Uncharacterized protein

Quick info Localization Phosphorylation Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HV41_LEIIN

TriTrypDb:

LINF_110019300

Length:

200

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Phosphorylation

Promastigote: 20, 92

Expansion

Sequence features

A4HV41

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HV41

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	137	141	PF00656	0.535
CLV_NRD_NRD_1	14	16	PF00675	0.525
CLV_NRD_NRD_1	143	145	PF00675	0.514
CLV_NRD_NRD_1	191	193	PF00675	0.424
CLV_NRD_NRD_1	2	4	PF00675	0.740
CLV_PCSK_KEX2_1	14	16	PF00082	0.525
CLV_PCSK_KEX2_1	143	145	PF00082	0.538
CLV_PCSK_KEX2_1	2	4	PF00082	0.740
CLV_PCSK_PC7_1	139	145	PF00082	0.530
CLV_PCSK_SKI1_1	65	69	PF00082	0.543
DEG_Nend_UBRbox_1	1	4	PF02207	0.586
DOC_CKS1_1	74	79	PF01111	0.614
DOC_CYCLIN_yCln2_LP_2	71	77	PF00134	0.542
DOC_PP2B_LxvP_1	52	55	PF13499	0.550
DOC_PP2B_LxvP_1	71	74	PF13499	0.582
DOC_PP2B_LxvP_1	79	82	PF13499	0.528
DOC_USP7_MATH_1	191	195	PF00917	0.515
DOC_WW_Pin1_4	73	78	PF00397	0.611
DOC_WW_Pin1_4	89	94	PF00397	0.619
LIG_14-3-3_CanoR_1	115	125	PF00244	0.474
LIG_14-3-3_CanoR_1	17	22	PF00244	0.448
LIG_14-3-3_CanoR_1	192	196	PF00244	0.472
LIG_14-3-3_CanoR_1	2	9	PF00244	0.691
LIG_EVH1_1	52	56	PF00568	0.520
LIG_FHA_1	62	68	PF00498	0.660
LIG_FHA_1	74	80	PF00498	0.595
LIG_FHA_1	95	101	PF00498	0.531
LIG_LIR_Gen_1	127	136	PF02991	0.493
LIG_LIR_Gen_1	178	187	PF02991	0.420
LIG_LIR_Gen_1	66	75	PF02991	0.571
LIG_LIR_Nem_3	124	128	PF02991	0.424
LIG_LIR_Nem_3	178	183	PF02991	0.444
LIG_LIR_Nem_3	57	62	PF02991	0.511
LIG_LIR_Nem_3	66	71	PF02991	0.500
LIG_SH3_1	87	93	PF00018	0.653
LIG_SH3_3	19	25	PF00018	0.553
LIG_SH3_3	50	56	PF00018	0.585
LIG_SH3_3	71	77	PF00018	0.575
LIG_SH3_3	87	93	PF00018	0.666
LIG_TRFH_1	59	63	PF08558	0.547
LIG_UBA3_1	169	176	PF00899	0.431
MOD_CK1_1	121	127	PF00069	0.459
MOD_GlcNHglycan	120	123	PF01048	0.459
MOD_GlcNHglycan	189	192	PF01048	0.495
MOD_GlcNHglycan	19	22	PF01048	0.539
MOD_GSK3_1	178	185	PF00069	0.471
MOD_GSK3_1	187	194	PF00069	0.543
MOD_GSK3_1	29	36	PF00069	0.621
MOD_GSK3_1	63	70	PF00069	0.526
MOD_N-GLC_1	33	38	PF02516	0.671
MOD_NEK2_1	116	121	PF00069	0.509
MOD_NEK2_2	63	68	PF00069	0.578
MOD_PKA_2	1	7	PF00069	0.580
MOD_PKA_2	191	197	PF00069	0.488
MOD_PKB_1	15	23	PF00069	0.594
MOD_Plk_1	178	184	PF00069	0.444
MOD_Plk_1	47	53	PF00069	0.558
MOD_Plk_2-3	96	102	PF00069	0.538
MOD_Plk_4	54	60	PF00069	0.557
MOD_Plk_4	63	69	PF00069	0.613
MOD_ProDKin_1	73	79	PF00069	0.612
MOD_ProDKin_1	89	95	PF00069	0.612
MOD_SUMO_for_1	103	106	PF00179	0.482
MOD_SUMO_rev_2	147	154	PF00179	0.503
MOD_SUMO_rev_2	172	177	PF00179	0.464
MOD_SUMO_rev_2	4	9	PF00179	0.556
TRG_DiLeu_BaEn_1	165	170	PF01217	0.393
TRG_DiLeu_BaLyEn_6	112	117	PF01217	0.481
TRG_ENDOCYTIC_2	128	131	PF00928	0.452
TRG_ENDOCYTIC_2	59	62	PF00928	0.549
TRG_ER_diArg_1	1	3	PF00400	0.707
TRG_ER_diArg_1	13	15	PF00400	0.535
TRG_ER_diArg_1	143	146	PF00400	0.545
TRG_Pf-PMV_PEXEL_1	143	147	PF00026	0.620
TRG_Pf-PMV_PEXEL_1	175	179	PF00026	0.461

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P412	Leptomonas seymouri	49%	98%
A0A3Q8I940	Leishmania donovani	100%	100%
A4H6Q7	Leishmania braziliensis	78%	100%
D0A7A7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9ANS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4QGU7	Leishmania major	94%	100%