LeishMANIAdb
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Putative translation initiation factor EIF-2b alpha subunit

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative translation initiation factor EIF-2b alpha subunit
Gene product:
translation initiation factor EIF-2b alpha subunit - putative
Species:
Leishmania infantum
UniProt:
A4HV45_LEIIN
TriTrypDb:
LINF_120005000
Length:
301

Annotations

Annotations by Jardim et al.

Translation, translation initiation factor EIF-2b alpha subunit LINJ.12.0001

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0005851 eukaryotic translation initiation factor 2B complex 2 1
GO:0032991 protein-containing complex 1 1
GO:0110165 cellular anatomical entity 1 2
GO:0016020 membrane 2 1

Expansion

Sequence features

A4HV45
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HV45

Function

Biological processes
Term Name Level Count
GO:0006413 translational initiation 3 1
GO:0008152 metabolic process 1 1
GO:0009987 cellular process 1 1
GO:0044237 cellular metabolic process 2 1
GO:0050790 regulation of catalytic activity 3 1
GO:0065007 biological regulation 1 1
GO:0065009 regulation of molecular function 2 1
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 12
GO:0003743 translation initiation factor activity 4 12
GO:0005488 binding 1 12
GO:0008135 translation factor activity, RNA binding 3 12
GO:0045182 translation regulator activity 1 12
GO:0090079 translation regulator activity, nucleic acid binding 2 12
GO:0097159 organic cyclic compound binding 2 12
GO:1901363 heterocyclic compound binding 2 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 142 144 PF00675 0.499
CLV_PCSK_KEX2_1 299 301 PF00082 0.634
CLV_PCSK_KEX2_1 44 46 PF00082 0.515
CLV_PCSK_KEX2_1 79 81 PF00082 0.521
CLV_PCSK_PC1ET2_1 299 301 PF00082 0.655
CLV_PCSK_PC1ET2_1 44 46 PF00082 0.515
CLV_PCSK_PC1ET2_1 79 81 PF00082 0.521
CLV_PCSK_SKI1_1 41 45 PF00082 0.404
CLV_PCSK_SKI1_1 62 66 PF00082 0.534
CLV_PCSK_SKI1_1 72 76 PF00082 0.452
DEG_Nend_UBRbox_2 1 3 PF02207 0.415
DEG_SCF_TRCP1_1 180 185 PF00400 0.527
DOC_CKS1_1 159 164 PF01111 0.493
DOC_PP4_FxxP_1 262 265 PF00568 0.431
DOC_SPAK_OSR1_1 133 137 PF12202 0.458
DOC_SPAK_OSR1_1 55 59 PF12202 0.365
DOC_USP7_MATH_1 147 151 PF00917 0.475
DOC_USP7_MATH_1 64 68 PF00917 0.474
DOC_USP7_UBL2_3 75 79 PF12436 0.562
DOC_WW_Pin1_4 158 163 PF00397 0.433
LIG_14-3-3_CanoR_1 104 111 PF00244 0.397
LIG_14-3-3_CanoR_1 27 33 PF00244 0.496
LIG_14-3-3_CanoR_1 289 294 PF00244 0.484
LIG_AP2alpha_1 49 53 PF02296 0.481
LIG_BRCT_BRCA1_1 25 29 PF00533 0.415
LIG_EH1_1 7 15 PF00400 0.372
LIG_FHA_1 104 110 PF00498 0.332
LIG_FHA_1 208 214 PF00498 0.453
LIG_FHA_1 241 247 PF00498 0.431
LIG_FHA_2 29 35 PF00498 0.395
LIG_LIR_Apic_2 261 265 PF02991 0.431
LIG_LIR_Gen_1 191 200 PF02991 0.441
LIG_LIR_Gen_1 232 241 PF02991 0.442
LIG_LIR_Gen_1 26 35 PF02991 0.406
LIG_LIR_Gen_1 51 60 PF02991 0.379
LIG_LIR_Nem_3 232 238 PF02991 0.454
LIG_LIR_Nem_3 26 32 PF02991 0.398
LIG_LIR_Nem_3 51 56 PF02991 0.374
LIG_NRP_CendR_1 299 301 PF00754 0.715
LIG_Pex14_2 235 239 PF04695 0.431
LIG_Pex14_2 49 53 PF04695 0.481
LIG_PTAP_UEV_1 293 298 PF05743 0.660
LIG_PTB_Apo_2 186 193 PF02174 0.511
LIG_SH2_CRK 174 178 PF00017 0.367
LIG_SH2_STAP1 8 12 PF00017 0.372
LIG_SH2_STAT5 135 138 PF00017 0.325
LIG_SH2_STAT5 174 177 PF00017 0.437
LIG_SH2_STAT5 198 201 PF00017 0.441
LIG_SH2_STAT5 227 230 PF00017 0.443
LIG_SH3_2 294 299 PF14604 0.677
LIG_SH3_3 291 297 PF00018 0.645
LIG_SH3_5 4 8 PF00018 0.380
LIG_SUMO_SIM_anti_2 266 274 PF11976 0.431
LIG_SUMO_SIM_anti_2 9 14 PF11976 0.389
LIG_SUMO_SIM_par_1 116 121 PF11976 0.429
LIG_TRAF2_1 125 128 PF00917 0.360
LIG_WRC_WIRS_1 29 34 PF05994 0.522
MOD_CK1_1 181 187 PF00069 0.527
MOD_CK1_1 209 215 PF00069 0.442
MOD_CK1_1 266 272 PF00069 0.449
MOD_CK2_1 122 128 PF00069 0.462
MOD_CK2_1 28 34 PF00069 0.416
MOD_Cter_Amidation 297 300 PF01082 0.610
MOD_GlcNHglycan 113 116 PF01048 0.430
MOD_GlcNHglycan 149 152 PF01048 0.420
MOD_GlcNHglycan 180 183 PF01048 0.297
MOD_GlcNHglycan 280 283 PF01048 0.337
MOD_GlcNHglycan 294 297 PF01048 0.534
MOD_GSK3_1 118 125 PF00069 0.436
MOD_GSK3_1 178 185 PF00069 0.518
MOD_GSK3_1 266 273 PF00069 0.431
MOD_GSK3_1 30 37 PF00069 0.436
MOD_N-GLC_1 104 109 PF02516 0.524
MOD_N-GLC_1 58 63 PF02516 0.496
MOD_N-GLC_2 173 175 PF02516 0.277
MOD_NEK2_1 118 123 PF00069 0.436
MOD_NEK2_1 206 211 PF00069 0.451
MOD_NEK2_1 229 234 PF00069 0.410
MOD_NEK2_1 70 75 PF00069 0.390
MOD_PIKK_1 88 94 PF00454 0.386
MOD_PKA_2 103 109 PF00069 0.408
MOD_Plk_1 104 110 PF00069 0.404
MOD_Plk_1 8 14 PF00069 0.353
MOD_Plk_2-3 2 8 PF00069 0.471
MOD_Plk_4 105 111 PF00069 0.445
MOD_Plk_4 182 188 PF00069 0.446
MOD_Plk_4 263 269 PF00069 0.440
MOD_Plk_4 8 14 PF00069 0.486
MOD_ProDKin_1 158 164 PF00069 0.427
MOD_SUMO_rev_2 242 249 PF00179 0.442
TRG_DiLeu_BaEn_1 202 207 PF01217 0.439
TRG_ENDOCYTIC_2 174 177 PF00928 0.437
TRG_ENDOCYTIC_2 46 49 PF00928 0.403

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5D7 Leptomonas seymouri 87% 100%
A0A0S4KHS3 Bodo saltans 56% 98%
A0A1X0NMS5 Trypanosomatidae 69% 100%
A0A3Q8IBD6 Leishmania donovani 100% 100%
A0A3R7NDG3 Trypanosoma rangeli 66% 99%
A4H6R5 Leishmania braziliensis 92% 100%
C9ZQE1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 70% 81%
E9ANS6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 98% 100%
P14741 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 27% 99%
P34604 Caenorhabditis elegans 24% 99%
Q0IIF2 Bos taurus 31% 99%
Q14232 Homo sapiens 29% 99%
Q4QGU3 Leishmania major 98% 100%
Q4R4V8 Macaca fascicularis 30% 99%
Q54I81 Dictyostelium discoideum 29% 94%
Q57586 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) 24% 98%
Q5RAR0 Pongo abelii 29% 99%
Q64270 Rattus norvegicus 30% 99%
Q99LC8 Mus musculus 30% 99%
Q9USP0 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 28% 88%
V5BMF9 Trypanosoma cruzi 67% 81%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS