FYVE-type domain-containing protein

Quick info Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Lipase (class 3) - putative

Species:

Leishmania infantum

UniProt:

A4HVG0_LEIIN

TriTrypDb:

LINF_130006900

Length:

809

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Phosphorylation

Amastigote: 12, 650, 77, 82, 83, 84

Expansion

Sequence features

A4HVG0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVG0

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	7
GO:0008152	metabolic process	1	7
GO:0044238	primary metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	5
GO:0043167	ion binding	2	5
GO:0043169	cation binding	3	5
GO:0046872	metal ion binding	4	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	641	645	PF00656	0.720
CLV_NRD_NRD_1	225	227	PF00675	0.725
CLV_NRD_NRD_1	256	258	PF00675	0.601
CLV_NRD_NRD_1	364	366	PF00675	0.436
CLV_NRD_NRD_1	429	431	PF00675	0.628
CLV_NRD_NRD_1	613	615	PF00675	0.641
CLV_NRD_NRD_1	670	672	PF00675	0.827
CLV_PCSK_KEX2_1	256	258	PF00082	0.601
CLV_PCSK_KEX2_1	351	353	PF00082	0.558
CLV_PCSK_KEX2_1	429	431	PF00082	0.628
CLV_PCSK_KEX2_1	676	678	PF00082	0.736
CLV_PCSK_KEX2_1	736	738	PF00082	0.667
CLV_PCSK_KEX2_1	93	95	PF00082	0.787
CLV_PCSK_PC1ET2_1	351	353	PF00082	0.558
CLV_PCSK_PC1ET2_1	676	678	PF00082	0.736
CLV_PCSK_PC1ET2_1	736	738	PF00082	0.667
CLV_PCSK_PC1ET2_1	93	95	PF00082	0.787
CLV_PCSK_SKI1_1	111	115	PF00082	0.588
CLV_PCSK_SKI1_1	2	6	PF00082	0.661
CLV_PCSK_SKI1_1	299	303	PF00082	0.664
CLV_PCSK_SKI1_1	351	355	PF00082	0.530
CLV_PCSK_SKI1_1	365	369	PF00082	0.433
CLV_PCSK_SKI1_1	785	789	PF00082	0.551
DEG_APCC_DBOX_1	241	249	PF00400	0.543
DEG_APCC_DBOX_1	364	372	PF00400	0.435
DEG_APCC_DBOX_1	540	548	PF00400	0.513
DEG_Nend_UBRbox_1	1	4	PF02207	0.664
DEG_SCF_TRCP1_1	305	311	PF00400	0.537
DEG_SPOP_SBC_1	23	27	PF00917	0.619
DEG_SPOP_SBC_1	80	84	PF00917	0.738
DOC_CYCLIN_RxL_1	171	180	PF00134	0.656
DOC_CYCLIN_RxL_1	348	356	PF00134	0.545
DOC_MAPK_gen_1	275	283	PF00069	0.497
DOC_MAPK_gen_1	365	371	PF00069	0.382
DOC_MAPK_gen_1	505	515	PF00069	0.513
DOC_MAPK_gen_1	541	549	PF00069	0.420
DOC_MAPK_gen_1	614	622	PF00069	0.573
DOC_MAPK_MEF2A_6	275	283	PF00069	0.519
DOC_MAPK_MEF2A_6	498	506	PF00069	0.459
DOC_MAPK_MEF2A_6	541	549	PF00069	0.513
DOC_MAPK_MEF2A_6	781	788	PF00069	0.668
DOC_MAPK_NFAT4_5	781	789	PF00069	0.458
DOC_PP1_RVXF_1	137	143	PF00149	0.509
DOC_PP1_RVXF_1	172	179	PF00149	0.658
