Cis-prenyltransferase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cis-prenyltransferase-like protein

Species:

Leishmania infantum

UniProt:

A4HVD8_LEIIN

TriTrypDb:

LINF_130005100

Length:

391

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	1
GO:0016020	membrane	2	10
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A4HVD8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVD8

Function

Biological processes
Term	Name	Level	Count
GO:0006066	alcohol metabolic process	3	1
GO:0006629	lipid metabolic process	3	1
GO:0006720	isoprenoid metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0008299	isoprenoid biosynthetic process	4	1
GO:0008610	lipid biosynthetic process	4	1
GO:0009058	biosynthetic process	2	1
GO:0009987	cellular process	1	1
GO:0016093	polyprenol metabolic process	4	1
GO:0016094	polyprenol biosynthetic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0044283	small molecule biosynthetic process	3	1
GO:0046165	alcohol biosynthetic process	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901576	organic substance biosynthetic process	3	1
GO:1901615	organic hydroxy compound metabolic process	3	1
GO:1901617	organic hydroxy compound biosynthetic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004659	prenyltransferase activity	4	6
GO:0008834	di-trans,poly-cis-decaprenylcistransferase activity	5	5
GO:0016740	transferase activity	2	12
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	3	12
GO:0002094	polyprenyltransferase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	157	161	PF00656	0.211
CLV_NRD_NRD_1	103	105	PF00675	0.514
CLV_NRD_NRD_1	215	217	PF00675	0.460
CLV_NRD_NRD_1	257	259	PF00675	0.451
CLV_NRD_NRD_1	283	285	PF00675	0.476
CLV_NRD_NRD_1	384	386	PF00675	0.421
CLV_NRD_NRD_1	387	389	PF00675	0.414
CLV_NRD_NRD_1	99	101	PF00675	0.484
CLV_PCSK_FUR_1	146	150	PF00082	0.423
CLV_PCSK_FUR_1	385	389	PF00082	0.408
CLV_PCSK_KEX2_1	103	105	PF00082	0.514
CLV_PCSK_KEX2_1	148	150	PF00082	0.501
CLV_PCSK_KEX2_1	257	259	PF00082	0.427
CLV_PCSK_KEX2_1	283	285	PF00082	0.451
CLV_PCSK_KEX2_1	384	386	PF00082	0.410
CLV_PCSK_KEX2_1	387	389	PF00082	0.406
CLV_PCSK_KEX2_1	99	101	PF00082	0.484
CLV_PCSK_PC1ET2_1	148	150	PF00082	0.512
CLV_PCSK_PC1ET2_1	387	389	PF00082	0.479
CLV_PCSK_PC7_1	279	285	PF00082	0.512
CLV_PCSK_PC7_1	99	105	PF00082	0.545
CLV_PCSK_SKI1_1	217	221	PF00082	0.462
CLV_PCSK_SKI1_1	222	226	PF00082	0.421
CLV_PCSK_SKI1_1	258	262	PF00082	0.476
CLV_PCSK_SKI1_1	308	312	PF00082	0.416
CLV_PCSK_SKI1_1	376	380	PF00082	0.423
CLV_PCSK_SKI1_1	74	78	PF00082	0.677
CLV_Separin_Metazoa	309	313	PF03568	0.275
DEG_APCC_DBOX_1	307	315	PF00400	0.299
DEG_Nend_Nbox_1	1	3	PF02207	0.691
DOC_MAPK_gen_1	257	265	PF00069	0.237
DOC_MAPK_MEF2A_6	257	265	PF00069	0.232
DOC_PP1_RVXF_1	237	244	PF00149	0.254
DOC_PP4_FxxP_1	234	237	PF00568	0.242
DOC_USP7_MATH_1	112	116	PF00917	0.416
DOC_USP7_MATH_1	132	136	PF00917	0.347
DOC_USP7_MATH_1	203	207	PF00917	0.260
DOC_USP7_MATH_1	70	74	PF00917	0.513
DOC_WW_Pin1_4	11	16	PF00397	0.624
LIG_14-3-3_CanoR_1	103	112	PF00244	0.336
LIG_14-3-3_CanoR_1	149	154	PF00244	0.213
LIG_14-3-3_CanoR_1	227	237	PF00244	0.299
LIG_Actin_WH2_2	324	342	PF00022	0.257
LIG_Actin_WH2_2	46	64	PF00022	0.263
LIG_BRCT_BRCA1_1	205	209	PF00533	0.352
LIG_FHA_1	1	7	PF00498	0.631
LIG_FHA_1	249	255	PF00498	0.313
LIG_FHA_1	37	43	PF00498	0.392
LIG_FHA_2	300	306	PF00498	0.272
LIG_FHA_2	313	319	PF00498	0.139
LIG_FHA_2	339	345	PF00498	0.208
LIG_FHA_2	369	375	PF00498	0.230
LIG_FHA_2	381	387	PF00498	0.264
LIG_LIR_Apic_2	191	197	PF02991	0.275
LIG_LIR_Apic_2	231	237	PF02991	0.223
LIG_LIR_Gen_1	354	363	PF02991	0.211
LIG_LIR_Nem_3	206	212	PF02991	0.253
LIG_LIR_Nem_3	348	353	PF02991	0.208
LIG_LIR_Nem_3	354	360	PF02991	0.208
LIG_LIR_Nem_3	364	370	PF02991	0.210
LIG_LIR_Nem_3	39	43	PF02991	0.347
LIG_MLH1_MIPbox_1	205	209	PF16413	0.223
LIG_NRP_CendR_1	388	391	PF00754	0.459
LIG_Pex14_2	208	212	PF04695	0.242
LIG_REV1ctd_RIR_1	208	218	PF16727	0.233
LIG_RPA_C_Fungi	274	286	PF08784	0.388
LIG_SH2_NCK_1	353	357	PF00017	0.257
LIG_SH2_STAP1	353	357	PF00017	0.270
LIG_SH2_STAT3	267	270	PF00017	0.388
LIG_SUMO_SIM_par_1	29	35	PF11976	0.474
LIG_TRFH_1	234	238	PF08558	0.263
LIG_UBA3_1	169	174	PF00899	0.241
LIG_WW_3	236	240	PF00397	0.388
MOD_CDK_SPxxK_3	11	18	PF00069	0.545
MOD_CK1_1	268	274	PF00069	0.388
MOD_CK1_1	380	386	PF00069	0.209
MOD_CK2_1	123	129	PF00069	0.501
MOD_CK2_1	132	138	PF00069	0.560
MOD_CK2_1	299	305	PF00069	0.255
MOD_CK2_1	312	318	PF00069	0.276
MOD_CK2_1	338	344	PF00069	0.242
MOD_CK2_1	380	386	PF00069	0.258
MOD_Cter_Amidation	101	104	PF01082	0.427
MOD_GlcNHglycan	113	117	PF01048	0.525
MOD_GlcNHglycan	125	128	PF01048	0.447
MOD_GlcNHglycan	134	137	PF01048	0.469
MOD_GlcNHglycan	21	24	PF01048	0.665
MOD_GlcNHglycan	267	270	PF01048	0.286
MOD_GlcNHglycan	292	295	PF01048	0.304
MOD_GlcNHglycan	341	344	PF01048	0.281
MOD_GSK3_1	128	135	PF00069	0.472
MOD_GSK3_1	286	293	PF00069	0.297
MOD_GSK3_1	32	39	PF00069	0.284
MOD_GSK3_1	70	77	PF00069	0.544
MOD_N-GLC_1	24	29	PF02516	0.536
MOD_N-GLC_2	262	264	PF02516	0.242
MOD_NEK2_1	130	135	PF00069	0.435
MOD_NEK2_1	2	7	PF00069	0.605
MOD_NEK2_1	310	315	PF00069	0.254
MOD_NEK2_1	61	66	PF00069	0.573
MOD_NEK2_2	203	208	PF00069	0.403
MOD_PIKK_1	312	318	PF00454	0.247
MOD_PIKK_1	368	374	PF00454	0.394
MOD_PK_1	149	155	PF00069	0.187
MOD_PKA_1	103	109	PF00069	0.509
MOD_PKA_2	103	109	PF00069	0.453
MOD_PKA_2	248	254	PF00069	0.460
MOD_PKA_2	285	291	PF00069	0.307
MOD_PKA_2	339	345	PF00069	0.270
MOD_PKA_2	70	76	PF00069	0.633
MOD_PKB_1	284	292	PF00069	0.307
MOD_Plk_1	137	143	PF00069	0.374
MOD_Plk_1	329	335	PF00069	0.309
MOD_Plk_4	149	155	PF00069	0.240
MOD_Plk_4	182	188	PF00069	0.257
MOD_Plk_4	203	209	PF00069	0.271
MOD_ProDKin_1	11	17	PF00069	0.547
TRG_DiLeu_BaEn_1	200	205	PF01217	0.242
TRG_DiLeu_BaEn_2	220	226	PF01217	0.313
TRG_ENDOCYTIC_2	147	150	PF00928	0.316
TRG_ENDOCYTIC_2	357	360	PF00928	0.242
TRG_ER_diArg_1	256	258	PF00400	0.296
TRG_ER_diArg_1	283	286	PF00400	0.340
TRG_ER_diArg_1	99	101	PF00400	0.349
TRG_ER_diLys_1	387	391	PF00400	0.369
TRG_Pf-PMV_PEXEL_1	118	122	PF00026	0.528
TRG_Pf-PMV_PEXEL_1	283	287	PF00026	0.307
TRG_Pf-PMV_PEXEL_1	312	316	PF00026	0.320

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P394	Leptomonas seymouri	58%	100%
A0A0S4JA70	Bodo saltans	45%	88%
A0A1X0NGI2	Trypanosomatidae	44%	96%
A0A3S7WSB2	Leishmania donovani	100%	100%
A0A422NM12	Trypanosoma rangeli	48%	94%
A4H710	Leishmania braziliensis	78%	100%
C9ZTQ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	93%
E9AP36	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
K4CA50	Solanum lycopersicum	28%	100%
K4D3U9	Solanum lycopersicum	28%	100%
K7W9N9	Solanum lycopersicum	27%	100%
K7X479	Solanum lycopersicum	28%	100%
O59258	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	30%	100%
Q4QGF2	Leishmania major	92%	100%
Q5JGE1	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	29%	100%
Q82TZ9	Nitrosomonas europaea (strain ATCC 19718 / CIP 103999 / KCTC 2705 / NBRC 14298)	28%	100%
Q8GY03	Arabidopsis thaliana	26%	100%
Q8RX73	Arabidopsis thaliana	27%	100%
Q8U0I8	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	29%	100%
Q9HH76	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	25%	100%
Q9HP68	Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)	24%	100%
Q9V157	Pyrococcus abyssi (strain GE5 / Orsay)	30%	100%
V5BT78	Trypanosoma cruzi	47%	94%