Putative class 3 lipase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Triglyceride lipase - putative

Species:

Leishmania infantum

UniProt:

A4HVF6_LEIIN

TriTrypDb:

LINF_130007000

Length:

665

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HVF6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVF6

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	7
GO:0008152	metabolic process	1	7
GO:0044238	primary metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004806	triglyceride lipase activity	5	1
GO:0016298	lipase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0052689	carboxylic ester hydrolase activity	4	1
GO:0005488	binding	1	2
GO:0043167	ion binding	2	2
GO:0043169	cation binding	3	2
GO:0046872	metal ion binding	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	18	22	PF00656	0.489
CLV_C14_Caspase3-7	449	453	PF00656	0.621
CLV_C14_Caspase3-7	467	471	PF00656	0.597
CLV_C14_Caspase3-7	483	487	PF00656	0.571
CLV_NRD_NRD_1	118	120	PF00675	0.371
CLV_NRD_NRD_1	248	250	PF00675	0.420
CLV_NRD_NRD_1	307	309	PF00675	0.299
CLV_NRD_NRD_1	545	547	PF00675	0.552
CLV_NRD_NRD_1	598	600	PF00675	0.497
CLV_NRD_NRD_1	602	604	PF00675	0.368
CLV_PCSK_KEX2_1	118	120	PF00082	0.371
CLV_PCSK_KEX2_1	307	309	PF00082	0.410
CLV_PCSK_KEX2_1	545	547	PF00082	0.552
CLV_PCSK_KEX2_1	598	600	PF00082	0.497
CLV_PCSK_KEX2_1	602	604	PF00082	0.368
CLV_PCSK_PC7_1	114	120	PF00082	0.335
CLV_PCSK_PC7_1	598	604	PF00082	0.410
CLV_PCSK_SKI1_1	114	118	PF00082	0.468
CLV_PCSK_SKI1_1	127	131	PF00082	0.331
CLV_PCSK_SKI1_1	137	141	PF00082	0.329
CLV_PCSK_SKI1_1	47	51	PF00082	0.348
CLV_PCSK_SKI1_1	510	514	PF00082	0.541
CLV_PCSK_SKI1_1	602	606	PF00082	0.364
DEG_APCC_DBOX_1	136	144	PF00400	0.322
DOC_CKS1_1	575	580	PF01111	0.607
DOC_CYCLIN_RxL_1	111	121	PF00134	0.446
DOC_CYCLIN_RxL_1	134	141	PF00134	0.396
DOC_MAPK_gen_1	118	126	PF00069	0.322
DOC_MAPK_gen_1	200	208	PF00069	0.487
DOC_MAPK_gen_1	307	313	PF00069	0.343
DOC_PP1_RVXF_1	185	191	PF00149	0.353
DOC_PP2B_LxvP_1	152	155	PF13499	0.450
DOC_PP2B_LxvP_1	182	185	PF13499	0.334
DOC_PP2B_LxvP_1	311	314	PF13499	0.308
DOC_PP2B_LxvP_1	329	332	PF13499	0.308
DOC_USP7_MATH_1	314	318	PF00917	0.325
DOC_USP7_MATH_1	389	393	PF00917	0.551
DOC_USP7_MATH_1	414	418	PF00917	0.703
DOC_USP7_MATH_1	457	461	PF00917	0.571
DOC_USP7_MATH_1	518	522	PF00917	0.608
DOC_USP7_MATH_1	594	598	PF00917	0.584
DOC_WW_Pin1_4	318	323	PF00397	0.383