DOC_PP1_RVXF_1	417	424	PF00149	0.562
DOC_PP2B_LxvP_1	696	699	PF13499	0.614
DOC_PP2B_PxIxI_1	683	689	PF00149	0.725
DOC_PP4_FxxP_1	412	415	PF00568	0.443
DOC_PP4_FxxP_1	549	552	PF00568	0.513
DOC_USP7_MATH_1	147	151	PF00917	0.511
DOC_USP7_MATH_1	190	194	PF00917	0.704
DOC_USP7_MATH_1	261	265	PF00917	0.560
DOC_USP7_MATH_1	308	312	PF00917	0.640
DOC_USP7_MATH_1	422	426	PF00917	0.592
DOC_USP7_MATH_1	451	455	PF00917	0.447
DOC_USP7_MATH_1	523	527	PF00917	0.389
DOC_USP7_MATH_1	555	559	PF00917	0.479
DOC_USP7_MATH_1	609	613	PF00917	0.601
DOC_USP7_MATH_1	647	651	PF00917	0.572
DOC_USP7_MATH_1	664	668	PF00917	0.510
DOC_USP7_UBL2_3	298	302	PF12436	0.669
DOC_USP7_UBL2_3	672	676	PF12436	0.820
DOC_WW_Pin1_4	128	133	PF00397	0.632
DOC_WW_Pin1_4	262	267	PF00397	0.572
DOC_WW_Pin1_4	275	280	PF00397	0.481
DOC_WW_Pin1_4	534	539	PF00397	0.416
DOC_WW_Pin1_4	677	682	PF00397	0.731
DOC_WW_Pin1_4	9	14	PF00397	0.609
LIG_14-3-3_CanoR_1	162	172	PF00244	0.655
LIG_14-3-3_CanoR_1	183	187	PF00244	0.721
LIG_14-3-3_CanoR_1	289	295	PF00244	0.594
LIG_14-3-3_CanoR_1	352	358	PF00244	0.527
LIG_14-3-3_CanoR_1	498	503	PF00244	0.513
LIG_14-3-3_CanoR_1	657	662	PF00244	0.687
LIG_14-3-3_CanoR_1	710	714	PF00244	0.576
LIG_14-3-3_CanoR_1	8	13	PF00244	0.661
LIG_Actin_WH2_2	492	507	PF00022	0.513
LIG_BIR_III_4	222	226	PF00653	0.677
LIG_BRCT_BRCA1_1	263	267	PF00533	0.519
LIG_eIF4E_1	70	76	PF01652	0.726
LIG_FHA_1	167	173	PF00498	0.558
LIG_FHA_1	278	284	PF00498	0.515
LIG_FHA_1	312	318	PF00498	0.523
LIG_FHA_1	362	368	PF00498	0.332
LIG_FHA_1	437	443	PF00498	0.588
LIG_FHA_1	477	483	PF00498	0.494
LIG_FHA_1	528	534	PF00498	0.399
LIG_FHA_1	770	776	PF00498	0.389
LIG_FHA_2	143	149	PF00498	0.578
LIG_FHA_2	27	33	PF00498	0.509
LIG_FHA_2	325	331	PF00498	0.502
LIG_FHA_2	709	715	PF00498	0.589
LIG_FHA_2	727	733	PF00498	0.449
LIG_GBD_Chelix_1	524	532	PF00786	0.389
LIG_LIR_Apic_2	410	415	PF02991	0.384
LIG_LIR_Apic_2	548	552	PF02991	0.411
LIG_LIR_Apic_2	802	808	PF02991	0.527
LIG_LIR_Gen_1	264	274	PF02991	0.539
LIG_LIR_Gen_1	323	329	PF02991	0.631
LIG_LIR_Gen_1	406	415	PF02991	0.527
LIG_LIR_Nem_3	240	246	PF02991	0.598
LIG_LIR_Nem_3	264	270	PF02991	0.543
LIG_LIR_Nem_3	323	328	PF02991	0.558
LIG_LIR_Nem_3	391	396	PF02991	0.470
LIG_LIR_Nem_3	406	412	PF02991	0.482
LIG_NRBOX	558	564	PF00104	0.323
LIG_PCNA_yPIPBox_3	498	507	PF02747	0.338
LIG_SH2_CRK	396	400	PF00017	0.472
LIG_SH2_CRK	70	74	PF00017	0.590
LIG_SH2_CRK	805	809	PF00017	0.563
LIG_SH2_GRB2like	572	575	PF00017	0.397
LIG_SH2_NCK_1	187	191	PF00017	0.762
LIG_SH2_NCK_1	70	74	PF00017	0.590
LIG_SH2_NCK_1	805	809	PF00017	0.563
LIG_SH2_SRC	587	590	PF00017	0.513
LIG_SH2_SRC	803	806	PF00017	0.535
LIG_SH2_STAP1	325	329	PF00017	0.621
LIG_SH2_STAP1	396	400	PF00017	0.450
LIG_SH2_STAT5	246	249	PF00017	0.582
LIG_SH2_STAT5	269	272	PF00017	0.571
LIG_SH2_STAT5	489	492	PF00017	0.472
LIG_SH2_STAT5	587	590	PF00017	0.513
LIG_SH2_STAT5	765	768	PF00017	0.464
LIG_SH2_STAT5	803	806	PF00017	0.532
LIG_SH3_3	378	384	PF00018	0.440
LIG_SH3_3	396	402	PF00018	0.350
LIG_SH3_3	675	681	PF00018	0.802
LIG_SUMO_SIM_anti_2	280	285	PF11976	0.417
LIG_TRAF2_1	626	629	PF00917	0.618
MOD_CDK_SPxxK_3	534	541	PF00069	0.416
MOD_CK1_1	12	18	PF00069	0.637
MOD_CK1_1	131	137	PF00069	0.512
MOD_CK1_1	193	199	PF00069	0.720
MOD_CK1_1	201	207	PF00069	0.626
MOD_CK1_1	209	215	PF00069	0.653
MOD_CK1_1	27	33	PF00069	0.557
MOD_CK1_1	311	317	PF00069	0.650
MOD_CK1_1	425	431	PF00069	0.563
MOD_CK1_1	526	532	PF00069	0.389
MOD_CK1_1	56	62	PF00069	0.593
MOD_CK1_1	599	605	PF00069	0.594
MOD_CK1_1	667	673	PF00069	0.615
MOD_CK1_1	779	785	PF00069	0.553
MOD_CK2_1	142	148	PF00069	0.462
MOD_CK2_1	324	330	PF00069	0.565
MOD_CK2_1	623	629	PF00069	0.630
MOD_CK2_1	94	100	PF00069	0.704
MOD_Cter_Amidation	224	227	PF01082	0.724
MOD_DYRK1A_RPxSP_1	677	681	PF00069	0.729
MOD_GlcNHglycan	14	17	PF01048	0.649
MOD_GlcNHglycan	188	191	PF01048	0.775
MOD_GlcNHglycan	29	32	PF01048	0.503
MOD_GlcNHglycan	305	308	PF01048	0.654
MOD_GlcNHglycan	310	313	PF01048	0.683
MOD_GlcNHglycan	332	335	PF01048	0.578
MOD_GlcNHglycan	36	39	PF01048	0.550
MOD_GlcNHglycan	412	415	PF01048	0.490
MOD_GlcNHglycan	424	427	PF01048	0.483
MOD_GlcNHglycan	56	59	PF01048	0.621
MOD_GlcNHglycan	593	596	PF01048	0.582
MOD_GlcNHglycan	647	650	PF01048	0.697
MOD_GlcNHglycan	793	796	PF01048	0.521
MOD_GlcNHglycan	805	808	PF01048	0.549
MOD_GlcNHglycan	83	86	PF01048	0.771
MOD_GSK3_1	182	189	PF00069	0.652
MOD_GSK3_1	22	29	PF00069	0.507
MOD_GSK3_1	275	282	PF00069	0.610
MOD_GSK3_1	290	297	PF00069	0.550
MOD_GSK3_1	324	331	PF00069	0.433
MOD_GSK3_1	384	391	PF00069	0.538
MOD_GSK3_1	4	11	PF00069	0.651
MOD_GSK3_1	403	410	PF00069	0.361
MOD_GSK3_1	421	428	PF00069	0.337
MOD_GSK3_1	436	443	PF00069	0.495
MOD_GSK3_1	472	479	PF00069	0.590
MOD_GSK3_1	523	530	PF00069	0.507
MOD_GSK3_1	53	60	PF00069	0.633
MOD_GSK3_1	553	560	PF00069	0.449
MOD_GSK3_1	587	594	PF00069	0.643
