Transmembrane protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2946), putative

Species:

Leishmania infantum

UniProt:

A4HVH6_LEIIN

TriTrypDb:

Length:

492

Annotations

LeishMANIAdb annotations

A putative 7TM transporter or receptor protein limited to Kinetoplastids. Very little similarity to animal GPCRs

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 6
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A4HVH6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVH6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	434	438	PF00656	0.508
CLV_NRD_NRD_1	245	247	PF00675	0.440
CLV_NRD_NRD_1	367	369	PF00675	0.422
CLV_NRD_NRD_1	462	464	PF00675	0.780
CLV_PCSK_KEX2_1	245	247	PF00082	0.443
CLV_PCSK_KEX2_1	367	369	PF00082	0.423
CLV_PCSK_KEX2_1	462	464	PF00082	0.780
CLV_PCSK_SKI1_1	246	250	PF00082	0.489
DEG_Nend_UBRbox_2	1	3	PF02207	0.471
DEG_SCF_FBW7_2	429	435	PF00400	0.533
DEG_SPOP_SBC_1	469	473	PF00917	0.607
DOC_CDC14_PxL_1	175	183	PF14671	0.464
DOC_CKS1_1	268	273	PF01111	0.335
DOC_CKS1_1	429	434	PF01111	0.532
DOC_CYCLIN_yCln2_LP_2	176	182	PF00134	0.436
DOC_CYCLIN_yCln2_LP_2	310	316	PF00134	0.434
DOC_MAPK_gen_1	116	123	PF00069	0.636
DOC_MAPK_gen_1	364	374	PF00069	0.612
DOC_MAPK_MEF2A_6	116	123	PF00069	0.636
DOC_PP1_RVXF_1	194	201	PF00149	0.572
DOC_PP1_RVXF_1	368	375	PF00149	0.525
DOC_PP1_RVXF_1	8	14	PF00149	0.479
DOC_PP2B_LxvP_1	176	179	PF13499	0.438
DOC_PP2B_LxvP_1	310	313	PF13499	0.429
DOC_USP7_MATH_1	18	22	PF00917	0.461
DOC_USP7_MATH_1	23	27	PF00917	0.455
DOC_USP7_MATH_1	238	242	PF00917	0.464
DOC_USP7_MATH_1	394	398	PF00917	0.529
DOC_USP7_MATH_1	445	449	PF00917	0.530
DOC_USP7_MATH_1	468	472	PF00917	0.565
DOC_WW_Pin1_4	267	272	PF00397	0.335
DOC_WW_Pin1_4	400	405	PF00397	0.560
DOC_WW_Pin1_4	428	433	PF00397	0.561
DOC_WW_Pin1_4	440	445	PF00397	0.517
LIG_14-3-3_CanoR_1	10	14	PF00244	0.480
LIG_14-3-3_CanoR_1	367	373	PF00244	0.644
LIG_14-3-3_CanoR_1	398	403	PF00244	0.567
LIG_APCC_ABBA_1	156	161	PF00400	0.443
LIG_BRCT_BRCA1_1	257	261	PF00533	0.662
LIG_BRCT_BRCA1_1	370	374	PF00533	0.589
LIG_CaM_IQ_9	296	311	PF13499	0.330
LIG_Clathr_ClatBox_1	387	391	PF01394	0.464
LIG_CSL_BTD_1	94	97	PF09270	0.335
LIG_deltaCOP1_diTrp_1	361	365	PF00928	0.623
LIG_deltaCOP1_diTrp_1	90	95	PF00928	0.479
LIG_eIF4E_1	166	172	PF01652	0.455
LIG_eIF4E_1	279	285	PF01652	0.408
LIG_FHA_1	100	106	PF00498	0.349
LIG_FHA_1	193	199	PF00498	0.556
LIG_FHA_1	227	233	PF00498	0.436
