Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HVF8_LEIIN

TriTrypDb:

LINF_130007200

Length:

419

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0000795	synaptonemal complex	3	6
GO:0099086	synaptonemal structure	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4HVF8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVF8

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	6
GO:0006259	DNA metabolic process	4	6
GO:0006310	DNA recombination	5	6
GO:0006725	cellular aromatic compound metabolic process	3	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0007131	reciprocal meiotic recombination	3	6
GO:0008152	metabolic process	1	6
GO:0009987	cellular process	1	6
GO:0022402	cell cycle process	2	6
GO:0022414	reproductive process	1	6
GO:0034641	cellular nitrogen compound metabolic process	3	6
GO:0035825	homologous recombination	6	6
GO:0043170	macromolecule metabolic process	3	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0044260	obsolete cellular macromolecule metabolic process	3	6
GO:0046483	heterocycle metabolic process	3	6
GO:0071704	organic substance metabolic process	2	6
GO:0090304	nucleic acid metabolic process	4	6
GO:0140527	reciprocal homologous recombination	7	6
GO:1901360	organic cyclic compound metabolic process	3	6
GO:1903046	meiotic cell cycle process	2	6
GO:0006996	organelle organization	4	1
GO:0007129	homologous chromosome pairing at meiosis	4	1
GO:0016043	cellular component organization	3	1
GO:0016925	protein sumoylation	7	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0036211	protein modification process	4	1
GO:0043412	macromolecule modification	4	1
GO:0051276	chromosome organization	5	1
GO:0070192	chromosome organization involved in meiotic cell cycle	3	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0016740	transferase activity	2	6
GO:0019787	ubiquitin-like protein transferase activity	3	6
GO:0019789	SUMO transferase activity	4	6
GO:0140096	catalytic activity, acting on a protein	2	6
GO:0005488	binding	1	3
GO:0043167	ion binding	2	3
GO:0043169	cation binding	3	3
GO:0046872	metal ion binding	4	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	109	111	PF00675	0.668
CLV_NRD_NRD_1	149	151	PF00675	0.678
CLV_NRD_NRD_1	251	253	PF00675	0.742
CLV_NRD_NRD_1	305	307	PF00675	0.760
CLV_NRD_NRD_1	384	386	PF00675	0.749
CLV_NRD_NRD_1	88	90	PF00675	0.590
CLV_PCSK_KEX2_1	251	253	PF00082	0.662
CLV_PCSK_KEX2_1	292	294	PF00082	0.818
CLV_PCSK_KEX2_1	304	306	PF00082	0.641
CLV_PCSK_KEX2_1	384	386	PF00082	0.749
CLV_PCSK_KEX2_1	88	90	PF00082	0.498
CLV_PCSK_PC1ET2_1	292	294	PF00082	0.818
CLV_PCSK_SKI1_1	326	330	PF00082	0.749
CLV_PCSK_SKI1_1	91	95	PF00082	0.660
DEG_APCC_DBOX_1	90	98	PF00400	0.663
DOC_CKS1_1	371	376	PF01111	0.791
DOC_CYCLIN_yCln2_LP_2	371	377	PF00134	0.788
DOC_PP4_FxxP_1	409	412	PF00568	0.817
DOC_USP7_MATH_1	105	109	PF00917	0.617
DOC_USP7_MATH_1	117	121	PF00917	0.512
DOC_USP7_MATH_1	220	224	PF00917	0.749
DOC_USP7_MATH_1	227	231	PF00917	0.689
DOC_USP7_MATH_1	232	236	PF00917	0.627
DOC_USP7_MATH_1	240	244	PF00917	0.526
DOC_USP7_MATH_1	265	269	PF00917	0.807
DOC_USP7_MATH_1	317	321	PF00917	0.774
DOC_USP7_MATH_1	344	348	PF00917	0.805
DOC_USP7_MATH_1	363	367	PF00917	0.474
DOC_USP7_MATH_1	392	396	PF00917	0.738
DOC_WW_Pin1_4	192	197	PF00397	0.792
DOC_WW_Pin1_4	223	228	PF00397	0.787
DOC_WW_Pin1_4	236	241	PF00397	0.686