MOD_GSK3_1	726	733	PF00069	0.528
MOD_GSK3_1	765	772	PF00069	0.464
MOD_GSK3_1	81	88	PF00069	0.719
MOD_N-GLC_1	294	299	PF02516	0.722
MOD_N-GLC_1	54	59	PF02516	0.553
MOD_N-GLC_1	576	581	PF02516	0.375
MOD_N-GLC_1	664	669	PF02516	0.616
MOD_N-GLC_1	688	693	PF02516	0.733
MOD_N-GLC_1	9	14	PF02516	0.613
MOD_NEK2_1	182	187	PF00069	0.680
MOD_NEK2_1	24	29	PF00069	0.598
MOD_NEK2_1	294	299	PF00069	0.752
MOD_NEK2_1	303	308	PF00069	0.585
MOD_NEK2_1	328	333	PF00069	0.629
MOD_NEK2_1	353	358	PF00069	0.532
MOD_NEK2_1	4	9	PF00069	0.658
MOD_NEK2_1	446	451	PF00069	0.404
MOD_NEK2_1	54	59	PF00069	0.760
MOD_NEK2_1	545	550	PF00069	0.406
MOD_NEK2_1	553	558	PF00069	0.495
MOD_NEK2_1	591	596	PF00069	0.563
MOD_NEK2_2	609	614	PF00069	0.563
MOD_OFUCOSY	117	122	PF10250	0.579
MOD_OFUCOSY	141	146	PF10250	0.461
MOD_PIKK_1	177	183	PF00454	0.681
MOD_PIKK_1	446	452	PF00454	0.563
MOD_PIKK_1	57	63	PF00454	0.581
MOD_PIKK_1	664	670	PF00454	0.607
MOD_PIKK_1	738	744	PF00454	0.484
MOD_PK_1	657	663	PF00069	0.735
MOD_PKA_1	672	678	PF00069	0.803
MOD_PKA_1	736	742	PF00069	0.653
MOD_PKA_2	142	148	PF00069	0.474
MOD_PKA_2	161	167	PF00069	0.556
MOD_PKA_2	182	188	PF00069	0.724
MOD_PKA_2	27	33	PF00069	0.622
MOD_PKA_2	709	715	PF00069	0.571
MOD_PKA_2	736	742	PF00069	0.607
MOD_Plk_1	726	732	PF00069	0.735
MOD_Plk_4	182	188	PF00069	0.647
MOD_Plk_4	279	285	PF00069	0.533
MOD_Plk_4	324	330	PF00069	0.416
MOD_Plk_4	498	504	PF00069	0.484
MOD_Plk_4	523	529	PF00069	0.411
MOD_Plk_4	587	593	PF00069	0.553
MOD_Plk_4	599	605	PF00069	0.639
MOD_ProDKin_1	128	134	PF00069	0.629
MOD_ProDKin_1	262	268	PF00069	0.567
MOD_ProDKin_1	275	281	PF00069	0.478
MOD_ProDKin_1	534	540	PF00069	0.416
MOD_ProDKin_1	677	683	PF00069	0.732
MOD_ProDKin_1	9	15	PF00069	0.609
MOD_SUMO_for_1	564	567	PF00179	0.299
TRG_DiLeu_BaLyEn_6	540	545	PF01217	0.478
TRG_DiLeu_BaLyEn_6	549	554	PF01217	0.399
TRG_ENDOCYTIC_2	325	328	PF00928	0.625
TRG_ENDOCYTIC_2	396	399	PF00928	0.479
TRG_ENDOCYTIC_2	572	575	PF00928	0.436
TRG_ENDOCYTIC_2	658	661	PF00928	0.733
TRG_ENDOCYTIC_2	70	73	PF00928	0.593
TRG_ENDOCYTIC_2	755	758	PF00928	0.454
TRG_ER_diArg_1	255	257	PF00400	0.614
TRG_ER_diArg_1	429	431	PF00400	0.581

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5R6	Leptomonas seymouri	47%	100%
A0A3S7WSB8	Leishmania donovani	99%	100%
A4HHS0	Leishmania braziliensis	52%	94%
E9AP54	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4QGD4	Leishmania major	86%	100%