Putative N-acetyltransferase subunit ARD1

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

N-acetyltransferase subunit ARD1 - putative

Species:

Leishmania infantum

UniProt:

A4HVG9_LEIIN

TriTrypDb:

LINF_130007500

Length:

260

Annotations

Annotations by Jardim et al.

Transferases, N-acetyltransferase subunit ARD1

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0031248	protein acetyltransferase complex	3	10
GO:0031414	N-terminal protein acetyltransferase complex	4	10
GO:0031415	NatA complex	5	10
GO:0032991	protein-containing complex	1	10
GO:0140535	intracellular protein-containing complex	2	10
GO:1902493	acetyltransferase complex	4	10
GO:1902494	catalytic complex	2	10
GO:1990234	transferase complex	3	10
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HVG9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVG9

Function

Biological processes
Term	Name	Level	Count
GO:0006473	protein acetylation	6	10
GO:0006474	N-terminal protein amino acid acetylation	5	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0019538	protein metabolic process	3	10
GO:0031365	N-terminal protein amino acid modification	5	10
GO:0036211	protein modification process	4	10
GO:0043170	macromolecule metabolic process	3	10
GO:0043412	macromolecule modification	4	10
GO:0043543	protein acylation	5	10
GO:0044238	primary metabolic process	2	10
GO:0051604	protein maturation	4	10
GO:0071704	organic substance metabolic process	2	10
GO:1901564	organonitrogen compound metabolic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0004596	peptide alpha-N-acetyltransferase activity	8	10
GO:0008080	N-acetyltransferase activity	6	10
GO:0016407	acetyltransferase activity	5	10
GO:0016410	N-acyltransferase activity	5	10
GO:0016740	transferase activity	2	10
GO:0016746	acyltransferase activity	3	10
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	10
GO:0034212	peptide N-acetyltransferase activity	7	10
GO:1990189	peptide-serine-alpha-N-acetyltransferase activity	9	1
GO:1990190	peptide-glutamate-alpha-N-acetyltransferase activity	9	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	112	114	PF00675	0.272
CLV_NRD_NRD_1	168	170	PF00675	0.477
CLV_NRD_NRD_1	4	6	PF00675	0.320
CLV_NRD_NRD_1	82	84	PF00675	0.250
CLV_PCSK_KEX2_1	165	167	PF00082	0.458
CLV_PCSK_KEX2_1	200	202	PF00082	0.681
CLV_PCSK_KEX2_1	253	255	PF00082	0.670
CLV_PCSK_KEX2_1	4	6	PF00082	0.320
CLV_PCSK_PC1ET2_1	165	167	PF00082	0.458
CLV_PCSK_PC1ET2_1	200	202	PF00082	0.681
CLV_PCSK_PC1ET2_1	253	255	PF00082	0.670
CLV_PCSK_SKI1_1	149	153	PF00082	0.365
CLV_PCSK_SKI1_1	205	209	PF00082	0.749
CLV_PCSK_SKI1_1	4	8	PF00082	0.335
DEG_Nend_UBRbox_3	1	3	PF02207	0.377
DOC_ANK_TNKS_1	168	175	PF00023	0.460
DOC_USP7_MATH_1	183	187	PF00917	0.646
DOC_WW_Pin1_4	176	181	PF00397	0.583
DOC_WW_Pin1_4	184	189	PF00397	0.573
LIG_14-3-3_CanoR_1	4	9	PF00244	0.364
LIG_14-3-3_CanoR_1	50	54	PF00244	0.365
LIG_14-3-3_CanoR_1	93	97	PF00244	0.272
LIG_APCC_ABBA_1	120	125	PF00400	0.248
LIG_Clathr_ClatBox_1	222	226	PF01394	0.502
LIG_eIF4E_1	30	36	PF01652	0.365
LIG_FHA_2	5	11	PF00498	0.352
LIG_FHA_2	93	99	PF00498	0.307
LIG_LIR_Nem_3	126	132	PF02991	0.313
LIG_LIR_Nem_3	37	41	PF02991	0.272
LIG_SH2_CRK	107	111	PF00017	0.307
LIG_SH2_CRK	33	37	PF00017	0.248
LIG_SH2_STAT3	12	15	PF00017	0.380
LIG_SH2_STAT3	43	46	PF00017	0.365
LIG_SH2_STAT5	107	110	PF00017	0.307
LIG_SH2_STAT5	160	163	PF00017	0.381
LIG_SH2_STAT5	43	46	PF00017	0.299
LIG_SUMO_SIM_anti_2	74	81	PF11976	0.248
LIG_UBA3_1	222	230	PF00899	0.604
LIG_WRC_WIRS_1	148	153	PF05994	0.398
MOD_CK1_1	187	193	PF00069	0.568
MOD_CK1_1	244	250	PF00069	0.579
MOD_CK2_1	208	214	PF00069	0.615
MOD_CK2_1	92	98	PF00069	0.272
MOD_Cter_Amidation	198	201	PF01082	0.644
MOD_Cter_Amidation	251	254	PF01082	0.781
MOD_GlcNHglycan	189	192	PF01048	0.538
MOD_GlcNHglycan	209	213	PF01048	0.610
MOD_GlcNHglycan	243	246	PF01048	0.667
MOD_GlcNHglycan	247	250	PF01048	0.580
MOD_GlcNHglycan	255	258	PF01048	0.489
MOD_GSK3_1	183	190	PF00069	0.554
MOD_GSK3_1	241	248	PF00069	0.769
MOD_N-GLC_1	245	250	PF02516	0.775
MOD_NEK2_1	14	19	PF00069	0.378
MOD_NEK2_1	92	97	PF00069	0.272
MOD_PKA_1	253	259	PF00069	0.671
MOD_PKA_1	4	10	PF00069	0.338
MOD_PKA_2	112	118	PF00069	0.127
MOD_PKA_2	253	259	PF00069	0.619
MOD_PKA_2	4	10	PF00069	0.355
MOD_PKA_2	49	55	PF00069	0.365
MOD_PKA_2	92	98	PF00069	0.272
MOD_Plk_4	147	153	PF00069	0.441
MOD_Plk_4	156	162	PF00069	0.345
MOD_ProDKin_1	176	182	PF00069	0.585
MOD_ProDKin_1	184	190	PF00069	0.574
MOD_SUMO_rev_2	159	167	PF00179	0.443
TRG_DiLeu_BaLyEn_6	163	168	PF01217	0.465
TRG_ENDOCYTIC_2	107	110	PF00928	0.307
TRG_ENDOCYTIC_2	32	35	PF00928	0.251
TRG_ER_diArg_1	3	5	PF00400	0.331
TRG_Pf-PMV_PEXEL_1	20	24	PF00026	0.328

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P642	Leptomonas seymouri	74%	98%
A0A0S4JB69	Bodo saltans	65%	92%
A0A1X0NPT1	Trypanosomatidae	63%	100%
A0A3R7M1B7	Trypanosoma rangeli	56%	100%
A0A3S7WSC5	Leishmania donovani	100%	100%
A4HDU9	Leishmania braziliensis	27%	100%
A4HHS3	Leishmania braziliensis	93%	100%
E9AP60	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
P07347	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	40%	100%
P36416	Dictyostelium discoideum	41%	100%
P41227	Homo sapiens	47%	100%
Q2KI14	Bos taurus	47%	100%
Q3UX61	Mus musculus	48%	100%
Q4QGC8	Leishmania major	98%	100%
Q8LGI8	Arabidopsis thaliana	28%	100%
Q9BSU3	Homo sapiens	46%	100%