Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HV58_LEIIN

TriTrypDb:

LINF_120006500

Length:

673

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7
GO:0005783	endoplasmic reticulum	5	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0070765	gamma-secretase complex	3	1
GO:0098796	membrane protein complex	2	1
GO:0098797	plasma membrane protein complex	3	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

A4HV58

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HV58

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0016485	protein processing	5	7
GO:0019538	protein metabolic process	3	7
GO:0043085	positive regulation of catalytic activity	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0044093	positive regulation of molecular function	3	7
GO:0044238	primary metabolic process	2	7
GO:0050790	regulation of catalytic activity	3	7
GO:0051604	protein maturation	4	7
GO:0065007	biological regulation	1	7
GO:0065009	regulation of molecular function	2	7
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0030674	protein-macromolecule adaptor activity	2	1
GO:0060090	molecular adaptor activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	171	173	PF00675	0.347
CLV_NRD_NRD_1	27	29	PF00675	0.397
CLV_NRD_NRD_1	367	369	PF00675	0.592
CLV_NRD_NRD_1	505	507	PF00675	0.458
CLV_NRD_NRD_1	556	558	PF00675	0.453
CLV_NRD_NRD_1	63	65	PF00675	0.372
CLV_NRD_NRD_1	634	636	PF00675	0.586
CLV_NRD_NRD_1	96	98	PF00675	0.576
CLV_PCSK_FUR_1	25	29	PF00082	0.401
CLV_PCSK_FUR_1	94	98	PF00082	0.569
CLV_PCSK_KEX2_1	171	173	PF00082	0.347
CLV_PCSK_KEX2_1	27	29	PF00082	0.397
CLV_PCSK_KEX2_1	367	369	PF00082	0.592
CLV_PCSK_KEX2_1	505	507	PF00082	0.458
CLV_PCSK_KEX2_1	634	636	PF00082	0.586
CLV_PCSK_KEX2_1	96	98	PF00082	0.576
CLV_PCSK_PC7_1	167	173	PF00082	0.350
CLV_PCSK_SKI1_1	172	176	PF00082	0.326
CLV_PCSK_SKI1_1	182	186	PF00082	0.188
CLV_PCSK_SKI1_1	361	365	PF00082	0.596
CLV_PCSK_SKI1_1	96	100	PF00082	0.574
DEG_APCC_DBOX_1	120	128	PF00400	0.364
DEG_APCC_DBOX_1	325	333	PF00400	0.466
DEG_Nend_UBRbox_4	1	3	PF02207	0.564
DOC_CYCLIN_yCln2_LP_2	245	251	PF00134	0.358
DOC_MAPK_DCC_7	121	129	PF00069	0.361
DOC_MAPK_gen_1	171	179	PF00069	0.517
DOC_MAPK_gen_1	25	34	PF00069	0.590
DOC_MAPK_gen_1	61	71	PF00069	0.556
DOC_MAPK_MEF2A_6	121	129	PF00069	0.361
DOC_MAPK_MEF2A_6	171	179	PF00069	0.517
DOC_MAPK_MEF2A_6	188	195	PF00069	0.185
DOC_MAPK_MEF2A_6	301	309	PF00069	0.527
DOC_MAPK_MEF2A_6	324	332	PF00069	0.466
DOC_MAPK_MEF2A_6	70	79	PF00069	0.194
DOC_PP1_RVXF_1	311	317	PF00149	0.536
DOC_PP1_RVXF_1	377	383	PF00149	0.325
DOC_PP2B_LxvP_1	144	147	PF13499	0.194
DOC_PP2B_LxvP_1	232	235	PF13499	0.358
DOC_PP4_FxxP_1	103	106	PF00568	0.371
DOC_USP7_MATH_1	199	203	PF00917	0.292
DOC_USP7_MATH_1	30	34	PF00917	0.580
DOC_USP7_MATH_1	341	345	PF00917	0.389
DOC_USP7_MATH_1	470	474	PF00917	0.688
DOC_USP7_MATH_1	500	504	PF00917	0.660
DOC_USP7_MATH_1	521	525	PF00917	0.751
DOC_USP7_MATH_1	549	553	PF00917	0.696
DOC_USP7_MATH_1	572	576	PF00917	0.601