DOC_WW_Pin1_4	399	404	PF00397	0.625
DOC_WW_Pin1_4	405	410	PF00397	0.600
DOC_WW_Pin1_4	422	427	PF00397	0.619
DOC_WW_Pin1_4	441	446	PF00397	0.541
DOC_WW_Pin1_4	451	456	PF00397	0.505
DOC_WW_Pin1_4	514	519	PF00397	0.620
DOC_WW_Pin1_4	574	579	PF00397	0.631
LIG_14-3-3_CanoR_1	127	134	PF00244	0.406
LIG_14-3-3_CanoR_1	137	143	PF00244	0.383
LIG_14-3-3_CanoR_1	171	175	PF00244	0.403
LIG_14-3-3_CanoR_1	210	216	PF00244	0.454
LIG_14-3-3_CanoR_1	307	312	PF00244	0.332
LIG_14-3-3_CanoR_1	364	373	PF00244	0.476
LIG_14-3-3_CanoR_1	432	440	PF00244	0.668
LIG_14-3-3_CanoR_1	552	558	PF00244	0.612
LIG_14-3-3_CanoR_1	6	11	PF00244	0.413
LIG_14-3-3_CanoR_1	602	610	PF00244	0.351
LIG_Actin_WH2_2	157	173	PF00022	0.422
LIG_BIR_III_2	452	456	PF00653	0.601
LIG_BIR_III_4	470	474	PF00653	0.608
LIG_BRCT_BRCA1_1	462	466	PF00533	0.671
LIG_FHA_1	104	110	PF00498	0.365
LIG_FHA_1	128	134	PF00498	0.401
LIG_FHA_1	156	162	PF00498	0.418
LIG_FHA_1	199	205	PF00498	0.421
LIG_FHA_1	210	216	PF00498	0.385
LIG_FHA_1	239	245	PF00498	0.520
LIG_FHA_1	282	288	PF00498	0.312
LIG_FHA_1	319	325	PF00498	0.296
LIG_FHA_1	366	372	PF00498	0.511
LIG_FHA_1	423	429	PF00498	0.658
LIG_FHA_1	460	466	PF00498	0.601
LIG_FHA_1	48	54	PF00498	0.374
LIG_FHA_1	67	73	PF00498	0.403
LIG_FHA_2	105	111	PF00498	0.394
LIG_FHA_2	16	22	PF00498	0.481
LIG_FHA_2	178	184	PF00498	0.335
LIG_FHA_2	216	222	PF00498	0.508
LIG_FHA_2	225	231	PF00498	0.514
LIG_FHA_2	271	277	PF00498	0.325
LIG_FHA_2	575	581	PF00498	0.655
LIG_FHA_2	585	591	PF00498	0.616
LIG_Integrin_RGD_1	19	21	PF01839	0.511
LIG_LIR_Gen_1	177	185	PF02991	0.434
LIG_LIR_Gen_1	201	211	PF02991	0.412
LIG_LIR_Gen_1	213	223	PF02991	0.424
LIG_LIR_Gen_1	280	287	PF02991	0.346
LIG_LIR_Gen_1	296	305	PF02991	0.212
LIG_LIR_Gen_1	345	356	PF02991	0.303
LIG_LIR_Nem_3	110	116	PF02991	0.443
LIG_LIR_Nem_3	177	182	PF02991	0.438
LIG_LIR_Nem_3	205	211	PF02991	0.410
LIG_LIR_Nem_3	213	219	PF02991	0.398
LIG_LIR_Nem_3	280	286	PF02991	0.346
LIG_LIR_Nem_3	296	302	PF02991	0.309
LIG_LIR_Nem_3	345	351	PF02991	0.303
LIG_LIR_Nem_3	605	610	PF02991	0.336
LIG_LIR_Nem_3	627	633	PF02991	0.374
LIG_PCNA_yPIPBox_3	245	258	PF02747	0.417
LIG_Pex14_1	348	352	PF04695	0.308
LIG_Pex14_2	113	117	PF04695	0.359
LIG_SH2_CRK	283	287	PF00017	0.308
LIG_SH2_CRK	610	614	PF00017	0.336
LIG_SH2_CRK	618	622	PF00017	0.391
LIG_SH2_NCK_1	337	341	PF00017	0.377
LIG_SH2_STAP1	120	124	PF00017	0.431
LIG_SH2_STAP1	166	170	PF00017	0.339
LIG_SH2_STAP1	283	287	PF00017	0.308
LIG_SH2_STAT5	151	154	PF00017	0.390
LIG_SH2_STAT5	179	182	PF00017	0.328
LIG_SH2_STAT5	283	286	PF00017	0.329
LIG_SH2_STAT5	29	32	PF00017	0.461
LIG_SH2_STAT5	299	302	PF00017	0.308
LIG_SH2_STAT5	620	623	PF00017	0.414
LIG_SH3_3	264	270	PF00018	0.308
LIG_SH3_3	572	578	PF00018	0.642
LIG_SH3_3	588	594	PF00018	0.521
LIG_SH3_3	61	67	PF00018	0.374
LIG_SH3_3	69	75	PF00018	0.412
LIG_SUMO_SIM_par_1	157	163	PF11976	0.424
LIG_SxIP_EBH_1	157	171	PF03271	0.352
LIG_TRAF2_1	317	320	PF00917	0.325
LIG_TRAF2_1	478	481	PF00917	0.660
LIG_TYR_ITIM	147	152	PF00017	0.367
MOD_CDK_SPK_2	318	323	PF00069	0.325
MOD_CK1_1	385	391	PF00069	0.524
MOD_CK1_1	399	405	PF00069	0.613
MOD_CK1_1	417	423	PF00069	0.628
MOD_CK1_1	446	452	PF00069	0.772
MOD_CK1_1	460	466	PF00069	0.630
MOD_CK1_1	485	491	PF00069	0.652
MOD_CK1_1	541	547	PF00069	0.504
MOD_CK2_1	104	110	PF00069	0.432
MOD_CK2_1	177	183	PF00069	0.346
MOD_CK2_1	215	221	PF00069	0.498
MOD_CK2_1	224	230	PF00069	0.500
MOD_CK2_1	270	276	PF00069	0.377
MOD_CK2_1	314	320	PF00069	0.325
MOD_CK2_1	557	563	PF00069	0.679
MOD_CK2_1	574	580	PF00069	0.560
MOD_DYRK1A_RPxSP_1	441	445	PF00069	0.590
MOD_GlcNHglycan	144	147	PF01048	0.530
MOD_GlcNHglycan	279	282	PF01048	0.429
MOD_GlcNHglycan	404	407	PF01048	0.771
MOD_GlcNHglycan	416	419	PF01048	0.585
MOD_GlcNHglycan	429	432	PF01048	0.590
MOD_GlcNHglycan	445	448	PF01048	0.653
MOD_GlcNHglycan	459	462	PF01048	0.729
MOD_GlcNHglycan	488	491	PF01048	0.752
MOD_GlcNHglycan	566	569	PF01048	0.786
MOD_GSK3_1	138	145	PF00069	0.469
MOD_GSK3_1	155	162	PF00069	0.249
MOD_GSK3_1	211	218	PF00069	0.462
MOD_GSK3_1	277	284	PF00069	0.389
MOD_GSK3_1	314	321	PF00069	0.442
MOD_GSK3_1	342	349	PF00069	0.268
MOD_GSK3_1	381	388	PF00069	0.543
MOD_GSK3_1	398	405	PF00069	0.531
MOD_GSK3_1	410	417	PF00069	0.693
MOD_GSK3_1	422	429	PF00069	0.644
MOD_GSK3_1	441	448	PF00069	0.613
MOD_GSK3_1	460	467	PF00069	0.689
MOD_GSK3_1	482	489	PF00069	0.627
MOD_GSK3_1	502	509	PF00069	0.713
MOD_GSK3_1	514	521	PF00069	0.602
MOD_GSK3_1	548	555	PF00069	0.563
MOD_GSK3_1	619	626	PF00069	0.379
MOD_GSK3_1	62	69	PF00069	0.467
MOD_N-GLC_1	155	160	PF02516	0.341
MOD_N-GLC_1	514	519	PF02516	0.755
MOD_NEK2_1	104	109	PF00069	0.420
MOD_NEK2_1	142	147	PF00069	0.445
MOD_NEK2_1	170	175	PF00069	0.359
MOD_NEK2_1	325	330	PF00069	0.308
MOD_NEK2_1	382	387	PF00069	0.476
MOD_NEK2_1	78	83	PF00069	0.361
MOD_NEK2_2	502	507	PF00069	0.594
MOD_NEK2_2	553	558	PF00069	0.548
MOD_OFUCOSY	41	46	PF10250	0.445
MOD_PIKK_1	104	110	PF00454	0.432
MOD_PIKK_1	314	320	PF00454	0.325
MOD_PIKK_1	396	402	PF00454	0.588
MOD_PIKK_1	62	68	PF00454	0.368
MOD_PKA_1	307	313	PF00069	0.286
MOD_PKA_1	602	608	PF00069	0.337
MOD_PKA_2	170	176	PF00069	0.402
MOD_PKA_2	177	183	PF00069	0.314
MOD_PKA_2	209	215	PF00069	0.455
MOD_PKA_2	307	313	PF00069	0.312
MOD_PKA_2	314	320	PF00069	0.289
MOD_PKA_2	363	369	PF00069	0.308
MOD_PKA_2	431	437	PF00069	0.649
MOD_PKA_2	5	11	PF00069	0.410
MOD_PKA_2	506	512	PF00069	0.539
MOD_PKA_2	541	547	PF00069	0.567
MOD_PKA_2	602	608	PF00069	0.337
MOD_Plk_1	155	161	PF00069	0.343
MOD_Plk_1	238	244	PF00069	0.479
MOD_Plk_1	502	508	PF00069	0.535
MOD_Plk_1	638	644	PF00069	0.500
MOD_Plk_2-3	177	183	PF00069	0.346
MOD_Plk_4	138	144	PF00069	0.460
MOD_Plk_4	177	183	PF00069	0.336
MOD_Plk_4	211	217	PF00069	0.457
MOD_Plk_4	238	244	PF00069	0.479
MOD_Plk_4	270	276	PF00069	0.376
MOD_Plk_4	281	287	PF00069	0.253
MOD_Plk_4	307	313	PF00069	0.325
MOD_Plk_4	382	388	PF00069	0.479
MOD_Plk_4	389	395	PF00069	0.525
MOD_Plk_4	553	559	PF00069	0.599
MOD_Plk_4	59	65	PF00069	0.424
MOD_Plk_4	6	12	PF00069	0.505
MOD_Plk_4	638	644	PF00069	0.539
MOD_Plk_4	78	84	PF00069	0.292
MOD_ProDKin_1	318	324	PF00069	0.383
MOD_ProDKin_1	399	405	PF00069	0.629
MOD_ProDKin_1	422	428	PF00069	0.685
MOD_ProDKin_1	441	447	PF00069	0.543
MOD_ProDKin_1	451	457	PF00069	0.504
MOD_ProDKin_1	514	520	PF00069	0.615
MOD_ProDKin_1	574	580	PF00069	0.632
MOD_SUMO_rev_2	533	541	PF00179	0.525
TRG_DiLeu_BaEn_1	320	325	PF01217	0.325
TRG_DiLeu_BaEn_4	493	499	PF01217	0.553
TRG_DiLeu_BaLyEn_6	329	334	PF01217	0.354
TRG_DiLeu_LyEn_5	320	325	PF01217	0.325
TRG_ENDOCYTIC_2	120	123	PF00928	0.427
TRG_ENDOCYTIC_2	149	152	PF00928	0.387
TRG_ENDOCYTIC_2	179	182	PF00928	0.406
TRG_ENDOCYTIC_2	283	286	PF00928	0.308
TRG_ENDOCYTIC_2	299	302	PF00928	0.407
TRG_ENDOCYTIC_2	610	613	PF00928	0.327
TRG_ENDOCYTIC_2	618	621	PF00928	0.394
TRG_ER_diArg_1	117	119	PF00400	0.357
TRG_ER_diArg_1	199	202	PF00400	0.491
TRG_ER_diArg_1	598	600	PF00400	0.497
TRG_ER_diArg_1	602	604	PF00400	0.368
TRG_Pf-PMV_PEXEL_1	47	52	PF00026	0.330
TRG_Pf-PMV_PEXEL_1	87	92	PF00026	0.338

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7D8	Leptomonas seymouri	52%	79%
A0A3Q8I9H1	Leishmania donovani	100%	100%
A4HHR9	Leishmania braziliensis	79%	100%
E9AP55	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QGD3	Leishmania major	91%	100%