ATP-binding cassette protein subfamily A, member 4

Quick info Annotations Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP-binding cassette protein subfamily A, member 4, putative

Species:

Leishmania infantum

UniProt:

A4HV32_LEIIN

TriTrypDb:

LINF_110018350

Length:

1897

Annotations

Annotations by Jardim et al.

Transporters, ATP-binding cassette A, member 4 ABCA4

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 46
NetGPI	no	yes: 0, no: 46

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	47
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0043229	intracellular organelle	3	7
GO:0043231	intracellular membrane-bounded organelle	4	7
GO:0110165	cellular anatomical entity	1	47

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Phosphorylation

Amastigote: 1888, 1889

Expansion

Sequence features

A4HV32

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HV32

Function

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Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	7
GO:0006869	lipid transport	5	7
GO:0051179	localization	1	7
GO:0051234	establishment of localization	2	7
GO:0071702	organic substance transport	4	7

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	47
GO:0003824	catalytic activity	1	1
GO:0005215	transporter activity	1	47
GO:0005319	lipid transporter activity	2	7
GO:0005488	binding	1	47
GO:0005524	ATP binding	5	47
GO:0015399	primary active transmembrane transporter activity	4	47
GO:0016787	hydrolase activity	2	1
GO:0017076	purine nucleotide binding	4	47
GO:0022804	active transmembrane transporter activity	3	47

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	105	109	PF00656	0.640
CLV_C14_Caspase3-7	1087	1091	PF00656	0.565
CLV_C14_Caspase3-7	1300	1304	PF00656	0.269
CLV_C14_Caspase3-7	1749	1753	PF00656	0.535
CLV_NRD_NRD_1	1051	1053	PF00675	0.490
CLV_NRD_NRD_1	1134	1136	PF00675	0.249
CLV_NRD_NRD_1	128	130	PF00675	0.459
CLV_NRD_NRD_1	1520	1522	PF00675	0.361
CLV_NRD_NRD_1	1549	1551	PF00675	0.350
CLV_NRD_NRD_1	1670	1672	PF00675	0.267

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0G2K1Q8	Rattus norvegicus	31%	100%
A0A0N0P411	Leptomonas seymouri	45%	95%
A0A0N1I1A6	Leptomonas seymouri	29%	100%
A0A0N1IH55	Leptomonas seymouri	65%	100%
A0A0S4IQH9	Bodo saltans	31%	100%
A0A0S4IUV3	Bodo saltans	48%	100%
A0A0S4IZR8	Bodo saltans	41%	100%
A0A0S4J5Z1	Bodo saltans	48%	100%
A0A0S4J9S9	Bodo saltans	40%	100%
A0A0S4JDK3	Bodo saltans	39%	100%

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