Putative MOZ/SAS family acetyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

MOZ/SAS family acetyltransferase - putative

Species:

Leishmania infantum

UniProt:

A4HVF3_LEIIN

TriTrypDb:

LINF_130006600

Length:

623

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HVF3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVF3

Function

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	11
GO:0009889	regulation of biosynthetic process	4	11
GO:0010468	regulation of gene expression	5	11
GO:0010556	regulation of macromolecule biosynthetic process	5	11
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	11
GO:0019222	regulation of metabolic process	3	11
GO:0031323	regulation of cellular metabolic process	4	11
GO:0031326	regulation of cellular biosynthetic process	5	11
GO:0050789	regulation of biological process	2	11
GO:0050794	regulation of cellular process	3	11
GO:0051171	regulation of nitrogen compound metabolic process	4	11
GO:0051252	regulation of RNA metabolic process	5	11
GO:0060255	regulation of macromolecule metabolic process	4	11
GO:0065007	biological regulation	1	11
GO:0080090	regulation of primary metabolic process	4	11
GO:1903506	regulation of nucleic acid-templated transcription	7	11
GO:2001141	regulation of RNA biosynthetic process	6	11
GO:0006357	regulation of transcription by RNA polymerase II	7	1
GO:0009890	negative regulation of biosynthetic process	5	1
GO:0009891	positive regulation of biosynthetic process	5	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0010557	positive regulation of macromolecule biosynthetic process	6	1
GO:0010558	negative regulation of macromolecule biosynthetic process	6	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0031324	negative regulation of cellular metabolic process	5	1
GO:0031325	positive regulation of cellular metabolic process	5	1
GO:0031327	negative regulation of cellular biosynthetic process	6	1
GO:0031328	positive regulation of cellular biosynthetic process	6	1
GO:0045892	negative regulation of DNA-templated transcription	7	1
GO:0045893	positive regulation of DNA-templated transcription	7	1
GO:0045934	negative regulation of nucleobase-containing compound metabolic process	6	1
GO:0045935	positive regulation of nucleobase-containing compound metabolic process	6	1
GO:0045944	positive regulation of transcription by RNA polymerase II	8	1
GO:0048518	positive regulation of biological process	3	1
GO:0048519	negative regulation of biological process	3	1
GO:0048522	positive regulation of cellular process	4	1
GO:0048523	negative regulation of cellular process	4	1
