FYVE-type domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HV55_LEIIN

TriTrypDb:

LINF_120006200

Length:

900

Annotations

Annotations by Jardim et al.

Metal Binding, Uncharacterized LINJ.12.0014

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HV55

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HV55

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0043167	ion binding	2	2
GO:0043169	cation binding	3	2
GO:0046872	metal ion binding	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	211	215	PF00656	0.543
CLV_C14_Caspase3-7	485	489	PF00656	0.553
CLV_C14_Caspase3-7	731	735	PF00656	0.578
CLV_NRD_NRD_1	290	292	PF00675	0.562
CLV_NRD_NRD_1	356	358	PF00675	0.609
CLV_NRD_NRD_1	469	471	PF00675	0.462
CLV_NRD_NRD_1	490	492	PF00675	0.530
CLV_NRD_NRD_1	513	515	PF00675	0.530
CLV_NRD_NRD_1	546	548	PF00675	0.512
CLV_NRD_NRD_1	583	585	PF00675	0.564
CLV_NRD_NRD_1	850	852	PF00675	0.526
CLV_NRD_NRD_1	873	875	PF00675	0.589
CLV_PCSK_FUR_1	288	292	PF00082	0.517
CLV_PCSK_FUR_1	848	852	PF00082	0.490
CLV_PCSK_KEX2_1	202	204	PF00082	0.549
CLV_PCSK_KEX2_1	288	290	PF00082	0.558
CLV_PCSK_KEX2_1	347	349	PF00082	0.663
CLV_PCSK_KEX2_1	469	471	PF00082	0.462
CLV_PCSK_KEX2_1	513	515	PF00082	0.528
CLV_PCSK_KEX2_1	583	585	PF00082	0.566
CLV_PCSK_KEX2_1	629	631	PF00082	0.420
CLV_PCSK_KEX2_1	79	81	PF00082	0.401
CLV_PCSK_KEX2_1	850	852	PF00082	0.570
CLV_PCSK_KEX2_1	857	859	PF00082	0.592
CLV_PCSK_PC1ET2_1	202	204	PF00082	0.549
CLV_PCSK_PC1ET2_1	347	349	PF00082	0.644
CLV_PCSK_PC1ET2_1	629	631	PF00082	0.409
CLV_PCSK_PC1ET2_1	79	81	PF00082	0.401
CLV_PCSK_PC1ET2_1	857	859	PF00082	0.642
CLV_PCSK_PC7_1	343	349	PF00082	0.632
CLV_PCSK_PC7_1	465	471	PF00082	0.456
CLV_PCSK_SKI1_1	121	125	PF00082	0.536
CLV_PCSK_SKI1_1	208	212	PF00082	0.544
CLV_PCSK_SKI1_1	213	217	PF00082	0.495
CLV_PCSK_SKI1_1	230	234	PF00082	0.389
CLV_PCSK_SKI1_1	314	318	PF00082	0.516
CLV_PCSK_SKI1_1	477	481	PF00082	0.523
CLV_PCSK_SKI1_1	530	534	PF00082	0.523
CLV_PCSK_SKI1_1	559	563	PF00082	0.518
CLV_PCSK_SKI1_1	629	633	PF00082	0.483
CLV_PCSK_SKI1_1	646	650	PF00082	0.494
CLV_PCSK_SKI1_1	695	699	PF00082	0.531
CLV_PCSK_SKI1_1	76	80	PF00082	0.309
DEG_APCC_DBOX_1	324	332	PF00400	0.512
DEG_Nend_Nbox_1	1	3	PF02207	0.524
DEG_SPOP_SBC_1	881	885	PF00917	0.557
DOC_CYCLIN_RxL_1	615	626	PF00134	0.481
DOC_MAPK_gen_1	524	533	PF00069	0.489
DOC_MAPK_gen_1	855	861	PF00069	0.581
DOC_PP2B_LxvP_1	57	60	PF13499	0.276
