Plus3 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Plus-3 domain/Zinc finger - C3HC4 type (RING finger) containing protein - putative

Species:

Leishmania infantum

UniProt:

A4HV54_LEIIN

TriTrypDb:

LINF_120006100

Length:

293

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 2
Forrest at al. (procyclic)	yes	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HV54

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HV54

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	14
GO:0003677	DNA binding	4	14
GO:0005488	binding	1	14
GO:0097159	organic cyclic compound binding	2	14
GO:1901363	heterocyclic compound binding	2	14

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	63	67	PF00656	0.483
CLV_NRD_NRD_1	169	171	PF00675	0.672
CLV_NRD_NRD_1	190	192	PF00675	0.670
CLV_NRD_NRD_1	206	208	PF00675	0.703
CLV_NRD_NRD_1	61	63	PF00675	0.432
CLV_PCSK_KEX2_1	169	171	PF00082	0.663
CLV_PCSK_KEX2_1	190	192	PF00082	0.680
CLV_PCSK_KEX2_1	206	208	PF00082	0.370
CLV_PCSK_KEX2_1	61	63	PF00082	0.429
CLV_PCSK_PC1ET2_1	190	192	PF00082	0.683
CLV_PCSK_SKI1_1	192	196	PF00082	0.648
CLV_PCSK_SKI1_1	224	228	PF00082	0.514
CLV_PCSK_SKI1_1	242	246	PF00082	0.280
CLV_PCSK_SKI1_1	49	53	PF00082	0.400
CLV_PCSK_SKI1_1	7	11	PF00082	0.614
DEG_APCC_DBOX_1	223	231	PF00400	0.535
DOC_CDC14_PxL_1	143	151	PF14671	0.609
DOC_CYCLIN_RxL_1	206	218	PF00134	0.655
DOC_CYCLIN_RxL_1	44	56	PF00134	0.401
DOC_PP1_RVXF_1	137	144	PF00149	0.677
DOC_USP7_UBL2_3	265	269	PF12436	0.526
DOC_WW_Pin1_4	118	123	PF00397	0.418
DOC_WW_Pin1_4	279	284	PF00397	0.427
DOC_WW_Pin1_4	61	66	PF00397	0.519
LIG_14-3-3_CanoR_1	105	113	PF00244	0.409
LIG_14-3-3_CanoR_1	191	199	PF00244	0.718
LIG_14-3-3_CanoR_1	249	257	PF00244	0.435
LIG_14-3-3_CanoR_1	27	31	PF00244	0.444
LIG_BIR_II_1	1	5	PF00653	0.664
LIG_deltaCOP1_diTrp_1	35	39	PF00928	0.428
LIG_FHA_1	136	142	PF00498	0.693
LIG_FHA_1	193	199	PF00498	0.659
LIG_LIR_Gen_1	66	76	PF02991	0.526
LIG_LIR_Gen_1	91	102	PF02991	0.407
LIG_LIR_Nem_3	140	146	PF02991	0.661
LIG_LIR_Nem_3	287	291	PF02991	0.506
LIG_LIR_Nem_3	35	39	PF02991	0.407
LIG_LIR_Nem_3	66	72	PF02991	0.498
LIG_LIR_Nem_3	91	97	PF02991	0.430
LIG_PTB_Apo_2	117	124	PF02174	0.418
LIG_SH2_GRB2like	128	131	PF00017	0.526
LIG_SH2_PTP2	47	50	PF00017	0.446
LIG_SH2_PTP2	69	72	PF00017	0.526
LIG_SH2_STAP1	286	290	PF00017	0.611
LIG_SH2_STAT5	286	289	PF00017	0.608
LIG_SH2_STAT5	47	50	PF00017	0.446
LIG_SH2_STAT5	69	72	PF00017	0.402
LIG_SH3_3	141	147	PF00018	0.651
LIG_SUMO_SIM_anti_2	225	231	PF11976	0.644
LIG_SUMO_SIM_par_1	225	231	PF11976	0.626
LIG_TRAF2_1	56	59	PF00917	0.524
MOD_CDC14_SPxK_1	121	124	PF00782	0.433
MOD_CDK_SPxK_1	118	124	PF00069	0.433
MOD_CK1_1	142	148	PF00069	0.649
MOD_CK1_1	83	89	PF00069	0.418
MOD_CK2_1	233	239	PF00069	0.507
MOD_CK2_1	53	59	PF00069	0.524
MOD_GlcNHglycan	82	85	PF01048	0.433
MOD_GSK3_1	114	121	PF00069	0.391
MOD_GSK3_1	135	142	PF00069	0.666
MOD_LATS_1	247	253	PF00433	0.451
MOD_LATS_1	5	11	PF00433	0.562
MOD_N-GLC_1	135	140	PF02516	0.664
MOD_N-GLC_1	37	42	PF02516	0.524
MOD_NEK2_1	104	109	PF00069	0.409
MOD_NEK2_1	25	30	PF00069	0.418
MOD_NEK2_2	267	272	PF00069	0.497
MOD_PIKK_1	104	110	PF00454	0.432
MOD_PKA_1	192	198	PF00069	0.637
MOD_PKA_2	104	110	PF00069	0.409
MOD_PKA_2	192	198	PF00069	0.637
MOD_PKA_2	233	239	PF00069	0.515
MOD_PKA_2	26	32	PF00069	0.446
MOD_PKA_2	54	60	PF00069	0.466
MOD_Plk_1	139	145	PF00069	0.674
MOD_Plk_4	26	32	PF00069	0.439
MOD_ProDKin_1	118	124	PF00069	0.418
MOD_ProDKin_1	279	285	PF00069	0.427
MOD_ProDKin_1	61	67	PF00069	0.519
TRG_DiLeu_BaEn_1	225	230	PF01217	0.645
TRG_ENDOCYTIC_2	47	50	PF00928	0.446
TRG_ENDOCYTIC_2	69	72	PF00928	0.463
TRG_ENDOCYTIC_2	82	85	PF00928	0.295
TRG_ER_diArg_1	168	170	PF00400	0.679
TRG_ER_diArg_1	191	194	PF00400	0.685
TRG_ER_diArg_1	205	207	PF00400	0.704
TRG_ER_diArg_1	271	274	PF00400	0.427
TRG_NES_CRM1_1	225	239	PF08389	0.548
TRG_NLS_MonoExtC_3	190	196	PF00514	0.679
TRG_NLS_MonoExtN_4	190	195	PF00514	0.676
TRG_Pf-PMV_PEXEL_1	185	189	PF00026	0.659
TRG_Pf-PMV_PEXEL_1	206	210	PF00026	0.639
TRG_Pf-PMV_PEXEL_1	224	228	PF00026	0.431
TRG_Pf-PMV_PEXEL_1	49	53	PF00026	0.384

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5T3	Leptomonas seymouri	87%	100%
A0A0S4JCN1	Bodo saltans	26%	90%
A0A0S4JLV2	Bodo saltans	53%	100%
A0A1X0NMT4	Trypanosomatidae	68%	100%
A0A3R7KK47	Trypanosoma rangeli	68%	100%
A0A3S5H6K3	Leishmania donovani	100%	100%
A4H6S6	Leishmania braziliensis	92%	99%
C9ZQD1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	100%
D0A9C1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	72%
E9ANT7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q4QGT3	Leishmania major	98%	100%
V5BHW6	Trypanosoma cruzi	66%	100%