SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HV71_LEIIN

TriTrypDb:

LINF_120007800

Length:

684

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HV71

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HV71

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016740	transferase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	138	142	PF00656	0.622
CLV_C14_Caspase3-7	237	241	PF00656	0.588
CLV_NRD_NRD_1	132	134	PF00675	0.582
CLV_NRD_NRD_1	227	229	PF00675	0.518
CLV_NRD_NRD_1	335	337	PF00675	0.580
CLV_NRD_NRD_1	417	419	PF00675	0.572
CLV_NRD_NRD_1	658	660	PF00675	0.406
CLV_NRD_NRD_1	86	88	PF00675	0.508
CLV_NRD_NRD_1	96	98	PF00675	0.469
CLV_PCSK_FUR_1	133	137	PF00082	0.573
CLV_PCSK_FUR_1	415	419	PF00082	0.531
CLV_PCSK_KEX2_1	132	134	PF00082	0.583
CLV_PCSK_KEX2_1	135	137	PF00082	0.573
CLV_PCSK_KEX2_1	226	228	PF00082	0.595
CLV_PCSK_KEX2_1	335	337	PF00082	0.581
CLV_PCSK_KEX2_1	417	419	PF00082	0.572
CLV_PCSK_KEX2_1	658	660	PF00082	0.408
CLV_PCSK_KEX2_1	662	664	PF00082	0.416
CLV_PCSK_KEX2_1	86	88	PF00082	0.570
CLV_PCSK_KEX2_1	95	97	PF00082	0.498
CLV_PCSK_PC1ET2_1	135	137	PF00082	0.571
CLV_PCSK_PC1ET2_1	662	664	PF00082	0.445
CLV_PCSK_PC7_1	658	664	PF00082	0.441
CLV_PCSK_SKI1_1	120	124	PF00082	0.527
CLV_PCSK_SKI1_1	186	190	PF00082	0.497
CLV_PCSK_SKI1_1	20	24	PF00082	0.357
CLV_PCSK_SKI1_1	316	320	PF00082	0.372
CLV_PCSK_SKI1_1	336	340	PF00082	0.240
CLV_PCSK_SKI1_1	658	662	PF00082	0.423
CLV_PCSK_SKI1_1	663	667	PF00082	0.395
CLV_PCSK_SKI1_1	670	674	PF00082	0.373
CLV_PCSK_SKI1_1	70	74	PF00082	0.408
CLV_PCSK_SKI1_1	90	94	PF00082	0.509
DEG_Nend_Nbox_1	1	3	PF02207	0.400
DEG_SPOP_SBC_1	114	118	PF00917	0.544
DEG_SPOP_SBC_1	448	452	PF00917	0.574
DOC_CKS1_1	195	200	PF01111	0.421
DOC_CYCLIN_RxL_1	313	320	PF00134	0.377
DOC_CYCLIN_RxL_1	58	66	PF00134	0.459
DOC_CYCLIN_RxL_1	585	597	PF00134	0.386
DOC_CYCLIN_RxL_1	658	668	PF00134	0.424
DOC_MAPK_gen_1	226	235	PF00069	0.457
DOC_MAPK_HePTP_8	223	235	PF00069	0.458
DOC_MAPK_HePTP_8	6	18	PF00069	0.376
DOC_MAPK_MEF2A_6	186	194	PF00069	0.460
DOC_MAPK_MEF2A_6	226	235	PF00069	0.481
DOC_MAPK_MEF2A_6	9	18	PF00069	0.378
DOC_PP2B_LxvP_1	339	342	PF13499	0.441
DOC_USP7_MATH_1	126	130	PF00917	0.664
DOC_USP7_MATH_1	239	243	PF00917	0.713
DOC_USP7_MATH_1	262	266	PF00917	0.611
DOC_USP7_MATH_1	286	290	PF00917	0.705
DOC_USP7_MATH_1	33	37	PF00917	0.485
DOC_USP7_MATH_1	38	42	PF00917	0.542
DOC_USP7_MATH_1	448	452	PF00917	0.686
DOC_USP7_MATH_1	506	510	PF00917	0.597
DOC_USP7_MATH_1	512	516	PF00917	0.621
DOC_USP7_MATH_1	537	541	PF00917	0.399
DOC_USP7_MATH_1	605	609	PF00917	0.515
DOC_USP7_MATH_1	619	623	PF00917	0.500
DOC_WW_Pin1_4	10	15	PF00397	0.382
DOC_WW_Pin1_4	158	163	PF00397	0.772
DOC_WW_Pin1_4	194	199	PF00397	0.466
DOC_WW_Pin1_4	274	279	PF00397	0.641
DOC_WW_Pin1_4	451	456	PF00397	0.538
LIG_14-3-3_CanoR_1	113	122	PF00244	0.545
LIG_14-3-3_CanoR_1	136	140	PF00244	0.630
LIG_14-3-3_CanoR_1	175	180	PF00244	0.562
LIG_14-3-3_CanoR_1	186	191	PF00244	0.516
LIG_14-3-3_CanoR_1	263	269	PF00244	0.715
LIG_14-3-3_CanoR_1	285	291	PF00244	0.756
LIG_14-3-3_CanoR_1	316	325	PF00244	0.386
LIG_14-3-3_CanoR_1	335	339	PF00244	0.549
LIG_14-3-3_CanoR_1	544	550	PF00244	0.485
LIG_14-3-3_CanoR_1	663	673	PF00244	0.479
LIG_14-3-3_CanoR_1	70	80	PF00244	0.705
LIG_14-3-3_CanoR_1	95	104	PF00244	0.547
LIG_BRCT_BRCA1_1	288	292	PF00533	0.671
LIG_BRCT_BRCA1_1	393	397	PF00533	0.381
LIG_DCNL_PONY_1	1	4	PF03556	0.397
LIG_EH1_1	584	592	PF00400	0.430
LIG_FHA_1	187	193	PF00498	0.532
LIG_FHA_1	195	201	PF00498	0.356
LIG_FHA_1	202	208	PF00498	0.372
LIG_FHA_1	216	222	PF00498	0.344
LIG_FHA_1	326	332	PF00498	0.419
LIG_FHA_1	363	369	PF00498	0.443
LIG_FHA_1	482	488	PF00498	0.376
LIG_FHA_1	72	78	PF00498	0.434
LIG_FHA_2	235	241	PF00498	0.527
LIG_FHA_2	394	400	PF00498	0.525
LIG_FHA_2	44	50	PF00498	0.499
LIG_LIR_Apic_2	35	40	PF02991	0.413
LIG_LIR_Apic_2	358	364	PF02991	0.445
LIG_LIR_Nem_3	211	216	PF02991	0.359
LIG_LIR_Nem_3	470	475	PF02991	0.448
LIG_LIR_Nem_3	667	672	PF02991	0.525
LIG_MAD2	61	69	PF02301	0.448
LIG_NRBOX	1	7	PF00104	0.384
LIG_NRBOX	187	193	PF00104	0.522
LIG_Pex14_1	17	21	PF04695	0.359
LIG_REV1ctd_RIR_1	479	489	PF16727	0.372
LIG_RPA_C_Fungi	170	182	PF08784	0.438
LIG_RPA_C_Insects	75	90	PF08784	0.463
LIG_SH2_CRK	361	365	PF00017	0.535
LIG_SH2_CRK	616	620	PF00017	0.487
LIG_SH2_CRK	669	673	PF00017	0.499
LIG_SH2_NCK_1	139	143	PF00017	0.637
LIG_SH2_NCK_1	361	365	PF00017	0.441
LIG_SH2_SRC	139	142	PF00017	0.631
LIG_SH2_SRC	614	617	PF00017	0.464
LIG_SH2_STAP1	213	217	PF00017	0.481
LIG_SH2_STAP1	25	29	PF00017	0.316
LIG_SH2_STAP1	497	501	PF00017	0.387
LIG_SH2_STAT5	199	202	PF00017	0.459
LIG_SH2_STAT5	216	219	PF00017	0.309
LIG_SH2_STAT5	307	310	PF00017	0.406
LIG_SH2_STAT5	361	364	PF00017	0.435
LIG_SH2_STAT5	531	534	PF00017	0.430
LIG_SH2_STAT5	614	617	PF00017	0.499
LIG_SH2_STAT5	671	674	PF00017	0.502
LIG_SH3_3	102	108	PF00018	0.485
LIG_SH3_3	529	535	PF00018	0.455
LIG_SH3_3	554	560	PF00018	0.604
LIG_SH3_3	563	569	PF00018	0.607
LIG_SUMO_SIM_anti_2	596	603	PF11976	0.436
LIG_SUMO_SIM_par_1	2	8	PF11976	0.480
LIG_SUMO_SIM_par_1	231	238	PF11976	0.512
LIG_SUMO_SIM_par_1	367	373	PF11976	0.442
LIG_SUMO_SIM_par_1	596	603	PF11976	0.377
LIG_SUMO_SIM_par_1	61	66	PF11976	0.457
LIG_TRAF2_1	488	491	PF00917	0.492
MOD_CDK_SPK_2	274	279	PF00069	0.535
MOD_CDK_SPxxK_3	278	285	PF00069	0.608
MOD_CK1_1	116	122	PF00069	0.710
MOD_CK1_1	125	131	PF00069	0.661
MOD_CK1_1	166	172	PF00069	0.688
MOD_CK1_1	312	318	PF00069	0.420
MOD_CK1_1	334	340	PF00069	0.477
MOD_CK1_1	391	397	PF00069	0.431
MOD_CK1_1	416	422	PF00069	0.709
MOD_CK1_1	427	433	PF00069	0.669
MOD_CK1_1	45	51	PF00069	0.498
MOD_CK1_1	451	457	PF00069	0.586
MOD_CK1_1	575	581	PF00069	0.457
MOD_CK1_1	626	632	PF00069	0.630
MOD_CK1_1	641	647	PF00069	0.662
MOD_CK2_1	238	244	PF00069	0.698
MOD_CK2_1	393	399	PF00069	0.527
MOD_CK2_1	43	49	PF00069	0.496
MOD_GlcNHglycan	124	127	PF01048	0.763
MOD_GlcNHglycan	128	131	PF01048	0.787
MOD_GlcNHglycan	171	174	PF01048	0.675
MOD_GlcNHglycan	209	213	PF01048	0.414
MOD_GlcNHglycan	264	267	PF01048	0.624
MOD_GlcNHglycan	273	277	PF01048	0.613
MOD_GlcNHglycan	390	393	PF01048	0.411
MOD_GlcNHglycan	418	421	PF01048	0.687
MOD_GlcNHglycan	426	429	PF01048	0.660
MOD_GlcNHglycan	461	464	PF01048	0.614
MOD_GlcNHglycan	508	511	PF01048	0.607
MOD_GlcNHglycan	538	542	PF01048	0.477
MOD_GlcNHglycan	607	610	PF01048	0.563
MOD_GlcNHglycan	641	644	PF01048	0.777
MOD_GSK3_1	103	110	PF00069	0.470
MOD_GSK3_1	114	121	PF00069	0.678
MOD_GSK3_1	122	129	PF00069	0.693
MOD_GSK3_1	131	138	PF00069	0.756
MOD_GSK3_1	165	172	PF00069	0.686
MOD_GSK3_1	234	241	PF00069	0.586
MOD_GSK3_1	274	281	PF00069	0.632
MOD_GSK3_1	286	293	PF00069	0.672
MOD_GSK3_1	308	315	PF00069	0.409
MOD_GSK3_1	355	362	PF00069	0.470
MOD_GSK3_1	38	45	PF00069	0.525
MOD_GSK3_1	447	454	PF00069	0.611
MOD_GSK3_1	477	484	PF00069	0.362
MOD_GSK3_1	491	498	PF00069	0.438
MOD_GSK3_1	619	626	PF00069	0.505
MOD_GSK3_1	91	98	PF00069	0.547
MOD_N-GLC_1	10	15	PF02516	0.383
MOD_N-GLC_1	381	386	PF02516	0.408
MOD_N-GLC_2	388	390	PF02516	0.347
MOD_NEK2_1	115	120	PF00069	0.767
MOD_NEK2_1	122	127	PF00069	0.703
MOD_NEK2_1	208	213	PF00069	0.406
MOD_NEK2_1	222	227	PF00069	0.378
MOD_NEK2_1	23	28	PF00069	0.387
MOD_NEK2_1	381	386	PF00069	0.488
MOD_NEK2_1	393	398	PF00069	0.509
MOD_NEK2_1	495	500	PF00069	0.416
MOD_NEK2_1	5	10	PF00069	0.378
MOD_NEK2_1	623	628	PF00069	0.545
MOD_NEK2_1	76	81	PF00069	0.756
MOD_NEK2_2	201	206	PF00069	0.564
MOD_NEK2_2	309	314	PF00069	0.380
MOD_PIKK_1	254	260	PF00454	0.580
MOD_PIKK_1	359	365	PF00454	0.483
MOD_PIKK_1	370	376	PF00454	0.367
MOD_PIKK_1	626	632	PF00454	0.718
MOD_PIKK_1	98	104	PF00454	0.614
MOD_PKA_1	135	141	PF00069	0.693
MOD_PKA_1	658	664	PF00069	0.501
MOD_PKA_1	95	101	PF00069	0.520
MOD_PKA_2	131	137	PF00069	0.555
MOD_PKA_2	262	268	PF00069	0.649
MOD_PKA_2	284	290	PF00069	0.779
MOD_PKA_2	325	331	PF00069	0.423
MOD_PKA_2	334	340	PF00069	0.413
MOD_PKA_2	416	422	PF00069	0.614
MOD_PKA_2	467	473	PF00069	0.561
MOD_PKA_2	658	664	PF00069	0.413
MOD_PKA_2	95	101	PF00069	0.478
MOD_PKB_1	95	103	PF00069	0.528
MOD_Plk_1	208	214	PF00069	0.410
MOD_Plk_1	491	497	PF00069	0.360
MOD_Plk_1	537	543	PF00069	0.463
MOD_Plk_2-3	491	497	PF00069	0.454
MOD_Plk_4	186	192	PF00069	0.509
MOD_Plk_4	217	223	PF00069	0.402
MOD_Plk_4	286	292	PF00069	0.720
MOD_Plk_4	343	349	PF00069	0.497
MOD_Plk_4	393	399	PF00069	0.508
MOD_Plk_4	477	483	PF00069	0.347
MOD_ProDKin_1	10	16	PF00069	0.381
MOD_ProDKin_1	158	164	PF00069	0.771
MOD_ProDKin_1	194	200	PF00069	0.464
MOD_ProDKin_1	274	280	PF00069	0.641
MOD_ProDKin_1	451	457	PF00069	0.533
MOD_SUMO_for_1	535	538	PF00179	0.430
TRG_DiLeu_BaEn_2	537	543	PF01217	0.467
TRG_DiLeu_BaEn_4	490	496	PF01217	0.309
TRG_DiLeu_BaLyEn_6	11	16	PF01217	0.378
TRG_DiLeu_BaLyEn_6	671	676	PF01217	0.423
TRG_ENDOCYTIC_2	669	672	PF00928	0.405
TRG_ER_diArg_1	179	182	PF00400	0.622
TRG_ER_diArg_1	226	228	PF00400	0.509
TRG_ER_diArg_1	415	418	PF00400	0.613
TRG_ER_diArg_1	58	61	PF00400	0.538
TRG_ER_diArg_1	657	659	PF00400	0.516
TRG_ER_diArg_1	95	97	PF00400	0.541
TRG_Pf-PMV_PEXEL_1	329	333	PF00026	0.455
TRG_Pf-PMV_PEXEL_1	61	66	PF00026	0.457
TRG_Pf-PMV_PEXEL_1	663	668	PF00026	0.462
TRG_Pf-PMV_PEXEL_1	674	678	PF00026	0.351

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7U7	Leptomonas seymouri	48%	100%
A0A3Q8I958	Leishmania donovani	100%	100%
A4H6U2	Leishmania braziliensis	71%	98%
C9ZQA8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9ANV4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	95%
Q4QGR6	Leishmania major	88%	100%
V5BD95	Trypanosoma cruzi	33%	100%