DOC_USP7_MATH_1	618	622	PF00917	0.372
DOC_USP7_MATH_1	633	637	PF00917	0.426
DOC_WW_Pin1_4	568	573	PF00397	0.680
DOC_WW_Pin1_4	64	69	PF00397	0.550
DOC_WW_Pin1_4	88	93	PF00397	0.408
LIG_14-3-3_CanoR_1	108	112	PF00244	0.389
LIG_14-3-3_CanoR_1	148	154	PF00244	0.194
LIG_14-3-3_CanoR_1	188	192	PF00244	0.194
LIG_14-3-3_CanoR_1	367	375	PF00244	0.441
LIG_14-3-3_CanoR_1	394	404	PF00244	0.350
LIG_14-3-3_CanoR_1	526	534	PF00244	0.665
LIG_14-3-3_CanoR_1	557	564	PF00244	0.682
LIG_14-3-3_CanoR_1	634	641	PF00244	0.367
LIG_14-3-3_CanoR_1	665	671	PF00244	0.612
LIG_Actin_WH2_2	260	278	PF00022	0.358
LIG_APCC_ABBA_1	127	132	PF00400	0.337
LIG_APCC_ABBAyCdc20_2	126	132	PF00400	0.342
LIG_BRCT_BRCA1_1	94	98	PF00533	0.369
LIG_CSL_BTD_1	89	92	PF09270	0.343
LIG_FHA_1	178	184	PF00498	0.194
LIG_FHA_1	195	201	PF00498	0.318
LIG_FHA_1	222	228	PF00498	0.323
LIG_FHA_1	266	272	PF00498	0.460
LIG_FHA_1	302	308	PF00498	0.530
LIG_FHA_1	443	449	PF00498	0.806
LIG_FHA_1	476	482	PF00498	0.662
LIG_FHA_1	625	631	PF00498	0.364
LIG_FHA_1	667	673	PF00498	0.633
LIG_LIR_Gen_1	131	141	PF02991	0.191
LIG_LIR_Gen_1	219	229	PF02991	0.251
LIG_LIR_Gen_1	258	267	PF02991	0.273
LIG_LIR_Gen_1	285	295	PF02991	0.311
LIG_LIR_Gen_1	669	673	PF02991	0.596
LIG_LIR_Nem_3	131	136	PF02991	0.191
LIG_LIR_Nem_3	202	206	PF02991	0.324
LIG_LIR_Nem_3	219	225	PF02991	0.259
LIG_LIR_Nem_3	258	262	PF02991	0.273
LIG_LIR_Nem_3	285	291	PF02991	0.311
LIG_LIR_Nem_3	325	330	PF02991	0.571
LIG_LIR_Nem_3	669	673	PF02991	0.596
LIG_NRBOX	391	397	PF00104	0.386
LIG_PCNA_yPIPBox_3	635	649	PF02747	0.258
LIG_Pex14_2	400	404	PF04695	0.335
LIG_SH2_CRK	222	226	PF00017	0.277
LIG_SH2_SRC	233	236	PF00017	0.358
LIG_SH2_STAP1	222	226	PF00017	0.332
LIG_SH2_STAP1	420	424	PF00017	0.435
LIG_SH2_STAT5	533	536	PF00017	0.619
LIG_SH3_3	122	128	PF00018	0.362
LIG_SH3_3	325	331	PF00018	0.508
LIG_SH3_3	511	517	PF00018	0.669
LIG_SH3_3	607	613	PF00018	0.270
LIG_Sin3_3	600	607	PF02671	0.251
LIG_SUMO_SIM_anti_2	650	656	PF11976	0.358
LIG_SUMO_SIM_par_1	140	145	PF11976	0.194
LIG_SUMO_SIM_par_1	248	254	PF11976	0.561
LIG_SUMO_SIM_par_1	647	653	PF11976	0.275
LIG_SUMO_SIM_par_1	659	664	PF11976	0.410
LIG_TRAF2_1	484	487	PF00917	0.618
LIG_TRAF2_1	517	520	PF00917	0.728
LIG_TRFH_1	327	331	PF08558	0.508
LIG_TRFH_1	609	613	PF08558	0.299
LIG_WRC_WIRS_1	200	205	PF05994	0.310
LIG_WRC_WIRS_1	256	261	PF05994	0.270
LIG_WW_3	91	95	PF00397	0.352
MOD_CDC14_SPxK_1	91	94	PF00782	0.353
MOD_CDK_SPxK_1	64	70	PF00069	0.549
MOD_CDK_SPxK_1	88	94	PF00069	0.412
MOD_CK1_1	115	121	PF00069	0.370
MOD_CK1_1	131	137	PF00069	0.184
MOD_CK1_1	151	157	PF00069	0.183
MOD_CK1_1	194	200	PF00069	0.326
MOD_CK1_1	221	227	PF00069	0.274
MOD_CK1_1	370	376	PF00069	0.535
MOD_CK1_1	38	44	PF00069	0.563
MOD_CK1_1	570	576	PF00069	0.631
MOD_CK1_1	623	629	PF00069	0.410
MOD_CK1_1	9	15	PF00069	0.581
MOD_CK2_1	470	476	PF00069	0.686
MOD_CK2_1	549	555	PF00069	0.698
MOD_CK2_1	571	577	PF00069	0.641
MOD_Cter_Amidation	169	172	PF01082	0.350
MOD_GlcNHglycan	132	136	PF01048	0.391