DOC_WW_Pin1_4	327	332	PF00397	0.828
DOC_WW_Pin1_4	359	364	PF00397	0.780
DOC_WW_Pin1_4	370	375	PF00397	0.645
DOC_WW_Pin1_4	408	413	PF00397	0.817
LIG_14-3-3_CanoR_1	150	159	PF00244	0.769
LIG_14-3-3_CanoR_1	174	182	PF00244	0.761
LIG_14-3-3_CanoR_1	221	227	PF00244	0.719
LIG_14-3-3_CanoR_1	293	302	PF00244	0.713
LIG_14-3-3_CanoR_1	311	315	PF00244	0.557
LIG_14-3-3_CanoR_1	332	338	PF00244	0.716
LIG_14-3-3_CanoR_1	407	412	PF00244	0.783
LIG_BIR_II_1	1	5	PF00653	0.609
LIG_BRCT_BRCA1_1	347	351	PF00533	0.769
LIG_BRCT_BRCA1_1	365	369	PF00533	0.476
LIG_Clathr_ClatBox_1	50	54	PF01394	0.650
LIG_FHA_1	187	193	PF00498	0.810
LIG_FHA_1	370	376	PF00498	0.791
LIG_FHA_1	392	398	PF00498	0.602
LIG_LIR_Apic_2	230	234	PF02991	0.763
LIG_LIR_Nem_3	2	6	PF02991	0.480
LIG_SH2_CRK	48	52	PF00017	0.631
LIG_SH2_CRK	83	87	PF00017	0.635
LIG_SH2_STAT5	26	29	PF00017	0.566
LIG_SH2_STAT5	396	399	PF00017	0.595
LIG_SH3_1	208	214	PF00018	0.828
LIG_SH3_2	300	305	PF14604	0.716
LIG_SH3_3	156	162	PF00018	0.810
LIG_SH3_3	208	214	PF00018	0.828
LIG_SH3_3	297	303	PF00018	0.714
LIG_SH3_3	394	400	PF00018	0.615
LIG_TRAF2_1	124	127	PF00917	0.563
MOD_CDK_SPK_2	223	228	PF00069	0.760
MOD_CDK_SPK_2	327	332	PF00069	0.790
MOD_CDK_SPK_2	408	413	PF00069	0.817
MOD_CK1_1	19	25	PF00069	0.389
MOD_CK1_1	223	229	PF00069	0.799
MOD_CK1_1	235	241	PF00069	0.690
MOD_CK1_1	243	249	PF00069	0.556
MOD_CK1_1	268	274	PF00069	0.772
MOD_CK1_1	285	291	PF00069	0.608
MOD_CK1_1	298	304	PF00069	0.617
MOD_CK1_1	395	401	PF00069	0.585
MOD_GlcNHglycan	273	276	PF01048	0.800
MOD_GlcNHglycan	284	287	PF01048	0.636
MOD_GlcNHglycan	356	359	PF01048	0.810
MOD_GSK3_1	137	144	PF00069	0.651
MOD_GSK3_1	145	152	PF00069	0.574
MOD_GSK3_1	223	230	PF00069	0.824
MOD_GSK3_1	232	239	PF00069	0.714
MOD_GSK3_1	26	33	PF00069	0.470
MOD_GSK3_1	265	272	PF00069	0.714
MOD_GSK3_1	359	366	PF00069	0.718
MOD_GSK3_1	391	398	PF00069	0.588
MOD_LATS_1	250	256	PF00433	0.667
MOD_NEK2_1	282	287	PF00069	0.816
MOD_NEK2_1	369	374	PF00069	0.793
MOD_PIKK_1	105	111	PF00454	0.639
MOD_PIKK_1	117	123	PF00454	0.409
MOD_PIKK_1	145	151	PF00454	0.694
MOD_PIKK_1	154	160	PF00454	0.674
MOD_PIKK_1	75	81	PF00454	0.507
MOD_PK_1	16	22	PF00069	0.419
MOD_PKA_1	150	156	PF00069	0.699
MOD_PKA_2	105	111	PF00069	0.597
MOD_PKA_2	149	155	PF00069	0.668
MOD_PKA_2	173	179	PF00069	0.837
MOD_PKA_2	220	226	PF00069	0.798
MOD_PKA_2	227	233	PF00069	0.766
MOD_PKA_2	310	316	PF00069	0.750
MOD_PKA_2	398	404	PF00069	0.801
MOD_PKB_1	293	301	PF00069	0.825
MOD_Plk_4	285	291	PF00069	0.823
MOD_Plk_4	385	391	PF00069	0.779
MOD_Plk_4	392	398	PF00069	0.674
MOD_Plk_4	64	70	PF00069	0.533
MOD_ProDKin_1	192	198	PF00069	0.792
MOD_ProDKin_1	223	229	PF00069	0.787
MOD_ProDKin_1	236	242	PF00069	0.684
MOD_ProDKin_1	327	333	PF00069	0.829
MOD_ProDKin_1	359	365	PF00069	0.778
MOD_ProDKin_1	370	376	PF00069	0.640
MOD_ProDKin_1	408	414	PF00069	0.814
TRG_DiLeu_BaEn_4	127	133	PF01217	0.565
TRG_ENDOCYTIC_2	48	51	PF00928	0.625
TRG_ENDOCYTIC_2	83	86	PF00928	0.635
TRG_ER_diArg_1	303	306	PF00400	0.760
TRG_ER_diArg_1	384	386	PF00400	0.749
TRG_ER_diArg_1	87	89	PF00400	0.548
TRG_NLS_MonoExtC_3	291	297	PF00514	0.820

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WSB0	Leishmania donovani	100%	100%
A4HHR7	Leishmania braziliensis	65%	100%
E9AP57	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QGD1	Leishmania major	94%	100%