Ribonuclease

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Ribonuclease

Gene product:

ribonuclease HII - putative

Species:

Leishmania infantum

UniProt:

A4HVE1_LEIIN

TriTrypDb:

LINF_130005400

Length:

268

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	7
GO:0110165	cellular anatomical entity	1	7
GO:0032299	ribonuclease H2 complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

A4HVE1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVE1

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006281	DNA repair	5	1
GO:0006298	mismatch repair	6	1
GO:0006401	RNA catabolic process	5	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0019439	aromatic compound catabolic process	4	1
GO:0033554	cellular response to stress	3	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034655	nucleobase-containing compound catabolic process	4	1
GO:0043137	DNA replication, removal of RNA primer	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0044270	cellular nitrogen compound catabolic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046700	heterocycle catabolic process	4	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901361	organic cyclic compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0003824	catalytic activity	1	7
GO:0004518	nuclease activity	4	7
GO:0004519	endonuclease activity	5	7
GO:0004521	RNA endonuclease activity	5	7
GO:0004523	RNA-DNA hybrid ribonuclease activity	7	7
GO:0004540	RNA nuclease activity	4	7
GO:0005488	binding	1	7
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0016891	RNA endonuclease activity, producing 5'-phosphomonoesters	6	7
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0097159	organic cyclic compound binding	2	7
GO:0140098	catalytic activity, acting on RNA	3	7
GO:0140640	catalytic activity, acting on a nucleic acid	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	44	48	PF00656	0.485
CLV_C14_Caspase3-7	57	61	PF00656	0.429
CLV_NRD_NRD_1	152	154	PF00675	0.261
CLV_NRD_NRD_1	157	159	PF00675	0.282
CLV_NRD_NRD_1	70	72	PF00675	0.295
CLV_PCSK_KEX2_1	159	161	PF00082	0.254
CLV_PCSK_KEX2_1	257	259	PF00082	0.567
CLV_PCSK_KEX2_1	70	72	PF00082	0.295
CLV_PCSK_PC1ET2_1	159	161	PF00082	0.254
CLV_PCSK_PC1ET2_1	257	259	PF00082	0.567
CLV_PCSK_SKI1_1	27	31	PF00082	0.314
CLV_PCSK_SKI1_1	90	94	PF00082	0.314
DEG_APCC_DBOX_1	70	78	PF00400	0.514
DOC_MAPK_gen_1	194	204	PF00069	0.454
DOC_USP7_MATH_1	187	191	PF00917	0.462
DOC_WW_Pin1_4	118	123	PF00397	0.454
DOC_WW_Pin1_4	14	19	PF00397	0.454
DOC_WW_Pin1_4	256	261	PF00397	0.555
LIG_14-3-3_CanoR_1	13	21	PF00244	0.454
LIG_14-3-3_CanoR_1	133	139	PF00244	0.454
LIG_14-3-3_CanoR_1	258	264	PF00244	0.568
LIG_BIR_II_1	1	5	PF00653	0.325
LIG_BIR_III_1	1	5	PF00653	0.325
LIG_BIR_III_3	1	5	PF00653	0.325
LIG_FHA_1	122	128	PF00498	0.518
LIG_FHA_1	172	178	PF00498	0.557
LIG_FHA_1	60	66	PF00498	0.421
LIG_FHA_2	55	61	PF00498	0.514
LIG_LIR_Gen_1	110	117	PF02991	0.514
LIG_LIR_Gen_1	235	245	PF02991	0.551
LIG_LIR_Nem_3	110	114	PF02991	0.496
LIG_LIR_Nem_3	164	168	PF02991	0.514
LIG_LIR_Nem_3	235	240	PF02991	0.509
LIG_LIR_Nem_3	241	245	PF02991	0.452
LIG_LYPXL_yS_3	165	168	PF13949	0.514
LIG_SH2_CRK	111	115	PF00017	0.496
LIG_SH2_CRK	242	246	PF00017	0.472
LIG_SH2_NCK_1	111	115	PF00017	0.459
LIG_SH2_SRC	242	245	PF00017	0.454
LIG_SH2_STAP1	200	204	PF00017	0.438
LIG_SH2_STAT5	220	223	PF00017	0.454
LIG_SH3_3	160	166	PF00018	0.496
LIG_SUMO_SIM_anti_2	83	89	PF11976	0.454
LIG_SUMO_SIM_par_1	80	85	PF11976	0.514
LIG_TRAF2_1	140	143	PF00917	0.514
LIG_TYR_ITIM	163	168	PF00017	0.514
LIG_TYR_ITIM	19	24	PF00017	0.431
LIG_TYR_ITIM	240	245	PF00017	0.454
MOD_CDK_SPxK_1	14	20	PF00069	0.514
MOD_CK2_1	137	143	PF00069	0.514
MOD_GlcNHglycan	100	103	PF01048	0.379
MOD_GlcNHglycan	114	117	PF01048	0.224
MOD_GlcNHglycan	139	142	PF01048	0.277
MOD_GlcNHglycan	14	17	PF01048	0.254
MOD_GlcNHglycan	252	255	PF01048	0.525
MOD_GSK3_1	112	119	PF00069	0.475
MOD_GSK3_1	259	266	PF00069	0.499
MOD_N-GLC_1	93	98	PF02516	0.254
MOD_NEK2_1	171	176	PF00069	0.514
MOD_NEK2_1	263	268	PF00069	0.519
MOD_NEK2_1	53	58	PF00069	0.539
MOD_PKA_2	12	18	PF00069	0.454
MOD_Plk_1	179	185	PF00069	0.566
MOD_Plk_1	82	88	PF00069	0.494
MOD_Plk_1	93	99	PF00069	0.424
MOD_Plk_4	172	178	PF00069	0.531
MOD_Plk_4	179	185	PF00069	0.466
MOD_Plk_4	187	193	PF00069	0.400
MOD_Plk_4	200	206	PF00069	0.454
MOD_Plk_4	7	13	PF00069	0.454
MOD_Plk_4	82	88	PF00069	0.455
MOD_ProDKin_1	118	124	PF00069	0.454
MOD_ProDKin_1	14	20	PF00069	0.454
MOD_ProDKin_1	256	262	PF00069	0.604
MOD_SUMO_rev_2	253	259	PF00179	0.510
TRG_ENDOCYTIC_2	111	114	PF00928	0.514
TRG_ENDOCYTIC_2	165	168	PF00928	0.514
TRG_ENDOCYTIC_2	21	24	PF00928	0.477
TRG_ENDOCYTIC_2	242	245	PF00928	0.477
TRG_ER_diArg_1	144	147	PF00400	0.549
TRG_ER_diArg_1	158	161	PF00400	0.400

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHU4	Leptomonas seymouri	65%	94%
A0A0S4J8A1	Bodo saltans	28%	100%
A0A3S7WSB6	Leishmania donovani	100%	100%
A0JXT5	Arthrobacter sp. (strain FB24)	31%	100%
A1B3V0	Paracoccus denitrificans (strain Pd 1222)	30%	100%
A1K6Q7	Azoarcus sp. (strain BH72)	34%	100%
A1VN54	Polaromonas naphthalenivorans (strain CJ2)	31%	100%
A2SH85	Methylibium petroleiphilum (strain ATCC BAA-1232 / LMG 22953 / PM1)	31%	100%
A3QG89	Shewanella loihica (strain ATCC BAA-1088 / PV-4)	34%	100%
A4H713	Leishmania braziliensis	80%	100%
A4VJT5	Pseudomonas stutzeri (strain A1501)	30%	100%
A5G7Z2	Geotalea uraniireducens (strain Rf4)	31%	100%
A5VF46	Rhizorhabdus wittichii (strain DSM 6014 / CCUG 31198 / JCM 15750 / NBRC 105917 / EY 4224 / RW1)	33%	100%
A5WDY2	Psychrobacter sp. (strain PRwf-1)	36%	89%
A6GYW0	Flavobacterium psychrophilum (strain ATCC 49511 / DSM 21280 / CIP 103535 / JIP02/86)	30%	100%
A6VUT6	Marinomonas sp. (strain MWYL1)	29%	100%
A7HQZ3	Parvibaculum lavamentivorans (strain DS-1 / DSM 13023 / NCIMB 13966)	29%	100%
A9KGD3	Coxiella burnetii (strain Dugway 5J108-111)	28%	100%
A9N8L5	Coxiella burnetii (strain RSA 331 / Henzerling II)	28%	100%
B0CAM1	Acaryochloris marina (strain MBIC 11017)	31%	100%
B0U235	Xylella fastidiosa (strain M12)	31%	100%
B1IQF8	Escherichia coli (strain ATCC 8739 / DSM 1576 / NBRC 3972 / NCIMB 8545 / WDCM 00012 / Crooks)	31%	100%
B1JBP6	Pseudomonas putida (strain W619)	30%	100%
B1LGY5	Escherichia coli (strain SMS-3-5 / SECEC)	31%	100%
B2I7N7	Xylella fastidiosa (strain M23)	31%	100%
B2U326	Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)	32%	100%
B3CM59	Wolbachia pipientis subsp. Culex pipiens (strain wPip)	26%	100%
B3PRG0	Rhizobium etli (strain CIAT 652)	35%	100%
B3QRP3	Chloroherpeton thalassium (strain ATCC 35110 / GB-78)	29%	100%
B5EBC6	Citrifermentans bemidjiense (strain ATCC BAA-1014 / DSM 16622 / JCM 12645 / Bem)	30%	100%
B5Z0G2	Escherichia coli O157:H7 (strain EC4115 / EHEC)	32%	100%
B5ZS20	Rhizobium leguminosarum bv. trifolii (strain WSM2304)	34%	100%
B6IZE4	Coxiella burnetii (strain CbuG_Q212)	28%	100%
B6J7Z2	Coxiella burnetii (strain CbuK_Q154)	28%	100%
B7LW62	Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CCUG 18766 / IAM 14443 / JCM 21226 / LMG 7866 / NBRC 102419 / NCTC 12128 / CDC 0568-73)	32%	100%
B7MP43	Escherichia coli O81 (strain ED1a)	31%	100%
B7N850	Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)	31%	100%
B7NIE5	Escherichia coli O7:K1 (strain IAI39 / ExPEC)	32%	100%
B7UJ84	Escherichia coli O127:H6 (strain E2348/69 / EPEC)	31%	100%
B7V7U6	Pseudomonas aeruginosa (strain LESB58)	32%	100%
E9AP39	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q02RB4	Pseudomonas aeruginosa (strain UCBPP-PA14)	31%	100%
Q0A7J3	Alkalilimnicola ehrlichii (strain ATCC BAA-1101 / DSM 17681 / MLHE-1)	33%	100%
Q0AWX1	Syntrophomonas wolfei subsp. wolfei (strain DSM 2245B / Goettingen)	30%	100%
Q0BQZ6	Granulibacter bethesdensis (strain ATCC BAA-1260 / CGDNIH1)	30%	100%
Q0BYK9	Hyphomonas neptunium (strain ATCC 15444)	31%	100%
Q0TLF0	Escherichia coli O6:K15:H31 (strain 536 / UPEC)	31%	100%
Q12NX3	Shewanella denitrificans (strain OS217 / ATCC BAA-1090 / DSM 15013)	31%	100%
Q18BC9	Clostridioides difficile (strain 630)	26%	100%
Q1G9U8	Lactobacillus delbrueckii subsp. bulgaricus (strain ATCC 11842 / DSM 20081 / BCRC 10696 / JCM 1002 / NBRC 13953 / NCIMB 11778 / NCTC 12712 / WDCM 00102 / Lb 14)	31%	100%
Q1MKS7	Rhizobium leguminosarum bv. viciae (strain 3841)	35%	100%
Q1QAL9	Psychrobacter cryohalolentis (strain ATCC BAA-1226 / DSM 17306 / VKM B-2378 / K5)	36%	94%
Q2GFP8	Ehrlichia chaffeensis (strain ATCC CRL-10679 / Arkansas)	27%	100%
Q2KBV7	Rhizobium etli (strain CFN 42 / ATCC 51251)	34%	100%
Q325V7	Shigella boydii serotype 4 (strain Sb227)	32%	100%
Q3YST1	Ehrlichia canis (strain Jake)	26%	100%
Q470F1	Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197)	29%	100%
Q4FPF7	Pelagibacter ubique (strain HTCC1062)	26%	100%
Q4QGE9	Leishmania major	96%	100%
Q50412	Magnetospirillum magneticum (strain AMB-1 / ATCC 700264)	30%	100%
Q5LIL2	Bacteroides fragilis (strain ATCC 25285 / DSM 2151 / CCUG 4856 / JCM 11019 / NCTC 9343 / Onslow)	32%	100%
Q5NZG1	Aromatoleum aromaticum (strain EbN1)	33%	100%
Q64ZN7	Bacteroides fragilis (strain YCH46)	32%	100%
Q6G4E3	Bartonella henselae (strain ATCC 49882 / DSM 28221 / Houston 1)	27%	100%
Q6MLA0	Bdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIMB 9529 / HD100)	28%	100%
Q82U06	Nitrosomonas europaea (strain ATCC 19718 / CIP 103999 / KCTC 2705 / NBRC 14298)	33%	100%
Q83BZ8	Coxiella burnetii (strain RSA 493 / Nine Mile phase I)	28%	100%
Q87EI6	Xylella fastidiosa (strain Temecula1 / ATCC 700964)	31%	100%
Q8A293	Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 / VPI-5482 / E50)	31%	100%
Q8EQZ4	Oceanobacillus iheyensis (strain DSM 14371 / CIP 107618 / JCM 11309 / KCTC 3954 / HTE831)	26%	100%
Q8FL06	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	31%	100%
Q8PML9	Xanthomonas axonopodis pv. citri (strain 306)	34%	100%
Q8X8X6	Escherichia coli O157:H7	32%	100%
Q9HXY9	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	31%	100%
Q9PEI7	Xylella fastidiosa (strain 9a5c)	31%	100%
Q9Z962	Chlamydia pneumoniae	28%	100%