DOC_USP7_MATH_1	17	21	PF00917	0.276
DOC_USP7_MATH_1	170	174	PF00917	0.652
DOC_USP7_MATH_1	182	186	PF00917	0.554
DOC_USP7_MATH_1	320	324	PF00917	0.426
DOC_USP7_MATH_1	416	420	PF00917	0.548
DOC_USP7_MATH_1	682	686	PF00917	0.475
DOC_USP7_MATH_1	880	884	PF00917	0.590
DOC_USP7_UBL2_3	104	108	PF12436	0.516
DOC_USP7_UBL2_3	127	131	PF12436	0.538
DOC_USP7_UBL2_3	213	217	PF12436	0.541
DOC_WW_Pin1_4	165	170	PF00397	0.659
DOC_WW_Pin1_4	739	744	PF00397	0.624
LIG_14-3-3_CanoR_1	181	191	PF00244	0.544
LIG_14-3-3_CanoR_1	3	9	PF00244	0.455
LIG_14-3-3_CanoR_1	547	554	PF00244	0.412
LIG_14-3-3_CanoR_1	584	594	PF00244	0.449
LIG_14-3-3_CanoR_1	596	605	PF00244	0.371
LIG_14-3-3_CanoR_1	683	691	PF00244	0.619
LIG_14-3-3_CanoR_1	805	810	PF00244	0.439
LIG_14-3-3_CanoR_1	832	839	PF00244	0.482
LIG_14-3-3_CanoR_1	864	870	PF00244	0.581
LIG_Actin_WH2_2	324	339	PF00022	0.451
LIG_Actin_WH2_2	859	876	PF00022	0.406
LIG_Clathr_ClatBox_1	758	762	PF01394	0.549
LIG_deltaCOP1_diTrp_1	787	792	PF00928	0.479
LIG_FHA_1	52	58	PF00498	0.270
LIG_FHA_1	647	653	PF00498	0.581
LIG_FHA_1	794	800	PF00498	0.653
LIG_FHA_1	819	825	PF00498	0.553
LIG_FHA_1	833	839	PF00498	0.395
LIG_FHA_2	184	190	PF00498	0.565
LIG_FHA_2	209	215	PF00498	0.540
LIG_FHA_2	540	546	PF00498	0.434
LIG_FHA_2	652	658	PF00498	0.579
LIG_FHA_2	663	669	PF00498	0.470
LIG_FHA_2	674	680	PF00498	0.490
LIG_FHA_2	713	719	PF00498	0.564
LIG_FHA_2	729	735	PF00498	0.457
LIG_FHA_2	79	85	PF00498	0.375
LIG_FHA_2	799	805	PF00498	0.435
LIG_FHA_2	821	827	PF00498	0.552
LIG_FHA_2	883	889	PF00498	0.580
LIG_LIR_Apic_2	14	19	PF02991	0.276
LIG_LIR_Gen_1	245	252	PF02991	0.488
LIG_LIR_Gen_1	6	12	PF02991	0.411
LIG_LIR_Gen_1	752	761	PF02991	0.661
LIG_LIR_Gen_1	787	795	PF02991	0.523
LIG_LIR_Nem_3	245	251	PF02991	0.486
LIG_LIR_Nem_3	31	35	PF02991	0.265
LIG_LIR_Nem_3	6	11	PF02991	0.411
LIG_LIR_Nem_3	752	758	PF02991	0.716
LIG_LIR_Nem_3	787	791	PF02991	0.424
LIG_PCNA_yPIPBox_3	415	424	PF02747	0.526
LIG_Pex14_1	788	792	PF04695	0.483
LIG_Pex14_2	248	252	PF04695	0.487
LIG_RPA_C_Fungi	579	591	PF08784	0.488
LIG_SH2_CRK	755	759	PF00017	0.559
LIG_SH2_CRK	781	785	PF00017	0.519
LIG_SH2_NCK_1	635	639	PF00017	0.436
LIG_SH2_NCK_1	781	785	PF00017	0.519
LIG_SH2_NCK_1	867	871	PF00017	0.473
LIG_SH2_STAP1	292	296	PF00017	0.542
LIG_SH2_STAP1	566	570	PF00017	0.443
LIG_SH2_STAP1	776	780	PF00017	0.530
LIG_SH2_STAT5	867	870	PF00017	0.448
LIG_SH3_3	163	169	PF00018	0.610
