LeishMANIAdb
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Kinesin-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Kinesin-like protein
Gene product:
Kinesin-13 2
Species:
Leishmania infantum
UniProt:
A4HVE9_LEIIN
TriTrypDb:
LINF_130006200
Length:
726

Annotations

Annotations by Jardim et al.

Structural Proteins, Kinesin-like

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 25
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 19
NetGPI no yes: 0, no: 19
Cellular components
Term Name Level Count
GO:0005874 microtubule 6 14
GO:0099080 supramolecular complex 2 14
GO:0099081 supramolecular polymer 3 14
GO:0099512 supramolecular fiber 4 14
GO:0099513 polymeric cytoskeletal fiber 5 14
GO:0110165 cellular anatomical entity 1 14
GO:0005737 cytoplasm 2 2
GO:0005929 cilium 4 1
GO:0005930 axoneme 2 1
GO:0042995 cell projection 2 1
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 1
GO:0097542 ciliary tip 2 1
GO:0120025 plasma membrane bounded cell projection 3 1
GO:0005730 nucleolus 5 1
GO:0005871 kinesin complex 3 2
GO:0005875 microtubule associated complex 2 2
GO:0032991 protein-containing complex 1 2
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0051286 cell tip 3 1
GO:0060187 cell pole 2 1

Expansion

Sequence features

A4HVE9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVE9

Function

Biological processes
Term Name Level Count
GO:0007017 microtubule-based process 2 20
GO:0007018 microtubule-based movement 3 20
GO:0009987 cellular process 1 20
GO:0000226 microtubule cytoskeleton organization 3 1
GO:0006996 organelle organization 4 1
GO:0007010 cytoskeleton organization 5 1
GO:0007019 microtubule depolymerization 5 1
GO:0010938 cytoplasmic microtubule depolymerization 5 1
GO:0016043 cellular component organization 3 1
GO:0022411 cellular component disassembly 4 1
GO:0022607 cellular component assembly 4 1
GO:0030030 cell projection organization 4 1
GO:0030031 cell projection assembly 5 1
GO:0031109 microtubule polymerization or depolymerization 4 1
GO:0031122 cytoplasmic microtubule organization 4 1
GO:0032984 protein-containing complex disassembly 5 1
GO:0043933 protein-containing complex organization 4 1
GO:0044782 cilium organization 5 1
GO:0051261 protein depolymerization 6 1
GO:0060271 cilium assembly 6 1
GO:0060404 axonemal microtubule depolymerization 6 1
GO:0061523 cilium disassembly 6 1
GO:0070925 organelle assembly 5 1
GO:0071840 cellular component organization or biogenesis 2 1
GO:0097435 supramolecular fiber organization 4 1
GO:0120031 plasma membrane bounded cell projection assembly 6 1
GO:0120036 plasma membrane bounded cell projection organization 5 1
GO:1903008 organelle disassembly 5 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 20