GO:0051172	negative regulation of nitrogen compound metabolic process	5	1
GO:0051173	positive regulation of nitrogen compound metabolic process	5	1
GO:0051253	negative regulation of RNA metabolic process	6	1
GO:0051254	positive regulation of RNA metabolic process	6	1
GO:1902679	negative regulation of RNA biosynthetic process	7	1
GO:1902680	positive regulation of RNA biosynthetic process	7	1
GO:1903507	negative regulation of nucleic acid-templated transcription	8	1
GO:1903508	positive regulation of nucleic acid-templated transcription	8	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004402	histone acetyltransferase activity	4	11
GO:0008080	N-acetyltransferase activity	6	11
GO:0016407	acetyltransferase activity	5	11
GO:0016410	N-acyltransferase activity	5	11
GO:0016740	transferase activity	2	11
GO:0016746	acyltransferase activity	3	11
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	11
GO:0034212	peptide N-acetyltransferase activity	7	11
GO:0061733	peptide-lysine-N-acetyltransferase activity	3	11
GO:0140096	catalytic activity, acting on a protein	2	11
GO:0003712	transcription coregulator activity	2	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0042393	histone binding	3	1
GO:0140110	transcription regulator activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	540	544	PF00656	0.791
CLV_NRD_NRD_1	441	443	PF00675	0.335
CLV_NRD_NRD_1	456	458	PF00675	0.660
CLV_NRD_NRD_1	49	51	PF00675	0.446
CLV_NRD_NRD_1	531	533	PF00675	0.756
CLV_NRD_NRD_1	69	71	PF00675	0.554
CLV_PCSK_FUR_1	67	71	PF00082	0.648
CLV_PCSK_KEX2_1	441	443	PF00082	0.334
CLV_PCSK_KEX2_1	456	458	PF00082	0.664
CLV_PCSK_KEX2_1	49	51	PF00082	0.446
CLV_PCSK_KEX2_1	527	529	PF00082	0.801
CLV_PCSK_KEX2_1	531	533	PF00082	0.753
CLV_PCSK_KEX2_1	603	605	PF00082	0.674
CLV_PCSK_KEX2_1	69	71	PF00082	0.554
CLV_PCSK_PC1ET2_1	527	529	PF00082	0.597
CLV_PCSK_PC1ET2_1	603	605	PF00082	0.746
CLV_PCSK_SKI1_1	270	274	PF00082	0.360
CLV_PCSK_SKI1_1	392	396	PF00082	0.358
CLV_PCSK_SKI1_1	441	445	PF00082	0.328
CLV_PCSK_SKI1_1	8	12	PF00082	0.431
DEG_APCC_DBOX_1	314	322	PF00400	0.452
DEG_APCC_DBOX_1	441	449	PF00400	0.564
DEG_APCC_DBOX_1	466	474	PF00400	0.557
DEG_Nend_UBRbox_2	1	3	PF02207	0.571
DOC_CKS1_1	253	258	PF01111	0.551
DOC_CKS1_1	616	621	PF01111	0.666
DOC_CYCLIN_RxL_1	5	15	PF00134	0.402
DOC_MAPK_gen_1	593	601	PF00069	0.652
DOC_MAPK_MEF2A_6	460	468	PF00069	0.671
DOC_MAPK_MEF2A_6	474	481	PF00069	0.435
DOC_PP2B_LxvP_1	215	218	PF13499	0.540
DOC_PP4_FxxP_1	205	208	PF00568	0.410
DOC_PP4_FxxP_1	497	500	PF00568	0.645
DOC_USP7_MATH_1	137	141	PF00917	0.707
DOC_USP7_MATH_1	150	154	PF00917	0.669
DOC_USP7_MATH_1	165	169	PF00917	0.649
DOC_USP7_MATH_1	19	23	PF00917	0.664
DOC_USP7_MATH_1	314	318	PF00917	0.436
DOC_USP7_MATH_1	324	328	PF00917	0.572
DOC_USP7_MATH_1	501	505	PF00917	0.541
DOC_USP7_MATH_1	557	561	PF00917	0.759
DOC_USP7_MATH_1	73	77	PF00917	0.588
DOC_USP7_MATH_1	99	103	PF00917	0.522
DOC_WW_Pin1_4	141	146	PF00397	0.758
DOC_WW_Pin1_4	231	236	PF00397	0.377
DOC_WW_Pin1_4	252	257	PF00397	0.523
DOC_WW_Pin1_4	426	431	PF00397	0.496
DOC_WW_Pin1_4	515	520	PF00397	0.759
DOC_WW_Pin1_4	615	620	PF00397	0.664
LIG_14-3-3_CanoR_1	284	289	PF00244	0.496
LIG_14-3-3_CanoR_1	315	319	PF00244	0.441
LIG_14-3-3_CanoR_1	392	397	PF00244	0.561
LIG_14-3-3_CanoR_1	467	471	PF00244	0.596
LIG_14-3-3_CanoR_1	534	541	PF00244	0.784
LIG_14-3-3_CanoR_1	572	578	PF00244	0.602
LIG_APCC_ABBA_1	40	45	PF00400	0.559
LIG_APCC_ABBA_1	479	484	PF00400	0.446
LIG_BRCT_BRCA1_1	233	237	PF00533	0.468
LIG_BRCT_BRCA1_1	27	31	PF00533	0.515
LIG_BRCT_BRCA1_1	424	428	PF00533	0.496
LIG_CSL_BTD_1	203	206	PF09270	0.505
LIG_deltaCOP1_diTrp_1	114	120	PF00928	0.438
LIG_eIF4E_1	439	445	PF01652	0.562
LIG_FHA_1	32	38	PF00498	0.551
LIG_FHA_1	393	399	PF00498	0.563
LIG_FHA_1	486	492	PF00498	0.539
LIG_FHA_1	572	578	PF00498	0.635
LIG_FHA_2	149	155	PF00498	0.793
LIG_FHA_2	181	187	PF00498	0.450
LIG_FHA_2	327	333	PF00498	0.720
LIG_FHA_2	467	473	PF00498	0.555
LIG_FHA_2	55	61	PF00498	0.557
LIG_FHA_2	580	586	PF00498	0.550
LIG_GSK3_LRP6_1	519	525	PF00069	0.725
LIG_LIR_Apic_2	494	500	PF02991	0.631
LIG_LIR_Gen_1	114	125	PF02991	0.440
LIG_LIR_Gen_1	240	250	PF02991	0.532
LIG_LIR_Gen_1	304	314	PF02991	0.482
LIG_LIR_Nem_3	114	120	PF02991	0.438
LIG_LIR_Nem_3	193	199	PF02991	0.374
LIG_LIR_Nem_3	240	246	PF02991	0.513
LIG_LIR_Nem_3	249	253	PF02991	0.544
LIG_LIR_Nem_3	266	272	PF02991	0.562
LIG_LIR_Nem_3	304	309	PF02991	0.482
LIG_LIR_Nem_3	45	51	PF02991	0.554
LIG_LIR_Nem_3	493	498	PF02991	0.551
LIG_MLH1_MIPbox_1	233	237	PF16413	0.501
LIG_PCNA_PIPBox_1	433	442	PF02747	0.480
LIG_PCNA_yPIPBox_3	333	344	PF02747	0.610
LIG_PCNA_yPIPBox_3	426	440	PF02747	0.467
LIG_Pex14_1	116	120	PF04695	0.545
LIG_Pex14_1	48	52	PF04695	0.560
LIG_Pex14_2	201	205	PF04695	0.413
LIG_Pex14_2	601	605	PF04695	0.607
LIG_PTB_Apo_2	103	110	PF02174	0.559
LIG_PTB_Phospho_1	103	109	PF10480	0.562
LIG_REV1ctd_RIR_1	234	243	PF16727	0.533
LIG_SH2_CRK	209	213	PF00017	0.525
LIG_SH2_CRK	250	254	PF00017	0.537
LIG_SH2_CRK	616	620	PF00017	0.742
LIG_SH2_NCK_1	616	620	PF00017	0.664
LIG_SH2_PTP2	243	246	PF00017	0.545
LIG_SH2_PTP2	308	311	PF00017	0.562
LIG_SH2_SRC	306	309	PF00017	0.562
LIG_SH2_SRC	320	323	PF00017	0.585
LIG_SH2_SRC	498	501	PF00017	0.650
LIG_SH2_STAP1	117	121	PF00017	0.425
LIG_SH2_STAP1	306	310	PF00017	0.482
LIG_SH2_STAP1	573	577	PF00017	0.620
LIG_SH2_STAT3	199	202	PF00017	0.519
LIG_SH2_STAT5	196	199	PF00017	0.379
LIG_SH2_STAT5	214	217	PF00017	0.438
LIG_SH2_STAT5	227	230	PF00017	0.374
LIG_SH2_STAT5	243	246	PF00017	0.328
LIG_SH2_STAT5	250	253	PF00017	0.415
LIG_SH2_STAT5	308	311	PF00017	0.530
LIG_SH2_STAT5	320	323	PF00017	0.427
LIG_SH2_STAT5	367	370	PF00017	0.483
LIG_SH2_STAT5	53	56	PF00017	0.394
LIG_SH2_STAT5	573	576	PF00017	0.692
LIG_SH2_STAT5	620	623	PF00017	0.614
LIG_SH2_STAT6	268	272	PF00017	0.562
LIG_SH3_3	142	148	PF00018	0.748
LIG_SH3_3	149	155	PF00018	0.704
LIG_SH3_3	200	206	PF00018	0.507
LIG_SH3_3	308	314	PF00018	0.496
LIG_SH3_3	316	322	PF00018	0.463
LIG_SH3_3	380	386	PF00018	0.534
LIG_SH3_3	424	430	PF00018	0.485
LIG_SH3_3	517	523	PF00018	0.737
LIG_SUMO_SIM_par_1	337	343	PF11976	0.595
LIG_SUMO_SIM_par_1	487	494	PF11976	0.552
LIG_SUMO_SIM_par_1	574	580	PF11976	0.626
LIG_TRAF2_1	177	180	PF00917	0.605
LIG_TRFH_1	120	124	PF08558	0.551
LIG_TYR_ITIM	212	217	PF00017	0.507
LIG_WRC_WIRS_1	393	398	PF05994	0.562
MOD_CDK_SPxxK_3	252	259	PF00069	0.526
MOD_CK1_1	102	108	PF00069	0.554
MOD_CK1_1	140	146	PF00069	0.763
MOD_CK1_1	327	333	PF00069	0.720
MOD_CK1_1	518	524	PF00069	0.770
MOD_CK1_1	536	542	PF00069	0.702
MOD_CK1_1	544	550	PF00069	0.652
MOD_CK1_1	553	559	PF00069	0.529
MOD_CK1_1	566	572	PF00069	0.626
MOD_CK2_1	141	147	PF00069	0.726
MOD_CK2_1	148	154	PF00069	0.767
MOD_CK2_1	180	186	PF00069	0.412
MOD_CK2_1	326	332	PF00069	0.700
MOD_CK2_1	444	450	PF00069	0.502
MOD_CK2_1	466	472	PF00069	0.553
MOD_CK2_1	54	60	PF00069	0.529
MOD_CK2_1	579	585	PF00069	0.508
MOD_CK2_1	89	95	PF00069	0.650
MOD_DYRK1A_RPxSP_1	426	430	PF00069	0.496
MOD_GlcNHglycan	125	128	PF01048	0.620
MOD_GlcNHglycan	139	142	PF01048	0.723
MOD_GlcNHglycan	209	212	PF01048	0.567
MOD_GlcNHglycan	329	332	PF01048	0.720
MOD_GlcNHglycan	419	422	PF01048	0.381
MOD_GlcNHglycan	503	506	PF01048	0.654
MOD_GlcNHglycan	524	527	PF01048	0.752
MOD_GlcNHglycan	547	550	PF01048	0.676
MOD_GlcNHglycan	555	558	PF01048	0.653
MOD_GlcNHglycan	559	562	PF01048	0.626
MOD_GlcNHglycan	568	571	PF01048	0.634
MOD_GlcNHglycan	77	80	PF01048	0.672
MOD_GlcNHglycan	86	89	PF01048	0.642
MOD_GSK3_1	13	20	PF00069	0.592
MOD_GSK3_1	137	144	PF00069	0.748
MOD_GSK3_1	231	238	PF00069	0.382
MOD_GSK3_1	25	32	PF00069	0.516
MOD_GSK3_1	293	300	PF00069	0.506
MOD_GSK3_1	377	384	PF00069	0.482
MOD_GSK3_1	388	395	PF00069	0.482
MOD_GSK3_1	422	429	PF00069	0.491
MOD_GSK3_1	431	438	PF00069	0.477
MOD_GSK3_1	514	521	PF00069	0.683
MOD_GSK3_1	533	540	PF00069	0.684
MOD_GSK3_1	541	548	PF00069	0.682
MOD_GSK3_1	553	560	PF00069	0.632
MOD_GSK3_1	80	87	PF00069	0.729
MOD_N-GLC_1	132	137	PF02516	0.719
MOD_N-GLC_1	20	25	PF02516	0.684
MOD_NEK2_1	293	298	PF00069	0.487
MOD_NEK2_1	31	36	PF00069	0.572
MOD_NEK2_1	388	393	PF00069	0.597
MOD_NEK2_1	435	440	PF00069	0.502
MOD_NEK2_1	444	449	PF00069	0.506
MOD_NEK2_1	466	471	PF00069	0.518
MOD_NEK2_1	541	546	PF00069	0.738
MOD_NEK2_1	552	557	PF00069	0.726
MOD_NEK2_1	579	584	PF00069	0.556
MOD_NEK2_2	86	91	PF00069	0.705
MOD_PIKK_1	541	547	PF00454	0.697
MOD_PKA_1	456	462	PF00069	0.678
MOD_PKA_2	186	192	PF00069	0.491
MOD_PKA_2	314	320	PF00069	0.438
MOD_PKA_2	456	462	PF00069	0.678
MOD_PKA_2	466	472	PF00069	0.597
MOD_PKA_2	508	514	PF00069	0.657
MOD_PKA_2	533	539	PF00069	0.710
MOD_PKA_2	571	577	PF00069	0.649
MOD_PKB_1	390	398	PF00069	0.558
MOD_PKB_1	532	540	PF00069	0.574
MOD_Plk_1	375	381	PF00069	0.562
MOD_Plk_1	579	585	PF00069	0.562
MOD_Plk_4	222	228	PF00069	0.475
MOD_Plk_4	284	290	PF00069	0.497
MOD_Plk_4	392	398	PF00069	0.562
MOD_Plk_4	431	437	PF00069	0.507
MOD_Plk_4	485	491	PF00069	0.495
MOD_Plk_4	573	579	PF00069	0.517
MOD_Plk_4	99	105	PF00069	0.559
MOD_ProDKin_1	141	147	PF00069	0.762
MOD_ProDKin_1	231	237	PF00069	0.377
MOD_ProDKin_1	252	258	PF00069	0.526
MOD_ProDKin_1	426	432	PF00069	0.496
MOD_ProDKin_1	515	521	PF00069	0.761
MOD_ProDKin_1	615	621	PF00069	0.666
TRG_DiLeu_BaEn_1	472	477	PF01217	0.571
TRG_DiLeu_BaLyEn_6	256	261	PF01217	0.562
TRG_DiLeu_BaLyEn_6	5	10	PF01217	0.443
TRG_ENDOCYTIC_2	117	120	PF00928	0.452
TRG_ENDOCYTIC_2	209	212	PF00928	0.440
TRG_ENDOCYTIC_2	214	217	PF00928	0.436
TRG_ENDOCYTIC_2	243	246	PF00928	0.475
TRG_ENDOCYTIC_2	250	253	PF00928	0.454
TRG_ENDOCYTIC_2	269	272	PF00928	0.560
TRG_ENDOCYTIC_2	306	309	PF00928	0.482
TRG_ER_diArg_1	390	393	PF00400	0.581
TRG_ER_diArg_1	408	411	PF00400	0.421
TRG_ER_diArg_1	440	442	PF00400	0.496
TRG_ER_diArg_1	48	50	PF00400	0.524
TRG_ER_diArg_1	6	9	PF00400	0.551
TRG_ER_diArg_1	67	70	PF00400	0.557
TRG_NLS_MonoCore_2	592	597	PF00514	0.515
TRG_Pf-PMV_PEXEL_1	291	295	PF00026	0.334
TRG_Pf-PMV_PEXEL_1	446	450	PF00026	0.346
TRG_Pf-PMV_PEXEL_1	474	478	PF00026	0.556
TRG_Pf-PMV_PEXEL_1	604	609	PF00026	0.723
TRG_Pf-PMV_PEXEL_1	8	13	PF00026	0.501

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4F2	Leptomonas seymouri	57%	100%
A0A0S4JFL5	Bodo saltans	29%	100%
A0A1X0NNC2	Trypanosomatidae	43%	100%
A0A3R7KIN4	Trypanosoma rangeli	41%	100%
A0A3S7WSE3	Leishmania donovani	100%	100%
A4H724	Leishmania braziliensis	81%	100%
E9AP51	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QGD7	Leishmania major	95%	100%
V5B9B5	Trypanosoma cruzi	42%	100%