TPH domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HV51_LEIIN

TriTrypDb:

LINF_120005700

Length:

621

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized LINJ.12.0008

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HV51

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HV51

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	454	458	PF00656	0.537
CLV_NRD_NRD_1	106	108	PF00675	0.594
CLV_NRD_NRD_1	124	126	PF00675	0.384
CLV_NRD_NRD_1	183	185	PF00675	0.461
CLV_NRD_NRD_1	191	193	PF00675	0.453
CLV_NRD_NRD_1	211	213	PF00675	0.383
CLV_NRD_NRD_1	235	237	PF00675	0.606
CLV_NRD_NRD_1	259	261	PF00675	0.666
CLV_NRD_NRD_1	282	284	PF00675	0.508
CLV_NRD_NRD_1	305	307	PF00675	0.573
CLV_NRD_NRD_1	308	310	PF00675	0.561
CLV_NRD_NRD_1	343	345	PF00675	0.550
CLV_NRD_NRD_1	359	361	PF00675	0.502
CLV_NRD_NRD_1	384	386	PF00675	0.561
CLV_NRD_NRD_1	447	449	PF00675	0.468
CLV_NRD_NRD_1	503	505	PF00675	0.502
CLV_NRD_NRD_1	510	512	PF00675	0.508
CLV_NRD_NRD_1	549	551	PF00675	0.469
CLV_NRD_NRD_1	561	563	PF00675	0.417
CLV_NRD_NRD_1	571	573	PF00675	0.508
CLV_PCSK_FUR_1	209	213	PF00082	0.461
CLV_PCSK_FUR_1	341	345	PF00082	0.643
CLV_PCSK_FUR_1	357	361	PF00082	0.535
CLV_PCSK_FUR_1	445	449	PF00082	0.538
CLV_PCSK_KEX2_1	106	108	PF00082	0.584
CLV_PCSK_KEX2_1	124	126	PF00082	0.642
CLV_PCSK_KEX2_1	148	150	PF00082	0.445
CLV_PCSK_KEX2_1	183	185	PF00082	0.463
CLV_PCSK_KEX2_1	191	193	PF00082	0.457
CLV_PCSK_KEX2_1	211	213	PF00082	0.360
CLV_PCSK_KEX2_1	259	261	PF00082	0.603
CLV_PCSK_KEX2_1	282	284	PF00082	0.515
CLV_PCSK_KEX2_1	305	307	PF00082	0.548
CLV_PCSK_KEX2_1	343	345	PF00082	0.470
CLV_PCSK_KEX2_1	359	361	PF00082	0.480
CLV_PCSK_KEX2_1	384	386	PF00082	0.612
CLV_PCSK_KEX2_1	396	398	PF00082	0.469
CLV_PCSK_KEX2_1	411	413	PF00082	0.433
CLV_PCSK_KEX2_1	447	449	PF00082	0.471
CLV_PCSK_KEX2_1	503	505	PF00082	0.472
CLV_PCSK_KEX2_1	510	512	PF00082	0.482
CLV_PCSK_KEX2_1	516	518	PF00082	0.494
CLV_PCSK_KEX2_1	561	563	PF00082	0.530
CLV_PCSK_KEX2_1	571	573	PF00082	0.526
CLV_PCSK_PC1ET2_1	106	108	PF00082	0.639
CLV_PCSK_PC1ET2_1	148	150	PF00082	0.449
CLV_PCSK_PC1ET2_1	396	398	PF00082	0.615
CLV_PCSK_PC1ET2_1	411	413	PF00082	0.438
CLV_PCSK_PC1ET2_1	516	518	PF00082	0.561
CLV_PCSK_PC1ET2_1	571	573	PF00082	0.659
CLV_PCSK_PC7_1	207	213	PF00082	0.461
CLV_PCSK_PC7_1	392	398	PF00082	0.474
CLV_PCSK_PC7_1	506	512	PF00082	0.450
CLV_PCSK_SKI1_1	183	187	PF00082	0.461
