TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Tetratricopeptide repeat - putative

Species:

Leishmania infantum

UniProt:

A4HVF4_LEIIN

TriTrypDb:

LINF_130006700

Length:

421

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HVF4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVF4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	316	320	PF00656	0.567
CLV_C14_Caspase3-7	82	86	PF00656	0.707
CLV_NRD_NRD_1	184	186	PF00675	0.634
CLV_NRD_NRD_1	192	194	PF00675	0.689
CLV_NRD_NRD_1	21	23	PF00675	0.427
CLV_NRD_NRD_1	298	300	PF00675	0.554
CLV_NRD_NRD_1	359	361	PF00675	0.368
CLV_PCSK_KEX2_1	184	186	PF00082	0.634
CLV_PCSK_KEX2_1	192	194	PF00082	0.689
CLV_PCSK_KEX2_1	21	23	PF00082	0.351
CLV_PCSK_KEX2_1	297	299	PF00082	0.546
CLV_PCSK_KEX2_1	358	360	PF00082	0.369
CLV_PCSK_KEX2_1	8	10	PF00082	0.504
CLV_PCSK_PC1ET2_1	8	10	PF00082	0.504
CLV_PCSK_SKI1_1	175	179	PF00082	0.495
CLV_PCSK_SKI1_1	256	260	PF00082	0.407
CLV_PCSK_SKI1_1	325	329	PF00082	0.414
CLV_PCSK_SKI1_1	376	380	PF00082	0.406
CLV_PCSK_SKI1_1	390	394	PF00082	0.298
DEG_APCC_DBOX_1	255	263	PF00400	0.402
DEG_APCC_DBOX_1	289	297	PF00400	0.500
DEG_Nend_UBRbox_4	1	3	PF02207	0.640
DEG_SPOP_SBC_1	219	223	PF00917	0.755
DOC_CYCLIN_RxL_1	250	261	PF00134	0.510
DOC_CYCLIN_RxL_1	385	397	PF00134	0.501
DOC_CYCLIN_yCln2_LP_2	217	220	PF00134	0.541
DOC_MAPK_gen_1	192	200	PF00069	0.524
DOC_MAPK_gen_1	21	28	PF00069	0.357
DOC_MAPK_MEF2A_6	21	28	PF00069	0.490
DOC_MAPK_MEF2A_6	285	293	PF00069	0.555
DOC_MAPK_NFAT4_5	21	29	PF00069	0.480
DOC_PP2B_LxvP_1	217	220	PF13499	0.541
DOC_PP2B_LxvP_1	252	255	PF13499	0.588
DOC_USP7_MATH_1	10	14	PF00917	0.556
DOC_USP7_MATH_1	150	154	PF00917	0.686
DOC_USP7_MATH_1	159	163	PF00917	0.553
DOC_USP7_MATH_1	224	228	PF00917	0.667
DOC_USP7_MATH_1	83	87	PF00917	0.595
DOC_WW_Pin1_4	183	188	PF00397	0.561
DOC_WW_Pin1_4	226	231	PF00397	0.611
DOC_WW_Pin1_4	404	409	PF00397	0.655
DOC_WW_Pin1_4	59	64	PF00397	0.589
LIG_14-3-3_CanoR_1	11	16	PF00244	0.595
LIG_14-3-3_CanoR_1	127	136	PF00244	0.403
LIG_14-3-3_CanoR_1	139	147	PF00244	0.501
LIG_14-3-3_CanoR_1	21	27	PF00244	0.385
LIG_14-3-3_CanoR_1	212	218	PF00244	0.693
LIG_14-3-3_CanoR_1	247	253	PF00244	0.597
LIG_CaM_IQ_9	277	292	PF13499	0.464
LIG_CaM_NSCaTE_8	136	143	PF13499	0.520
LIG_DLG_GKlike_1	22	30	PF00625	0.372
LIG_FHA_1	106	112	PF00498	0.478
LIG_FHA_1	21	27	PF00498	0.574
LIG_FHA_1	212	218	PF00498	0.718
LIG_FHA_1	263	269	PF00498	0.501
LIG_FHA_1	319	325	PF00498	0.511
LIG_FHA_1	363	369	PF00498	0.485
LIG_FHA_1	370	376	PF00498	0.370
LIG_FHA_2	150	156	PF00498	0.670
LIG_Integrin_RGD_1	193	195	PF01839	0.636
LIG_LIR_Apic_2	197	202	PF02991	0.615
LIG_LIR_Gen_1	113	123	PF02991	0.491
LIG_LIR_Nem_3	113	119	PF02991	0.479
LIG_LYPXL_SIV_4	172	180	PF13949	0.493
LIG_RPA_C_Fungi	44	56	PF08784	0.485
LIG_SH2_CRK	116	120	PF00017	0.493
LIG_SH2_NCK_1	122	126	PF00017	0.499
LIG_SH2_NCK_1	271	275	PF00017	0.557
LIG_SH2_NCK_1	33	37	PF00017	0.500
LIG_SH2_PTP2	361	364	PF00017	0.334
LIG_SH2_SRC	122	125	PF00017	0.495
LIG_SH2_SRC	33	36	PF00017	0.502
LIG_SH2_STAP1	413	417	PF00017	0.470
LIG_SH2_STAT5	276	279	PF00017	0.438
LIG_SH2_STAT5	361	364	PF00017	0.332
LIG_SH3_1	184	190	PF00018	0.591
LIG_SH3_1	361	367	PF00018	0.344
LIG_SH3_2	187	192	PF14604	0.499
LIG_SH3_3	184	190	PF00018	0.591
LIG_SH3_3	197	203	PF00018	0.669
LIG_SH3_3	361	367	PF00018	0.332
LIG_Sin3_3	237	244	PF02671	0.436
LIG_SUMO_SIM_anti_2	108	114	PF11976	0.397
LIG_SUMO_SIM_par_1	107	114	PF11976	0.398
LIG_SUMO_SIM_par_1	53	60	PF11976	0.537
LIG_SxIP_EBH_1	212	224	PF03271	0.740
LIG_TRAF2_1	416	419	PF00917	0.608
LIG_TRAF2_1	51	54	PF00917	0.567
LIG_WW_3	253	257	PF00397	0.561
MOD_CDC14_SPxK_1	189	192	PF00782	0.584
MOD_CDK_SPxK_1	186	192	PF00069	0.560
MOD_CDK_SPxxK_3	186	193	PF00069	0.617
MOD_CK1_1	142	148	PF00069	0.643
MOD_CK1_1	149	155	PF00069	0.587
MOD_CK1_1	27	33	PF00069	0.571
MOD_CK1_1	62	68	PF00069	0.590
MOD_CK2_1	149	155	PF00069	0.615
MOD_GlcNHglycan	148	151	PF01048	0.597
MOD_GlcNHglycan	152	155	PF01048	0.567
MOD_GlcNHglycan	226	229	PF01048	0.620
MOD_GlcNHglycan	235	238	PF01048	0.523
MOD_GlcNHglycan	396	399	PF01048	0.444
MOD_GSK3_1	138	145	PF00069	0.626
MOD_GSK3_1	146	153	PF00069	0.550
MOD_GSK3_1	20	27	PF00069	0.557
MOD_GSK3_1	219	226	PF00069	0.662
MOD_GSK3_1	229	236	PF00069	0.527
MOD_GSK3_1	350	357	PF00069	0.425
MOD_GSK3_1	404	411	PF00069	0.608
MOD_GSK3_1	55	62	PF00069	0.604
MOD_LATS_1	144	150	PF00433	0.606
MOD_NEK2_1	105	110	PF00069	0.432
MOD_NEK2_1	111	116	PF00069	0.361
MOD_NEK2_1	140	145	PF00069	0.566
MOD_NEK2_1	213	218	PF00069	0.645
MOD_NEK2_1	233	238	PF00069	0.388
MOD_NEK2_1	24	29	PF00069	0.477
MOD_NEK2_1	248	253	PF00069	0.509
MOD_NEK2_1	350	355	PF00069	0.445
MOD_NEK2_1	383	388	PF00069	0.453
MOD_NEK2_1	57	62	PF00069	0.524
MOD_NEK2_2	305	310	PF00069	0.470
MOD_PIKK_1	91	97	PF00454	0.648
MOD_PKA_1	297	303	PF00069	0.514
MOD_PKA_2	10	16	PF00069	0.594
MOD_PKA_2	138	144	PF00069	0.599
MOD_PKA_2	145	151	PF00069	0.630
MOD_PKA_2	20	26	PF00069	0.393
MOD_PKA_2	211	217	PF00069	0.696
MOD_PKA_2	297	303	PF00069	0.585
MOD_PKA_2	394	400	PF00069	0.446
MOD_PKB_1	137	145	PF00069	0.544
MOD_PKB_1	9	17	PF00069	0.533
MOD_Plk_1	34	40	PF00069	0.559
MOD_Plk_2-3	341	347	PF00069	0.485
MOD_Plk_4	105	111	PF00069	0.434
MOD_Plk_4	213	219	PF00069	0.735
MOD_Plk_4	229	235	PF00069	0.429
MOD_ProDKin_1	183	189	PF00069	0.571
MOD_ProDKin_1	226	232	PF00069	0.604
MOD_ProDKin_1	404	410	PF00069	0.650
MOD_ProDKin_1	59	65	PF00069	0.632
MOD_SUMO_rev_2	319	327	PF00179	0.534
TRG_DiLeu_BaEn_1	124	129	PF01217	0.439
TRG_DiLeu_BaEn_1	346	351	PF01217	0.401
TRG_DiLeu_BaLyEn_6	335	340	PF01217	0.444
TRG_DiLeu_LyEn_5	124	129	PF01217	0.487
TRG_ENDOCYTIC_2	116	119	PF00928	0.489
TRG_ENDOCYTIC_2	337	340	PF00928	0.362
TRG_ER_diArg_1	101	104	PF00400	0.481
TRG_ER_diArg_1	183	185	PF00400	0.554
TRG_ER_diArg_1	296	299	PF00400	0.589
TRG_ER_diArg_1	358	360	PF00400	0.346
TRG_NLS_MonoExtN_4	5	12	PF00514	0.431
TRG_Pf-PMV_PEXEL_1	256	261	PF00026	0.420

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBN7	Leptomonas seymouri	47%	100%
A0A0S4JF77	Bodo saltans	30%	85%
A0A1X0NNA0	Trypanosomatidae	30%	100%
A0A3S7WSE7	Leishmania donovani	99%	100%
A0A422NP89	Trypanosoma rangeli	32%	100%
A4H725	Leishmania braziliensis	78%	100%
E9AP52	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QGD6	Leishmania major	93%	100%