LIG_FHA_1	249	255	PF00498	0.687
LIG_FHA_1	383	389	PF00498	0.471
LIG_FHA_1	397	403	PF00498	0.488
LIG_FHA_1	474	480	PF00498	0.583
LIG_FHA_2	17	23	PF00498	0.507
LIG_FHA_2	429	435	PF00498	0.532
LIG_HP1_1	111	115	PF01393	0.436
LIG_IRF3_LxIS_1	374	381	PF10401	0.324
LIG_LIR_Gen_1	164	173	PF02991	0.349
LIG_LIR_Gen_1	234	244	PF02991	0.320
LIG_LIR_Gen_1	258	269	PF02991	0.527
LIG_LIR_Gen_1	338	349	PF02991	0.464
LIG_LIR_Gen_1	40	49	PF02991	0.496
LIG_LIR_Gen_1	90	101	PF02991	0.340
LIG_LIR_Nem_3	164	169	PF02991	0.349
LIG_LIR_Nem_3	174	180	PF02991	0.335
LIG_LIR_Nem_3	188	194	PF02991	0.617
LIG_LIR_Nem_3	234	240	PF02991	0.320
LIG_LIR_Nem_3	258	264	PF02991	0.527
LIG_LIR_Nem_3	338	344	PF02991	0.464
LIG_LIR_Nem_3	40	44	PF02991	0.453
LIG_LIR_Nem_3	90	96	PF02991	0.324
LIG_NRBOX	171	177	PF00104	0.397
LIG_NRBOX	78	84	PF00104	0.479
LIG_PCNA_PIPBox_1	150	159	PF02747	0.473
LIG_Pex14_1	211	215	PF04695	0.392
LIG_Pex14_2	132	136	PF04695	0.405
LIG_Pex14_2	257	261	PF04695	0.662
LIG_Pex14_2	337	341	PF04695	0.383
LIG_SH2_CRK	166	170	PF00017	0.335
LIG_SH2_CRK	173	177	PF00017	0.335
LIG_SH2_CRK	237	241	PF00017	0.436
LIG_SH2_CRK	332	336	PF00017	0.284
LIG_SH2_PTP2	239	242	PF00017	0.436
LIG_SH2_SRC	237	240	PF00017	0.436
LIG_SH2_STAP1	173	177	PF00017	0.464
LIG_SH2_STAP1	280	284	PF00017	0.334
LIG_SH2_STAP1	392	396	PF00017	0.530
LIG_SH2_STAT3	306	309	PF00017	0.398
LIG_SH2_STAT5	101	104	PF00017	0.374
LIG_SH2_STAT5	166	169	PF00017	0.360
LIG_SH2_STAT5	173	176	PF00017	0.353
LIG_SH2_STAT5	226	229	PF00017	0.407
LIG_SH2_STAT5	239	242	PF00017	0.248
LIG_SH2_STAT5	243	246	PF00017	0.475
LIG_SH2_STAT5	263	266	PF00017	0.464
LIG_SH2_STAT5	283	286	PF00017	0.359
LIG_SH2_STAT5	353	356	PF00017	0.596
LIG_SH2_STAT5	43	46	PF00017	0.503
LIG_SH2_STAT5	430	433	PF00017	0.534
LIG_SH3_3	265	271	PF00018	0.335
LIG_SH3_3	438	444	PF00018	0.595
LIG_SH3_3	60	66	PF00018	0.453
LIG_SH3_3	91	97	PF00018	0.300
LIG_SUMO_SIM_anti_2	220	225	PF11976	0.321
LIG_SUMO_SIM_anti_2	54	59	PF11976	0.487
LIG_SUMO_SIM_par_1	111	117	PF11976	0.412
LIG_SUMO_SIM_par_1	385	391	PF11976	0.464
LIG_TRAF2_1	432	435	PF00917	0.489
LIG_TYR_ITIM	171	176	PF00017	0.360
LIG_TYR_ITIM	277	282	PF00017	0.402
MOD_CK1_1	379	385	PF00069	0.464
MOD_CK1_1	403	409	PF00069	0.580
MOD_CK1_1	443	449	PF00069	0.601
MOD_CK1_1	61	67	PF00069	0.425
MOD_CK2_1	16	22	PF00069	0.476
MOD_CK2_1	285	291	PF00069	0.477
MOD_CK2_1	428	434	PF00069	0.530
MOD_CMANNOS	362	365	PF00535	0.426
MOD_CMANNOS	92	95	PF00535	0.482