CLV_PCSK_SKI1_1	251	255	PF00082	0.596
CLV_PCSK_SKI1_1	561	565	PF00082	0.420
CLV_PCSK_SKI1_1	77	81	PF00082	0.575
CLV_Separin_Metazoa	42	46	PF03568	0.443
DEG_APCC_DBOX_1	183	191	PF00400	0.453
DEG_APCC_DBOX_1	281	289	PF00400	0.408
DEG_APCC_DBOX_1	3	11	PF00400	0.423
DEG_ODPH_VHL_1	69	82	PF01847	0.470
DOC_CYCLIN_RxL_1	180	189	PF00134	0.497
DOC_CYCLIN_RxL_1	246	258	PF00134	0.456
DOC_MAPK_gen_1	124	131	PF00069	0.487
DOC_MAPK_gen_1	396	403	PF00069	0.496
DOC_MAPK_gen_1	445	455	PF00069	0.441
DOC_MAPK_MEF2A_6	396	405	PF00069	0.409
DOC_PP2B_LxvP_1	22	25	PF13499	0.419
DOC_PP2B_LxvP_1	69	72	PF13499	0.532
DOC_PP4_FxxP_1	21	24	PF00568	0.442
DOC_PP4_FxxP_1	484	487	PF00568	0.485
DOC_USP7_MATH_1	110	114	PF00917	0.549
DOC_USP7_MATH_1	374	378	PF00917	0.622
DOC_USP7_MATH_1	72	76	PF00917	0.691
DOC_USP7_UBL2_3	126	130	PF12436	0.464
DOC_WW_Pin1_4	160	165	PF00397	0.538
DOC_WW_Pin1_4	20	25	PF00397	0.402
DOC_WW_Pin1_4	488	493	PF00397	0.562
DOC_WW_Pin1_4	9	14	PF00397	0.440
LIG_14-3-3_CanoR_1	4	8	PF00244	0.432
LIG_BRCT_BRCA1_1	13	17	PF00533	0.427
LIG_BRCT_BRCA1_1	162	166	PF00533	0.466
LIG_BRCT_BRCA1_1	46	50	PF00533	0.474
LIG_BRCT_BRCA1_1	5	9	PF00533	0.444
LIG_FHA_1	116	122	PF00498	0.469
LIG_FHA_1	25	31	PF00498	0.470
LIG_FHA_1	289	295	PF00498	0.505
LIG_FHA_1	602	608	PF00498	0.388
LIG_FHA_1	97	103	PF00498	0.735
LIG_FHA_2	252	258	PF00498	0.587
LIG_FHA_2	573	579	PF00498	0.565
LIG_FHA_2	93	99	PF00498	0.667
LIG_LIR_Apic_2	113	117	PF02991	0.536
LIG_LIR_Gen_1	14	25	PF02991	0.571
LIG_LIR_Gen_1	376	383	PF02991	0.649
LIG_LIR_Gen_1	47	58	PF02991	0.458
LIG_LIR_Nem_3	14	20	PF02991	0.569
LIG_LIR_Nem_3	376	382	PF02991	0.571
LIG_LIR_Nem_3	47	53	PF02991	0.455
LIG_NRP_CendR_1	619	621	PF00754	0.637
LIG_Pex14_2	17	21	PF04695	0.413
LIG_Pex14_2	5	9	PF04695	0.444
LIG_RPA_C_Fungi	338	350	PF08784	0.593
LIG_SH2_CRK	599	603	PF00017	0.380
LIG_SH2_NCK_1	114	118	PF00017	0.562
LIG_SH2_NCK_1	429	433	PF00017	0.481
LIG_SH2_SRC	114	117	PF00017	0.553
LIG_SH2_STAP1	425	429	PF00017	0.450
LIG_SH2_STAT5	133	136	PF00017	0.335
LIG_SH3_3	79	85	PF00018	0.526
LIG_TRAF2_1	201	204	PF00917	0.539
LIG_TRAF2_1	228	231	PF00917	0.488
LIG_TRAF2_1	521	524	PF00917	0.519
LIG_TRAF2_1	541	544	PF00917	0.303
LIG_TRAF2_1	95	98	PF00917	0.600
LIG_WRC_WIRS_1	434	439	PF05994	0.431
MOD_CDK_SPxxK_3	160	167	PF00069	0.467
MOD_CK2_1	198	204	PF00069	0.540
MOD_CK2_1	251	257	PF00069	0.626