LIG_SH3_3	44	50	PF00018	0.269
LIG_SH3_3	57	63	PF00018	0.233
LIG_TRAF2_1	193	196	PF00917	0.520
LIG_TRAF2_1	232	235	PF00917	0.542
LIG_TRAF2_1	362	365	PF00917	0.657
LIG_TRAF2_1	429	432	PF00917	0.504
LIG_TRAF2_1	561	564	PF00917	0.481
LIG_TRAF2_1	579	582	PF00917	0.407
LIG_TRAF2_1	659	662	PF00917	0.575
LIG_TRAF2_1	81	84	PF00917	0.370
MOD_CDC14_SPxK_1	742	745	PF00782	0.599
MOD_CDK_SPxK_1	739	745	PF00069	0.604
MOD_CK1_1	161	167	PF00069	0.621
MOD_CK1_1	187	193	PF00069	0.567
MOD_CK1_1	4	10	PF00069	0.446
MOD_CK1_1	51	57	PF00069	0.265
MOD_CK1_1	685	691	PF00069	0.520
MOD_CK1_1	774	780	PF00069	0.484
MOD_CK1_1	794	800	PF00069	0.398
MOD_CK1_1	865	871	PF00069	0.514
MOD_CK2_1	183	189	PF00069	0.576
MOD_CK2_1	247	253	PF00069	0.533
MOD_CK2_1	339	345	PF00069	0.554
MOD_CK2_1	359	365	PF00069	0.597
MOD_CK2_1	465	471	PF00069	0.535
MOD_CK2_1	522	528	PF00069	0.515
MOD_CK2_1	535	541	PF00069	0.424
MOD_CK2_1	651	657	PF00069	0.553
MOD_CK2_1	662	668	PF00069	0.469
MOD_CK2_1	712	718	PF00069	0.642
MOD_CK2_1	78	84	PF00069	0.361
MOD_CK2_1	798	804	PF00069	0.435
MOD_CK2_1	820	826	PF00069	0.553
MOD_CK2_1	882	888	PF00069	0.590
MOD_GlcNHglycan	186	189	PF01048	0.624
MOD_GlcNHglycan	3	6	PF01048	0.461
MOD_GlcNHglycan	333	336	PF01048	0.490
MOD_GlcNHglycan	446	449	PF01048	0.523
MOD_GlcNHglycan	484	487	PF01048	0.526
MOD_GlcNHglycan	537	540	PF01048	0.463
MOD_GlcNHglycan	587	590	PF01048	0.475
MOD_GlcNHglycan	598	601	PF01048	0.454
MOD_GlcNHglycan	657	660	PF01048	0.533
MOD_GlcNHglycan	686	690	PF01048	0.583
MOD_GlcNHglycan	891	894	PF01048	0.593
MOD_GSK3_1	126	133	PF00069	0.538
MOD_GSK3_1	154	161	PF00069	0.554
MOD_GSK3_1	165	172	PF00069	0.628
MOD_GSK3_1	17	24	PF00069	0.265
MOD_GSK3_1	183	190	PF00069	0.514
MOD_GSK3_1	242	249	PF00069	0.512
MOD_GSK3_1	359	366	PF00069	0.563
MOD_GSK3_1	518	525	PF00069	0.520
MOD_GSK3_1	535	542	PF00069	0.395
MOD_GSK3_1	651	658	PF00069	0.536
MOD_GSK3_1	678	685	PF00069	0.552
MOD_GSK3_1	791	798	PF00069	0.494
MOD_N-GLC_1	182	187	PF02516	0.650
MOD_N-GLC_1	818	823	PF02516	0.532
MOD_N-GLC_2	72	74	PF02516	0.232
MOD_NEK2_1	1	6	PF00069	0.511
MOD_NEK2_1	130	135	PF00069	0.532
MOD_NEK2_1	331	336	PF00069	0.487
MOD_NEK2_1	363	368	PF00069	0.554
MOD_NEK2_1	508	513	PF00069	0.499
MOD_NEK2_1	673	678	PF00069	0.671
MOD_NEK2_1	719	724	PF00069	0.510
MOD_NEK2_1	795	800	PF00069	0.556
MOD_NEK2_1	817	822	PF00069	0.557
MOD_NEK2_2	170	175	PF00069	0.632
MOD_OFUCOSY	537	543	PF10250	0.371
