PITH domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PITH domain-containing protein

Species:

Leishmania infantum

UniProt:

A4HV46_LEIIN

TriTrypDb:

LINF_120005100

Length:

288

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized LINJ.12.0002

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HV46

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HV46

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	212	218	PF00089	0.294
CLV_NRD_NRD_1	61	63	PF00675	0.540
CLV_PCSK_KEX2_1	60	62	PF00082	0.792
CLV_PCSK_PC1ET2_1	60	62	PF00082	0.792
CLV_PCSK_PC7_1	57	63	PF00082	0.538
CLV_PCSK_SKI1_1	281	285	PF00082	0.653
CLV_PCSK_SKI1_1	57	61	PF00082	0.747
DOC_MAPK_gen_1	176	183	PF00069	0.606
DOC_MAPK_MEF2A_6	176	183	PF00069	0.606
DOC_MAPK_MEF2A_6	5	14	PF00069	0.493
DOC_PP1_RVXF_1	159	166	PF00149	0.610
DOC_PP1_RVXF_1	279	286	PF00149	0.560
DOC_PP2B_LxvP_1	100	103	PF13499	0.567
DOC_PP4_FxxP_1	165	168	PF00568	0.612
DOC_USP7_MATH_1	139	143	PF00917	0.526
DOC_USP7_MATH_1	153	157	PF00917	0.526
DOC_USP7_MATH_1	83	87	PF00917	0.693
DOC_WW_Pin1_4	118	123	PF00397	0.623
DOC_WW_Pin1_4	29	34	PF00397	0.489
LIG_14-3-3_CanoR_1	215	221	PF00244	0.570
LIG_14-3-3_CanoR_1	61	68	PF00244	0.533
LIG_APCC_ABBA_1	10	15	PF00400	0.488
LIG_APCC_ABBA_1	245	250	PF00400	0.555
LIG_APCC_ABBAyCdc20_2	244	250	PF00400	0.540
LIG_APCC_ABBAyCdc20_2	9	15	PF00400	0.489
LIG_BRCT_BRCA1_1	225	229	PF00533	0.606
LIG_FHA_1	19	25	PF00498	0.622
LIG_FHA_1	238	244	PF00498	0.534
LIG_FHA_1	260	266	PF00498	0.595
LIG_FHA_1	62	68	PF00498	0.733
LIG_FHA_2	119	125	PF00498	0.627
LIG_LIR_Apic_2	164	168	PF02991	0.637
LIG_Pex14_2	231	235	PF04695	0.535
LIG_Pex14_2	34	38	PF04695	0.473
LIG_SH2_STAT5	13	16	PF00017	0.490
LIG_SH2_STAT5	28	31	PF00017	0.438
LIG_SH2_STAT5	3	6	PF00017	0.501
LIG_TRAF2_1	277	280	PF00917	0.611
MOD_CK1_1	118	124	PF00069	0.591
MOD_CK1_1	222	228	PF00069	0.557
MOD_CK2_1	118	124	PF00069	0.557
MOD_CK2_1	274	280	PF00069	0.700
MOD_GlcNHglycan	109	113	PF01048	0.386
MOD_GlcNHglycan	133	136	PF01048	0.397
MOD_GlcNHglycan	150	153	PF01048	0.345
MOD_GlcNHglycan	216	219	PF01048	0.345
MOD_GlcNHglycan	35	38	PF01048	0.466
MOD_GSK3_1	148	155	PF00069	0.567
MOD_GSK3_1	219	226	PF00069	0.578
MOD_GSK3_1	249	256	PF00069	0.695
MOD_GSK3_1	29	36	PF00069	0.486
MOD_GSK3_1	79	86	PF00069	0.718
MOD_N-GLC_1	169	174	PF02516	0.427
MOD_NEK2_1	115	120	PF00069	0.578
MOD_NEK2_1	129	134	PF00069	0.578
MOD_NEK2_1	148	153	PF00069	0.594
MOD_NEK2_1	231	236	PF00069	0.548
MOD_PIKK_1	253	259	PF00454	0.662
MOD_PIKK_1	62	68	PF00454	0.667
MOD_PK_1	220	226	PF00069	0.610
MOD_PKA_1	61	67	PF00069	0.533
MOD_PKA_2	214	220	PF00069	0.494
MOD_PKA_2	61	67	PF00069	0.533
MOD_Plk_1	108	114	PF00069	0.627
MOD_Plk_1	231	237	PF00069	0.540
MOD_Plk_4	161	167	PF00069	0.591
MOD_Plk_4	225	231	PF00069	0.578
MOD_ProDKin_1	118	124	PF00069	0.623
MOD_ProDKin_1	29	35	PF00069	0.486
MOD_SUMO_rev_2	233	243	PF00179	0.494
MOD_SUMO_rev_2	274	284	PF00179	0.655
TRG_DiLeu_BaEn_1	279	284	PF01217	0.569
TRG_NLS_MonoCore_2	59	64	PF00514	0.536
TRG_NLS_MonoExtN_4	57	64	PF00514	0.537
TRG_Pf-PMV_PEXEL_1	282	286	PF00026	0.737

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5T0	Leptomonas seymouri	73%	100%
A0A0S4KLB0	Bodo saltans	41%	100%
A0A1X0NNQ9	Trypanosomatidae	49%	100%
A0A3S7WRT2	Leishmania donovani	100%	100%
A0A422N6F9	Trypanosoma rangeli	52%	100%
C9ZQE0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9ANS7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4QGU2	Leishmania major	94%	100%