MOD_CK2_1	538	544	PF00069	0.470
MOD_CK2_1	92	98	PF00069	0.667
MOD_GlcNHglycan	271	274	PF01048	0.638
MOD_GlcNHglycan	46	49	PF01048	0.573
MOD_GlcNHglycan	540	543	PF01048	0.433
MOD_GlcNHglycan	610	613	PF01048	0.445
MOD_GlcNHglycan	64	68	PF01048	0.691
MOD_GSK3_1	135	142	PF00069	0.446
MOD_GSK3_1	20	27	PF00069	0.504
MOD_GSK3_1	44	51	PF00069	0.443
MOD_GSK3_1	88	95	PF00069	0.627
MOD_NEK2_2	374	379	PF00069	0.658
MOD_OFUCOSY	93	100	PF10250	0.592
MOD_PIKK_1	486	492	PF00454	0.653
MOD_PIKK_1	83	89	PF00454	0.618
MOD_PK_1	139	145	PF00069	0.398
MOD_PKA_1	550	556	PF00069	0.468
MOD_PKA_1	572	578	PF00069	0.664
MOD_PKA_2	198	204	PF00069	0.377
MOD_PKA_2	3	9	PF00069	0.425
MOD_PKA_2	358	364	PF00069	0.534
MOD_PKA_2	44	50	PF00069	0.450
MOD_PKB_1	474	482	PF00069	0.569
MOD_PKB_1	548	556	PF00069	0.409
MOD_Plk_1	476	482	PF00069	0.623
MOD_Plk_1	48	54	PF00069	0.519
MOD_Plk_1	585	591	PF00069	0.601
MOD_Plk_4	139	145	PF00069	0.445
MOD_Plk_4	374	380	PF00069	0.544
MOD_ProDKin_1	160	166	PF00069	0.541
MOD_ProDKin_1	20	26	PF00069	0.402
MOD_ProDKin_1	488	494	PF00069	0.554
MOD_ProDKin_1	9	15	PF00069	0.441
MOD_SUMO_for_1	430	433	PF00179	0.478
MOD_SUMO_rev_2	303	311	PF00179	0.562
MOD_SUMO_rev_2	544	553	PF00179	0.579
TRG_ER_diArg_1	123	125	PF00400	0.508
TRG_ER_diArg_1	190	192	PF00400	0.498
TRG_ER_diArg_1	209	212	PF00400	0.379
TRG_ER_diArg_1	341	344	PF00400	0.510
TRG_ER_diArg_1	359	362	PF00400	0.565
TRG_ER_diArg_1	384	387	PF00400	0.493
TRG_ER_diArg_1	445	448	PF00400	0.502
TRG_ER_diArg_1	503	505	PF00400	0.506
TRG_ER_diArg_1	509	511	PF00400	0.508
TRG_ER_diArg_1	560	562	PF00400	0.550
TRG_NLS_Bipartite_1	561	575	PF00514	0.437
TRG_NLS_MonoExtC_3	235	241	PF00514	0.402
TRG_NLS_MonoExtN_4	105	110	PF00514	0.609
TRG_Pf-PMV_PEXEL_1	148	152	PF00026	0.440
TRG_Pf-PMV_PEXEL_1	184	188	PF00026	0.518
TRG_Pf-PMV_PEXEL_1	211	216	PF00026	0.487
TRG_Pf-PMV_PEXEL_1	292	296	PF00026	0.491
TRG_Pf-PMV_PEXEL_1	329	333	PF00026	0.645
TRG_Pf-PMV_PEXEL_1	532	536	PF00026	0.448
TRG_Pf-PMV_PEXEL_1	561	565	PF00026	0.450

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK43	Leptomonas seymouri	48%	100%
A0A1X0NM25	Trypanosomatidae	27%	100%
A0A3Q8I971	Leishmania donovani	100%	100%
A0A422N6D2	Trypanosoma rangeli	30%	100%
A4H6S2	Leishmania braziliensis	72%	100%
C9ZQD4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9ANT3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QGT6	Leishmania major	83%	100%