MOD_PIKK_1	11	17	PF00454	0.385
MOD_PIKK_1	276	282	PF00454	0.419
MOD_PIKK_1	320	326	PF00454	0.427
MOD_PIKK_1	350	356	PF00454	0.701
MOD_PIKK_1	477	483	PF00454	0.515
MOD_PIKK_1	508	514	PF00454	0.493
MOD_PIKK_1	518	524	PF00454	0.455
MOD_PIKK_1	582	588	PF00454	0.438
MOD_PIKK_1	62	68	PF00454	0.276
MOD_PIKK_1	646	652	PF00454	0.580
MOD_PIKK_1	786	792	PF00454	0.520
MOD_PIKK_1	832	838	PF00454	0.482
MOD_PKA_1	217	223	PF00069	0.532
MOD_PKA_1	535	541	PF00069	0.461
MOD_PKA_2	398	404	PF00069	0.530
MOD_PKA_2	482	488	PF00069	0.549
MOD_PKA_2	546	552	PF00069	0.413
MOD_PKA_2	582	588	PF00069	0.492
MOD_PKA_2	662	668	PF00069	0.611
MOD_PKA_2	673	679	PF00069	0.600
MOD_PKA_2	682	688	PF00069	0.500
MOD_PKB_1	644	652	PF00069	0.580
MOD_Plk_1	208	214	PF00069	0.527
MOD_Plk_1	363	369	PF00069	0.555
MOD_Plk_1	522	528	PF00069	0.500
MOD_Plk_1	750	756	PF00069	0.518
MOD_Plk_1	786	792	PF00069	0.547
MOD_Plk_1	881	887	PF00069	0.573
MOD_Plk_2-3	341	347	PF00069	0.566
MOD_Plk_2-3	882	888	PF00069	0.590
MOD_Plk_4	247	253	PF00069	0.533
MOD_Plk_4	771	777	PF00069	0.485
MOD_ProDKin_1	165	171	PF00069	0.661
MOD_ProDKin_1	739	745	PF00069	0.627
MOD_SUMO_for_1	429	432	PF00179	0.504
MOD_SUMO_for_1	561	564	PF00179	0.470
MOD_SUMO_rev_2	115	123	PF00179	0.565
MOD_SUMO_rev_2	523	532	PF00179	0.494
MOD_SUMO_rev_2	564	570	PF00179	0.499
TRG_DiLeu_BaEn_1	118	123	PF01217	0.565
TRG_DiLeu_BaEn_1	453	458	PF01217	0.498
TRG_DiLeu_BaEn_4	118	124	PF01217	0.541
TRG_DiLeu_BaEn_4	254	260	PF01217	0.525
TRG_DiLeu_BaEn_4	528	534	PF01217	0.484
TRG_DiLeu_BaEn_4	686	692	PF01217	0.583
TRG_ENDOCYTIC_2	292	295	PF00928	0.548
TRG_ENDOCYTIC_2	755	758	PF00928	0.600
TRG_ENDOCYTIC_2	781	784	PF00928	0.521
TRG_ER_diArg_1	256	259	PF00400	0.523
TRG_ER_diArg_1	288	291	PF00400	0.558
TRG_ER_diArg_1	809	812	PF00400	0.534
TRG_ER_diArg_1	831	834	PF00400	0.550
TRG_ER_diArg_1	850	852	PF00400	0.519
TRG_NES_CRM1_1	128	142	PF08389	0.534
TRG_NLS_MonoCore_2	199	204	PF00514	0.547
TRG_NLS_MonoExtC_3	200	206	PF00514	0.548
TRG_NLS_MonoExtN_4	200	205	PF00514	0.550
TRG_Pf-PMV_PEXEL_1	319	324	PF00026	0.483
TRG_Pf-PMV_PEXEL_1	392	396	PF00026	0.551
TRG_Pf-PMV_PEXEL_1	703	707	PF00026	0.635
TRG_Pf-PMV_PEXEL_1	80	84	PF00026	0.415

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WRW5	Leishmania donovani	99%	100%
A4H6S7	Leishmania braziliensis	69%	98%
E9ANT8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QGT2	Leishmania major	87%	99%