LeishMANIAdb
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Protein kinase A regulatory subunit

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Protein kinase A regulatory subunit
Gene product:
protein kinase A regulatory subunit
Species:
Leishmania infantum
UniProt:
A4HVF2_LEIIN
TriTrypDb:
LINF_130006500
Length:
502

Annotations

Annotations by Jardim et al.

Protein kinase, kinase A regulatory subunit Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 4
Forrest at al. (procyclic) yes yes: 4
Silverman et al. no yes: 0
Pissara et al. yes yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 12
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 12
NetGPI no yes: 0, no: 12
Cellular components
Term Name Level Count
GO:0005929 cilium 4 13
GO:0042995 cell projection 2 13
GO:0043226 organelle 2 13
GO:0043227 membrane-bounded organelle 3 13
GO:0110165 cellular anatomical entity 1 13
GO:0120025 plasma membrane bounded cell projection 3 13

Phosphorylation

Promastigote: 206

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HVF2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVF2

Function

Biological processes
Term Name Level Count
GO:0003341 cilium movement 4 1
GO:0007017 microtubule-based process 2 1
GO:0007018 microtubule-based movement 3 1
GO:0009987 cellular process 1 5
GO:0044145 modulation of formation of structure involved in a symbiotic process 3 1
GO:0050789 regulation of biological process 2 1
GO:0060294 cilium movement involved in cell motility 5 1
GO:0065007 biological regulation 1 1
GO:0006793 phosphorus metabolic process 3 4
GO:0006796 phosphate-containing compound metabolic process 4 4
GO:0008152 metabolic process 1 4
GO:0016310 phosphorylation 5 4
GO:0044237 cellular metabolic process 2 4
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 4
GO:0016301 kinase activity 4 4
GO:0016740 transferase activity 2 4
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 122 124 PF00675 0.397
CLV_NRD_NRD_1 133 135 PF00675 0.375
CLV_NRD_NRD_1 203 205 PF00675 0.573
CLV_NRD_NRD_1 351 353 PF00675 0.404
CLV_NRD_NRD_1 460 462 PF00675 0.324
CLV_PCSK_FUR_1 201 205 PF00082 0.637
CLV_PCSK_KEX2_1 133 135 PF00082 0.372
CLV_PCSK_KEX2_1 203 205 PF00082 0.570
CLV_PCSK_KEX2_1 350 352 PF00082 0.401
CLV_PCSK_KEX2_1 460 462 PF00082 0.324
CLV_PCSK_KEX2_1 475 477 PF00082 0.478
CLV_PCSK_PC1ET2_1 475 477 PF00082 0.455
CLV_PCSK_SKI1_1 123 127 PF00082 0.384
CLV_PCSK_SKI1_1 152 156 PF00082 0.481
CLV_PCSK_SKI1_1 251 255 PF00082 0.473
CLV_PCSK_SKI1_1 53 57 PF00082 0.341
DEG_APCC_DBOX_1 133 141 PF00400 0.530
DEG_APCC_DBOX_1 52 60 PF00400 0.350
DOC_CDC14_PxL_1 359 367 PF14671 0.420
DOC_CKS1_1 20 25 PF01111 0.544
DOC_CKS1_1 315 320 PF01111 0.324
DOC_CYCLIN_RxL_1 120 127 PF00134 0.408
DOC_MAPK_gen_1 133 140 PF00069 0.362
DOC_MAPK_gen_1 201 209 PF00069 0.668
DOC_PP1_RVXF_1 142 148 PF00149 0.404
DOC_PP1_RVXF_1 24 31 PF00149 0.550
DOC_USP7_MATH_1 379 383 PF00917 0.419
DOC_USP7_UBL2_3 294 298 PF12436 0.337
DOC_WW_Pin1_4 19 24 PF00397 0.373
DOC_WW_Pin1_4 3 8 PF00397 0.540
DOC_WW_Pin1_4 314 319 PF00397 0.324
LIG_14-3-3_CanoR_1 123 129 PF00244 0.495
LIG_14-3-3_CanoR_1 203 208 PF00244 0.563
LIG_14-3-3_CanoR_1 476 486 PF00244 0.468
LIG_BIR_II_1 1 5 PF00653 0.531
LIG_BIR_III_4 415 419 PF00653 0.389
LIG_BRCT_BRCA1_1 381 385 PF00533 0.412
LIG_eIF4E_1 120 126 PF01652 0.388
LIG_FHA_1 189 195 PF00498 0.706
LIG_FHA_1 204 210 PF00498 0.587
LIG_FHA_1 230 236 PF00498 0.447
LIG_FHA_1 315 321 PF00498 0.324
LIG_FHA_1 325 331 PF00498 0.324
LIG_FHA_1 406 412 PF00498 0.345
LIG_FHA_1 453 459 PF00498 0.346
LIG_FHA_2 141 147 PF00498 0.414
LIG_FHA_2 275 281 PF00498 0.389
LIG_FHA_2 379 385 PF00498 0.482
LIG_FHA_2 441 447 PF00498 0.412
LIG_LIR_Apic_2 312 318 PF02991 0.324
LIG_LIR_Gen_1 35 45 PF02991 0.517
LIG_LIR_Gen_1 353 363 PF02991 0.405
LIG_LIR_Gen_1 369 379 PF02991 0.343
LIG_LIR_Gen_1 397 405 PF02991 0.324
LIG_LIR_Gen_1 484 490 PF02991 0.470
LIG_LIR_Nem_3 338 343 PF02991 0.319
LIG_LIR_Nem_3 35 40 PF02991 0.524
LIG_LIR_Nem_3 397 403 PF02991 0.312
LIG_LIR_Nem_3 480 486 PF02991 0.452
LIG_LIR_Nem_3 66 71 PF02991 0.415
LIG_PCNA_yPIPBox_3 21 31 PF02747 0.452
LIG_PTB_Apo_2 77 84 PF02174 0.523
LIG_Rb_pABgroove_1 309 317 PF01858 0.340
LIG_SH2_CRK 315 319 PF00017 0.311
LIG_SH2_CRK 340 344 PF00017 0.340
LIG_SH2_CRK 486 490 PF00017 0.450
LIG_SH2_NCK_1 315 319 PF00017 0.406
LIG_SH2_PTP2 220 223 PF00017 0.545
LIG_SH2_PTP2 402 405 PF00017 0.399
LIG_SH2_SRC 220 223 PF00017 0.567
LIG_SH2_SRC 390 393 PF00017 0.358
LIG_SH2_SRC 402 405 PF00017 0.358
LIG_SH2_STAT3 283 286 PF00017 0.324
LIG_SH2_STAT3 485 488 PF00017 0.574
LIG_SH2_STAT5 220 223 PF00017 0.489
LIG_SH2_STAT5 283 286 PF00017 0.324
LIG_SH2_STAT5 390 393 PF00017 0.340
LIG_SH2_STAT5 402 405 PF00017 0.340
LIG_SH2_STAT5 49 52 PF00017 0.352
LIG_SH3_3 17 23 PF00018 0.412
LIG_SUMO_SIM_anti_2 310 317 PF11976 0.324
LIG_SUMO_SIM_anti_2 408 413 PF11976 0.340
LIG_SUMO_SIM_par_1 136 143 PF11976 0.501
LIG_SUMO_SIM_par_1 38 44 PF11976 0.536
LIG_SUMO_SIM_par_1 446 452 PF11976 0.439
LIG_SUMO_SIM_par_1 54 60 PF11976 0.302
LIG_UBA3_1 244 251 PF00899 0.439
MOD_CDK_SPxxK_3 19 26 PF00069 0.566
MOD_CK1_1 33 39 PF00069 0.458
MOD_CK1_1 81 87 PF00069 0.525
MOD_CK2_1 36 42 PF00069 0.450
MOD_CK2_1 378 384 PF00069 0.413
MOD_Cter_Amidation 121 124 PF01082 0.392
MOD_GlcNHglycan 1 4 PF01048 0.596
MOD_GlcNHglycan 174 177 PF01048 0.735
MOD_GlcNHglycan 286 289 PF01048 0.327
MOD_GlcNHglycan 427 430 PF01048 0.460
MOD_GlcNHglycan 479 482 PF01048 0.542
MOD_GSK3_1 106 113 PF00069 0.511
MOD_GSK3_1 188 195 PF00069 0.669
MOD_GSK3_1 225 232 PF00069 0.492
MOD_GSK3_1 319 326 PF00069 0.413
MOD_GSK3_1 448 455 PF00069 0.324
MOD_N-GLC_1 110 115 PF02516 0.449
MOD_N-GLC_1 418 423 PF02516 0.411
MOD_N-GLC_1 476 481 PF02516 0.523
MOD_NEK2_1 110 115 PF00069 0.390
MOD_NEK2_1 274 279 PF00069 0.382
MOD_NEK2_2 319 324 PF00069 0.380
MOD_NEK2_2 63 68 PF00069 0.305
MOD_PIKK_1 185 191 PF00454 0.659
MOD_PIKK_1 225 231 PF00454 0.589
MOD_PKA_1 203 209 PF00069 0.563
MOD_PKA_1 351 357 PF00069 0.396
MOD_PKA_1 475 481 PF00069 0.460
MOD_PKA_2 203 209 PF00069 0.553
MOD_PKA_2 336 342 PF00069 0.334
MOD_PKA_2 351 357 PF00069 0.396
MOD_PKA_2 475 481 PF00069 0.449
MOD_PKB_1 201 209 PF00069 0.621
MOD_Plk_1 192 198 PF00069 0.559
MOD_Plk_2-3 440 446 PF00069 0.285
MOD_Plk_4 351 357 PF00069 0.394
MOD_Plk_4 36 42 PF00069 0.504
MOD_ProDKin_1 19 25 PF00069 0.379
MOD_ProDKin_1 3 9 PF00069 0.536
MOD_ProDKin_1 314 320 PF00069 0.324
MOD_SUMO_for_1 266 269 PF00179 0.434
MOD_SUMO_for_1 301 304 PF00179 0.324
TRG_DiLeu_BaEn_4 396 402 PF01217 0.340
TRG_ENDOCYTIC_2 340 343 PF00928 0.324
TRG_ENDOCYTIC_2 355 358 PF00928 0.379
TRG_ENDOCYTIC_2 371 374 PF00928 0.369
TRG_ENDOCYTIC_2 402 405 PF00928 0.329
TRG_ENDOCYTIC_2 486 489 PF00928 0.454
TRG_ER_diArg_1 133 135 PF00400 0.387
TRG_ER_diArg_1 201 204 PF00400 0.573
TRG_ER_diArg_1 349 352 PF00400 0.407
TRG_NES_CRM1_1 399 415 PF08389 0.329

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P645 Leptomonas seymouri 80% 100%
A0A0S4JEQ3 Bodo saltans 63% 100%
A0A1X0NG29 Trypanosomatidae 23% 92%
A0A1X0NNW8 Trypanosomatidae 68% 100%
A0A3S7WSB4 Leishmania donovani 100% 100%
A0A422NNY9 Trypanosoma rangeli 66% 100%
A4H723 Leishmania braziliensis 88% 100%
D0A6V7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 64% 100%
E9AP50 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
Q4QGD8 Leishmania major 98% 100%
V5BIC8 Trypanosoma cruzi 67% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS