LeishMANIAdb
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Putative carboxypeptidase

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative carboxypeptidase
Gene product:
carboxypeptidase - putative
Species:
Leishmania infantum
UniProt:
A4HVE5_LEIIN
TriTrypDb:
LINF_130005800
Length:
503

Annotations

Annotations by Jardim et al.

Proteases, carboxypeptidase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 1
Forrest at al. (metacyclic) yes yes: 3
Forrest at al. (procyclic) yes yes: 3
Silverman et al. no yes: 2
Pissara et al. yes yes: 12
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 9
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 6
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 24
NetGPI no yes: 0, no: 24
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0005829 cytosol 2 1
GO:0110165 cellular anatomical entity 1 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HVE5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVE5

Function

Biological processes
Term Name Level Count
GO:0006508 proteolysis 4 25
GO:0006807 nitrogen compound metabolic process 2 25
GO:0008152 metabolic process 1 25
GO:0019538 protein metabolic process 3 25
GO:0043170 macromolecule metabolic process 3 25
GO:0044238 primary metabolic process 2 25
GO:0071704 organic substance metabolic process 2 25
GO:1901564 organonitrogen compound metabolic process 3 25
GO:0006518 peptide metabolic process 4 1
GO:0043603 amide metabolic process 3 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 25
GO:0004180 carboxypeptidase activity 5 25
GO:0004181 metallocarboxypeptidase activity 6 25
GO:0008233 peptidase activity 3 25
GO:0008235 metalloexopeptidase activity 5 25
GO:0008237 metallopeptidase activity 4 25
GO:0008238 exopeptidase activity 4 25
GO:0016787 hydrolase activity 2 25
GO:0140096 catalytic activity, acting on a protein 2 25
GO:0016853 isomerase activity 2 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 138 140 PF00675 0.391
CLV_NRD_NRD_1 496 498 PF00675 0.337
CLV_NRD_NRD_1 86 88 PF00675 0.297
CLV_PCSK_KEX2_1 138 140 PF00082 0.391
CLV_PCSK_KEX2_1 496 498 PF00082 0.309
CLV_PCSK_KEX2_1 86 88 PF00082 0.303
CLV_PCSK_SKI1_1 171 175 PF00082 0.449
CLV_PCSK_SKI1_1 258 262 PF00082 0.358
CLV_PCSK_SKI1_1 290 294 PF00082 0.437
CLV_PCSK_SKI1_1 61 65 PF00082 0.355
DEG_Nend_UBRbox_3 1 3 PF02207 0.498
DOC_CYCLIN_RxL_1 168 178 PF00134 0.211
DOC_CYCLIN_RxL_1 255 263 PF00134 0.351
DOC_MAPK_gen_1 13 23 PF00069 0.279
DOC_MAPK_gen_1 387 394 PF00069 0.315
DOC_PP4_FxxP_1 315 318 PF00568 0.249
DOC_USP7_MATH_1 25 29 PF00917 0.274
DOC_USP7_UBL2_3 459 463 PF12436 0.288
DOC_USP7_UBL2_3 9 13 PF12436 0.360
DOC_WW_Pin1_4 107 112 PF00397 0.205
DOC_WW_Pin1_4 54 59 PF00397 0.302
LIG_14-3-3_CanoR_1 144 152 PF00244 0.173
LIG_14-3-3_CanoR_1 246 253 PF00244 0.426
LIG_14-3-3_CanoR_1 86 96 PF00244 0.348
LIG_BRCT_BRCA1_1 308 312 PF00533 0.266
LIG_CtBP_PxDLS_1 278 282 PF00389 0.343
LIG_deltaCOP1_diTrp_1 219 225 PF00928 0.369
LIG_deltaCOP1_diTrp_1 407 415 PF00928 0.315
LIG_eIF4E_1 15 21 PF01652 0.232
LIG_eIF4E_1 356 362 PF01652 0.230
LIG_eIF4E_1 471 477 PF01652 0.422
LIG_FHA_1 107 113 PF00498 0.230
LIG_FHA_1 255 261 PF00498 0.430
LIG_FHA_1 418 424 PF00498 0.272
LIG_FHA_1 471 477 PF00498 0.305
LIG_FHA_1 58 64 PF00498 0.382
LIG_FHA_2 247 253 PF00498 0.340
LIG_FHA_2 261 267 PF00498 0.365
LIG_FHA_2 291 297 PF00498 0.205
LIG_FHA_2 3 9 PF00498 0.434
LIG_LIR_Apic_2 314 318 PF02991 0.315