GO:0003774 cytoskeletal motor activity 1 20
GO:0003777 microtubule motor activity 2 20
GO:0005488 binding 1 20
GO:0005515 protein binding 2 20
GO:0005524 ATP binding 5 20
GO:0008017 microtubule binding 5 20
GO:0008092 cytoskeletal protein binding 3 20
GO:0008270 zinc ion binding 6 11
GO:0015631 tubulin binding 4 20
GO:0017076 purine nucleotide binding 4 20
GO:0030554 adenyl nucleotide binding 5 20
GO:0032553 ribonucleotide binding 3 20
GO:0032555 purine ribonucleotide binding 4 20
GO:0032559 adenyl ribonucleotide binding 5 20
GO:0035639 purine ribonucleoside triphosphate binding 4 20
GO:0036094 small molecule binding 2 20
GO:0043167 ion binding 2 20
GO:0043168 anion binding 3 20
GO:0043169 cation binding 3 11
GO:0046872 metal ion binding 4 11
GO:0046914 transition metal ion binding 5 11
GO:0097159 organic cyclic compound binding 2 20
GO:0097367 carbohydrate derivative binding 2 20
GO:0140657 ATP-dependent activity 1 20
GO:1901265 nucleoside phosphate binding 3 20
GO:1901363 heterocyclic compound binding 2 20
GO:0003824 catalytic activity 1 4
GO:0016787 hydrolase activity 2 4
GO:0016462 pyrophosphatase activity 5 2
GO:0016817 hydrolase activity, acting on acid anhydrides 3 2
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 2
GO:0016887 ATP hydrolysis activity 7 2
GO:0017111 ribonucleoside triphosphate phosphatase activity 6 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 275 277 PF00675 0.281
CLV_NRD_NRD_1 297 299 PF00675 0.322
CLV_NRD_NRD_1 36 38 PF00675 0.365
CLV_NRD_NRD_1 432 434 PF00675 0.241
CLV_NRD_NRD_1 501 503 PF00675 0.352
CLV_NRD_NRD_1 504 506 PF00675 0.371
CLV_NRD_NRD_1 705 707 PF00675 0.464
CLV_PCSK_FUR_1 502 506 PF00082 0.458
CLV_PCSK_KEX2_1 275 277 PF00082 0.260
CLV_PCSK_KEX2_1 299 301 PF00082 0.299
CLV_PCSK_KEX2_1 38 40 PF00082 0.388
CLV_PCSK_KEX2_1 383 385 PF00082 0.588
CLV_PCSK_KEX2_1 432 434 PF00082 0.270
CLV_PCSK_KEX2_1 503 505 PF00082 0.429
CLV_PCSK_KEX2_1 705 707 PF00082 0.464
CLV_PCSK_PC1ET2_1 299 301 PF00082 0.280
CLV_PCSK_PC1ET2_1 38 40 PF00082 0.351
CLV_PCSK_PC1ET2_1 383 385 PF00082 0.530
CLV_PCSK_PC1ET2_1 503 505 PF00082 0.465
CLV_PCSK_PC7_1 379 385 PF00082 0.529
CLV_PCSK_SKI1_1 104 108 PF00082 0.280
CLV_PCSK_SKI1_1 283 287 PF00082 0.246
CLV_PCSK_SKI1_1 350 354 PF00082 0.434
CLV_PCSK_SKI1_1 477 481 PF00082 0.389
CLV_PCSK_SKI1_1 558 562 PF00082 0.536
DEG_APCC_DBOX_1 103 111 PF00400 0.239
DEG_APCC_DBOX_1 137 145 PF00400 0.266
DEG_Nend_UBRbox_1 1 4 PF02207 0.594
DEG_SCF_FBW7_1 521 527 PF00400 0.624
DEG_SCF_FBW7_2 72 79 PF00400 0.260
DEG_SPOP_SBC_1 544 548 PF00917 0.793
DOC_CKS1_1 521 526 PF01111 0.626
DOC_CYCLIN_RxL_1 280 290 PF00134 0.246
DOC_CYCLIN_RxL_1 474 484 PF00134 0.470
DOC_CYCLIN_yCln2_LP_2 352 358 PF00134 0.554
DOC_MAPK_gen_1 227 237 PF00069 0.260
DOC_MAPK_gen_1 298 304 PF00069 0.286
DOC_MAPK_MEF2A_6 230 239 PF00069 0.285
DOC_MAPK_RevD_3 490 505 PF00069 0.291
DOC_PP1_RVXF_1 250 256 PF00149 0.373
DOC_PP1_SILK_1 554 559 PF00149 0.515
DOC_PP2B_PxIxI_1 29 35 PF00149 0.390
DOC_USP7_MATH_1 28 32 PF00917 0.476
DOC_USP7_MATH_1 331 335 PF00917 0.271
DOC_USP7_MATH_1 533 537 PF00917 0.611
DOC_USP7_MATH_1 544 548 PF00917 0.604
DOC_USP7_MATH_1 552 556 PF00917 0.580
DOC_USP7_MATH_1 565 569 PF00917 0.767
DOC_USP7_MATH_1 608 612 PF00917 0.710
DOC_USP7_MATH_1 621 625 PF00917 0.532
DOC_WW_Pin1_4 19 24 PF00397 0.566
DOC_WW_Pin1_4 2 7 PF00397 0.728
DOC_WW_Pin1_4 26 31 PF00397 0.563
DOC_WW_Pin1_4 327 332 PF00397 0.321
DOC_WW_Pin1_4 408 413 PF00397 0.338
DOC_WW_Pin1_4 520 525 PF00397 0.519
DOC_WW_Pin1_4 604 609 PF00397 0.625
DOC_WW_Pin1_4 72 77 PF00397 0.305
LIG_14-3-3_CanoR_1 13 21 PF00244 0.689
LIG_14-3-3_CanoR_1 227 237 PF00244 0.283
LIG_14-3-3_CanoR_1 252 256 PF00244 0.246
LIG_14-3-3_CanoR_1 293 298 PF00244 0.359
LIG_14-3-3_CanoR_1 320 329 PF00244 0.288
LIG_14-3-3_CanoR_1 525 532 PF00244 0.746
LIG_14-3-3_CanoR_1 569 578 PF00244 0.741
LIG_14-3-3_CanoR_1 603 608 PF00244 0.667
LIG_14-3-3_CanoR_1 718 722 PF00244 0.433
LIG_Actin_WH2_2 202 219 PF00022 0.260
LIG_Actin_WH2_2 666 682 PF00022 0.517
LIG_BRCT_BRCA1_1 616 620 PF00533 0.638
LIG_FHA_1 145 151 PF00498 0.387
LIG_FHA_1 16 22 PF00498 0.674
LIG_FHA_1 194 200 PF00498 0.280
LIG_FHA_1 308 314 PF00498 0.299
LIG_FHA_1 321 327 PF00498 0.321
LIG_FHA_1 594 600 PF00498 0.565
LIG_FHA_1 710 716 PF00498 0.527
LIG_FHA_1 73 79 PF00498 0.335
LIG_FHA_2 149 155 PF00498 0.289
LIG_FHA_2 252 258 PF00498 0.277
LIG_FHA_2 272 278 PF00498 0.239
LIG_FHA_2 455 461 PF00498 0.453
LIG_FHA_2 62 68 PF00498 0.412
LIG_FHA_2 690 696 PF00498 0.403
LIG_FHA_2 92 98 PF00498 0.313
LIG_GBD_Chelix_1 675 683 PF00786 0.506
LIG_LIR_Apic_2 662 667 PF02991 0.522
LIG_LIR_Gen_1 185 195 PF02991 0.313
LIG_LIR_Gen_1 254 259 PF02991 0.291
LIG_LIR_Gen_1 82 92 PF02991 0.275
LIG_LIR_Nem_3 161 166 PF02991 0.263
LIG_LIR_Nem_3 185 190 PF02991 0.260
LIG_LIR_Nem_3 254 258 PF02991 0.291
LIG_LIR_Nem_3 82 88 PF02991 0.302
LIG_NRBOX 169 175 PF00104 0.246
LIG_PCNA_yPIPBox_3 696 708 PF02747 0.447
LIG_SH2_CRK 171 175 PF00017 0.373
LIG_SH2_CRK 187 191 PF00017 0.313
LIG_SH2_CRK 664 668 PF00017 0.457
LIG_SH2_GRB2like 187 190 PF00017 0.373
LIG_SH2_NCK_1 85 89 PF00017 0.373
LIG_SH2_SRC 187 190 PF00017 0.373
LIG_SH2_SRC 85 88 PF00017 0.373
LIG_SH2_STAP1 142 146 PF00017 0.373
LIG_SH2_STAP1 345 349 PF00017 0.321
LIG_SH2_STAP1 693 697 PF00017 0.398
LIG_SH2_STAP1 85 89 PF00017 0.373
LIG_SH2_STAT5 417 420 PF00017 0.375
LIG_SH2_STAT5 470 473 PF00017 0.425
LIG_SH3_1 37 43 PF00018 0.381
LIG_SH3_2 40 45 PF14604 0.417
LIG_SH3_3 20 26 PF00018 0.556
LIG_SH3_3 352 358 PF00018 0.624
LIG_SH3_3 37 43 PF00018 0.304
LIG_SH3_3 489 495 PF00018 0.419
LIG_SH3_3 62 68 PF00018 0.397
LIG_SH3_3 654 660 PF00018 0.467
LIG_SUMO_SIM_par_1 284 290 PF11976 0.246
LIG_TRAF2_1 457 460 PF00917 0.439
LIG_TRAF2_1 94 97 PF00917 0.266
LIG_TRAF2_2 449 454 PF00917 0.439
LIG_UBA3_1 285 289 PF00899 0.294
MOD_CDC14_SPxK_1 411 414 PF00782 0.339
MOD_CDK_SPK_2 520 525 PF00069 0.630
MOD_CDK_SPK_2 604 609 PF00069 0.515
MOD_CDK_SPxK_1 408 414 PF00069 0.340
MOD_CK1_1 12 18 PF00069 0.713
MOD_CK1_1 126 132 PF00069 0.321
MOD_CK1_1 156 162 PF00069 0.266
MOD_CK1_1 228 234 PF00069 0.335
MOD_CK1_1 307 313 PF00069 0.299
MOD_CK1_1 5 11 PF00069 0.694
MOD_CK1_1 536 542 PF00069 0.595
MOD_CK1_1 545 551 PF00069 0.586
MOD_CK1_1 567 573 PF00069 0.663
MOD_CK1_1 607 613 PF00069 0.652
MOD_CK1_1 717 723 PF00069 0.562
MOD_CK1_1 81 87 PF00069 0.313
MOD_CK2_1 148 154 PF00069 0.391
MOD_CK2_1 158 164 PF00069 0.295
MOD_CK2_1 271 277 PF00069 0.339
MOD_CK2_1 331 337 PF00069 0.271
MOD_CK2_1 454 460 PF00069 0.494
MOD_CK2_1 61 67 PF00069 0.444
MOD_CK2_1 91 97 PF00069 0.266
MOD_GlcNHglycan 125 128 PF01048 0.321
MOD_GlcNHglycan 533 536 PF01048 0.524
MOD_GlcNHglycan 558 561 PF01048 0.657
MOD_GlcNHglycan 610 613 PF01048 0.624
MOD_GlcNHglycan 616 619 PF01048 0.608
MOD_GlcNHglycan 644 649 PF01048 0.578
MOD_GSK3_1 128 135 PF00069 0.350
MOD_GSK3_1 140 147 PF00069 0.210
MOD_GSK3_1 15 22 PF00069 0.686
MOD_GSK3_1 150 157 PF00069 0.310
MOD_GSK3_1 258 265 PF00069 0.343
MOD_GSK3_1 267 274 PF00069 0.366
MOD_GSK3_1 327 334 PF00069 0.333
MOD_GSK3_1 422 429 PF00069 0.411
MOD_GSK3_1 5 12 PF00069 0.727
MOD_GSK3_1 520 527 PF00069 0.549
MOD_GSK3_1 533 540 PF00069 0.570
MOD_GSK3_1 542 549 PF00069 0.639
MOD_GSK3_1 552 559 PF00069 0.657
MOD_GSK3_1 561 568 PF00069 0.655
MOD_GSK3_1 593 600 PF00069 0.646
MOD_GSK3_1 603 610 PF00069 0.622
MOD_GSK3_1 709 716 PF00069 0.486
MOD_N-GLC_1 243 248 PF02516 0.496
MOD_N-GLC_1 281 286 PF02516 0.321
MOD_N-GLC_1 515 520 PF02516 0.435
MOD_N-GLC_1 621 626 PF02516 0.757
MOD_N-GLC_2 652 654 PF02516 0.553
MOD_NEK2_1 121 126 PF00069 0.256
MOD_NEK2_1 158 163 PF00069 0.287
MOD_NEK2_1 304 309 PF00069 0.301
MOD_NEK2_1 313 318 PF00069 0.285
MOD_NEK2_1 537 542 PF00069 0.585
MOD_NEK2_1 543 548 PF00069 0.588
MOD_NEK2_1 599 604 PF00069 0.554
MOD_NEK2_1 614 619 PF00069 0.597
MOD_NEK2_1 679 684 PF00069 0.562
MOD_NEK2_1 689 694 PF00069 0.469
MOD_NEK2_2 61 66 PF00069 0.468
MOD_PIKK_1 245 251 PF00454 0.413
MOD_PIKK_1 307 313 PF00454 0.265
MOD_PIKK_1 454 460 PF00454 0.420
MOD_PIKK_1 537 543 PF00454 0.768
MOD_PIKK_1 621 627 PF00454 0.707
MOD_PIKK_1 7 13 PF00454 0.576
MOD_PK_1 424 430 PF00069 0.326
MOD_PKA_2 12 18 PF00069 0.824
MOD_PKA_2 226 232 PF00069 0.346
MOD_PKA_2 251 257 PF00069 0.267
MOD_PKA_2 262 268 PF00069 0.311
MOD_PKA_2 304 310 PF00069 0.289
MOD_PKA_2 313 319 PF00069 0.321
MOD_PKA_2 454 460 PF00069 0.420
MOD_PKA_2 524 530 PF00069 0.702
MOD_PKA_2 568 574 PF00069 0.693
MOD_PKA_2 608 614 PF00069 0.554
MOD_PKA_2 717 723 PF00069 0.583
MOD_Plk_1 153 159 PF00069 0.439
MOD_Plk_1 281 287 PF00069 0.321
MOD_Plk_1 336 342 PF00069 0.246
MOD_Plk_2-3 148 154 PF00069 0.266
MOD_Plk_4 128 134 PF00069 0.285
MOD_Plk_4 158 164 PF00069 0.326
MOD_Plk_4 28 34 PF00069 0.587
MOD_Plk_4 281 287 PF00069 0.321
MOD_Plk_4 313 319 PF00069 0.315
MOD_Plk_4 552 558 PF00069 0.494
MOD_Plk_4 61 67 PF00069 0.428
MOD_Plk_4 653 659 PF00069 0.519
MOD_ProDKin_1 19 25 PF00069 0.561
MOD_ProDKin_1 2 8 PF00069 0.727
MOD_ProDKin_1 26 32 PF00069 0.544
MOD_ProDKin_1 327 333 PF00069 0.321
MOD_ProDKin_1 408 414 PF00069 0.340
MOD_ProDKin_1 520 526 PF00069 0.520
MOD_ProDKin_1 604 610 PF00069 0.623
MOD_ProDKin_1 72 78 PF00069 0.305
MOD_SUMO_rev_2 176 183 PF00179 0.335
MOD_SUMO_rev_2 231 239 PF00179 0.328
MOD_SUMO_rev_2 265 274 PF00179 0.381
MOD_SUMO_rev_2 347 355 PF00179 0.291
MOD_SUMO_rev_2 402 411 PF00179 0.338
MOD_SUMO_rev_2 460 466 PF00179 0.439
TRG_DiLeu_BaLyEn_6 102 107 PF01217 0.246
TRG_ENDOCYTIC_2 171 174 PF00928 0.390
TRG_ENDOCYTIC_2 187 190 PF00928 0.345
TRG_ENDOCYTIC_2 85 88 PF00928 0.410
TRG_ER_diArg_1 297 300 PF00400 0.313
TRG_ER_diArg_1 36 39 PF00400 0.428
TRG_ER_diArg_1 501 504 PF00400 0.417
TRG_ER_diArg_1 704 706 PF00400 0.460
TRG_NES_CRM1_1 249 262 PF08389 0.333
TRG_NLS_MonoCore_2 37 42 PF00514 0.389
TRG_NLS_MonoCore_2 501 506 PF00514 0.452
TRG_NLS_MonoExtC_3 36 41 PF00514 0.359
TRG_NLS_MonoExtC_3 501 507 PF00514 0.377
TRG_NLS_MonoExtN_4 37 42 PF00514 0.370
TRG_Pf-PMV_PEXEL_1 104 108 PF00026 0.220
TRG_Pf-PMV_PEXEL_1 421 426 PF00026 0.349
TRG_Pf-PMV_PEXEL_1 450 454 PF00026 0.321

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P647 Leptomonas seymouri 70% 99%
A0A0S4IJP8 Bodo saltans 50% 97%
A0A1X0NNY0 Trypanosomatidae 64% 100%
A0A3Q8IEL2 Leishmania donovani 30% 100%
A0A3S7WS99 Leishmania donovani 100% 100%
A0A3S7X9Y1 Leishmania donovani 32% 100%
A0A422NBP2 Trypanosoma rangeli 64% 100%
A4H720 Leishmania braziliensis 86% 100%
A4HND6 Leishmania braziliensis 31% 100%
A4I4V3 Leishmania infantum 30% 100%
A4IC09 Leishmania infantum 32% 100%
D0A6W1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 43% 100%
E9AEA1 Leishmania major 30% 100%
E9AFU7 Leishmania major 32% 100%
E9ALI5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
E9AP47 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
E9B6Z9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
Q4QGE1 Leishmania major 95% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS