Putative surface antigen protein 2

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

surface antigen protein 2 - putative

Species:

Leishmania infantum

UniProt:

A4HVB0_LEIIN

TriTrypDb:

LINF_120013700

Length:

403

Annotations

LeishMANIAdb annotations

Publication identifier(s): 8702946
A surface coat protein involved in immune evasion in Leishmaniids. Extremely fast evolving, almost completely disordered mucin-like protein. . Localization: Cell surface (experimental)

LeishMANIAdb interaction annotations

by homology
Contact email: handman@wehi.edu.au
Publication title: A Leucine-Rich Repeat Motif of Leishmania Parasite Surface Antigen 2 Binds to Macrophages through the Complement Receptor 3
Publication 1st author(s): Kedzierski
Publication Identifier(s): 15067069
Host organism: -1
Interaction detection method(s): fluorescence activated cell sorting
Interaction type: physical association
Identification method participant A: identification by antibody
Identification method participant B: identification by antibody
ID(s) interactor A: P11215
ID(s) interactor B: E9AGG4
Taxid interactor A: Homo sapiens
Taxid interactor B: Leishmania infantum
Biological role(s) interactor A: unspecified role
Biological role(s) interactor B: unspecified role
Experimental role(s) interactor A: unspecified role

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 140

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 58, no: 9
NetGPI	no	yes: 0, no: 67

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	68
GO:0042995	cell projection	2	68
GO:0043226	organelle	2	68
GO:0043227	membrane-bounded organelle	3	68
GO:0110165	cellular anatomical entity	1	68
GO:0120025	plasma membrane bounded cell projection	3	68
GO:0016020	membrane	2	22
GO:0005886	plasma membrane	3	5

Expansion

Sequence features

A4HVB0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVB0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0004672	protein kinase activity	3	3
GO:0004674	protein serine/threonine kinase activity	4	3
GO:0016301	kinase activity	4	3
GO:0016740	transferase activity	2	3
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	3
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	3
GO:0140096	catalytic activity, acting on a protein	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	6	8	PF00675	0.663
CLV_PCSK_KEX2_1	6	8	PF00082	0.663
CLV_PCSK_SKI1_1	235	239	PF00082	0.574
CLV_PCSK_SKI1_1	7	11	PF00082	0.623
CLV_Separin_Metazoa	214	218	PF03568	0.241
DEG_SCF_FBW7_2	388	395	PF00400	0.563
DEG_SPOP_SBC_1	334	338	PF00917	0.539
DEG_SPOP_SBC_1	344	348	PF00917	0.543
DEG_SPOP_SBC_1	354	358	PF00917	0.528
DEG_SPOP_SBC_1	379	383	PF00917	0.565
DOC_CYCLIN_RxL_1	216	225	PF00134	0.302
DOC_CYCLIN_RxL_1	3	13	PF00134	0.503
DOC_MAPK_MEF2A_6	306	313	PF00069	0.430
DOC_MAPK_MEF2A_6	95	102	PF00069	0.454
DOC_USP7_MATH_1	222	226	PF00917	0.456
DOC_USP7_MATH_1	52	56	PF00917	0.509
DOC_USP7_MATH_2	204	210	PF00917	0.319
DOC_USP7_MATH_2	228	234	PF00917	0.259
DOC_WW_Pin1_4	382	387	PF00397	0.595
DOC_WW_Pin1_4	388	393	PF00397	0.557
LIG_14-3-3_CanoR_1	43	48	PF00244	0.542
LIG_BIR_II_1	1	5	PF00653	0.628
LIG_BRCT_BRCA1_1	165	169	PF00533	0.287
LIG_Clathr_ClatBox_1	285	289	PF01394	0.260
LIG_Clathr_ClatBox_1	310	314	PF01394	0.310
LIG_deltaCOP1_diTrp_1	62	69	PF00928	0.537
LIG_EH1_1	144	152	PF00400	0.275
LIG_eIF4E_1	145	151	PF01652	0.284
LIG_FHA_1	198	204	PF00498	0.448
LIG_FHA_1	337	343	PF00498	0.809
LIG_FHA_1	373	379	PF00498	0.538
LIG_FHA_1	42	48	PF00498	0.527
LIG_FHA_2	122	128	PF00498	0.512
LIG_FHA_2	394	400	PF00498	0.841
LIG_FHA_2	63	69	PF00498	0.547
LIG_FHA_2	92	98	PF00498	0.357
LIG_LIR_Gen_1	103	112	PF02991	0.261
LIG_LIR_Gen_1	157	164	PF02991	0.349
LIG_LIR_Gen_1	181	188	PF02991	0.404
LIG_LIR_Gen_1	206	215	PF02991	0.459
LIG_LIR_Gen_1	278	286	PF02991	0.482
LIG_LIR_Nem_3	103	107	PF02991	0.273
LIG_LIR_Nem_3	133	137	PF02991	0.536
LIG_LIR_Nem_3	157	161	PF02991	0.428
LIG_LIR_Nem_3	189	195	PF02991	0.417
LIG_LIR_Nem_3	245	251	PF02991	0.310
LIG_LIR_Nem_3	71	75	PF02991	0.449
LIG_MYND_3	210	214	PF01753	0.262
LIG_PCNA_PIPBox_1	185	194	PF02747	0.264
LIG_PTAP_UEV_1	369	374	PF05743	0.523
LIG_SH2_CRK	104	108	PF00017	0.252
LIG_SH2_CRK	248	252	PF00017	0.260
LIG_SH2_STAP1	104	108	PF00017	0.252
LIG_SH2_STAT5	104	107	PF00017	0.511
LIG_SH2_STAT5	145	148	PF00017	0.466
LIG_SH2_STAT5	195	198	PF00017	0.299
LIG_SH3_3	123	129	PF00018	0.553
LIG_SH3_3	339	345	PF00018	0.526
LIG_SH3_3	367	373	PF00018	0.541
LIG_SH3_3	93	99	PF00018	0.298
LIG_SUMO_SIM_anti_2	236	241	PF11976	0.236
LIG_SUMO_SIM_par_1	110	115	PF11976	0.254
LIG_TYR_ITIM	102	107	PF00017	0.262
LIG_TYR_ITIM	132	137	PF00017	0.584
LIG_UBA3_1	309	318	PF00899	0.317
LIG_WW_3	251	255	PF00397	0.255
MOD_CK1_1	168	174	PF00069	0.389
MOD_CK1_1	181	187	PF00069	0.442
MOD_CK1_1	233	239	PF00069	0.450
MOD_CK1_1	256	262	PF00069	0.478
MOD_CK2_1	121	127	PF00069	0.532
MOD_CK2_1	393	399	PF00069	0.590
MOD_CK2_1	91	97	PF00069	0.389
MOD_GlcNHglycan	121	124	PF01048	0.476
MOD_GlcNHglycan	174	177	PF01048	0.398
MOD_GlcNHglycan	25	28	PF01048	0.646
MOD_GlcNHglycan	255	258	PF01048	0.464
MOD_GlcNHglycan	270	274	PF01048	0.442
MOD_GlcNHglycan	54	57	PF01048	0.364
MOD_GlcNHglycan	79	82	PF01048	0.410
MOD_GSK3_1	150	157	PF00069	0.445
MOD_GSK3_1	168	175	PF00069	0.388
MOD_GSK3_1	180	187	PF00069	0.421
MOD_GSK3_1	195	202	PF00069	0.431
MOD_GSK3_1	32	39	PF00069	0.647
MOD_GSK3_1	323	330	PF00069	0.625
MOD_GSK3_1	333	340	PF00069	0.702
MOD_GSK3_1	343	350	PF00069	0.682
MOD_GSK3_1	353	360	PF00069	0.649
MOD_GSK3_1	364	371	PF00069	0.542
MOD_GSK3_1	373	380	PF00069	0.760
MOD_GSK3_1	382	389	PF00069	0.736
MOD_GSK3_1	82	89	PF00069	0.446
MOD_N-GLC_1	82	87	PF02516	0.479
MOD_NEK2_1	10	15	PF00069	0.636
MOD_NEK2_1	112	117	PF00069	0.374
MOD_NEK2_1	119	124	PF00069	0.408
MOD_NEK2_1	138	143	PF00069	0.459
MOD_NEK2_1	150	155	PF00069	0.460
MOD_NEK2_1	21	26	PF00069	0.629
MOD_NEK2_1	242	247	PF00069	0.410
MOD_NEK2_1	271	276	PF00069	0.412
MOD_NEK2_1	86	91	PF00069	0.504
MOD_PIKK_1	112	118	PF00454	0.330
MOD_PIKK_1	242	248	PF00454	0.492
MOD_PKA_2	253	259	PF00069	0.336
MOD_PKA_2	328	334	PF00069	0.469
MOD_Plk_1	102	108	PF00069	0.381
MOD_Plk_1	112	118	PF00069	0.428
MOD_Plk_1	82	88	PF00069	0.459
MOD_Plk_2-3	68	74	PF00069	0.512
MOD_Plk_4	103	109	PF00069	0.452
MOD_Plk_4	165	171	PF00069	0.477
MOD_Plk_4	187	193	PF00069	0.485
MOD_Plk_4	235	241	PF00069	0.334
MOD_Plk_4	305	311	PF00069	0.434
MOD_ProDKin_1	382	388	PF00069	0.590
MOD_SUMO_rev_2	127	137	PF00179	0.312
TRG_ENDOCYTIC_2	104	107	PF00928	0.255
TRG_ENDOCYTIC_2	134	137	PF00928	0.587
TRG_ENDOCYTIC_2	248	251	PF00928	0.266
TRG_ER_diArg_1	216	219	PF00400	0.255
TRG_ER_diArg_1	223	226	PF00400	0.271
TRG_ER_diArg_1	5	7	PF00400	0.659

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2L4	Leptomonas seymouri	36%	100%
A0A0N1I121	Leptomonas seymouri	28%	80%
A0A0N1I661	Leptomonas seymouri	36%	71%
A0A0S4IR61	Bodo saltans	28%	100%
A0A0S4IW93	Bodo saltans	24%	66%
A0A0S4IZC7	Bodo saltans	24%	98%
A0A0S4J1A6	Bodo saltans	25%	94%
A0A0S4JD35	Bodo saltans	28%	67%
A0A0S4JEP2	Bodo saltans	23%	69%
A0A0S4JMG0	Bodo saltans	26%	100%
A0A0S4JS89	Bodo saltans	25%	91%
A0A0S4KMV2	Bodo saltans	28%	100%
A0A3Q8I9A6	Leishmania donovani	53%	100%
A0A3Q8I9D0	Leishmania donovani	62%	100%
A0A3Q8IC27	Leishmania donovani	36%	84%
A0A3Q8IFC2	Leishmania donovani	36%	92%
A0A3Q8IIJ9	Leishmania donovani	33%	100%
A0A3Q8IK15	Leishmania donovani	35%	76%
A0A3S5H6D6	Leishmania donovani	25%	100%
A0A3S5H6L9	Leishmania donovani	68%	70%
A0A3S7WPB2	Leishmania donovani	24%	94%
A0A3S7X4J4	Leishmania donovani	33%	100%
A4H4G6	Leishmania braziliensis	23%	100%
A4H5P0	Leishmania braziliensis	24%	93%
A4HBX3	Leishmania braziliensis	36%	89%
A4HJC8	Leishmania braziliensis	31%	100%
A4HJX1	Leishmania braziliensis	38%	92%
A4HTX9	Leishmania infantum	26%	100%
A4HZ93	Leishmania infantum	36%	84%
A4I6S2	Leishmania infantum	35%	92%
A4I6S3	Leishmania infantum	36%	81%
A4I6S4	Leishmania infantum	34%	100%
D1GJ51	Leishmania infantum	47%	87%
E8NHG5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	91%
E8NHP8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	99%
E9ACQ0	Leishmania major	24%	94%
E9AEF4	Leishmania major	36%	88%
E9AG65	Leishmania infantum	24%	94%
E9AGG5	Leishmania infantum	53%	97%
E9AGG9	Leishmania infantum	49%	74%
E9AGH0	Leishmania infantum	56%	100%
E9AKM8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9AMQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	95%
E9AP02	Leishmania mexicana (strain MHOM/GT/2001/U1103)	52%	100%
E9AP03	Leishmania mexicana (strain MHOM/GT/2001/U1103)	56%	100%
E9AP05	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	78%
E9AP07	Leishmania mexicana (strain MHOM/GT/2001/U1103)	52%	100%
E9AP08	Leishmania mexicana (strain MHOM/GT/2001/U1103)	54%	100%
E9AVA1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	87%
E9B1U3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	89%
E9B1U4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9B1U5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
E9B1U6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	99%
Q25331	Leishmania major	50%	96%
Q4Q6B6	Leishmania major	34%	100%
Q4Q6B7	Leishmania major	34%	99%
Q4Q6B8	Leishmania major	35%	76%
Q4QC79	Leishmania major	36%	88%
Q4QGI0	Leishmania major	54%	79%
Q4QGI2	Leishmania major	49%	72%
Q4QGI4	Leishmania major	50%	75%
Q4QGI6	Leishmania major	50%	74%
Q4QGJ4	Leishmania major	51%	96%
Q4QGJ6	Leishmania major	53%	70%
Q4QGJ7	Leishmania major	51%	100%
Q4QGJ9	Leishmania major	44%	69%
Q4QGK0	Leishmania major	53%	71%
Q4QGK2	Leishmania major	50%	72%
Q4QGK6	Leishmania major	51%	96%
Q4QGK8	Leishmania major	47%	79%
Q4QGL2	Leishmania major	47%	79%
Q4QGL4	Leishmania major	52%	100%
Q4QGL5	Leishmania major	52%	74%
Q4QGL8	Leishmania major	53%	66%
Q4QHW6	Leishmania major	26%	100%
Q5PP26	Arabidopsis thaliana	25%	95%