LeishMANIAdb
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Putative flagellar radial spoke protein

Quick info Annotations Function or PPIs Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative flagellar radial spoke protein
Gene product:
flagellar radial spoke protein - putative
Species:
Leishmania infantum
UniProt:
A4HVG6_LEIIN
TriTrypDb:
LINF_130009200
Length:
598

Annotations

Annotations by Jardim et al.

Flagella, flagellar radial spoke

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0001534 radial spoke 2 12
GO:0005929 cilium 4 12
GO:0031514 motile cilium 5 12
GO:0032991 protein-containing complex 1 12
GO:0042995 cell projection 2 12
GO:0043226 organelle 2 12
GO:0043227 membrane-bounded organelle 3 12
GO:0110165 cellular anatomical entity 1 12
GO:0120025 plasma membrane bounded cell projection 3 12
GO:0005930 axoneme 2 1
GO:0097730 non-motile cilium 5 1

Phosphorylation

Promastigote: 585

Expansion

Sequence features

A4HVG6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVG6

Function

Biological processes
Term Name Level Count
GO:0003341 cilium movement 4 12
GO:0006996 organelle organization 4 12
GO:0007017 microtubule-based process 2 12
GO:0007018 microtubule-based movement 3 12
GO:0009987 cellular process 1 12
GO:0016043 cellular component organization 3 12
GO:0022607 cellular component assembly 4 12
GO:0030030 cell projection organization 4 11
GO:0030031 cell projection assembly 5 11
GO:0044782 cilium organization 5 11
GO:0060271 cilium assembly 6 11
GO:0060294 cilium movement involved in cell motility 5 12
GO:0070925 organelle assembly 5 11
GO:0071840 cellular component organization or biogenesis 2 12
GO:0120031 plasma membrane bounded cell projection assembly 6 11
GO:0120036 plasma membrane bounded cell projection organization 5 11
GO:0000226 microtubule cytoskeleton organization 3 1
GO:0001578 microtubule bundle formation 4 1
GO:0007010 cytoskeleton organization 5 1
GO:0035082 axoneme assembly 5 1
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 193 195 PF00675 0.289
CLV_NRD_NRD_1 213 215 PF00675 0.117
CLV_NRD_NRD_1 327 329 PF00675 0.334
CLV_NRD_NRD_1 575 577 PF00675 0.541
CLV_NRD_NRD_1 91 93 PF00675 0.351
CLV_PCSK_FUR_1 191 195 PF00082 0.334
CLV_PCSK_KEX2_1 193 195 PF00082 0.273
CLV_PCSK_KEX2_1 263 265 PF00082 0.257
CLV_PCSK_KEX2_1 527 529 PF00082 0.293
CLV_PCSK_KEX2_1 575 577 PF00082 0.541
CLV_PCSK_KEX2_1 91 93 PF00082 0.322
CLV_PCSK_PC1ET2_1 263 265 PF00082 0.260
CLV_PCSK_PC1ET2_1 527 529 PF00082 0.303
CLV_PCSK_SKI1_1 160 164 PF00082 0.252
CLV_PCSK_SKI1_1 263 267 PF00082 0.258
CLV_PCSK_SKI1_1 331 335 PF00082 0.247
CLV_PCSK_SKI1_1 97 101 PF00082 0.309
DEG_APCC_DBOX_1 286 294 PF00400 0.440
DEG_SCF_SKP2-CKS1_1 466 473 PF00560 0.534
DOC_MAPK_gen_1 211 221 PF00069 0.440
DOC_MAPK_gen_1 331 340 PF00069 0.534
DOC_MAPK_gen_1 527 534 PF00069 0.460
DOC_PP2B_LxvP_1 102 105 PF13499 0.565
DOC_PP2B_LxvP_1 128 131 PF13499 0.534
DOC_PP2B_LxvP_1 338 341 PF13499 0.534
DOC_PP2B_LxvP_1 423 426 PF13499 0.495
DOC_PP4_FxxP_1 100 103 PF00568 0.489
DOC_PP4_FxxP_1 545 548 PF00568 0.470
DOC_USP7_MATH_1 239 243 PF00917 0.553
DOC_USP7_MATH_1 552 556 PF00917 0.553
DOC_USP7_UBL2_3 175 179 PF12436 0.523
DOC_USP7_UBL2_3 211 215 PF12436 0.503
DOC_USP7_UBL2_3 375 379 PF12436 0.460
DOC_WW_Pin1_4 237 242 PF00397 0.501
DOC_WW_Pin1_4 249 254 PF00397 0.394
DOC_WW_Pin1_4 339 344 PF00397 0.555
DOC_WW_Pin1_4 467 472 PF00397 0.534
DOC_WW_Pin1_4 543 548 PF00397 0.446
LIG_14-3-3_CanoR_1 232 236 PF00244 0.448
LIG_14-3-3_CanoR_1 292 301 PF00244 0.494
LIG_14-3-3_CanoR_1 528 534 PF00244 0.552
LIG_BIR_II_1 1 5 PF00653 0.571
LIG_BIR_III_4 403 407 PF00653 0.553
LIG_BRCT_BRCA1_1 184 188 PF00533 0.526
LIG_FHA_1 120 126 PF00498 0.443
LIG_FHA_1 199 205 PF00498 0.498
LIG_FHA_1 232 238 PF00498 0.514
LIG_FHA_1 265 271 PF00498 0.473
LIG_FHA_1 492 498 PF00498 0.473
LIG_FHA_1 565 571 PF00498 0.467
LIG_FHA_2 107 113 PF00498 0.448
LIG_FHA_2 181 187 PF00498 0.489
LIG_FHA_2 312 318 PF00498 0.553
LIG_FHA_2 559 565 PF00498 0.496
LIG_HCF-1_HBM_1 430 433 PF13415 0.597
LIG_Integrin_isoDGR_2 370 372 PF01839 0.260
LIG_KLC1_Yacidic_2 200 205 PF13176 0.534
LIG_LIR_Apic_2 542 548 PF02991 0.520
LIG_LIR_Gen_1 115 125 PF02991 0.448
LIG_LIR_Gen_1 132 138 PF02991 0.489
LIG_LIR_Gen_1 242 253 PF02991 0.492
LIG_LIR_Gen_1 31 40 PF02991 0.458
LIG_LIR_Nem_3 115 120 PF02991 0.448
LIG_LIR_Nem_3 132 136 PF02991 0.489
LIG_LIR_Nem_3 185 190 PF02991 0.459
LIG_LIR_Nem_3 224 230 PF02991 0.472
LIG_LIR_Nem_3 242 248 PF02991 0.373
LIG_LIR_Nem_3 31 36 PF02991 0.458
LIG_LIR_Nem_3 332 338 PF02991 0.460
LIG_LIR_Nem_3 422 427 PF02991 0.448
LIG_LIR_Nem_3 430 436 PF02991 0.576
LIG_MLH1_MIPbox_1 184 188 PF16413 0.526
LIG_NRBOX 38 44 PF00104 0.553
LIG_Pex14_1 529 533 PF04695 0.460
LIG_Pex14_2 177 181 PF04695 0.489
LIG_REV1ctd_RIR_1 174 183 PF16727 0.489
LIG_SH2_CRK 117 121 PF00017 0.460
LIG_SH2_CRK 33 37 PF00017 0.460
LIG_SH2_CRK 335 339 PF00017 0.460
LIG_SH2_NCK_1 117 121 PF00017 0.460
LIG_SH2_PTP2 227 230 PF00017 0.553
LIG_SH2_SRC 195 198 PF00017 0.505
LIG_SH2_STAP1 233 237 PF00017 0.534
LIG_SH2_STAT5 117 120 PF00017 0.460
LIG_SH2_STAT5 187 190 PF00017 0.454
LIG_SH2_STAT5 195 198 PF00017 0.439
LIG_SH2_STAT5 203 206 PF00017 0.425
LIG_SH2_STAT5 21 24 PF00017 0.448
LIG_SH2_STAT5 227 230 PF00017 0.543
LIG_SH2_STAT5 233 236 PF00017 0.523
LIG_SH2_STAT5 285 288 PF00017 0.448
LIG_SH2_STAT5 366 369 PF00017 0.460
LIG_SH2_STAT5 533 536 PF00017 0.445
LIG_SH3_2 471 476 PF14604 0.534
LIG_SH3_3 337 343 PF00018 0.551
LIG_SH3_3 374 380 PF00018 0.509
LIG_SH3_3 394 400 PF00018 0.317
LIG_SH3_3 433 439 PF00018 0.546
LIG_SH3_3 468 474 PF00018 0.452
LIG_SH3_3 545 551 PF00018 0.487
LIG_SH3_3 560 566 PF00018 0.406
LIG_SH3_4 211 218 PF00018 0.509
LIG_SH3_5 341 345 PF00018 0.498
LIG_SUMO_SIM_par_1 336 342 PF11976 0.562
LIG_TRAF2_1 151 154 PF00917 0.460
LIG_TRAF2_1 304 307 PF00917 0.460
LIG_TRAF2_1 310 313 PF00917 0.460
LIG_TRAF2_1 456 459 PF00917 0.502
LIG_TRAF2_1 86 89 PF00917 0.534
LIG_WRC_WIRS_1 61 66 PF05994 0.534
LIG_WW_3 211 215 PF00397 0.526
MOD_CDK_SPxK_1 467 473 PF00069 0.534
MOD_CDK_SPxxK_3 237 244 PF00069 0.553
MOD_CK1_1 132 138 PF00069 0.509
MOD_CK1_1 295 301 PF00069 0.534
MOD_CK2_1 106 112 PF00069 0.448
MOD_CK2_1 4 10 PF00069 0.581
MOD_CK2_1 558 564 PF00069 0.534
MOD_CK2_1 582 588 PF00069 0.619
MOD_Cter_Amidation 525 528 PF01082 0.260
MOD_GlcNHglycan 269 273 PF01048 0.300
MOD_GlcNHglycan 30 33 PF01048 0.304
MOD_GlcNHglycan 6 9 PF01048 0.550
MOD_GlcNHglycan 76 79 PF01048 0.322
MOD_GSK3_1 115 122 PF00069 0.446
MOD_GSK3_1 231 238 PF00069 0.453
MOD_GSK3_1 264 271 PF00069 0.508
MOD_GSK3_1 291 298 PF00069 0.451
MOD_GSK3_1 60 67 PF00069 0.514
MOD_N-GLC_1 499 504 PF02516 0.260
MOD_NEK2_1 1 6 PF00069 0.613
MOD_NEK2_1 158 163 PF00069 0.448
MOD_NEK2_1 235 240 PF00069 0.465
MOD_NEK2_1 270 275 PF00069 0.498
MOD_NEK2_1 64 69 PF00069 0.497
MOD_NEK2_2 198 203 PF00069 0.498
MOD_NEK2_2 491 496 PF00069 0.473
MOD_PIKK_1 80 86 PF00454 0.553
MOD_PKA_1 527 533 PF00069 0.553
MOD_PKA_2 231 237 PF00069 0.448
MOD_PKA_2 259 265 PF00069 0.553
MOD_PKA_2 291 297 PF00069 0.515
MOD_PKA_2 371 377 PF00069 0.448
MOD_PKA_2 527 533 PF00069 0.553
MOD_Plk_1 158 164 PF00069 0.448
MOD_Plk_1 80 86 PF00069 0.515
MOD_Plk_2-3 106 112 PF00069 0.523
MOD_Plk_2-3 311 317 PF00069 0.553
MOD_Plk_2-3 582 588 PF00069 0.619
MOD_Plk_4 121 127 PF00069 0.523
MOD_Plk_4 198 204 PF00069 0.498
MOD_Plk_4 231 237 PF00069 0.448
MOD_Plk_4 60 66 PF00069 0.462
MOD_ProDKin_1 237 243 PF00069 0.501
MOD_ProDKin_1 249 255 PF00069 0.394
MOD_ProDKin_1 339 345 PF00069 0.555
MOD_ProDKin_1 467 473 PF00069 0.534
MOD_ProDKin_1 543 549 PF00069 0.446
MOD_SUMO_rev_2 168 177 PF00179 0.534
MOD_SUMO_rev_2 89 99 PF00179 0.498
TRG_DiLeu_BaEn_1 153 158 PF01217 0.460
TRG_DiLeu_BaEn_2 59 65 PF01217 0.534
TRG_DiLeu_BaEn_4 153 159 PF01217 0.460
TRG_ENDOCYTIC_2 117 120 PF00928 0.448
TRG_ENDOCYTIC_2 187 190 PF00928 0.441
TRG_ENDOCYTIC_2 227 230 PF00928 0.553
TRG_ENDOCYTIC_2 33 36 PF00928 0.448
TRG_ENDOCYTIC_2 335 338 PF00928 0.460
TRG_ENDOCYTIC_2 433 436 PF00928 0.507
TRG_ER_diArg_1 190 193 PF00400 0.495
TRG_ER_diArg_1 574 576 PF00400 0.551
TRG_ER_diArg_1 90 92 PF00400 0.553
TRG_NES_CRM1_1 34 46 PF08389 0.553
TRG_NLS_MonoExtN_4 211 218 PF00514 0.534

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PDF4 Leptomonas seymouri 75% 100%
A0A0S4JGY1 Bodo saltans 50% 100%
A0A1X0NN98 Trypanosomatidae 57% 100%
A0A3S7WSD6 Leishmania donovani 99% 99%
A0A422NNZ6 Trypanosoma rangeli 58% 100%
A4H732 Leishmania braziliensis 88% 99%
D0A6U3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 58% 100%
E9AP67 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
Q4QGB1 Leishmania major 94% 99%
Q9H0K4 Homo sapiens 28% 83%
V5BDZ5 Trypanosoma cruzi 58% 93%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS