LeishMANIAdb
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UPF0301 protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
UPF0301 protein
Gene product:
Uncharacterized ACR - COG1678 - putative
Species:
Leishmania infantum
UniProt:
A4HVI4_LEIIN
TriTrypDb:
LINF_130010400
Length:
667

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0005829 cytosol 2 1
GO:0110165 cellular anatomical entity 1 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HVI4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVI4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 59 63 PF00656 0.339
CLV_NRD_NRD_1 17 19 PF00675 0.335
CLV_NRD_NRD_1 252 254 PF00675 0.565
CLV_NRD_NRD_1 325 327 PF00675 0.610
CLV_NRD_NRD_1 371 373 PF00675 0.303
CLV_NRD_NRD_1 418 420 PF00675 0.303
CLV_NRD_NRD_1 620 622 PF00675 0.495
CLV_NRD_NRD_1 66 68 PF00675 0.339
CLV_NRD_NRD_1 9 11 PF00675 0.325
CLV_PCSK_FUR_1 617 621 PF00082 0.495
CLV_PCSK_KEX2_1 17 19 PF00082 0.325
CLV_PCSK_KEX2_1 252 254 PF00082 0.556
CLV_PCSK_KEX2_1 325 327 PF00082 0.610
CLV_PCSK_KEX2_1 371 373 PF00082 0.303
CLV_PCSK_KEX2_1 418 420 PF00082 0.303
CLV_PCSK_KEX2_1 616 618 PF00082 0.491
CLV_PCSK_KEX2_1 619 621 PF00082 0.485
CLV_PCSK_KEX2_1 66 68 PF00082 0.356
CLV_PCSK_PC1ET2_1 616 618 PF00082 0.547
CLV_PCSK_PC7_1 367 373 PF00082 0.303
CLV_PCSK_SKI1_1 200 204 PF00082 0.552
CLV_PCSK_SKI1_1 3 7 PF00082 0.340
CLV_PCSK_SKI1_1 367 371 PF00082 0.238
CLV_PCSK_SKI1_1 372 376 PF00082 0.238
CLV_PCSK_SKI1_1 379 383 PF00082 0.238
CLV_PCSK_SKI1_1 58 62 PF00082 0.398
DEG_APCC_DBOX_1 371 379 PF00400 0.303
DEG_APCC_DBOX_1 57 65 PF00400 0.335
DEG_Nend_UBRbox_2 1 3 PF02207 0.379
DEG_SPOP_SBC_1 116 120 PF00917 0.526
DEG_SPOP_SBC_1 206 210 PF00917 0.545
DOC_MAPK_gen_1 352 361 PF00069 0.406
DOC_MAPK_gen_1 371 378 PF00069 0.168
DOC_MAPK_MEF2A_6 145 153 PF00069 0.392
DOC_MAPK_MEF2A_6 262 271 PF00069 0.553
DOC_MAPK_MEF2A_6 352 361 PF00069 0.574
DOC_MAPK_MEF2A_6 371 378 PF00069 0.161
DOC_USP7_MATH_1 108 112 PF00917 0.579
DOC_USP7_MATH_1 117 121 PF00917 0.507
DOC_USP7_MATH_1 131 135 PF00917 0.462
DOC_USP7_MATH_1 206 210 PF00917 0.545
DOC_USP7_MATH_1 277 281 PF00917 0.576
DOC_USP7_MATH_1 317 321 PF00917 0.656
DOC_USP7_MATH_1 329 333 PF00917 0.505
DOC_USP7_MATH_1 431 435 PF00917 0.238
DOC_USP7_MATH_1 456 460 PF00917 0.238
DOC_USP7_MATH_1 516 520 PF00917 0.370
DOC_USP7_MATH_1 550 554 PF00917 0.623
DOC_USP7_MATH_1 641 645 PF00917 0.328
DOC_WW_Pin1_4 167 172 PF00397 0.384
DOC_WW_Pin1_4 572 577 PF00397 0.486
DOC_WW_Pin1_4 606 611 PF00397 0.467
DOC_WW_Pin1_4 69 74 PF00397 0.398
LIG_14-3-3_CanoR_1 145 150 PF00244 0.406
LIG_14-3-3_CanoR_1 244 248 PF00244 0.598
LIG_14-3-3_CanoR_1 325 329 PF00244 0.500
LIG_14-3-3_CanoR_1 371 375 PF00244 0.238
LIG_14-3-3_CanoR_1 379 388 PF00244 0.238
LIG_14-3-3_CanoR_1 640 646 PF00244 0.338
LIG_BRCT_BRCA1_1 56 60 PF00533 0.423
LIG_deltaCOP1_diTrp_1 43 47 PF00928 0.387
LIG_deltaCOP1_diTrp_1 51 60 PF00928 0.379
LIG_FAT_LD_1 467 475 PF03623 0.238
LIG_FHA_1 136 142 PF00498 0.597
LIG_FHA_1 146 152 PF00498 0.404
LIG_FHA_1 156 162 PF00498 0.191
LIG_FHA_1 197 203 PF00498 0.641
LIG_FHA_1 223 229 PF00498 0.500
LIG_FHA_1 371 377 PF00498 0.238
LIG_FHA_1 405 411 PF00498 0.238
LIG_FHA_1 423 429 PF00498 0.238
LIG_FHA_1 82 88 PF00498 0.414
LIG_FHA_2 289 295 PF00498 0.557
LIG_FHA_2 57 63 PF00498 0.391
LIG_LIR_Apic_2 72 78 PF02991 0.414
LIG_LIR_Gen_1 178 189 PF02991 0.397
LIG_LIR_Nem_3 178 184 PF02991 0.393
LIG_LIR_Nem_3 43 47 PF02991 0.387
LIG_LIR_Nem_3 624 628 PF02991 0.515
LIG_LIR_Nem_3 7 12 PF02991 0.310
LIG_Pex14_1 638 642 PF04695 0.323
LIG_REV1ctd_RIR_1 367 376 PF16727 0.238
LIG_SH2_CRK 156 160 PF00017 0.376
LIG_SH2_CRK 642 646 PF00017 0.340
LIG_SH2_CRK 9 13 PF00017 0.306
LIG_SH2_NCK_1 642 646 PF00017 0.405
LIG_SH2_PTP2 75 78 PF00017 0.412
LIG_SH2_SRC 75 78 PF00017 0.545
LIG_SH2_STAP1 37 41 PF00017 0.389
LIG_SH2_STAP1 649 653 PF00017 0.377
LIG_SH2_STAT3 90 93 PF00017 0.373
LIG_SH2_STAT5 189 192 PF00017 0.334
LIG_SH2_STAT5 75 78 PF00017 0.552
LIG_SH3_3 446 452 PF00018 0.303
LIG_SH3_3 642 648 PF00018 0.424
LIG_SH3_3 74 80 PF00018 0.427
LIG_SUMO_SIM_anti_2 225 230 PF11976 0.458
LIG_SUMO_SIM_anti_2 373 378 PF11976 0.238
LIG_SUMO_SIM_anti_2 466 471 PF11976 0.412
LIG_SUMO_SIM_anti_2 482 489 PF11976 0.154
LIG_TRAF2_1 121 124 PF00917 0.543
LIG_TRAF2_1 328 331 PF00917 0.659
LIG_TRAF2_1 336 339 PF00917 0.544
LIG_TRAF2_1 480 483 PF00917 0.303
LIG_TRAF2_1 576 579 PF00917 0.618
LIG_TRAF2_2 33 38 PF00917 0.383
LIG_TYR_ITIM 154 159 PF00017 0.384
LIG_WW_2 77 80 PF00397 0.440
MOD_CK1_1 134 140 PF00069 0.524
MOD_CK1_1 157 163 PF00069 0.309
MOD_CK1_1 175 181 PF00069 0.351
MOD_CK1_1 208 214 PF00069 0.547
MOD_CK1_1 258 264 PF00069 0.582
MOD_CK1_1 362 368 PF00069 0.545
MOD_CK1_1 434 440 PF00069 0.238
MOD_CK1_1 512 518 PF00069 0.238
MOD_CK1_1 96 102 PF00069 0.461
MOD_CK2_1 117 123 PF00069 0.649
MOD_CK2_1 209 215 PF00069 0.547
MOD_CK2_1 288 294 PF00069 0.554
MOD_CK2_1 324 330 PF00069 0.773
MOD_CK2_1 333 339 PF00069 0.584
MOD_CK2_1 477 483 PF00069 0.303
MOD_GlcNHglycan 119 122 PF01048 0.529
MOD_GlcNHglycan 133 136 PF01048 0.669
MOD_GlcNHglycan 212 215 PF01048 0.550
MOD_GlcNHglycan 258 261 PF01048 0.563
MOD_GlcNHglycan 291 294 PF01048 0.570
MOD_GlcNHglycan 326 329 PF01048 0.543
MOD_GlcNHglycan 335 338 PF01048 0.568
MOD_GlcNHglycan 384 387 PF01048 0.238
MOD_GlcNHglycan 433 436 PF01048 0.238
MOD_GlcNHglycan 477 482 PF01048 0.437
MOD_GlcNHglycan 511 514 PF01048 0.238
MOD_GlcNHglycan 559 562 PF01048 0.525
MOD_GlcNHglycan 567 570 PF01048 0.539
MOD_GlcNHglycan 572 575 PF01048 0.533
MOD_GlcNHglycan 629 632 PF01048 0.474
MOD_GSK3_1 131 138 PF00069 0.524
MOD_GSK3_1 196 203 PF00069 0.534
MOD_GSK3_1 205 212 PF00069 0.502
MOD_GSK3_1 329 336 PF00069 0.583
MOD_GSK3_1 400 407 PF00069 0.238
MOD_GSK3_1 434 441 PF00069 0.238
MOD_GSK3_1 512 519 PF00069 0.344
MOD_GSK3_1 523 530 PF00069 0.338
MOD_GSK3_1 606 613 PF00069 0.421
MOD_N-GLC_1 175 180 PF02516 0.414
MOD_N-GLC_1 47 52 PF02516 0.401
MOD_N-GLC_1 69 74 PF02516 0.398
MOD_NEK2_1 172 177 PF00069 0.439
MOD_NEK2_1 231 236 PF00069 0.529
MOD_NEK2_1 359 364 PF00069 0.523
MOD_NEK2_1 370 375 PF00069 0.238
MOD_NEK2_1 433 438 PF00069 0.238
MOD_NEK2_1 523 528 PF00069 0.319
MOD_NEK2_1 586 591 PF00069 0.504
MOD_PIKK_1 24 30 PF00454 0.348
MOD_PIKK_1 532 538 PF00454 0.579
MOD_PKA_1 255 261 PF00069 0.575
MOD_PKA_2 144 150 PF00069 0.420
MOD_PKA_2 243 249 PF00069 0.510
MOD_PKA_2 324 330 PF00069 0.501
MOD_PKA_2 370 376 PF00069 0.238
MOD_PKA_2 528 534 PF00069 0.520
MOD_PKB_1 253 261 PF00069 0.554
MOD_Plk_1 19 25 PF00069 0.337
MOD_Plk_1 329 335 PF00069 0.587
MOD_Plk_1 400 406 PF00069 0.238
MOD_Plk_1 438 444 PF00069 0.238
MOD_Plk_1 516 522 PF00069 0.407
MOD_Plk_1 586 592 PF00069 0.500
MOD_Plk_2-3 56 62 PF00069 0.437
MOD_Plk_4 231 237 PF00069 0.495
MOD_Plk_4 422 428 PF00069 0.371
MOD_Plk_4 438 444 PF00069 0.151
MOD_Plk_4 610 616 PF00069 0.407
MOD_Plk_4 634 640 PF00069 0.338
MOD_Plk_4 93 99 PF00069 0.429
MOD_ProDKin_1 167 173 PF00069 0.382
MOD_ProDKin_1 572 578 PF00069 0.486
MOD_ProDKin_1 606 612 PF00069 0.470
MOD_ProDKin_1 69 75 PF00069 0.394
MOD_SUMO_for_1 499 502 PF00179 0.259
MOD_SUMO_for_1 590 593 PF00179 0.484
MOD_SUMO_rev_2 349 357 PF00179 0.513
MOD_SUMO_rev_2 50 55 PF00179 0.462
TRG_DiLeu_BaEn_1 356 361 PF01217 0.407
TRG_DiLeu_BaEn_1 384 389 PF01217 0.303
TRG_DiLeu_BaEn_2 55 61 PF01217 0.418
TRG_DiLeu_BaEn_3 338 344 PF01217 0.561
TRG_ENDOCYTIC_2 156 159 PF00928 0.378
TRG_ENDOCYTIC_2 507 510 PF00928 0.238
TRG_ENDOCYTIC_2 642 645 PF00928 0.335
TRG_ENDOCYTIC_2 649 652 PF00928 0.380
TRG_ENDOCYTIC_2 9 12 PF00928 0.325
TRG_ER_diArg_1 17 19 PF00400 0.328
TRG_ER_diArg_1 252 255 PF00400 0.532
TRG_ER_diArg_1 370 372 PF00400 0.303
TRG_ER_diArg_1 417 419 PF00400 0.303
TRG_ER_diArg_1 617 620 PF00400 0.491
TRG_ER_diArg_1 65 67 PF00400 0.339
TRG_NLS_MonoCore_2 615 620 PF00514 0.544
TRG_NLS_MonoExtC_3 615 620 PF00514 0.544
TRG_Pf-PMV_PEXEL_1 164 168 PF00026 0.352
TRG_Pf-PMV_PEXEL_1 419 423 PF00026 0.303

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IMM6 Leptomonas seymouri 58% 100%
A0A3S7WSH5 Leishmania donovani 100% 100%
A4H744 Leishmania braziliensis 80% 98%
E9AP79 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 99%
Q4QG99 Leishmania major 93% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS