Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HVF5_LEIIN

TriTrypDb:

LINF_130006800

Length:

248

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HVF5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVF5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	120	122	PF00675	0.606
CLV_NRD_NRD_1	134	136	PF00675	0.690
CLV_NRD_NRD_1	139	141	PF00675	0.538
CLV_NRD_NRD_1	208	210	PF00675	0.540
CLV_NRD_NRD_1	8	10	PF00675	0.672
CLV_PCSK_KEX2_1	139	141	PF00082	0.586
CLV_PCSK_KEX2_1	27	29	PF00082	0.617
CLV_PCSK_KEX2_1	66	68	PF00082	0.470
CLV_PCSK_KEX2_1	8	10	PF00082	0.672
CLV_PCSK_PC1ET2_1	27	29	PF00082	0.617
CLV_PCSK_PC1ET2_1	66	68	PF00082	0.552
CLV_PCSK_PC7_1	135	141	PF00082	0.567
CLV_PCSK_SKI1_1	121	125	PF00082	0.739
CLV_PCSK_SKI1_1	2	6	PF00082	0.491
CLV_PCSK_SKI1_1	63	67	PF00082	0.561
CLV_PCSK_SKI1_1	76	80	PF00082	0.519
DEG_Nend_UBRbox_1	1	4	PF02207	0.493
DOC_ANK_TNKS_1	177	184	PF00023	0.493
DOC_CKS1_1	54	59	PF01111	0.496
DOC_CKS1_1	82	87	PF01111	0.601
DOC_MAPK_MEF2A_6	178	186	PF00069	0.460
DOC_USP7_MATH_1	15	19	PF00917	0.668
DOC_USP7_MATH_1	156	160	PF00917	0.697
DOC_USP7_UBL2_3	59	63	PF12436	0.546
DOC_WW_Pin1_4	152	157	PF00397	0.726
DOC_WW_Pin1_4	191	196	PF00397	0.546
DOC_WW_Pin1_4	53	58	PF00397	0.521
DOC_WW_Pin1_4	81	86	PF00397	0.669
LIG_14-3-3_CanoR_1	121	127	PF00244	0.603
LIG_14-3-3_CanoR_1	2	7	PF00244	0.676
LIG_14-3-3_CanoR_1	28	36	PF00244	0.599
LIG_14-3-3_CanoR_1	51	57	PF00244	0.661
LIG_14-3-3_CanoR_1	8	16	PF00244	0.682
LIG_APCC_ABBA_1	230	235	PF00400	0.524
LIG_EVH1_1	81	85	PF00568	0.586
LIG_FHA_1	1	7	PF00498	0.677
LIG_FHA_1	203	209	PF00498	0.494
LIG_LIR_Gen_1	159	167	PF02991	0.621
LIG_LIR_Nem_3	125	129	PF02991	0.595
LIG_LIR_Nem_3	130	134	PF02991	0.561
LIG_LIR_Nem_3	154	160	PF02991	0.646
LIG_LIR_Nem_3	18	24	PF02991	0.508
LIG_LIR_Nem_3	64	68	PF02991	0.478
LIG_PTB_Apo_2	125	132	PF02174	0.551
LIG_SH2_CRK	201	205	PF00017	0.456
LIG_SH2_GRB2like	160	163	PF00017	0.610
LIG_SH2_NCK_1	160	164	PF00017	0.615
LIG_SH2_NCK_1	69	73	PF00017	0.587
LIG_SH2_STAT5	236	239	PF00017	0.541
LIG_SH2_STAT5	24	27	PF00017	0.630
LIG_SH2_STAT5	245	248	PF00017	0.500
LIG_SH2_STAT5	36	39	PF00017	0.503
LIG_SH3_3	51	57	PF00018	0.610
LIG_SH3_3	79	85	PF00018	0.575
LIG_SUMO_SIM_anti_2	3	8	PF11976	0.583
LIG_TYR_ITIM	124	129	PF00017	0.629
MOD_CDK_SPxK_1	53	59	PF00069	0.594
MOD_CK1_1	138	144	PF00069	0.641
MOD_CK1_1	149	155	PF00069	0.778
MOD_CK1_1	171	177	PF00069	0.708
MOD_CK1_1	55	61	PF00069	0.558
MOD_CK2_1	105	111	PF00069	0.449
MOD_CK2_1	158	164	PF00069	0.619
MOD_CK2_1	190	196	PF00069	0.574
MOD_GlcNHglycan	140	143	PF01048	0.574
MOD_GlcNHglycan	17	20	PF01048	0.566
MOD_GlcNHglycan	170	173	PF01048	0.713
MOD_GlcNHglycan	220	223	PF01048	0.468
MOD_GlcNHglycan	240	243	PF01048	0.315
MOD_GlcNHglycan	31	34	PF01048	0.600
MOD_GlcNHglycan	47	50	PF01048	0.685
MOD_GSK3_1	145	152	PF00069	0.679
MOD_GSK3_1	72	79	PF00069	0.546
MOD_N-GLC_1	218	223	PF02516	0.459
MOD_N-GLC_1	29	34	PF02516	0.659
MOD_OFUCOSY	103	109	PF10250	0.556
MOD_PKA_1	135	141	PF00069	0.700
MOD_PKA_2	138	144	PF00069	0.486
MOD_PKA_2	7	13	PF00069	0.691
MOD_PKB_1	74	82	PF00069	0.609
MOD_Plk_1	76	82	PF00069	0.533
MOD_Plk_4	2	8	PF00069	0.768
MOD_ProDKin_1	152	158	PF00069	0.725
MOD_ProDKin_1	191	197	PF00069	0.539
MOD_ProDKin_1	53	59	PF00069	0.520
MOD_ProDKin_1	81	87	PF00069	0.672
MOD_SUMO_rev_2	114	124	PF00179	0.586
MOD_SUMO_rev_2	58	68	PF00179	0.550
TRG_ENDOCYTIC_2	126	129	PF00928	0.593
TRG_ENDOCYTIC_2	160	163	PF00928	0.623
TRG_ENDOCYTIC_2	201	204	PF00928	0.462
TRG_ENDOCYTIC_2	69	72	PF00928	0.643
TRG_ER_diArg_1	7	9	PF00400	0.667
TRG_Pf-PMV_PEXEL_1	93	98	PF00026	0.510

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ69	Leptomonas seymouri	59%	100%
A0A3Q8I9J1	Leishmania donovani	97%	100%
A4H726	Leishmania braziliensis	75%	100%
E9AP53	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QGD5	Leishmania major	93%	100%