Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SH3 domain/Variant SH3 domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4HV44_LEIIN

TriTrypDb:

LINF_110019700

Length:

386

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HV44

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HV44

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	274	278	PF00656	0.351
CLV_C14_Caspase3-7	34	38	PF00656	0.306
CLV_MEL_PAP_1	80	86	PF00089	0.465
CLV_NRD_NRD_1	117	119	PF00675	0.559
CLV_NRD_NRD_1	169	171	PF00675	0.527
CLV_NRD_NRD_1	190	192	PF00675	0.566
CLV_NRD_NRD_1	311	313	PF00675	0.377
CLV_NRD_NRD_1	342	344	PF00675	0.515
CLV_NRD_NRD_1	352	354	PF00675	0.405
CLV_NRD_NRD_1	379	381	PF00675	0.580
CLV_NRD_NRD_1	82	84	PF00675	0.403
CLV_PCSK_FUR_1	377	381	PF00082	0.524
CLV_PCSK_KEX2_1	242	244	PF00082	0.535
CLV_PCSK_KEX2_1	311	313	PF00082	0.376
CLV_PCSK_KEX2_1	341	343	PF00082	0.490
CLV_PCSK_KEX2_1	379	381	PF00082	0.608
CLV_PCSK_KEX2_1	82	84	PF00082	0.508
CLV_PCSK_PC1ET2_1	242	244	PF00082	0.421
CLV_PCSK_PC1ET2_1	341	343	PF00082	0.467
CLV_PCSK_PC7_1	338	344	PF00082	0.396
CLV_PCSK_SKI1_1	171	175	PF00082	0.472
CLV_PCSK_SKI1_1	192	196	PF00082	0.397
CLV_PCSK_SKI1_1	231	235	PF00082	0.427
CLV_PCSK_SKI1_1	292	296	PF00082	0.508
CLV_PCSK_SKI1_1	329	333	PF00082	0.512
CLV_PCSK_SKI1_1	338	342	PF00082	0.402
CLV_PCSK_SKI1_1	354	358	PF00082	0.300
CLV_PCSK_SKI1_1	51	55	PF00082	0.360
CLV_PCSK_SKI1_1	76	80	PF00082	0.528
DEG_APCC_DBOX_1	230	238	PF00400	0.524
DOC_MAPK_gen_1	24	33	PF00069	0.334
DOC_MAPK_gen_1	341	349	PF00069	0.542
DOC_MAPK_gen_1	82	88	PF00069	0.443
DOC_MAPK_MEF2A_6	342	351	PF00069	0.501
DOC_PP1_RVXF_1	270	276	PF00149	0.520
DOC_PP4_FxxP_1	64	67	PF00568	0.510
DOC_SPAK_OSR1_1	83	87	PF12202	0.505
DOC_USP7_MATH_1	216	220	PF00917	0.598
DOC_USP7_MATH_1	229	233	PF00917	0.421
DOC_USP7_MATH_1	307	311	PF00917	0.503
DOC_USP7_MATH_1	36	40	PF00917	0.410
DOC_USP7_UBL2_3	238	242	PF12436	0.510
DOC_WW_Pin1_4	106	111	PF00397	0.597
LIG_14-3-3_CanoR_1	118	122	PF00244	0.605
LIG_14-3-3_CanoR_1	155	161	PF00244	0.371
LIG_14-3-3_CanoR_1	170	177	PF00244	0.372
LIG_14-3-3_CanoR_1	178	182	PF00244	0.337
LIG_14-3-3_CanoR_1	209	214	PF00244	0.378
LIG_14-3-3_CanoR_1	264	269	PF00244	0.459
LIG_BIR_III_4	37	41	PF00653	0.306
LIG_FHA_1	55	61	PF00498	0.410
LIG_FHA_2	118	124	PF00498	0.547
LIG_FHA_2	203	209	PF00498	0.312
LIG_FHA_2	299	305	PF00498	0.422
LIG_FHA_2	371	377	PF00498	0.537
LIG_KLC1_Yacidic_2	29	34	PF13176	0.222
LIG_LIR_Apic_2	14	18	PF02991	0.383
LIG_LIR_Apic_2	56	61	PF02991	0.373
LIG_LIR_Gen_1	20	30	PF02991	0.282
LIG_LIR_Gen_1	205	215	PF02991	0.428
LIG_LIR_Nem_3	20	25	PF02991	0.432
LIG_LIR_Nem_3	203	207	PF02991	0.477
LIG_LIR_Nem_3	335	340	PF02991	0.553
LIG_MYND_3	94	98	PF01753	0.527
LIG_SH2_CRK	15	19	PF00017	0.355
LIG_SH2_CRK	337	341	PF00017	0.493
LIG_SH2_CRK	58	62	PF00017	0.507
LIG_SH2_NCK_1	15	19	PF00017	0.410
LIG_SH2_NCK_1	186	190	PF00017	0.312
LIG_SH2_NCK_1	58	62	PF00017	0.507
LIG_SH2_PTP2	62	65	PF00017	0.553
LIG_SH2_SRC	10	13	PF00017	0.351
LIG_SH2_SRC	15	18	PF00017	0.317
LIG_SH2_STAP1	186	190	PF00017	0.312
LIG_SH2_STAT5	298	301	PF00017	0.397
LIG_SH2_STAT5	32	35	PF00017	0.368
LIG_SH2_STAT5	359	362	PF00017	0.335
LIG_SH2_STAT5	58	61	PF00017	0.465
LIG_SH2_STAT5	62	65	PF00017	0.525
LIG_SH3_3	107	113	PF00018	0.624
LIG_SH3_3	60	66	PF00018	0.439
LIG_TRAF2_1	256	259	PF00917	0.466
LIG_TRAF2_1	373	376	PF00917	0.538
LIG_WRC_WIRS_1	201	206	PF05994	0.316
MOD_CK1_1	220	226	PF00069	0.615
MOD_CK1_1	56	62	PF00069	0.435
MOD_CK2_1	117	123	PF00069	0.591
MOD_CK2_1	202	208	PF00069	0.493
MOD_CK2_1	298	304	PF00069	0.464
MOD_CK2_1	370	376	PF00069	0.492
MOD_Cter_Amidation	80	83	PF01082	0.371
MOD_GlcNHglycan	19	22	PF01048	0.306
MOD_GlcNHglycan	219	222	PF01048	0.573
MOD_GlcNHglycan	231	234	PF01048	0.270
MOD_GlcNHglycan	37	41	PF01048	0.193
MOD_GlcNHglycan	89	92	PF01048	0.551
MOD_GSK3_1	177	184	PF00069	0.428
MOD_GSK3_1	216	223	PF00069	0.653
MOD_GSK3_1	246	253	PF00069	0.471
MOD_NEK2_1	181	186	PF00069	0.530
MOD_NEK2_1	251	256	PF00069	0.474
MOD_PIKK_1	137	143	PF00454	0.454
MOD_PKA_2	117	123	PF00069	0.496
MOD_PKA_2	154	160	PF00069	0.567
MOD_PKA_2	169	175	PF00069	0.293
MOD_PKA_2	177	183	PF00069	0.476
MOD_PKA_2	249	255	PF00069	0.577
MOD_Plk_1	181	187	PF00069	0.542
MOD_Plk_1	246	252	PF00069	0.473
MOD_Plk_4	181	187	PF00069	0.398
MOD_Plk_4	264	270	PF00069	0.573
MOD_ProDKin_1	106	112	PF00069	0.592
MOD_SUMO_rev_2	163	173	PF00179	0.303
MOD_SUMO_rev_2	232	240	PF00179	0.476
TRG_DiLeu_BaEn_4	246	252	PF01217	0.478
TRG_DiLeu_BaLyEn_6	73	78	PF01217	0.494
TRG_DiLeu_BaLyEn_6	92	97	PF01217	0.563
TRG_ENDOCYTIC_2	207	210	PF00928	0.484
TRG_ENDOCYTIC_2	337	340	PF00928	0.507
TRG_ER_diArg_1	132	135	PF00400	0.514
TRG_ER_diArg_1	319	322	PF00400	0.450
TRG_ER_diArg_1	377	380	PF00400	0.607
TRG_ER_diArg_1	82	84	PF00400	0.403

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJ47	Leptomonas seymouri	46%	100%
A0A1X0NUT5	Trypanosomatidae	26%	100%
A0A3Q8I836	Leishmania donovani	99%	100%
A0A3R7RDU1	Trypanosoma rangeli	29%	98%
A4H6R1	Leishmania braziliensis	64%	100%
D0A7A4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9ANS5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4QGU4	Leishmania major	84%	100%
V5DT68	Trypanosoma cruzi	29%	98%