MOD_GlcNHglycan	150	153	PF01048	0.588
MOD_GlcNHglycan	25	28	PF01048	0.699
MOD_GlcNHglycan	451	454	PF01048	0.747
MOD_GlcNHglycan	58	61	PF01048	0.698
MOD_GSK3_1	18	25	PF00069	0.476
MOD_GSK3_1	378	385	PF00069	0.484
MOD_GSK3_1	394	401	PF00069	0.436
MOD_GSK3_1	436	443	PF00069	0.530
MOD_GSK3_1	445	452	PF00069	0.480
MOD_GSK3_1	469	476	PF00069	0.547
MOD_GSK3_1	49	56	PF00069	0.434
MOD_GSK3_1	61	68	PF00069	0.357
MOD_GSK3_1	95	102	PF00069	0.392
MOD_LATS_1	366	372	PF00433	0.662
MOD_N-GLC_1	185	190	PF02516	0.449
MOD_N-GLC_1	28	33	PF02516	0.708
MOD_N-GLC_1	37	42	PF02516	0.741
MOD_N-GLC_1	394	399	PF02516	0.740
MOD_N-GLC_1	435	440	PF02516	0.794
MOD_NEK2_1	114	119	PF00069	0.545
MOD_NEK2_1	135	140	PF00069	0.410
MOD_NEK2_1	171	176	PF00069	0.444
MOD_NEK2_1	192	197	PF00069	0.560
MOD_NEK2_1	231	236	PF00069	0.388
MOD_NEK2_1	28	33	PF00069	0.474
MOD_NEK2_1	285	290	PF00069	0.449
MOD_NEK2_1	325	330	PF00069	0.367
MOD_NEK2_1	378	383	PF00069	0.394
MOD_NEK2_1	457	462	PF00069	0.549
MOD_NEK2_1	49	54	PF00069	0.447
MOD_NEK2_1	67	72	PF00069	0.300
MOD_NEK2_2	238	243	PF00069	0.436
MOD_PIKK_1	457	463	PF00454	0.576
MOD_PKA_2	9	15	PF00069	0.483
MOD_Plk_1	185	191	PF00069	0.628
MOD_Plk_1	28	34	PF00069	0.484
MOD_Plk_1	37	43	PF00069	0.477
MOD_Plk_4	161	167	PF00069	0.289
MOD_Plk_4	171	177	PF00069	0.335
MOD_Plk_4	185	191	PF00069	0.544
MOD_Plk_4	231	237	PF00069	0.407
MOD_Plk_4	238	244	PF00069	0.413
MOD_Plk_4	348	354	PF00069	0.383
MOD_Plk_4	37	43	PF00069	0.482
MOD_Plk_4	9	15	PF00069	0.483
MOD_ProDKin_1	267	273	PF00069	0.335
MOD_ProDKin_1	400	406	PF00069	0.562
MOD_ProDKin_1	428	434	PF00069	0.562
MOD_ProDKin_1	440	446	PF00069	0.517
TRG_DiLeu_BaLyEn_6	193	198	PF01217	0.620
TRG_DiLeu_BaLyEn_6	310	315	PF01217	0.353
TRG_ENDOCYTIC_2	166	169	PF00928	0.335
TRG_ENDOCYTIC_2	173	176	PF00928	0.335
TRG_ENDOCYTIC_2	210	213	PF00928	0.412
TRG_ENDOCYTIC_2	237	240	PF00928	0.335
TRG_ENDOCYTIC_2	279	282	PF00928	0.333
TRG_ENDOCYTIC_2	86	89	PF00928	0.407
TRG_ER_diArg_1	115	118	PF00400	0.654
TRG_ER_diArg_1	244	246	PF00400	0.630
TRG_ER_diArg_1	367	370	PF00400	0.606
TRG_ER_diArg_1	462	464	PF00400	0.580

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8F6	Leptomonas seymouri	54%	93%
A0A1X0NN68	Trypanosomatidae	35%	84%
A0A3Q8ICT8	Leishmania donovani	100%	100%
A0A3R7NUA8	Trypanosoma rangeli	41%	88%
E9AP71	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QGA7	Leishmania major	94%	100%
V5BAW0	Trypanosoma cruzi	39%	82%