MOD_GlcNHglycan	385	388	PF01048	0.649
MOD_GlcNHglycan	40	43	PF01048	0.361
MOD_GlcNHglycan	460	463	PF01048	0.473
MOD_GlcNHglycan	509	512	PF01048	0.481
MOD_GlcNHglycan	529	532	PF01048	0.603
MOD_GlcNHglycan	535	539	PF01048	0.526
MOD_GlcNHglycan	547	550	PF01048	0.500
MOD_GlcNHglycan	561	564	PF01048	0.435
MOD_GlcNHglycan	574	577	PF01048	0.385
MOD_GlcNHglycan	620	623	PF01048	0.575
MOD_GlcNHglycan	631	634	PF01048	0.624
MOD_GSK3_1	142	149	PF00069	0.194
MOD_GSK3_1	187	194	PF00069	0.194
MOD_GSK3_1	205	212	PF00069	0.340
MOD_GSK3_1	251	258	PF00069	0.420
MOD_GSK3_1	297	304	PF00069	0.375
MOD_GSK3_1	363	370	PF00069	0.452
MOD_GSK3_1	496	503	PF00069	0.699
MOD_GSK3_1	5	12	PF00069	0.568
MOD_GSK3_1	545	552	PF00069	0.686
MOD_GSK3_1	566	573	PF00069	0.717
MOD_GSK3_1	620	627	PF00069	0.410
MOD_GSK3_1	629	636	PF00069	0.480
MOD_GSK3_1	88	95	PF00069	0.412
MOD_N-GLC_1	10	15	PF02516	0.384
MOD_N-GLC_1	297	302	PF02516	0.397
MOD_N-GLC_1	641	646	PF02516	0.288
MOD_N-GLC_1	77	82	PF02516	0.194
MOD_NEK2_1	10	15	PF00069	0.584
MOD_NEK2_1	191	196	PF00069	0.194
MOD_NEK2_1	205	210	PF00069	0.355
MOD_NEK2_1	251	256	PF00069	0.325
MOD_NEK2_1	265	270	PF00069	0.385
MOD_NEK2_1	322	327	PF00069	0.552
MOD_NEK2_1	363	368	PF00069	0.425
MOD_NEK2_1	382	387	PF00069	0.465
MOD_NEK2_1	395	400	PF00069	0.352
MOD_NEK2_1	534	539	PF00069	0.704
MOD_NEK2_2	470	475	PF00069	0.720
MOD_NEK2_2	500	505	PF00069	0.669
MOD_OFUCOSY	112	119	PF10250	0.570
MOD_PIKK_1	521	527	PF00454	0.660
MOD_PK_1	368	374	PF00069	0.369
MOD_PKA_1	367	373	PF00069	0.374
MOD_PKA_1	557	563	PF00069	0.629
MOD_PKA_2	107	113	PF00069	0.366
MOD_PKA_2	187	193	PF00069	0.194
MOD_PKA_2	367	373	PF00069	0.432
MOD_PKA_2	390	396	PF00069	0.356
MOD_PKA_2	633	639	PF00069	0.373
MOD_PKB_1	207	215	PF00069	0.356
MOD_Plk_1	10	16	PF00069	0.587
MOD_Plk_1	115	121	PF00069	0.370
MOD_Plk_1	131	137	PF00069	0.184
MOD_Plk_1	297	303	PF00069	0.402
MOD_Plk_1	30	36	PF00069	0.571
MOD_Plk_1	470	476	PF00069	0.761
MOD_Plk_1	641	647	PF00069	0.288
MOD_Plk_1	77	83	PF00069	0.224
MOD_Plk_4	134	140	PF00069	0.194
MOD_Plk_4	151	157	PF00069	0.185
MOD_Plk_4	251	257	PF00069	0.379
MOD_Plk_4	341	347	PF00069	0.299
MOD_Plk_4	400	406	PF00069	0.365
MOD_Plk_4	583	589	PF00069	0.568
MOD_Plk_4	647	653	PF00069	0.299
MOD_Plk_4	77	83	PF00069	0.224
MOD_ProDKin_1	568	574	PF00069	0.674
MOD_ProDKin_1	64	70	PF00069	0.549
MOD_ProDKin_1	88	94	PF00069	0.412
TRG_DiLeu_BaLyEn_6	391	396	PF01217	0.354
TRG_ENDOCYTIC_2	222	225	PF00928	0.277
TRG_ENDOCYTIC_2	420	423	PF00928	0.461
TRG_ENDOCYTIC_2	670	673	PF00928	0.599
TRG_ER_diArg_1	206	209	PF00400	0.345
TRG_ER_diArg_1	25	28	PF00400	0.604
TRG_ER_diArg_1	323	326	PF00400	0.556
TRG_ER_diArg_1	504	506	PF00400	0.665
TRG_ER_diArg_1	93	96	PF00400	0.360
TRG_Pf-PMV_PEXEL_1	172	176	PF00026	0.326

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HY04	Leptomonas seymouri	42%	100%
A0A3S7WRT9	Leishmania donovani	99%	100%
A4H6T0	Leishmania braziliensis	66%	100%
E9ANU1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	99%
Q4QGS9	Leishmania major	88%	100%