LIG_LIR_Gen_1 122 130 PF02991 0.411
LIG_LIR_Gen_1 299 306 PF02991 0.292
LIG_LIR_Gen_1 309 320 PF02991 0.257
LIG_LIR_Gen_1 97 106 PF02991 0.197
LIG_LIR_Nem_3 122 126 PF02991 0.288
LIG_LIR_Nem_3 154 160 PF02991 0.403
LIG_LIR_Nem_3 299 304 PF02991 0.371
LIG_LIR_Nem_3 309 315 PF02991 0.299
LIG_LIR_Nem_3 46 51 PF02991 0.259
LIG_LIR_Nem_3 97 102 PF02991 0.197
LIG_NRBOX 16 22 PF00104 0.249
LIG_PCNA_PIPBox_1 210 219 PF02747 0.327
LIG_PCNA_yPIPBox_3 382 392 PF02747 0.310
LIG_Pex14_1 221 225 PF04695 0.215
LIG_PTB_Apo_2 483 490 PF02174 0.315
LIG_PTB_Phospho_1 483 489 PF10480 0.315
LIG_SH2_CRK 48 52 PF00017 0.173
LIG_SH2_STAP1 153 157 PF00017 0.300
LIG_SH2_STAP1 89 93 PF00017 0.230
LIG_SH2_STAT3 251 254 PF00017 0.360
LIG_SH2_STAT3 498 501 PF00017 0.287
LIG_SH2_STAT3 89 92 PF00017 0.230
LIG_SH2_STAT5 323 326 PF00017 0.239
LIG_SH2_STAT5 391 394 PF00017 0.261
LIG_SH2_STAT5 4 7 PF00017 0.237
LIG_SH2_STAT5 417 420 PF00017 0.309
LIG_SH2_STAT5 489 492 PF00017 0.406
LIG_SH2_STAT5 493 496 PF00017 0.427
LIG_SH2_STAT5 498 501 PF00017 0.288
LIG_SH2_STAT5 89 92 PF00017 0.464
LIG_SH3_3 195 201 PF00018 0.207
LIG_SH3_3 351 357 PF00018 0.307
LIG_SUMO_SIM_par_1 172 178 PF11976 0.377
LIG_UBA3_1 431 436 PF00899 0.422
LIG_WRC_WIRS_1 123 128 PF05994 0.346
MOD_CDK_SPxxK_3 54 61 PF00069 0.205
MOD_CK1_1 107 113 PF00069 0.325
MOD_CK1_1 145 151 PF00069 0.333
MOD_CK1_1 162 168 PF00069 0.188
MOD_CK1_1 245 251 PF00069 0.230
MOD_CK1_1 422 428 PF00069 0.463
MOD_CK1_1 57 63 PF00069 0.228
MOD_CK2_1 2 8 PF00069 0.412
MOD_CK2_1 260 266 PF00069 0.435
MOD_CK2_1 267 273 PF00069 0.469
MOD_CK2_1 290 296 PF00069 0.205
MOD_GlcNHglycan 161 164 PF01048 0.325
MOD_GlcNHglycan 226 229 PF01048 0.283
MOD_GlcNHglycan 309 312 PF01048 0.239
MOD_GSK3_1 242 249 PF00069 0.438
MOD_GSK3_1 260 267 PF00069 0.449
MOD_GSK3_1 27 34 PF00069 0.385
MOD_GSK3_1 290 297 PF00069 0.316
MOD_GSK3_1 53 60 PF00069 0.305
MOD_GSK3_1 97 104 PF00069 0.241
MOD_LATS_1 269 275 PF00433 0.230
MOD_N-GLC_1 338 343 PF02516 0.382
MOD_NEK2_1 106 111 PF00069 0.382
MOD_NEK2_1 260 265 PF00069 0.332
MOD_NEK2_1 338 343 PF00069 0.403
MOD_NEK2_1 431 436 PF00069 0.235
MOD_NEK2_1 88 93 PF00069 0.332
MOD_PIKK_1 2 8 PF00454 0.461
MOD_PIKK_1 294 300 PF00454 0.365
MOD_PIKK_1 463 469 PF00454 0.419
MOD_PIKK_1 88 94 PF00454 0.317
MOD_PKA_2 143 149 PF00069 0.173
MOD_PKA_2 245 251 PF00069 0.305
MOD_Plk_1 242 248 PF00069 0.413
MOD_Plk_1 338 344 PF00069 0.356
MOD_Plk_1 440 446 PF00069 0.230
MOD_Plk_1 72 78 PF00069 0.432
MOD_Plk_1 97 103 PF00069 0.199
MOD_Plk_4 122 128 PF00069 0.411
MOD_Plk_4 175 181 PF00069 0.318
MOD_Plk_4 27 33 PF00069 0.329
MOD_Plk_4 422 428 PF00069 0.307
MOD_ProDKin_1 107 113 PF00069 0.205
MOD_ProDKin_1 54 60 PF00069 0.302
MOD_SUMO_for_1 435 438 PF00179 0.230
MOD_SUMO_for_1 70 73 PF00179 0.307
MOD_SUMO_rev_2 170 178 PF00179 0.358
MOD_SUMO_rev_2 22 31 PF00179 0.205
TRG_DiLeu_BaEn_1 333 338 PF01217 0.230
TRG_DiLeu_BaEn_1 46 51 PF01217 0.382
TRG_DiLeu_BaLyEn_6 108 113 PF01217 0.230
TRG_DiLeu_BaLyEn_6 315 320 PF01217 0.351
TRG_ENDOCYTIC_2 153 156 PF00928 0.307
TRG_ENDOCYTIC_2 391 394 PF00928 0.310
TRG_ENDOCYTIC_2 4 7 PF00928 0.329
TRG_ENDOCYTIC_2 48 51 PF00928 0.173
TRG_ER_diArg_1 347 350 PF00400 0.332
TRG_ER_diArg_1 496 498 PF00400 0.309
TRG_ER_diArg_1 85 87 PF00400 0.297
TRG_Pf-PMV_PEXEL_1 150 154 PF00026 0.369
TRG_Pf-PMV_PEXEL_1 215 219 PF00026 0.300
TRG_Pf-PMV_PEXEL_1 368 372 PF00026 0.300
TRG_Pf-PMV_PEXEL_1 497 501 PF00026 0.456

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0S4IZ28 Bodo saltans 45% 100%
A0A1X0NY67 Trypanosomatidae 53% 99%
A0A1X0P441 Trypanosomatidae 56% 100%
A0A1X0P598 Trypanosomatidae 57% 100%
A0A3Q8IBW2 Leishmania donovani 53% 100%
A0A3Q8IJY8 Leishmania donovani 49% 100%
A0A3Q8IU74 Leishmania donovani 55% 100%
A0A3S7WSA3 Leishmania donovani 100% 100%
A0A422P042 Trypanosoma rangeli 54% 100%
A0A422P4R1 Trypanosoma rangeli 54% 100%
A4H716 Leishmania braziliensis 81% 100%
A4HLW4 Leishmania braziliensis 55% 100%
A4HVW0 Leishmania infantum 53% 100%
A4I993 Leishmania infantum 55% 100%
A4IC85 Leishmania infantum 49% 100%
D0A656 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 54% 100%
E9AP43 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
E9B493 Leishmania mexicana (strain MHOM/GT/2001/U1103) 54% 100%
P42663 Thermus aquaticus 36% 98%
P50848 Bacillus subtilis (strain 168) 33% 100%
Q4Q0D4 Leishmania major 51% 100%
Q4Q3T3 Leishmania major 55% 100%
Q4QFW7 Leishmania major 53% 100%
Q4QGE5 Leishmania major 95% 100%
Q5SLM3 Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) 35% 99%
Q8U3L0 Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) 35% 100%
V5DQA0 Trypanosoma cruzi 55% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS