082	0.433
MOD_GlcNHglycan	106	109	PF01048	0.571
MOD_GlcNHglycan	110	113	PF01048	0.676
MOD_GlcNHglycan	204	207	PF01048	0.686
MOD_GlcNHglycan	229	232	PF01048	0.646
MOD_GlcNHglycan	241	244	PF01048	0.498
MOD_GlcNHglycan	259	262	PF01048	0.655
MOD_GlcNHglycan	287	290	PF01048	0.551
MOD_GlcNHglycan	291	295	PF01048	0.482
MOD_GlcNHglycan	403	407	PF01048	0.553
MOD_GlcNHglycan	57	60	PF01048	0.639
MOD_GlcNHglycan	81	84	PF01048	0.635
MOD_GlcNHglycan	89	92	PF01048	0.579
MOD_GSK3_1	104	111	PF00069	0.467
MOD_GSK3_1	125	132	PF00069	0.790
MOD_GSK3_1	154	161	PF00069	0.644
MOD_GSK3_1	209	216	PF00069	0.638
MOD_GSK3_1	235	242	PF00069	0.774
MOD_GSK3_1	246	253	PF00069	0.620
MOD_GSK3_1	278	285	PF00069	0.523
MOD_GSK3_1	339	346	PF00069	0.395
MOD_GSK3_1	35	42	PF00069	0.656
MOD_GSK3_1	55	62	PF00069	0.471
MOD_GSK3_1	75	82	PF00069	0.508
MOD_GSK3_1	87	94	PF00069	0.559
MOD_GSK3_1	95	102	PF00069	0.446
MOD_N-GLC_1	55	60	PF02516	0.572
MOD_NEK2_1	125	130	PF00069	0.648
MOD_NEK2_1	252	257	PF00069	0.642
MOD_NEK2_1	306	311	PF00069	0.430
MOD_NEK2_1	339	344	PF00069	0.418
MOD_NEK2_1	93	98	PF00069	0.566
MOD_NEK2_1	99	104	PF00069	0.545
MOD_PKA_1	118	124	PF00069	0.691
MOD_PKA_1	381	387	PF00069	0.469
MOD_PKA_2	118	124	PF00069	0.715
MOD_PKA_2	388	394	PF00069	0.588
MOD_PKA_2	73	79	PF00069	0.714
MOD_Plk_1	290	296	PF00069	0.422
MOD_Plk_4	388	394	PF00069	0.479
MOD_ProDKin_1	127	133	PF00069	0.740
MOD_ProDKin_1	154	160	PF00069	0.648
MOD_ProDKin_1	171	177	PF00069	0.494
MOD_ProDKin_1	209	215	PF00069	0.642
MOD_ProDKin_1	28	34	PF00069	0.521
MOD_ProDKin_1	35	41	PF00069	0.585
MOD_SUMO_rev_2	324	330	PF00179	0.404
TRG_DiLeu_BaEn_1	335	340	PF01217	0.417
TRG_DiLeu_BaEn_4	325	331	PF01217	0.502
TRG_DiLeu_BaLyEn_6	302	307	PF01217	0.428
TRG_DiLeu_BaLyEn_6	49	54	PF01217	0.558
TRG_ENDOCYTIC_2	11	14	PF00928	0.592
TRG_ENDOCYTIC_2	18	21	PF00928	0.534
TRG_ENDOCYTIC_2	189	192	PF00928	0.527
TRG_ENDOCYTIC_2	224	227	PF00928	0.674
TRG_ER_diArg_1	118	120	PF00400	0.613
TRG_ER_diArg_1	274	276	PF00400	0.452
TRG_ER_diArg_1	304	306	PF00400	0.435
TRG_ER_diArg_1	311	313	PF00400	0.430
TRG_Pf-PMV_PEXEL_1	276	280	PF00026	0.458
TRG_Pf-PMV_PEXEL_1	362	366	PF00026	0.407
TRG_Pf-PMV_PEXEL_1	381	385	PF00026	0.432

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEE7	Leptomonas seymouri	45%	100%
A0A3Q8I9J2	Leishmania donovani	100%	100%
A4H751	Leishmania braziliensis	71%	98%
E9AP86	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	99%
Q4QG92	Leishmania major	90%	100%